Detailed information for compound 1620631

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 396.35 | Formula: C19H14F2N6O2
  • H donors: 1 H acceptors: 5 LogP: 2.37 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)c1nc2n(c1c1ccc3n(n1)c(nn3)C(O)(C)C)cco2
  • InChi: 1S/C19H14F2N6O2/c1-19(2,28)17-24-23-14-6-5-13(25-27(14)17)16-15(22-18-26(16)7-8-29-18)11-4-3-10(20)9-12(11)21/h3-9,28H,1-2H3
  • InChiKey: QFDLVEUFUHCRNH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase D3 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL No references
Homo sapiens casein kinase 1, delta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CAMK/PKD protein kinase Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Candida albicans Casein kinase I: DNA repair, meiosis Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, delta isoform, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania major casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Giardia lamblia Kinase, CK1 Casein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi Phorbol esters/diacylglycerol binding domain Get druggable targets OG5_130080 All targets in OG5_130080
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Onchocerca volvulus Get druggable targets OG5_130080 All targets in OG5_130080
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma mansoni protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium falciparum casein kinase 1 Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi casein kinase 1, delta Get druggable targets OG5_126780 All targets in OG5_126780
Cryptosporidium parvum casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Cryptosporidium hominis casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Onchocerca volvulus Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania infantum casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni protein kinase C mu Get druggable targets OG5_130080 All targets in OG5_130080
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum ko:K06070 protein kinase D, putative Get druggable targets OG5_130080 All targets in OG5_130080
Trypanosoma congolense casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum ko:K02218 casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Entamoeba histolytica casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum ko:K06070 protein kinase D, putative Get druggable targets OG5_130080 All targets in OG5_130080
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium berghei casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CAMK/PKD protein kinase Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum expressed protein Get druggable targets OG5_130080 All targets in OG5_130080
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma cruzi casein kinase, delta isoform, putative Get druggable targets OG5_126780 All targets in OG5_126780
Onchocerca volvulus Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Brugia malayi C1-like domain containing protein Get druggable targets OG5_130080 All targets in OG5_130080
Leishmania donovani casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Theileria parva casein kinase I, putative Get druggable targets OG5_126780 All targets in OG5_126780
Babesia bovis casein kinase I, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum ko:K08959 casein kinase 1, delta, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium knowlesi casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania mexicana casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Candida albicans Casein kinase I: DNA repair, meiosis Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Onchocerca volvulus Get druggable targets OG5_130080 All targets in OG5_130080
Trypanosoma brucei gambiense casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum Casein kinase I isoform delta, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma congolense casein kinase I, isoform 2 Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Plasmodium yoelii casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Neospora caninum AFL091Wp, related Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma brucei casein kinase I, isoform 2 Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Onchocerca volvulus Get druggable targets OG5_130080 All targets in OG5_130080
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Toxoplasma gondii casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium vivax casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni diacylglycerol kinase theta 0.0009 0.0365 0.0357
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.1721 0.6194
Brugia malayi diacylglycerol kinase 0.0009 0.0365 0.0569
Brugia malayi diacylglycerol kinase 0.0009 0.0365 0.0569
Plasmodium vivax casein kinase 1, putative 0.0047 0.2769 1
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0047 0.2769 0.4366
Loa Loa (eye worm) hypothetical protein 0.0074 0.4488 0.7077
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.1721 0.6194
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.1721 0.1746
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0041 0.2383 0.2383
Plasmodium falciparum casein kinase 1 0.0047 0.2769 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0365 0.0576
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0009 0.0365 0.0576
