TDR Targets

Basic information

Technical information

TDR Targets ID: 1614896
Name: 6-morpholin-4-yl-3,4-dihydro-1H-quinoxalin-2- one
MW: 233.266 | Formula: C12H15N3O2
H donors: 2 H acceptors: 1 LogP: 0.64 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CNc2c(N1)ccc(c2)N1CCOCC1
InChi: 1S/C12H15N3O2/c16-12-8-13-11-7-9(1-2-10(11)14-12)15-3-5-17-6-4-15/h1-2,7,13H,3-6,8H2,(H,14,16)
InChiKey: FKRRSRIVFUELDS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-morpholino-3,4-dihydro-1H-quinoxalin-2-one
NSC696227
NCI60_034365
6-(4-Morpholinyl)-3,4-dihydro-2(1H)-quinoxalinone
AIDS-152363
AIDS152363

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	GTP binding protein rare7l, putative	0.0072	0.037	0.3722
Echinococcus multilocularis	leucine rich repeat containing protein 23	0.0016	0.0039	0.0028
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0097	0.5
Schistosoma mansoni	hypothetical protein	0.0072	0.037	1
Trichomonas vaginalis	protein phosphatases pp1 regulatory subunit, putative	0.0016	0.0039	0.0149
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.037	1
Brugia malayi	Leucine Rich Repeat family protein	0.0016	0.0039	0.0028
Toxoplasma gondii	ABC1 family protein	0.0026	0.0097	1
Onchocerca volvulus		0.0026	0.0097	0.0775
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0022	0.0071	0.006
Loa Loa (eye worm)	beta-lactamase	0.0026	0.0097	0.0087
Echinococcus multilocularis	leucine rich repeat containing protein 9	0.0014	0.0026	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0087
Onchocerca volvulus		0.0026	0.0097	0.0775
Schistosoma mansoni	dynein light chain	0.0014	0.0026	0.0398
Trichomonas vaginalis	penicillin-binding protein, putative	0.0026	0.0097	0.0775
Echinococcus granulosus	leucine rich repeat containing protein 23	0.0016	0.0039	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0089	0.0079
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.037	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0087
Trichomonas vaginalis	set domain proteins, putative	0.0171	0.0952	1
Onchocerca volvulus		0.0171	0.0952	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0156	0.0146
Onchocerca volvulus	Mitochondrial Rho GTPase homolog	0.0072	0.037	0.3722
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0097	0.2082
Echinococcus granulosus	histone lysine methyltransferase setb	0.0022	0.0071	0.0063
Trichomonas vaginalis	esterase, putative	0.0026	0.0097	0.0775
Trichomonas vaginalis	D-aminoacylase, putative	0.0026	0.0097	0.0775
Trichomonas vaginalis	hypothetical protein	0.0072	0.037	0.3722
Brugia malayi	beta-lactamase family protein	0.0026	0.0097	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0087
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0011	0.0011	0.0003
Entamoeba histolytica	leucine-rich repeat containing protein	0.0014	0.0026	0.0689
Entamoeba histolytica	hypothetical protein	0.0026	0.0097	0.2624
Schistosoma mansoni	protein phosphatases pp1 regulatory subunit	0.0014	0.0026	0.0398
Echinococcus granulosus	rab protein 3	0.0072	0.037	0.0362
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0036	0.0156	0.0146
Mycobacterium ulcerans	lipase LipD	0.0026	0.0097	0.5
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0166	0.0923	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0022	0.0071	0.1668
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.1695	0.9932	1
Trichomonas vaginalis	toll, putative	0.0016	0.0039	0.0149
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0011	0.0011	0.0003
Brugia malayi	hypothetical protein	0.0072	0.037	0.0362
Entamoeba histolytica	hypothetical protein	0.0026	0.0097	0.2624
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0022	0.0071	0.006
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0087
Brugia malayi	Leucine Rich Repeat family protein	0.0014	0.0026	0.0014
Onchocerca volvulus		0.0016	0.0039	0.0149
Plasmodium vivax	ras-related protein Rab-5A, putative	0.0072	0.037	1
Plasmodium vivax	protein phosphatases PP1 regulatory subunit sds22, putative	0.0016	0.0039	0.04
Brugia malayi	Leucine Rich Repeat family protein	0.0016	0.0039	0.0028
Onchocerca volvulus		0.0022	0.0071	0.0492
Brugia malayi	latrophilin 2 splice variant baaae	0.0025	0.0089	0.0079
Trichomonas vaginalis	penicillin-binding protein, putative	0.0026	0.0097	0.0775
Onchocerca volvulus		0.0026	0.0097	0.0775
Echinococcus granulosus	GTP binding protein Parf	0.0072	0.037	0.0362
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0026	0.0097	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0015	0.0034	0.009
Entamoeba histolytica	leucine rich repeat and phosphatase domain containing protein	0.0014	0.0026	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0087
Entamoeba histolytica	hypothetical protein	0.0026	0.0097	0.2624
Toxoplasma gondii	leucine-rich repeat protein LRR1	0.0016	0.0039	0.1921
Brugia malayi	Ras-related protein ypt4	0.0072	0.037	0.0362
Entamoeba histolytica	hypothetical protein	0.0072	0.037	1
Leishmania major	hypothetical protein, conserved	0.0072	0.037	1
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.1695	0.9932	1
Brugia malayi	RAB, member of RAS oncogene family-like 5	0.0072	0.037	0.0362
Entamoeba histolytica	hypothetical protein	0.0072	0.037	1
Mycobacterium ulcerans	beta-lactamase	0.0026	0.0097	0.5
