TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 441.889 | Formula: C17H20ClN5O5S
H donors: 3 H acceptors: 6 LogP: 2.73 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccnc(n1)NC(=O)NS(=O)(=O)c1cc(ccc1Cl)NC(=O)C(C)(C)C
InChi: 1S/C17H20ClN5O5S/c1-17(2,3)14(24)20-10-5-6-11(18)12(9-10)29(26,27)23-16(25)22-15-19-8-7-13(21-15)28-4/h5-9H,1-4H3,(H,20,24)(H2,19,21,22,23,25)
InChiKey: NPDPWDRJHKOLMK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.0948	0.0311	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0133	0.001	0.001
Onchocerca volvulus		0.0133	0.001	0.0318
Echinococcus multilocularis	epidermal growth factor receptor	0.0133	0.001	0.001
Brugia malayi	RhoGAP domain containing protein	0.0948	0.0311	0.0322
Loa Loa (eye worm)	TK/INSR protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0133	0.001	0.0318
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0133	0.001	0.001
Entamoeba histolytica	receptor protein kinase, putative	0.0133	0.001	0.0318
Echinococcus granulosus	integrin linked protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	epidermal growth factor receptor	0.0133	0.001	0.001
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0165	0.0022	0.0697
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0133	0.001	0.001
Onchocerca volvulus		0.0133	0.001	0.0318
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase pr2	0.0133	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Entamoeba histolytica	serine/threonine kinase, putative	0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Brugia malayi	RhoGAP domain containing protein	0.0948	0.0311	0.0322
Brugia malayi	Tyrosine-protein kinase abl-1	0.0133	0.001	0.001
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Loa Loa (eye worm)	TK/FAK protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Echinococcus granulosus	protein kinase c epsilon type	0.098	0.0323	0.0323
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0133	0.001	0.001
Brugia malayi	Furin-like cysteine rich region family protein	0.0133	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.098	0.0323	0.0323
Loa Loa (eye worm)	TK/ABL protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Entamoeba histolytica	cysteine surface protein, putative	0.0133	0.001	0.0318
Schistosoma mansoni	serine/threonine protein kinase	0.4241	0.1527	0.1527
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0948	0.0311	0.0311
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0133	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.098	0.0323	0.0323
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Schistosoma mansoni	protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Schistosoma mansoni	ephrin receptor	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine kinase	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase Srms	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine kinase	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0133	0.001	0.001
Leishmania major	protein kinase, putative	0.0133	0.001	0.4562
Echinococcus multilocularis	N chimaerin	0.0948	0.0311	0.0311
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Schistosoma mansoni	diacylglycerol kinase theta	0.0948	0.0311	0.0311
Loa Loa (eye worm)	TK protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.098	0.0323	0.0323
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Echinococcus granulosus	c src tyrosine kinase	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine kinase	0.0133	0.001	0.001
Echinococcus granulosus	activated cdc42 kinase 1	0.0133	0.001	0.001
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0133	0.001	0.001
Plasmodium falciparum	protein kinase, putative	0.0133	0.001	0.4562
Trichomonas vaginalis	CAMK family protein kinase	0.8514	0.3105	0.6657
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.4241	0.1527	0.1527
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0133	0.001	0.001
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/Met protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Schistosoma mansoni	protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Echinococcus granulosus	epidermal growth factor receptor	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Giardia lamblia	Kinase, NEK	0.0133	0.001	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	ephrin type A receptor 4 A	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0133	0.001	0.001
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0133	0.001	1
Brugia malayi	diacylglycerol kinase	0.0948	0.0311	0.0322
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.098	0.0323	0.0324
Echinococcus granulosus	natriuretic peptide receptor 1	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Schistosoma mansoni	protein kinase	0.0133	0.001	0.001
Onchocerca volvulus		0.0133	0.001	0.0318
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0133	0.001	0.001
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0133	0.001	0.0318
Toxoplasma gondii	protein kinase domain-containing protein	0.0133	0.001	0.0318
Onchocerca volvulus		0.0133	0.001	0.0318
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.4241	0.1527	0.1527
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0133	0.001	0.001
Onchocerca volvulus		0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0133	0.001	0.001
Onchocerca volvulus		0.0133	0.001	0.0318
Echinococcus granulosus	protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0133	0.001	0.001
Echinococcus granulosus	activated cdc42 kinase 1	0.0133	0.001	0.001
Loa Loa (eye worm)	TK protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	TK protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	myotubularin protein 13	0.0948	0.0311	0.0311
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Echinococcus multilocularis	integrin linked protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0133	0.001	0.001
Brugia malayi	Protein kinase c protein 2	0.098	0.0323	0.0335
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	ankyrin repeat protein	0.0133	0.001	0.0318