Echinococcus granulosus ankyrin repeat protein 0.0156 0.9781 0.9796
Echinococcus granulosus serine/threonine protein kinase 0.0004 0.0017 0.0017
Schistosoma mansoni unc-13 (munc13) 0.0009 0.0365 0.0357
Trypanosoma brucei casein kinase I, isoform 2 0.0047 0.2769 1
Onchocerca volvulus 0.0074 0.4488 0.8473
Onchocerca volvulus 0.0085 0.5231 1
Schistosoma mansoni vav2 0.0012 0.0524 0.0519
Schistosoma mansoni protein kinase C mu 0.0009 0.0365 0.0357
Brugia malayi protein kinase C II. 0.001 0.0442 0.0689
Trypanosoma cruzi casein kinase, putative 0.0047 0.2769 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0009 0.0365 0.1266
Echinococcus granulosus raf serine:threonine protein kinase 0.0009 0.0365 0.0366
Schistosoma mansoni protein kinase 0.0047 0.2769 0.2818
Echinococcus multilocularis ankyrin repeat protein 0.0156 0.9781 0.9781
Schistosoma mansoni unc-13 (munc13) 0.0009 0.0365 0.0357
Echinococcus granulosus casein kinase I delta 0.0047 0.2769 0.2773
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.003 0.1721 0.1721
Schistosoma mansoni hypothetical protein 0.0009 0.0365 0.0357
Trichomonas vaginalis CK1 family protein kinase 0.0047 0.2769 1
Echinococcus granulosus myotubularin protein 13 0.0012 0.0524 0.0525
Echinococcus granulosus casein kinase I alpha 0.0047 0.2769 0.2773
Echinococcus granulosus Diacylglycerol kinase theta 0.0009 0.0365 0.0366
Echinococcus multilocularis protein kinase c iota type 0.001 0.0442 0.0442
Toxoplasma gondii diacylglycerol kinase, putative 0.0009 0.0365 0.1266
Echinococcus granulosus casein kinase I delta 0.0047 0.2769 0.2773
Onchocerca volvulus 0.0083 0.5072 0.9674
Brugia malayi Protein kinase c protein 2 0.001 0.0442 0.0689
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0032 0.1799 0.1801
Loa Loa (eye worm) hypothetical protein 0.003 0.1721 0.2714
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0041 0.2383 0.2386
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0047 0.2769 0.4366
Schistosoma mansoni vam6/vps39 related 0.003 0.1721 0.1746
Echinococcus granulosus casein kinase I alpha 0.0047 0.2769 0.2773
Entamoeba histolytica casein kinase 1, putative 0.0047 0.2769 1
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0009 0.0365 0.0366
Trichomonas vaginalis CK1 family protein kinase 0.0047 0.2769 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.1721 0.1746
Loa Loa (eye worm) hypothetical protein 0.003 0.1721 0.2714
Trypanosoma cruzi casein kinase, putative 0.0047 0.2769 1
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0442 0.0436
Brugia malayi Protein kinase domain containing protein 0.001 0.0442 0.0689
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0009 0.0365 0.0357
Brugia malayi C1-like domain containing protein 0.0084 0.5149 0.8022
Echinococcus multilocularis calcium activated potassium channel 0.0004 0.0062 0.0062
Trypanosoma cruzi casein kinase, putative 0.0047 0.2769 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0365 0.0576
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0032 0.1799 0.1799
Entamoeba histolytica hypothetical protein 0.0009 0.0365 0.1266
Brugia malayi probable protein kinase 0.0104 0.6419 1
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.2383 0.2423
Echinococcus multilocularis raf serine:threonine protein kinase 0.0009 0.0365 0.0365
Loa Loa (eye worm) AGC/AKT protein kinase 0.0004 0.0017 0.0027
Schistosoma mansoni protein kinase 0.0032 0.1799 0.1825
Echinococcus granulosus protein kinase c iota type 0.001 0.0442 0.0443
Loa Loa (eye worm) hypothetical protein 0.0012 0.0524 0.0826
Entamoeba histolytica casein kinase, putative 0.0047 0.2769 1
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0102 0.6342 0.6352
Loa Loa (eye worm) hypothetical protein 0.0009 0.0365 0.0576
Echinococcus multilocularis casein kinase I alpha 0.0047 0.2769 0.2769
Echinococcus multilocularis Rac GTPase activating protein 1 0.0009 0.0365 0.0365
Schistosoma mansoni rac gtpase activating protein 0.0009 0.0365 0.0357
Brugia malayi Protein kinase domain containing protein 0.0004 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0074 0.4488 0.7077
Schistosoma mansoni rap gtpase-activating protein 0.003 0.1721 0.1746
Echinococcus multilocularis rac serine:threonine kinase 0.0004 0.0017 0.0017
Echinococcus multilocularis Protein kinase C, brain isozyme 0.001 0.0442 0.0442
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0009 0.0365 0.0576
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0032 0.1799 0.1799
Giardia lamblia Kinase, CK1 Casein kinase 0.0047 0.2769 0.5
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0032 0.1799 0.2836
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.003 0.1721 0.1724
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0084 0.5149 0.8022
Echinococcus multilocularis N chimaerin 0.0009 0.0365 0.0365
Echinococcus multilocularis casein kinase I delta 0.0047 0.2769 0.2769
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0047 0.2769 0.4366
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0073 0.4479 0.7062
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0075 0.4565 0.7198
Loa Loa (eye worm) hypothetical protein 0.0009 0.0365 0.0576
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0032 0.1799 0.1801
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0009 0.0365 0.0357
Trypanosoma cruzi casein kinase, putative 0.0047 0.2769 1