Mycobacterium leprae	Probable lipase LipE	0.0026	0.0097	0.5
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.015	0.083	0.0825
Brugia malayi	beta-lactamase	0.0026	0.0097	0.0087
Schistosoma mansoni	hypothetical protein	0.0026	0.0097	0.2394
Echinococcus multilocularis	cell polarity protein leucine rich repeat	0.0016	0.0039	0.0028
Leishmania major	hypothetical protein, conserved	0.0026	0.0097	0.2082
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.037	0.3722
Brugia malayi	Leucine Rich Repeat family protein	0.0014	0.0026	0.0014
Schistosoma mansoni	calpain 4 6 7 invertebrate	0.0014	0.0026	0.0398
Plasmodium vivax	SET domain protein, putative	0.0022	0.0071	0.1322
Echinococcus multilocularis	ras-related protein rab-5	0.0072	0.037	0.0362
Entamoeba histolytica	hypothetical protein	0.0015	0.0034	0.0913
Echinococcus granulosus	GPCR family 2	0.0011	0.0011	0.0003
Trypanosoma brucei	Rab-like 5, small G protein	0.0072	0.037	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0097	0.2082
Echinococcus multilocularis	leucine rich repeat and coiled coil	0.0014	0.0026	0.0014
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0026	0.0097	0.0087
Leishmania major	hypothetical protein, conserved	0.0072	0.037	1
Brugia malayi	Pre-SET motif family protein	0.015	0.083	0.0825
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0022	0.0071	0.1668
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0026	0.0097	0.2397
Plasmodium falciparum	ras-related protein Rab-5A	0.0072	0.037	1
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0014	0.0026	0.0014
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0016	0.0039	0.04
Onchocerca volvulus	Peroxidasin homolog	0.0016	0.0039	0.0149
Schistosoma mansoni	hypothetical protein	0.0025	0.0089	0.2169
Echinococcus multilocularis	leucine rich repeat containing protein 57	0.0016	0.0039	0.0028
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0022	0.0071	0.6353
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0097	0.2082
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0036	0.0156	0.0146
Brugia malayi	Protein kinase domain containing protein	0.1695	0.9932	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.037	0.0362
Trypanosoma cruzi	Rab-like 5, small G protein	0.0072	0.037	1
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0097	0.2082
Trypanosoma cruzi	protein phosphatase 1, regulatory subunit, putative	0.0016	0.0039	0.04
Giardia lamblia	Leucine-rich repeat protein	0.0016	0.0039	1
Entamoeba histolytica	hypothetical protein	0.0026	0.0097	0.2624
Schistosoma mansoni	protein phosphatases pp1 regulatory subunit	0.0014	0.0026	0.0398
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0026	0.0097	0.0087
Leishmania major	hypothetical protein, conserved	0.0016	0.0039	0.04
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0022	0.0071	0.1668
Schistosoma mansoni	transcription factor LCR-F1	0.0026	0.0097	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0072	0.037	0.0362
Mycobacterium leprae	conserved hypothetical protein	0.0026	0.0097	0.5
Brugia malayi	beta-lactamase family protein	0.0026	0.0097	0.0087
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0026	0.0097	0.2397
Brugia malayi	hypothetical protein	0.0026	0.0097	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0071	0.006
Mycobacterium ulcerans	esterase/lipase LipP	0.0026	0.0097	0.5
Trichomonas vaginalis	leucine-rich repeat-containing protein, putative	0.0016	0.0039	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0087
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0014	0.0026	0.0014
Onchocerca volvulus		0.0016	0.0039	0.0149
Echinococcus multilocularis	GTP binding protein Parf	0.0072	0.037	0.0362
Schistosoma mansoni	hypothetical protein	0.0014	0.0026	0.0398
Trichomonas vaginalis	D-aminoacylase, putative	0.0026	0.0097	0.0775
Brugia malayi	Leucine Rich Repeat family protein	0.0014	0.0026	0.0014
Echinococcus granulosus	beta LACTamase domain containing family member	0.0026	0.0097	0.0089
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.037	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0026	0.0398
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0026	0.0097	0.0089
Trichomonas vaginalis	D-aminoacylase, putative	0.0026	0.0097	0.0775
Onchocerca volvulus		0.0072	0.037	0.3722
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0026	0.0097	0.0087
Trichomonas vaginalis	leucine-rich repeat-containing protein, putative	0.0016	0.0039	0.0149
Brugia malayi	Pre-SET motif family protein	0.0022	0.0071	0.006
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0022	0.0071	0.1668
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0036	0.0156	0.0146
Onchocerca volvulus		0.0016	0.0039	0.0149
Echinococcus multilocularis	rab protein 3	0.0072	0.037	0.0362
Echinococcus multilocularis	nischarin	0.0014	0.0026	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0072	0.037	0.0362
Echinococcus multilocularis	protein phosphatase 1 regulatory subunit 7	0.0014	0.0026	0.0014
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0021	0.0066	0.0058
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0026	0.0097	0.0087
Echinococcus granulosus	nischarin	0.0014	0.0026	0.0017

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1970823

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1614896