Detailed information for compound 1623153

Basic information

Technical information
  • TDR Targets ID: 1623153
  • Name: ethyl (3R)-3-acetyl-2-methyl-3-phenyl-1-oxa-8 -azaspiro[4.5]decane-8-carboxylate
  • MW: 345.433 | Formula: C20H27NO4
  • H donors: 0 H acceptors: 2 LogP: 2.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)N1CCC2(CC1)OC([C@](C2)(C(=O)C)c1ccccc1)C
  • InChi: 1S/C20H27NO4/c1-4-24-18(23)21-12-10-19(11-13-21)14-20(15(2)22,16(3)25-19)17-8-6-5-7-9-17/h5-9,16H,4,10-14H2,1-3H3/t16?,20-/m0/s1
  • InChiKey: JFJUUXOJEHWYQH-FZCLLLDFSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • (3R)-3-acetyl-2-methyl-3-phenyl-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid ethyl ester
  • ethyl (3R)-3-ethanoyl-2-methyl-3-phenyl-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
  • NCI60_035575
  • NSC699396

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.028 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0269 0.0803 0.0777
Loa Loa (eye worm) phosphatidylinositol kinase 0.0151 0.0232 0.0205
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1026 0.4437 0.4421
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.017 0.0325 0.0298
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0169 0.0321 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.1746 0.7894 0.7894
Trichomonas vaginalis PIKK family atypical protein kinase 0.1855 0.8421 0.8421
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.017 0.0325 0.0298
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.017 0.0325 0.0298
Leishmania major phosphatidylinositol kinase related protein, putative 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.2184 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.017 0.0325 0.0298
Plasmodium falciparum phosphatidylinositol 3-kinase 0.017 0.0325 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.077 0.3209 0.319
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1746 0.7894 0.7894
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0431 0.1579 0.1555
Trichomonas vaginalis PIKK family atypical protein kinase 0.1198 0.5264 0.5264
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0209 0.0514 0.0514
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.017 0.0325 0.013
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.077 0.3209 0.319
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0151 0.0232 0.0205
Entamoeba histolytica hypothetical protein 0.0431 0.1579 0.1555
Trichomonas vaginalis PIKK family atypical protein kinase 0.1198 0.5264 0.5264
Trichomonas vaginalis PIKK family atypical protein kinase 0.1635 0.7362 0.7362
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0337 0.1128 0.1103
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0209 0.0514 0.0487
Loa Loa (eye worm) phosphatidylinositol 3 0.2184 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0151 0.0232 0.0205
Leishmania major phosphatidylinositol 3-kinase, putative 0.017 0.0325 0.0298
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0151 0.0232 0.0205
Loa Loa (eye worm) hypothetical protein 0.0437 0.1606 0.1583
Loa Loa (eye worm) phosphatidylinositol 3 0.0151 0.0232 0.0205
Loa Loa (eye worm) phosphatidylinositol 3 0.0467 0.1752 0.1729
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.076 0.3158 0.3139
Schistosoma mansoni voltage-gated potassium channel 0.012 0.0083 0.0055
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0277 0.0839 0.0839
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0329 0.1088 0.1063
Trichomonas vaginalis PIKK family atypical protein kinase 0.1417 0.6314 0.6314
Trichomonas vaginalis conserved hypothetical protein 0.048 0.1812 0.1812
Loa Loa (eye worm) phosphatidylinositol 3 0.0151 0.0232 0.0205
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.017 0.0325 0.0298
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.011 0.0035 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0337 0.1128 0.1128
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.017 0.0325 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0587 0.233 0.233
Giardia lamblia Hypothetical protein 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1306 0.5783 0.5783
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2184 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.019 0.0421 0.0394
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0441 0.1629 0.1606
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2184 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.077 0.3209 0.3209
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0209 0.0514 0.0487
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0431 0.1579 0.1555
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0209 0.0514 0.0487
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0209 0.0514 0.0487
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2184 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0809 0.3395 0.3377
Echinococcus granulosus potassium voltage gated channel subfamily H 0.011 0.0035 0.0007
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0809 0.3395 0.3377
Trichomonas vaginalis PIKK family atypical protein kinase 0.1309 0.5796 0.5796
Trichomonas vaginalis PIKK family atypical protein kinase 0.076 0.3158 0.3158