Brugia malayi RhoGAP domain containing protein 0.0009 0.0365 0.0569
Onchocerca volvulus 0.003 0.1721 0.2787
Loa Loa (eye worm) hypothetical protein 0.0009 0.0365 0.0576
Brugia malayi RhoGAP domain containing protein 0.0009 0.0365 0.0569
Echinococcus multilocularis protein kinase c epsilon type 0.001 0.0442 0.0442
Brugia malayi Protein kinase domain containing protein 0.0032 0.1799 0.2802
Echinococcus granulosus protein kinase c epsilon type 0.001 0.0442 0.0443
Echinococcus granulosus Vam6:Vps39 protein 0.003 0.1721 0.1724
Echinococcus granulosus N chimaerin 0.0009 0.0365 0.0366
Loa Loa (eye worm) hypothetical protein 0.0085 0.5231 0.8248
Brugia malayi RhoGEF domain containing protein 0.0009 0.0365 0.0569
Brugia malayi protein kinase C3,putative 0.001 0.0442 0.0689
Loa Loa (eye worm) hypothetical protein 0.0009 0.0365 0.0576
Echinococcus multilocularis casein kinase i 0.0047 0.2769 0.2769
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.2383 0.2423
Onchocerca volvulus 0.0047 0.2769 0.494
Loa Loa (eye worm) RasGEF domain-containing protein 0.0009 0.0365 0.0576
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0084 0.5149 0.812
Schistosoma mansoni protein kinase C 0.0009 0.0365 0.0357
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0045 0.2691 0.9719
Echinococcus granulosus protein kinase c eta type 0.0009 0.0365 0.0366
Loa Loa (eye worm) hypothetical protein 0.0009 0.0365 0.0576
Echinococcus multilocularis myotubularin protein 13 0.0012 0.0524 0.0524
Echinococcus granulosus protein kinase 0.0073 0.4479 0.4486
Loa Loa (eye worm) hypothetical protein 0.0102 0.6342 1
Schistosoma mansoni protein kinase C mu 0.0084 0.5149 0.5257
Echinococcus granulosus casein kinase I alpha 0.0047 0.2769 0.2773
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0442 0.0436
Toxoplasma gondii casein kinase I 0.0047 0.2769 1
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0365 0.0357
Brugia malayi Ras association domain family 1 isoform A 0.0009 0.0365 0.0569
Echinococcus granulosus Protein kinase C brain isozyme 0.001 0.0442 0.0443
Trypanosoma cruzi casein kinase, putative 0.0047 0.2769 1
Echinococcus granulosus unc 13 munc13 0.0009 0.0365 0.0366
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0009 0.0365 0.0365
Echinococcus multilocularis 0.0073 0.4479 0.4479
Loa Loa (eye worm) hypothetical protein 0.003 0.1721 0.2714
Echinococcus multilocularis casein kinase I alpha 0.0047 0.2769 0.2769
Brugia malayi Pleckstrin Homology Domain 0.0012 0.0524 0.0816
Echinococcus granulosus casein kinase i 0.0047 0.2769 0.2773
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0442 0.0436
Echinococcus multilocularis casein kinase I alpha 0.0047 0.2769 0.2769
Echinococcus multilocularis Diacylglycerol kinase theta 0.0009 0.0365 0.0365
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.2769 0.2818
Trichomonas vaginalis CK1 family protein kinase 0.0047 0.2769 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0009 0.0365 0.1266
Loa Loa (eye worm) hypothetical protein 0.0083 0.5072 0.7998
Brugia malayi hypothetical protein 0.003 0.1721 0.2682
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0047 0.2769 1
Brugia malayi Temporarily assigned gene name protein 59 0.003 0.1721 0.2682
Echinococcus granulosus calcium activated potassium channel 0.0004 0.0062 0.0062
Schistosoma mansoni protein kinase 0.0073 0.4479 0.457
Schistosoma mansoni hypothetical protein 0.003 0.1721 0.1746
Loa Loa (eye worm) hypothetical protein 0.0009 0.0365 0.0576
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0009 0.0365 0.0366
Brugia malayi casein kinase I 0.0047 0.2769 0.4313
Echinococcus granulosus transient receptor potential cation channel 0.0159 0.9985 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.001 0.0442 0.0698
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.1721 0.6194
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.001 0.0442 0.0698
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0156 0.9781 1
Echinococcus multilocularis casein kinase I delta 0.0047 0.2769 0.2769
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0009 0.0365 0.0365
Schistosoma mansoni protein kinase 0.0104 0.6419 0.6557
Leishmania major casein kinase, putative 0.0047 0.2769 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0365 0.0576
Echinococcus granulosus Rac GTPase activating protein 1 0.0009 0.0365 0.0366
Schistosoma mansoni atypical protein kinase C 0.001 0.0442 0.0436
Echinococcus multilocularis unc 13 (munc13) 0.0009 0.0365 0.0365
Brugia malayi casein kinase 1, delta 0.0047 0.2769 0.4313
Loa Loa (eye worm) raf kinase 0.0009 0.0365 0.0576
Loa Loa (eye worm) hypothetical protein 0.0009 0.0365 0.0576
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0365 0.0569
Schistosoma mansoni diacylglycerol kinase theta 0.0009 0.0365 0.0357
Onchocerca volvulus 0.0045 0.2691 0.4781
Echinococcus multilocularis protein kinase c eta type 0.0009 0.0365 0.0365

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 5.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKCN ChEMBL. No reference
Ki (functional) = 5.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 ChEMBL. No reference
Ki (functional) = 5.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK1D ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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