TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 377.433 | Formula: C23H23NO4
H donors: 0 H acceptors: 0 LogP: 4.6 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(cc1OC)c1CN3CCCC3Cc1c1c2cc2OCOc2c1
InChi: 1S/C23H23NO4/c1-25-20-7-15-17-10-23-22(27-12-28-23)9-16(17)14-6-13-4-3-5-24(13)11-19(14)18(15)8-21(20)26-2/h7-10,13H,3-6,11-12H2,1-2H3
InChiKey: XYIVQGONBIUUEZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0074	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0353	0.194	0.1928
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1335	0.7919	0.7894
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1677	1	1
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0108	0.0446	0.0432
Echinococcus granulosus	serine protein kinase ATM	0.0317	0.1719	0.1707
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0108	0.0446	0.0432
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0209	0.106	0.0952
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0108	0.0446	0.033
Schistosoma mansoni	immunophilin	0.0055	0.012	0.0085
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0108	0.0446	0.0432
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0108	0.0446	0.033
Plasmodium vivax	hypothetical protein, conserved	0.0108	0.0446	1
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0108	0.0446	1
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0108	0.0446	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0562	0.3212	0.313
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1247	0.7383	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0317	0.1719	0.1689
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1677	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0108	0.0446	0.0432
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0904	0.5294	0.5294
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0108	0.0446	0.0412
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1002	0.589	0.589
Leishmania major	hypothetical protein, unknown function	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1247	0.7383	0.7383
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1247	0.7383	0.7383
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0108	0.0446	0.033
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0108	0.0446	0.033
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1335	0.7919	0.7894
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0245	0.1281	0.1268
Schistosoma mansoni	immunophilin	0.0047	0.0074	0.0039
Toxoplasma gondii	FATC domain-containing protein	0.0317	0.1719	0.1835
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0055	0.012	0.0085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1247	0.7383	0.7383
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1125	0.6638	0.6638
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0108	0.0446	0.0432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1247	0.7383	0.7383
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0108	0.0446	0.0412
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0108	0.0446	0.033
Onchocerca volvulus		0.0108	0.0446	0.5
Leishmania major	phosphatidylinositol kinase, putative	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0108	0.0446	0.0446
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0108	0.0446	0.0446
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1677	1	1
Giardia lamblia	GTOR	0.1677	1	1
Schistosoma mansoni	hypothetical protein	0.0245	0.1281	0.1249
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0108	0.0446	0.033
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1677	1	1
Loa Loa (eye worm)	FKBP5 protein	0.0055	0.012	0.0105
Trichomonas vaginalis	conserved hypothetical protein	0.0353	0.194	0.194
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0317	0.1719	0.1707
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0108	0.0446	0.0432
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0108	0.0446	0.033
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0108	0.0446	0.0432
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0904	0.5294	0.5294
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1677	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1334	0.791	0.791
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0906	0.5302	0.5302
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0108	0.0446	0.0446
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0055	0.012	0.0105
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0108	0.0446	0.0446
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0108	0.0446	0.0446
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0562	0.3212	0.3202
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0562	0.3212	0.3212
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0317	0.1719	0.1618
Entamoeba histolytica	hypothetical protein	0.0108	0.0446	0.033
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0108	0.0446	0.0432
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0317	0.1719	0.1707
Entamoeba histolytica	protein kinase rad3, putative	0.0317	0.1719	0.1618
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1247	0.7383	0.7383
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0055	0.012	0.0105
Plasmodium vivax	hypothetical protein	0.0108	0.0446	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0108	0.0446	0.0432
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0108	0.0446	0.0446
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0317	0.1719	0.1618
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0055	0.012	0.0105
Loa Loa (eye worm)	phosphatidylinositol 3	0.0108	0.0446	0.0432
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0108	0.0446	0.0432
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0108	0.0446	0.0446
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0055	0.012	0.5
Trichomonas vaginalis	fk506-binding protein, putative	0.0055	0.012	0.012
Loa Loa (eye worm)	phosphatidylinositol 3	0.0108	0.0446	0.0432
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0209	0.106	0.106
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0108	0.0446	0.0432
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0108	0.0446	0.033
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1677	1	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0562	0.3212	0.313
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0108	0.0446	0.033
Loa Loa (eye worm)	phosphatidylinositol 3	0.0108	0.0446	0.0432
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0108	0.0446	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1677	1	1
Mycobacterium leprae	conserved hypothetical protein	0.0108	0.0446	0.5
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0697	0.4029	0.3957
Leishmania major	hypothetical protein, conserved	0.0108	0.0446	0.033
Trichomonas vaginalis	conserved hypothetical protein	0.0245	0.1281	0.1281
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0108	0.0446	0.0412
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0562	0.3212	0.3202
Entamoeba histolytica	hypothetical protein	0.0317	0.1719	0.1618
Onchocerca volvulus		0.0108	0.0446	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1677	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0562	0.3212	0.3212
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0108	0.0446	0.0446
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0317	0.1719	0.1719
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1677	1	1
Loa Loa (eye worm)	hypothetical protein	0.0209	0.106	0.1047
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0108	0.0446	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0342	0.1869	0.1857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1089	0.6417	0.6417
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0055	0.012	0.0105
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0108	0.0446	0.033
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0108	0.0446	0.033
Echinococcus multilocularis		0.0108	0.0446	0.0432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0562	0.3212	0.3212
Trichomonas vaginalis	immunophilin, putative	0.0055	0.012	0.012