Schistosoma mansoni	serine/threonine protein kinase	0.4241	0.1527	0.1527
Entamoeba histolytica	serine/threonine kinase, putative	0.0133	0.001	0.0318
Echinococcus granulosus	tyrosine protein kinase csk	0.0133	0.001	0.001
Toxoplasma gondii	protein kinase	0.0133	0.001	0.0318
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Schistosoma mansoni	ephrin receptor	0.0133	0.001	0.001
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Brugia malayi	hypothetical protein	0.0133	0.001	0.001
Brugia malayi	diacylglycerol kinase	0.0948	0.0311	0.0322
Plasmodium falciparum	protein kinase, putative	0.0165	0.0022	1
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0948	0.0311	0.0311
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	1.5411	0.5653	0.5681
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0133	0.001	0.0318
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0133	0.001	0.001
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0133	0.001	0.001
Echinococcus granulosus	maternal embryonic leucine zipper kinase	0.8514	0.3105	0.3105
Loa Loa (eye worm)	TK/EPH protein kinase	0.0133	0.001	0.001
Onchocerca volvulus	Tyrosine kinase homolog	0.0133	0.001	0.0318
Brugia malayi	SH2 domain containing protein	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Schistosoma mansoni	protein kinase C mu	0.0948	0.0311	0.0311
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.4241	0.1527	0.1527
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0133	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0133	0.001	0.001
Echinococcus multilocularis	protein kinase c epsilon type	0.098	0.0323	0.0323
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0133	0.001	0.001
Schistosoma mansoni	protein kinase	0.0165	0.0022	0.0022
Brugia malayi	Pleckstrin Homology Domain	0.0948	0.0311	0.0322
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Loa Loa (eye worm)	TK protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	tyrosin kinase, putative	0.0133	0.001	0.0318
Onchocerca volvulus		0.0133	0.001	0.0318
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Brugia malayi	Tyrosine-protein kinase PR2	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Brugia malayi	C1-like domain containing protein	0.098	0.0323	0.0335
Echinococcus multilocularis	unc 13 (munc13)	0.0948	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Echinococcus granulosus	N chimaerin	0.0948	0.0311	0.0311
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Loa Loa (eye worm)	TK/ACK protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	atypical protein kinase C	0.098	0.0323	0.0323
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0133	0.001	0.001
Echinococcus multilocularis	heat shock protein 70	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase Blk	0.0133	0.001	0.001
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0948	0.0311	0.0313
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0948	0.0311	0.0313
Loa Loa (eye worm)	TK protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0133	0.001	0.0318
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Brugia malayi	Ras association domain family 1 isoform A	0.0948	0.0311	0.0322
Leishmania major	protein kinase, putative	0.0165	0.0022	1
Echinococcus multilocularis	maternal embryonic leucine zipper kinase	0.8514	0.3105	0.3105
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0165	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Echinococcus multilocularis	hypothetical protein	0.4209	0.1516	0.1516
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0133	0.001	0.4562
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Echinococcus granulosus	protein kinase c eta type	0.0948	0.0311	0.0311
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/ROR protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.4241	0.1527	0.1527
Echinococcus multilocularis	protein kinase	0.0133	0.001	0.001
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0948	0.0311	0.0311
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Giardia lamblia	Kinase, NEK	0.0133	0.001	0.5
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Brugia malayi	Raf kinase	2.6234	0.965	1
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0133	0.001	0.001
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0165	0.0022	1
Schistosoma mansoni	protein kinase C	0.0948	0.0311	0.0311
Echinococcus multilocularis	c src tyrosine kinase	0.0133	0.001	0.001
Toxoplasma gondii	STE kinase	0.0133	0.001	0.0318
Loa Loa (eye worm)	TK protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.098	0.0323	0.0324
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Onchocerca volvulus		0.0133	0.001	0.0318
Plasmodium vivax	protein kinase, putative	0.0133	0.001	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0948	0.0311	0.0311
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0165	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Trypanosoma cruzi	protein kinase, putative	0.0133	0.001	0.4562
Echinococcus granulosus	tyrosine protein kinase csk	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	1.2723	0.466	0.4829
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Echinococcus multilocularis	tyrosine protein kinase csk	0.0133	0.001	0.001
Plasmodium falciparum	tyrosine kinase-like protein	0.0133	0.001	0.4562
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase csk	0.0133	0.001	0.001
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0165	0.0022	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/ALK protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	protein kinase	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Giardia lamblia	Protein 21.1	0.0133	0.001	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Onchocerca volvulus		0.0133	0.001	0.0318
Echinococcus multilocularis	insulin receptor	0.0133	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.098	0.0323	0.0323
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0133	0.001	1
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase csk	0.0133	0.001	0.001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0133	0.001	0.001
