TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.357 | Formula: C19H17N3O2
H donors: 1 H acceptors: 2 LogP: 3.17 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: N#CCC(=O)N/N=C\c1ccccc1OC/C=C/c1ccccc1
InChi: 1S/C19H17N3O2/c20-13-12-19(23)22-21-15-17-10-4-5-11-18(17)24-14-6-9-16-7-2-1-3-8-16/h1-11,15H,12,14H2,(H,22,23)/b9-6+,21-15-
InChiKey: LGKPJZFVLDXRFJ-OQTFOHMESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Niemann-Pick disease, type C1	Starlite/ChEMBL	No references
Homo sapiens	breast cancer 1, early onset	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home	Get druggable targets OG5_128206	All targets in OG5_128206
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Niemann-Pick C1 protein precursor	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus granulosus	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Niemann-Pick C1 protein precursor, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	expressed conserved protein	Get druggable targets OG5_128206	All targets in OG5_128206
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Entamoeba histolytica	Niemann-Pick C1 protein, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	niemann-pick C1 (NPC1)	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus multilocularis	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K07003 Niemann Pick type C1, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus multilocularis	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma japonicum	Niemann-Pick C1 protein precursor, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0337	0.221	0.2151
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0244	0.017
Brugia malayi	latrophilin 2 splice variant baaae	0.0078	0.0371	0.0527
Brugia malayi	TAR-binding protein	0.0076	0.0362	0.0514
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0071	0.0322	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.0673	0.0955
Schistosoma mansoni	hypothetical protein	0.0049	0.0169	0.0094
Loa Loa (eye worm)	CAMK/CAMKL/MELK protein kinase	0.1019	0.7045	1
Echinococcus multilocularis	geminin	0.0205	0.1271	0.1205
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0212	0.03
Echinococcus granulosus	calcium activated potassium channel	0.034	0.2228	0.217
Echinococcus multilocularis	protein dispatched 1	0.0058	0.0233	0.0159
Echinococcus granulosus	Niemann Pick C1 protein	0.017	0.1025	0.0957
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.6766	0.6741
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0212	0.0138
Brugia malayi	MH2 domain containing protein	0.012	0.0673	0.0955
Echinococcus multilocularis	sterol regulatory element binding protein	0.0051	0.0182	0.0108
Echinococcus multilocularis	Niemann Pick C1 protein	0.017	0.1025	0.0957
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0362	0.0514
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0077	0.0002
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0119	0.0663	1
Echinococcus granulosus	tumor protein p63	0.0408	0.2714	0.2659
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0051	0.0182	0.0258
Echinococcus multilocularis	maternal embryonic leucine zipper kinase	0.0682	0.4655	0.4615
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0077	0.0002
Echinococcus multilocularis	hypothetical protein	0.0337	0.221	0.2151
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.034	0.2228	0.217
Schistosoma mansoni	hypothetical protein	0.0049	0.0169	0.0094
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0362	0.0514
Brugia malayi	Protein kinase domain containing protein	0.1019	0.7045	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0626	0.0889
Echinococcus granulosus	maternal embryonic leucine zipper kinase	0.0682	0.4655	0.4615
Trichomonas vaginalis	CAMK family protein kinase	0.1019	0.7045	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0362	0.029
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0036	0.0075	0.0106
Schistosoma mansoni	hypothetical protein	0.0049	0.0169	0.0094
Echinococcus granulosus	geminin	0.0205	0.1271	0.1205
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0322	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0077	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0362	0.029
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0114	0.0626	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0663	0.0941
Schistosoma mansoni	serine/threonine protein kinase	0.034	0.2228	0.217
Brugia malayi	CHE-14 protein	0.0051	0.0182	0.0258
Trichomonas vaginalis	CAMK family protein kinase	0.0682	0.4655	0.6517
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.0663	0.0593
Echinococcus multilocularis	calcium activated potassium channel	0.034	0.2228	0.217
Echinococcus granulosus	sterol regulatory element binding protein	0.0051	0.0182	0.0108
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0114	0.0626	0.0889
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0212	0.0138
