TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 430.466 | Formula: C23H25F3N4O
H donors: 0 H acceptors: 2 LogP: 5.43 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: FC(c1ccc(cc1)c1cnc2c(c1)oc(n2)N1CCC(CC1)N1CCCCC1)(F)F
InChi: 1S/C23H25F3N4O/c24-23(25,26)18-6-4-16(5-7-18)17-14-20-21(27-15-17)28-22(31-20)30-12-8-19(9-13-30)29-10-2-1-3-11-29/h4-7,14-15,19H,1-3,8-13H2
InChiKey: MATFYLMKSWRGBD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	histamine receptor H3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0113	0.0455	0.0344
Schistosoma mansoni	hypothetical protein	0.0256	0.1289	0.1259
Loa Loa (eye worm)	FKBP5 protein	0.0055	0.0115	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.1947	0.1947
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.175	1	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0331	0.1726	0.1715
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0113	0.0455	0.0344
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0113	0.0455	0.0441
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0113	0.0455	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0455	0.0455
Leishmania major	phosphatidylinositol kinase, putative	0.0113	0.0455	0.0344
Onchocerca volvulus		0.0113	0.0455	0.5
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0113	0.0455	0.0455
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.175	1	1
Giardia lamblia	GTOR	0.175	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1302	0.7385	0.7385
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0113	0.0455	0.0344
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0113	0.0455	0.0422
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0113	0.0455	0.0344
Schistosoma mansoni	immunophilin	0.0047	0.0071	0.0037
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1394	0.7921	0.7896
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0256	0.1289	0.1276
Toxoplasma gondii	FATC domain-containing protein	0.0331	0.1726	0.1835
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0055	0.0115	0.0081
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0113	0.0455	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1302	0.7385	0.7385
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1174	0.6641	0.6641
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0944	0.5298	0.5298
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0113	0.0455	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1046	0.5893	0.5893
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1302	0.7385	0.7385
Leishmania major	hypothetical protein, unknown function	0.0113	0.0455	0.0344
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1302	0.7385	0.7385
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0113	0.0455	0.0344
Plasmodium vivax	hypothetical protein, conserved	0.0113	0.0455	1
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0113	0.0455	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0113	0.0455	0.0344
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1302	0.7385	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0331	0.1726	0.1698
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0113	0.0455	0.0344
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0113	0.0455	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0587	0.3218	0.314
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0113	0.0455	0.0344
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0455	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.175	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0218	0.1068	0.0964
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0113	0.0455	0.0344
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0113	0.0455	0.0441
Echinococcus granulosus	serine protein kinase ATM	0.0331	0.1726	0.1715
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0113	0.0455	0.0441
Schistosoma mansoni	immunophilin	0.0055	0.0115	0.0081
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0113	0.0455	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0071	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0369	0.1947	0.1935
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.175	1	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1394	0.7921	0.7896
Leishmania major	hypothetical protein, conserved	0.0113	0.0455	0.0344
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0727	0.4035	0.3965
Mycobacterium leprae	conserved hypothetical protein	0.0113	0.0455	0.5
Entamoeba histolytica	hypothetical protein	0.0331	0.1726	0.163
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0587	0.3218	0.3209
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0113	0.0455	0.0422
Trichomonas vaginalis	conserved hypothetical protein	0.0256	0.1289	0.1289
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0455	0.0441
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0113	0.0455	0.0344
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0113	0.0455	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.175	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0218	0.1068	0.1068
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0113	0.0455	0.0344
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0455	0.0441
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0587	0.3218	0.314
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.175	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0113	0.0455	0.0344
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0331	0.1726	0.163
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0113	0.0455	0.0455
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0113	0.0455	0.0441
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0455	0.0441
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0055	0.0115	0.0101
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0455	0.0441
Trichomonas vaginalis	fk506-binding protein, putative	0.0055	0.0115	0.0115
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0055	0.0115	0.5
Entamoeba histolytica	protein kinase rad3, putative	0.0331	0.1726	0.163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1302	0.7385	0.7385
Plasmodium vivax	hypothetical protein	0.0113	0.0455	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0055	0.0115	0.0101
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0455	0.0441
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0113	0.0455	0.0455
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0113	0.0455	0.0344
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0587	0.3218	0.3209
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0331	0.1726	0.163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0587	0.3218	0.3218
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0113	0.0455	0.0441
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0331	0.1726	0.1715
Entamoeba histolytica	hypothetical protein	0.0113	0.0455	0.0344
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0113	0.0455	0.0344
Trichomonas vaginalis	PIKK family atypical protein kinase	0.175	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0944	0.5298	0.5298
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0113	0.0455	0.0344
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0055	0.0115	0.0101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0945	0.5306	0.5306
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1392	0.7912	0.7912
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0113	0.0455	0.0455
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0113	0.0455	0.0455
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0113	0.0455	0.0455
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0587	0.3218	0.314
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0455	0.0441
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0113	0.0455	0.0441
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.175	1	1
Giardia lamblia	Hypothetical protein	0.0113	0.0455	0.0344
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0113	0.0455	0.0344
Schistosoma mansoni	hypothetical protein	0.0113	0.0455	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1494	0.8508	0.8508