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0133	0.001	0.4562
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Echinococcus granulosus	kinase suppressor of Ras 1	0.0133	0.001	0.001
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.098	0.0323	0.0323
Plasmodium falciparum	protein kinase, putative	0.0133	0.001	0.4562
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase csk	0.0133	0.001	0.001
Entamoeba histolytica	serine/threonine kinase, putative	0.0133	0.001	0.0318
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.098	0.0323	0.0335
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	unc-13 (munc13)	0.0948	0.0311	0.0311
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Echinococcus multilocularis	myotubularin protein 13	0.0948	0.0311	0.0311
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0133	0.001	0.001
Trypanosoma brucei	protein kinase, putative	0.0165	0.0022	1
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.4241	0.1527	0.1527
Echinococcus granulosus	tyrosine kinase	0.0133	0.001	0.001
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0133	0.001	0.001
Onchocerca volvulus		0.0133	0.001	0.0318
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0133	0.001	0.001
Brugia malayi	SRC-1	0.0133	0.001	0.001
Entamoeba histolytica	tyrosin kinase, putative	0.0133	0.001	0.0318
Schistosoma mansoni	unc-13 (munc13)	0.0948	0.0311	0.0311
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0133	0.001	0.001
Schistosoma mansoni	rac gtpase activating protein	0.0948	0.0311	0.0311
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0948	0.0311	0.0311
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0133	0.001	0.001
Giardia lamblia	Kinase	0.0133	0.001	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Schistosoma mansoni	hypothetical protein	0.4209	0.1516	0.1516
Entamoeba histolytica	serine/threonine kinase, putative	0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Entamoeba histolytica	tyrosin kinase, putative	0.0133	0.001	0.0318
Entamoeba histolytica	diacylglycerol kinase, putative	0.0948	0.0311	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0948	0.0311	0.0313
Brugia malayi	Variant SH3 domain containing protein	0.0948	0.0311	0.0322
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.098	0.0323	0.0324
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0133	0.001	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Schistosoma mansoni	protein kinase	0.0165	0.0022	0.0022
Echinococcus multilocularis	calcium activated potassium channel	0.4241	0.1527	0.1527
Plasmodium falciparum	tyrosine kinase-like protein	0.0133	0.001	0.4562
Loa Loa (eye worm)	SRC-1	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Onchocerca volvulus		0.0133	0.001	0.0318
Echinococcus multilocularis	activin receptor type	0.0165	0.0022	0.0022
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0948	0.0311	0.0311
Echinococcus granulosus	protein kinase c iota type	0.098	0.0323	0.0323
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0133	0.001	0.001
Schistosoma mansoni	protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	serine/threonine protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.4241	0.1527	0.1527
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Schistosoma mansoni	serine/threonine kinase	1.2723	0.466	0.466
Echinococcus granulosus	Protein kinase C brain isozyme	0.098	0.0323	0.0323
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0948	0.0311	0.0311
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Echinococcus multilocularis	activated cdc42 kinase 1	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase csk	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Echinococcus granulosus	tyrosine protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	tyrosin kinase, putative	0.0133	0.001	0.0318
Entamoeba histolytica	serine/threonine kinase, putative	0.0133	0.001	0.0318
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0133	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Echinococcus granulosus	Rac GTPase activating protein 1	0.0948	0.0311	0.0311
Onchocerca volvulus		0.0948	0.0311	1
Schistosoma mansoni	protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Brugia malayi	SH2 domain containing protein	0.0133	0.001	0.001
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0133	0.001	0.001
Echinococcus multilocularis	protein tyrosine kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.4209	0.1516	0.1523
Onchocerca volvulus		0.0133	0.001	0.0318
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0133	0.001	0.001
Brugia malayi	RhoGEF domain containing protein	0.0948	0.0311	0.0322
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0133	0.001	0.001
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0133	0.001	0.001
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0948	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Toxoplasma gondii	diacylglycerol kinase, putative	0.0948	0.0311	1
Schistosoma mansoni	protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	TK protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0133	0.001	0.001
Echinococcus multilocularis	FL cytokine receptor	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.4241	0.1527	0.1527
Loa Loa (eye worm)	CAMK/CAMKL/MELK protein kinase	1.2723	0.466	0.4683
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase shark	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine kinase	0.0133	0.001	0.001
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/DDR protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase	0.0133	0.001	0.001
Brugia malayi	Guanylyl cyclase protein 23	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Echinococcus multilocularis	transfer RNA-Thr	0.0133	0.001	0.001
Echinococcus granulosus	Diacylglycerol kinase theta	0.0948	0.0311	0.0311
Onchocerca volvulus		0.0948	0.0311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Schistosoma mansoni	protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Entamoeba histolytica	hypothetical protein, conserved	0.0133	0.001	0.0318