Echinococcus multilocularis	neuropeptide s receptor	0.0496	0.3337	0.3287
Schistosoma mansoni	hypothetical protein	0.0337	0.221	0.2151
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0212	0.03
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0182	0.0258
Schistosoma mansoni	serine/threonine protein kinase	0.034	0.2228	0.217
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0071	0.0322	0.4179
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0752	0.1067
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0212	0.0138
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0362	0.029
Schistosoma mansoni	serine/threonine protein kinase	0.034	0.2228	0.217
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.0663	0.0593
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0071	0.0322	0.0249
Schistosoma mansoni	serine/threonine kinase	0.1019	0.7045	0.7023
Brugia malayi	hypothetical protein	0.0131	0.0752	0.1067
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.011	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0371	0.0527
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.034	0.2228	0.217
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0322	1
Loa Loa (eye worm)	hypothetical protein	0.0337	0.221	0.3137
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.034	0.2228	0.217
Onchocerca volvulus	Huntingtin homolog	0.0131	0.0752	1
Onchocerca volvulus	Huntingtin homolog	0.0131	0.0752	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0244	0.0346
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0114	0.0626	0.0889
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0362	0.0514
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0362	0.029
Brugia malayi	hypothetical protein	0.0036	0.0077	0.0109
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.0673	0.0955
Schistosoma mansoni	serine/threonine protein kinase	0.034	0.2228	0.217
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0362	0.029
Brugia malayi	Niemann-Pick C1 protein precursor	0.0119	0.0663	0.0941
Echinococcus granulosus	neuropeptide s receptor	0.0496	0.3337	0.3287
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.034	0.2228	0.217
Schistosoma mansoni	hypothetical protein	0.0049	0.0169	0.0094
Brugia malayi	RNA binding protein	0.0076	0.0362	0.0514
Echinococcus multilocularis	neuropeptide receptor A26	0.0496	0.3337	0.3287
Echinococcus multilocularis	expressed conserved protein	0.0112	0.0612	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0752	0.1067
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0212	0.0138
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0362	0.0514
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0362	0.029
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0263	0.0374
Trichomonas vaginalis	CAMK family protein kinase	0.0682	0.4655	0.6517
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0075	0.0106
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0212	0.0138
Echinococcus granulosus	neuropeptide receptor A26	0.0496	0.3337	0.3287
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0212	0.0138
Schistosoma mansoni	patched 1	0.0051	0.0182	0.0108
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0071	0.0322	0.0249
Schistosoma mansoni	hypothetical protein	0.0205	0.1271	0.1205
Schistosoma mansoni	hypothetical protein	0.0078	0.0371	0.0298
Schistosoma mansoni	hypothetical protein	0.0205	0.1271	0.1205
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0322	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0362	0.029
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0077	0.0002
Echinococcus granulosus	Protein patched homolog 1	0.0051	0.0182	0.0108
Echinococcus multilocularis	tumor protein p63	0.0408	0.2714	0.2659
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0212	0.0138
Schistosoma mansoni	serine/threonine protein kinase	0.034	0.2228	0.217
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0071	0.0322	0.0249
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0121	0.0676	0.0606
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0071	0.0322	0.0457
Echinococcus granulosus	expressed conserved protein	0.0112	0.0612	0.0541
Echinococcus multilocularis	protein patched	0.0051	0.0182	0.0108
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.011	0.0036
Brugia malayi	Latrophilin receptor protein 2	0.0036	0.0075	0.0106
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0071	0.0322	0.0457
Brugia malayi	Kinase associated domain 1 family protein	0.0337	0.221	0.3137
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0036	0.0075	0.0106

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3294 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	2.5119 uM	PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	9.1962 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3489 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1964833

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1620207