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2184 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0151 0.0232 0.0205
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0506 0.194 0.1917
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0269 0.0803 0.0777
Mycobacterium tuberculosis Conserved hypothetical protein 0.0151 0.0232 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.011 0.0035 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.023 0.0614 0.0588
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0402 0.1438 0.1415
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0809 0.3395 0.3377
Leishmania major hypothetical protein, conserved 0.024 0.066 0.0634
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0809 0.3395 0.3377
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0151 0.0232 0.6879
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.017 0.0325 0.0298
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0151 0.0232 0.0205
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0809 0.3395 0.3377
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0431 0.1579 0.1555
Leishmania major phosphatidylinositol 3-kinase, putative 0.076 0.3158 0.3139
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2184 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1746 0.7894 0.7894
Echinococcus granulosus serine protein kinase ATM 0.0431 0.1579 0.1555
Onchocerca volvulus 0.0151 0.0232 0.5
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.017 0.0325 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.2184 1 1
Trichomonas vaginalis conserved hypothetical protein 0.028 0.0854 0.0854
Toxoplasma gondii target of rapamycin (TOR), putative 0.1635 0.7362 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0151 0.0232 0.0205
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0431 0.1579 0.1555
Giardia lamblia Phosphatidylinositol 4-kinase 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1198 0.5264 0.5264
Brugia malayi FAT domain containing protein 0.0329 0.1088 0.1063
Loa Loa (eye worm) hypothetical protein 0.0329 0.1088 0.1063
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0431 0.1579 0.1555
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0209 0.0514 0.0487
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0151 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1746 0.7894 0.7894
Leishmania major phosphatidylinositol kinase, putative 0.0151 0.0232 0.0205
Entamoeba histolytica protein kinase rad3, putative 0.0431 0.1579 0.1555
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0151 0.0232 0.6879
Trypanosoma cruzi target of rapamycin kinase 3 0.1747 0.7902 0.7896
Entamoeba histolytica hypothetical protein 0.0298 0.0939 0.0914
Trichomonas vaginalis PIKK family atypical protein kinase 0.1306 0.5783 0.5783
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0431 0.1579 0.1555
Schistosoma mansoni phosphatidylinositol 4-kinase 0.017 0.0325 0.0298
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.017 0.0325 0.0325
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0337 0.1128 0.1103
Schistosoma mansoni voltage-gated potassium channel 0.012 0.0083 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.1196 0.5256 0.5256
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.028 0.0854 0.0829
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0337 0.1128 0.1103
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0209 0.0514 0.0514
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0151 0.0232 0.6879
Trichomonas vaginalis PIKK family atypical protein kinase 0.1306 0.5783 0.5783
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0151 0.0232 0.0205
Trichomonas vaginalis fk506-binding protein, putative 0.0108 0.0028 0.0028
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2184 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2184 1 1
Plasmodium vivax hypothetical protein, conserved 0.0151 0.0232 0.6879
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0269 0.0803 0.0777
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0209 0.0514 0.0514
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.017 0.0325 0.0298
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0151 0.0232 0.0205
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0298 0.0939 0.0914
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0151 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.048 0.1812 0.1789
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2184 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0108 0.0028 0.5
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0506 0.194 0.1917
Loa Loa (eye worm) hypothetical protein 0.0431 0.1579 0.1555
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1465 0.6548 0.6548
Trichomonas vaginalis PIKK family atypical protein kinase 0.1635 0.7362 0.7362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0232 0.0232
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0431 0.1579 0.1555
Trichomonas vaginalis immunophilin, putative 0.0108 0.0028 0.0028
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0431 0.1579 0.1555
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1747 0.7902 0.7896
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0151 0.0232 0.0205
Entamoeba histolytica hypothetical protein 0.0151 0.0232 0.0205
