Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0231 | 0.5753 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0231 | 0.5753 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0187 | 0.4448 | 0.4825 |
Trichomonas vaginalis | conserved hypothetical protein | 0.006 | 0.0742 | 0.021 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.005 | 0.0448 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.013 | 0.2775 | 0.323 |
Mycobacterium ulcerans | thioesterase TesA | 0.0166 | 0.3857 | 0.4731 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0197 | 0.4758 | 0.5982 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.005 | 0.0448 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0296 | 0.7653 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0197 | 0.4758 | 0.5765 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0194 | 0.4653 | 0.5859 |
Giardia lamblia | Methyltransferase like 2 | 0.006 | 0.0742 | 0.1273 |
Mycobacterium ulcerans | polyketide synthase | 0.021 | 0.5122 | 0.6486 |
Trypanosoma cruzi | Protein kinase B | 0.0039 | 0.0114 | 0.0178 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.013 | 0.2776 | 0.4982 |
Leishmania major | hypothetical protein, conserved | 0.006 | 0.0742 | 0.0555 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0053 | 0.0532 | 0.0102 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.021 | 0.5122 | 0.6505 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.005 | 0.0448 | 0.5 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0231 | 0.5753 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0035 | 0.0011 | 0.002 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0187 | 0.4448 | 0.5576 |
Brugia malayi | Methyltransferase-like protein 4 | 0.006 | 0.0742 | 0.0308 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.021 | 0.5122 | 0.6505 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0158 | 0.3614 | 0.4394 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0037 | 0.0048 | 0.0841 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0066 | 0.0916 | 0.07 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0061 | 0.0779 | 0.0459 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0197 | 0.4758 | 0.6003 |
Mycobacterium tuberculosis | Hypothetical protein | 0.006 | 0.0742 | 0.046 |
Leishmania major | silent information regulator 2, putative | 0.0231 | 0.5753 | 1 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0063 | 0.0818 | 0.0513 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.021 | 0.5122 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0063 | 0.0818 | 0.0564 |
Brugia malayi | AMP-binding enzyme family protein | 0.0061 | 0.0779 | 0.0346 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0158 | 0.3614 | 0.4091 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0061 | 0.0779 | 0.051 |
Giardia lamblia | Hypothetical protein | 0.0231 | 0.5753 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0296 | 0.7653 | 1 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0231 | 0.5753 | 0.5554 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0194 | 0.4653 | 0.5859 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0231 | 0.5753 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0197 | 0.4758 | 0.6003 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0231 | 0.5753 | 1 |
Loa Loa (eye worm) | acyl carrier protein | 0.0092 | 0.1671 | 0.1475 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.2184 | 0.2094 |
Loa Loa (eye worm) | fatty acid synthase | 0.0197 | 0.4755 | 0.5195 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.005 | 0.0448 | 0.0779 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0231 | 0.5753 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0101 | 0.1937 | 0.3186 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0035 | 0.0011 | 0.002 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.005 | 0.0448 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.021 | 0.5122 | 0.6505 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.013 | 0.2775 | 0.2864 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0161 | 0.3691 | 0.4531 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0114 | 0.2307 | 0.262 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0197 | 0.4758 | 0.5765 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0197 | 0.4758 | 0.5982 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0039 | 0.0114 | 0.0178 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0231 | 0.5753 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.021 | 0.5122 | 0.6486 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0231 | 0.5753 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.021 | 0.5122 | 0.6296 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0231 | 0.5753 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0231 | 0.5753 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.005 | 0.0448 | 0.076 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0166 | 0.3857 | 0.4446 |
Mycobacterium ulcerans | thioesterase | 0.0166 | 0.3857 | 0.4731 |
Mycobacterium tuberculosis | Conserved protein | 0.006 | 0.0742 | 0.046 |
Schistosoma mansoni | methyltransferase-related | 0.006 | 0.0742 | 0.1114 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0231 | 0.5753 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.021 | 0.5122 | 0.6296 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0039 | 0.0114 | 0.0198 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.005 | 0.0448 | 0.0779 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.013 | 0.2775 | 0.323 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0039 | 0.0114 | 0.0178 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0081 | 0.1346 | 0.1293 |
Onchocerca volvulus | 0.0348 | 0.9168 | 0.9285 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0144 | 0.3184 | 0.3831 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0053 | 0.0532 | 0.0088 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0039 | 0.0114 | 0.0178 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.021 | 0.5122 | 0.6296 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.021 | 0.5122 | 0.6486 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0057 | 0.0635 | 0.0225 |
Brugia malayi | AMP-binding enzyme family protein | 0.0187 | 0.4448 | 0.4188 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0231 | 0.5753 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0197 | 0.4758 | 0.5982 |
Entamoeba histolytica | protein kinase, putative | 0.0057 | 0.0635 | 0.1085 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0296 | 0.7653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.8738 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0057 | 0.0635 | 0.1085 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0166 | 0.3857 | 0.4759 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.005 | 0.0448 | 0.076 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.005 | 0.0448 | 0.0593 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0296 | 0.7653 | 1 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.036 | 0.9532 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0197 | 0.4758 | 0.5982 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0197 | 0.4758 | 0.4512 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0158 | 0.3614 | 0.4394 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0039 | 0.0114 | 0.0198 |
Toxoplasma gondii | AGC kinase | 0.0053 | 0.0532 | 0.0181 |
Loa Loa (eye worm) | transcriptional regulator | 0.0231 | 0.5753 | 0.6399 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0197 | 0.4758 | 0.6003 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0057 | 0.0635 | 0.0352 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0035 | 0.0011 | 0.002 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0197 | 0.4758 | 0.5982 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0231 | 0.5753 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0231 | 0.5753 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0053 | 0.0532 | 0.0907 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0048 | 0.0841 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0142 | 0.3146 | 0.5772 |
Brugia malayi | Protein kinase domain containing protein | 0.0057 | 0.0635 | 0.0195 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.