Onchocerca volvulus		0.0133	0.001	0.0318
Schistosoma mansoni	protein tyrosine kinase	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0133	0.001	0.001
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0165	0.0022	0.0022
Loa Loa (eye worm)	TK/RYK protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0133	0.001	0.001
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0133	0.001	0.0318
Echinococcus multilocularis	epidermal growth factor receptor	0.0133	0.001	0.001
Schistosoma mansoni	diacylglycerol kinase theta	0.0948	0.0311	0.0311
Echinococcus multilocularis	protein kinase c eta type	0.0948	0.0311	0.0311
Schistosoma mansoni	serine/threonine protein kinase	0.098	0.0323	0.0323
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Brugia malayi	protein kinase C3,putative	0.098	0.0323	0.0335
Trypanosoma brucei	Pseudokinase, putative	0.0133	0.001	0.4562
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Brugia malayi	protein-tyrosine kinase	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/CSK protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0133	0.001	0.001
Schistosoma mansoni	serine/threonine RGC	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Entamoeba histolytica	tyrosine kinase, putative	0.0133	0.001	0.0318
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Brugia malayi	integrin-linked kinase	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0948	0.0311	0.0311
Entamoeba histolytica	protein kinase, putative	0.0133	0.001	0.0318
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0133	0.001	0.001
Entamoeba histolytica	diacylglycerol kinase, putative	0.0948	0.0311	1
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Schistosoma mansoni	vav2	0.0948	0.0311	0.0311
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0133	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.098	0.0323	0.0323
Loa Loa (eye worm)	TK protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	activin receptor type	0.0165	0.0022	0.0022
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0133	0.001	0.001
Brugia malayi	hypothetical protein	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0133	0.001	0.0318
Trypanosoma cruzi	protein kinase, putative	0.0133	0.001	0.4562
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0133	0.001	0.001
Trichomonas vaginalis	CAMK family protein kinase	1.2723	0.466	1
Entamoeba histolytica	protein kinase domain containing protein	0.0165	0.0022	0.0697
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase shark	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0133	0.001	0.001
Loa Loa (eye worm)	raf kinase	2.7049	0.9951	1
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Entamoeba histolytica	ankyrin repeat protein	0.0133	0.001	0.0318
Entamoeba histolytica	hypothetical protein	0.0133	0.001	0.0318
Trichomonas vaginalis	CAMK family protein kinase	0.8514	0.3105	0.6657
Brugia malayi	C-terminal src kinase protein 1	0.0133	0.001	0.001
Brugia malayi	protein kinase C II.	0.098	0.0323	0.0335
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0133	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.4209	0.1516	0.1516
Echinococcus granulosus	protein tyrosine kinase	0.0133	0.001	0.001
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.098	0.0323	0.0323
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Entamoeba histolytica	receptor protein kinase, putative	0.0133	0.001	0.0318
Entamoeba histolytica	serine/threonine kinase, putative	0.0133	0.001	0.0318
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0133	0.001	0.001
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	TK protein kinase	0.0133	0.001	0.001
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.098	0.0323	0.0335
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Brugia malayi	Protein kinase domain containing protein	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0133	0.001	0.001
Echinococcus granulosus	insulin receptor	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0948	0.0311	0.0313
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0948	0.0311	0.0313
Loa Loa (eye worm)	TK protein kinase	0.0133	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Echinococcus multilocularis	protein kinase c iota type	0.098	0.0323	0.0323
Onchocerca volvulus		0.0133	0.001	0.0318
Echinococcus granulosus	tyrosine protein kinase HCK	0.0133	0.001	0.001
Echinococcus granulosus	calcium activated potassium channel	0.4241	0.1527	0.1527
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Echinococcus multilocularis	protein kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0133	0.001	0.001
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0133	0.001	0.0318
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0133	0.001	0.001
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0165	0.0022	1
Echinococcus granulosus	unc 13 munc13	0.0948	0.0311	0.0311
Onchocerca volvulus		0.0948	0.0311	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0133	0.001	0.001
Schistosoma mansoni	protein kinase	0.0165	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0133	0.001	0.0318
Schistosoma mansoni	tyrosine kinase	0.0133	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0133	0.001	0.001
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0133	0.001	0.001
Brugia malayi	ephrin receptor 1 precursor	0.0133	0.001	0.001
Brugia malayi	Kinase associated domain 1 family protein	0.4209	0.1516	0.157
Schistosoma mansoni	hypothetical protein	0.0133	0.001	0.001
Schistosoma mansoni	protein kinase C mu	0.098	0.0323	0.0323
Brugia malayi	hypothetical protein	0.0133	0.001	0.001
Leishmania major	hypothetical protein, conserved	0.0133	0.001	0.4562
Onchocerca volvulus		0.0133	0.001	0.0318
Schistosoma mansoni	serine/threonine protein kinase	0.0133	0.001	0.001
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0133	0.001	0.001
Echinococcus granulosus	receptor type guanylyl cyclase	0.0133	0.001	0.001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1951375

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1614538