Entamoeba histolytica hypothetical protein 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1635 0.7362 0.7362
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0151 0.0232 0.0205
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.017 0.0325 0.0325
Giardia lamblia GTOR 0.2184 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0186 0.0403 0.0377
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0809 0.3395 0.3377
Toxoplasma gondii FATC domain-containing protein 0.0431 0.1579 0.1888
Mycobacterium leprae conserved hypothetical protein 0.0151 0.0232 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1635 0.7362 0.7362
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0151 0.0232 0.0205
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.017 0.0325 0.0298
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.017 0.0325 0.0298
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1635 0.7362 0.7362
Trichomonas vaginalis PIKK family atypical protein kinase 0.1309 0.5796 0.5796
Trichomonas vaginalis PIKK family atypical protein kinase 0.1635 0.7362 0.7362
Echinococcus multilocularis 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1196 0.5256 0.5256
Onchocerca volvulus 0.0151 0.0232 0.5
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1747 0.7902 0.7896
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2184 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0506 0.194 0.1917
Loa Loa (eye worm) hypothetical protein 0.028 0.0854 0.0829
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0441 0.1629 0.1629
Schistosoma mansoni hypothetical protein 0.0329 0.1088 0.1063
Entamoeba histolytica hypothetical protein 0.0151 0.0232 0.0205
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0151 0.0232 0.6879
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0337 0.1128 0.1128
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2184 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.017 0.0325 0.013
Loa Loa (eye worm) hypothetical protein 0.0151 0.0232 0.0205
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0209 0.0514 0.0487
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.017 0.0325 0.0298
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0402 0.1438 0.1415
Toxoplasma gondii non-specific serine/threonine protein kinase 0.048 0.1812 0.2215
Trichomonas vaginalis PIKK family atypical protein kinase 0.076 0.3158 0.3158
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0277 0.0839 0.0839
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0918 0.3918 0.3901
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0151 0.0232 0.6879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0232 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.2184 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.076 0.3158 0.3158
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.017 0.0325 0.0298
Loa Loa (eye worm) phosphatidylinositol 3 0.0151 0.0232 0.0205
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0337 0.1128 0.1128
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0329 0.1088 0.1063
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.017 0.0325 0.0298
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0108 0.0028 0.0028
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.017 0.0325 0.0325
Echinococcus multilocularis serine protein kinase ATM 0.0431 0.1579 0.1555
Trichomonas vaginalis PIKK family atypical protein kinase 0.1635 0.7362 0.7362
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0108 0.0028 0.0028
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0269 0.0803 0.0777
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.011 0.0035 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0329 0.1088 0.1088
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0238 0.065 0.0624
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0431 0.1579 0.1579
Leishmania major phosphatidylinositol 4-kinase, putative 0.0151 0.0232 0.0205
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0337 0.1128 0.1103
Leishmania major hypothetical protein, unknown function 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1198 0.5264 0.5264
Trichomonas vaginalis PIKK family atypical protein kinase 0.1746 0.7894 0.7894
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0108 0.0028 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1196 0.5256 0.5256
Plasmodium vivax hypothetical protein 0.0151 0.0232 0.6879
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2184 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0151 0.0232 0.0205
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0151 0.0232 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0431 0.1579 0.1579
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0151 0.0232 0.0205
Loa Loa (eye worm) phosphatidylinositol 3 0.077 0.3209 0.319
Schistosoma mansoni fkbp-rapamycin associated protein 0.0431 0.1579 0.1555
Trichomonas vaginalis PIKK family atypical protein kinase 0.076 0.3158 0.3158
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0151 0.0232 0.0205

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.214 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.07 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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