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1392	0.7912	0.7912
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0113	0.0455	0.0344
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0828	0.4622	0.4559
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0113	0.0455	0.0344
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0113	0.0455	0.0344
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0455	0.0441
Echinococcus multilocularis	Zinc finger, PHD finger	0.0113	0.0455	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0331	0.1726	0.1726
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0113	0.0455	0.0344
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0331	0.1726	0.1715
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0113	0.0455	0.0422
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0455	0.0441
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.175	1	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0113	0.0455	0.0344
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0113	0.0455	0.0455
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0113	0.0455	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0945	0.5306	0.5306
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1302	0.7385	0.7385
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0331	0.1726	0.1715
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0113	0.0455	0.0441
Loa Loa (eye worm)	phosphatidylinositol 3	0.0587	0.3218	0.3209
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1392	0.7912	0.7912
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0256	0.1289	0.1276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0945	0.5306	0.5306
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0113	0.0455	0.0441
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0113	0.0455	1
Echinococcus multilocularis	fk506 binding protein	0.0055	0.0115	0.0101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1036	0.5833	0.5833
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0455	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.047	0.2534	0.2534
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0113	0.0455	1
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0047	0.0071	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0218	0.1068	0.1055
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0055	0.0115	0.0101
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0113	0.0455	0.0344
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0113	0.0455	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0357	0.1876	0.1864
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0113	0.0455	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1136	0.642	0.642
Echinococcus multilocularis		0.0113	0.0455	0.0441
Trichomonas vaginalis	immunophilin, putative	0.0055	0.0115	0.0115
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0587	0.3218	0.3218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0587	0.3218	0.3218
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0113	0.0455	0.0455
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.175	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0331	0.1726	0.1726
Onchocerca volvulus		0.0113	0.0455	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.175	1	1
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0055	0.0115	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0455	0.0441
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0113	0.0455	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0113	0.0455	0.5
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0369	0.1947	0.2153
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.175	1	1
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0055	0.0115	0.0115
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0587	0.3218	0.3209
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1046	0.5893	0.5893
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0587	0.3218	0.314
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0055	0.0115	0.0101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0587	0.3218	0.3218
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.175	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0455	0.0455
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0113	0.0455	0.0455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0331	0.1726	0.1726
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0113	0.0455	0.0344
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0331	0.1726	0.1698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1392	0.7912	0.7912
Loa Loa (eye worm)	phosphatidylinositol 3	0.175	1	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0587	0.3218	0.314
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0331	0.1726	0.163
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0587	0.3218	0.314
Entamoeba histolytica	hypothetical protein	0.0113	0.0455	0.0344
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0113	0.0455	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0113	0.0455	0.0344
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0113	0.0455	0.0455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0587	0.3218	0.3218
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0587	0.3218	0.3195
Loa Loa (eye worm)	hypothetical protein	0.0256	0.1289	0.1276
Entamoeba histolytica	hypothetical protein	0.0113	0.0455	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0331	0.1726	0.1715
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0113	0.0455	0.0344
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1392	0.7912	0.7912
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0113	0.0455	0.0344
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0113	0.0455	0.0441
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0113	0.0455	0.0455
Echinococcus multilocularis	serine protein kinase ATM	0.0331	0.1726	0.1715
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0455	0.0441
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0113	0.0455	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0945	0.5306	0.5306
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0113	0.0455	0.0455
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0331	0.1726	0.163
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0047	0.0071	0.0057
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1302	0.7385	0.7385
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0113	0.0455	0.0441
Schistosoma mansoni	immunophilin	0.0055	0.0115	0.0081
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.175	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0113	0.0455	0.0344
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0055	0.0115	0.0101
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0113	0.0455	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1036	0.5833	0.5833
Entamoeba histolytica	hypothetical protein	0.0113	0.0455	0.0344
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0455	0.0441
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0113	0.0455	0.0455
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0113	0.0455	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0944	0.5298	0.5298
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0055	0.0115	0.0115
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0113	0.0455	0.0344
Trichomonas vaginalis	conserved hypothetical protein	0.0218	0.1068	0.1068
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0113	0.0455	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1046	0.5893	0.5893
Brugia malayi	FAT domain containing protein	0.0256	0.1289	0.1276
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0113	0.0455	0.0441
Trypanosoma cruzi	target of rapamycin kinase 3	0.1394	0.7921	0.7896

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 238 nM	Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cell membrane after 30 mins by Scintillation counting	ChEMBL.	22326166

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1958152

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1623150