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0108	0.0446	0.0432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0992	0.5829	0.5829
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0108	0.0446	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.045	0.2528	0.2528
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0047	0.0074	0.0059
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0108	0.0446	0.0432
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0317	0.1719	0.1707
Loa Loa (eye worm)	phosphatidylinositol 3	0.0562	0.3212	0.3202
Echinococcus multilocularis	fk506 binding protein	0.0055	0.012	0.0105
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0245	0.1281	0.1268
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1334	0.791	0.791
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0108	0.0446	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0108	0.0446	0.0432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0906	0.5302	0.5302
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0317	0.1719	0.1707
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0317	0.1719	0.1719
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0108	0.0446	0.0412
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0108	0.0446	0.0446
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0108	0.0446	0.033
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1677	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0108	0.0446	0.0432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1247	0.7383	0.7383
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0108	0.0446	0.0432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0906	0.5302	0.5302
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1334	0.791	0.791
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0793	0.4617	0.4552
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0108	0.0446	0.033
Loa Loa (eye worm)	phosphatidylinositol 3	0.0108	0.0446	0.0432
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0108	0.0446	0.033
Echinococcus multilocularis	Zinc finger, PHD finger	0.0108	0.0446	0.0432
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0108	0.0446	0.0432
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0562	0.3212	0.313
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1677	1	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0108	0.0446	0.0432
Schistosoma mansoni	hypothetical protein	0.0108	0.0446	0.0412
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0108	0.0446	0.033
Giardia lamblia	Hypothetical protein	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1432	0.8507	0.8507
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.106	0.106
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0108	0.0446	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1002	0.589	0.589
Brugia malayi	FAT domain containing protein	0.0245	0.1281	0.1268
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0108	0.0446	0.0412
Trypanosoma cruzi	target of rapamycin kinase 3	0.1335	0.7919	0.7894
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0108	0.0446	0.0432
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0108	0.0446	0.0412
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0992	0.5829	0.5829
Entamoeba histolytica	hypothetical protein	0.0108	0.0446	0.033
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0055	0.012	0.0105
Loa Loa (eye worm)	phosphatidylinositol 3	0.0108	0.0446	0.0432
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0108	0.0446	0.0446
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0108	0.0446	0.0432
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0055	0.012	0.012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0904	0.5294	0.5294
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0108	0.0446	0.0412
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0906	0.5302	0.5302
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0108	0.0446	0.0446
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0317	0.1719	0.1618
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1677	1	1
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0047	0.0074	0.0059
Schistosoma mansoni	immunophilin	0.0055	0.012	0.0085
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0108	0.0446	0.0432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1247	0.7383	0.7383
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0108	0.0446	0.033
Entamoeba histolytica	hypothetical protein	0.0108	0.0446	0.033
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0108	0.0446	0.033
Loa Loa (eye worm)	hypothetical protein	0.0317	0.1719	0.1707
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0108	0.0446	0.033
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0108	0.0446	0.0432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1334	0.791	0.791
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0446	0.0432
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0108	0.0446	0.0446
Echinococcus multilocularis	serine protein kinase ATM	0.0317	0.1719	0.1707
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0562	0.3212	0.3212
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0108	0.0446	0.0446
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0108	0.0446	0.033
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0108	0.0446	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0562	0.3212	0.3188
Loa Loa (eye worm)	hypothetical protein	0.0245	0.1281	0.1268
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0317	0.1719	0.1689
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1334	0.791	0.791
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0108	0.0446	0.033
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0562	0.3212	0.313
Loa Loa (eye worm)	phosphatidylinositol 3	0.1677	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0317	0.1719	0.1618
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0562	0.3212	0.313
Entamoeba histolytica	hypothetical protein	0.0108	0.0446	0.033
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0562	0.3212	0.313
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1002	0.589	0.589
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0562	0.3212	0.3202
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0562	0.3212	0.3212
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0055	0.012	0.0105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0108	0.0446	0.0446
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1677	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0317	0.1719	0.1719
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0108	0.0446	0.0446
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0108	0.0446	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0446	0.0432
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0055	0.012	0.5
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0108	0.0446	0.5
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0055	0.012	0.012
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1677	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0353	0.194	0.2153

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 9.4 %	Antiproliferative activity against human HL60 cells at 10'-7 mol/L after 72 hrs by SRB assay	ChEMBL.	22417638
Inhibition (functional)	= 11.7 %	Antiproliferative activity against human HL60 cells at 10'-8 mol/L after 72 hrs by SRB assay	ChEMBL.	22417638
Inhibition (functional)	= 15.9 %	Antiproliferative activity against human A549 cells at 10'-8 mol/L after 72 hrs by MTT assay	ChEMBL.	22417638
Inhibition (functional)	= 22.4 %	Antiproliferative activity against human A549 cells at 10'-7 mol/L after 72 hrs by MTT assay	ChEMBL.	22417638
Inhibition (functional)	= 62.9 %	Antiproliferative activity against human HL60 cells at 10'-6 mol/L after 72 hrs by SRB assay	ChEMBL.	22417638
Inhibition (functional)	= 70.3 %	Antiproliferative activity against human A549 cells at 10'-6 mol/L after 72 hrs by MTT assay	ChEMBL.	22417638

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1958048

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1623148