Detailed information for compound 1623164

Basic information

Technical information
  • TDR Targets ID: 1623164
  • Name: ethyl 4-oxo-1,3-di(phenyl)-6-(phenylmethylami no)-2-sulfanylidenepyrimidine-5-carboxylate
  • MW: 457.544 | Formula: C26H23N3O3S
  • H donors: 1 H acceptors: 2 LogP: 5.78 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(NCc2ccccc2)n(c2ccccc2)c(=S)n(c1=O)c1ccccc1
  • InChi: 1S/C26H23N3O3S/c1-2-32-25(31)22-23(27-18-19-12-6-3-7-13-19)28(20-14-8-4-9-15-20)26(33)29(24(22)30)21-16-10-5-11-17-21/h3-17,27H,2,18H2,1H3
  • InChiKey: URPGXRRFSWCLHF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-oxo-1,3-di(phenyl)-6-(phenylmethylamino)-2-thioxo-pyrimidine-5-carboxylate
  • 4-oxo-1,3-di(phenyl)-6-(phenylmethylamino)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester
  • 4-(benzylamino)-6-keto-1,3-di(phenyl)-2-thioxo-pyrimidine-5-carboxylic acid ethyl ester
  • ethyl 4-oxo-1,3-di(phenyl)-6-(phenylmethylamino)-2-sulfanylidene-pyrimidine-5-carboxylate
  • AIDS-141301
  • AIDS141301
  • Ethyl 6-(benzylamino)-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
  • NSC656438
  • NCI60_019550

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.4803 0.7407 0.7386
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0426 0.0486 0.0486
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0426 0.0486 0.9242
Loa Loa (eye worm) hypothetical protein 0.0148 0.0046 0.0046
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5139 0.7938 0.7921
Schistosoma mansoni hypothetical protein 0.0952 0.1318 0.1303
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0426 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.4803 0.7407 0.7386
Trichomonas vaginalis PIKK family atypical protein kinase 0.4322 0.6647 0.6618
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0426 0.0486 0.9242
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0172 0.0084 0.5
Toxoplasma gondii FATC domain-containing protein 0.1238 0.177 0.1854
Schistosoma mansoni immunophilin 0.0172 0.0084 0.0066
Loa Loa (eye worm) hypothetical protein 0.1379 0.1992 0.1992
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6443 1 1
Giardia lamblia Hypothetical protein 0.0426 0.0486 0.0406
Loa Loa (eye worm) hypothetical protein 0.0952 0.1318 0.1318
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0628 0.0805 0.0805
Leishmania major hypothetical protein, unknown function 0.0426 0.0486 0.0406
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0426 0.0486 0.047
Trichomonas vaginalis PIKK family atypical protein kinase 0.1249 0.1788 0.1718
Leishmania major phosphatidylinositol kinase related protein, putative 0.0426 0.0486 0.0406
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.049 0.0586 0.0507
Loa Loa (eye worm) hypothetical protein 0.0426 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0555 0.0689 0.0689
Trichomonas vaginalis PIKK family atypical protein kinase 0.6443 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6443 1 1
Onchocerca volvulus 0.0426 0.0486 0.5
Loa Loa (eye worm) hypothetical protein 0.0812 0.1095 0.1095
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0628 0.0805 0.0727
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0426 0.0486 0.0486
Entamoeba histolytica protein kinase rad3, putative 0.1238 0.177 0.17
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0628 0.0805 0.0727
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0183 0.0101 0.0101
Schistosoma mansoni immunophilin 0.0148 0.0046 0.0029
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6443 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5139 0.7938 0.7921
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1379 0.1992 0.2176
Trichomonas vaginalis PIKK family atypical protein kinase 0.3851 0.5902 0.5867
Echinococcus multilocularis 0.0426 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.4803 0.7407 0.7386
Trichomonas vaginalis PIKK family atypical protein kinase 0.3494 0.5337 0.5298
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0426 0.0486 0.9242
Giardia lamblia Phosphatidylinositol 4-kinase 0.0426 0.0486 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.4803 0.7407 0.7386
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0447 0.0519 0.0439
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0447 0.0519 0.0519
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0426 0.0486 0.0486
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0447 0.0519 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.6443 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0426 0.0486 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.4803 0.7407 0.7386
Trichomonas vaginalis PIKK family atypical protein kinase 0.1238 0.177 0.17
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0426 0.0486 0.0406
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2243 0.336 0.3304
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0447 0.0519 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0812 0.1095 0.102
Trichomonas vaginalis PIKK family atypical protein kinase 0.219 0.3275 0.3219
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6443 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0426 0.0486 0.5
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0447 0.0519 0.0439
Leishmania major phosphatidylinositol kinase, putative 0.0426 0.0486 0.0406
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2688 0.4062 0.4012
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0426 0.0486 0.0406
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0563 0.0702 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.219 0.3275 0.3219
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1249 0.1788 0.1718
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0952 0.1318 0.1318
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0447 0.0519 0.0439
Loa Loa (eye worm) phosphatidylinositol kinase 0.0426 0.0486 0.0486
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.049 0.0586 0.0507
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6443 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0447 0.0519 1
Schistosoma mansoni hypothetical protein 0.0426 0.0486 0.047
Trichomonas vaginalis PIKK family atypical protein kinase 0.219 0.3275 0.3219
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1238 0.177 0.17
Entamoeba histolytica hypothetical protein 0.0426 0.0486 0.0406
Entamoeba histolytica hypothetical protein 0.0426 0.0486 0.0406
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1238 0.177 0.177
Loa Loa (eye worm) phosphatidylinositol 3 0.2202 0.3293 0.3293
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6443 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3494 0.5337 0.5298
Loa Loa (eye worm) phosphatidylinositol 3 0.0426 0.0486 0.0486
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0426 0.0486 0.0486
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.081 0.1094 0.1094
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0426 0.0486 0.047
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0172 0.0084 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.5134 0.793 0.7912
Trichomonas vaginalis PIKK family atypical protein kinase 0.3499 0.5346 0.5306
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0426 0.0486 0.0406
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1238 0.177 0.177
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0555 0.0689 0.0689
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0172 0.0084 0.0084
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0172 0.0084 0.0084
Plasmodium vivax hypothetical protein 0.0426 0.0486 0.9242
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.052 0.0635 0.0556
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0628 0.0805 0.0727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0172 0.0084 0.0084
Echinococcus multilocularis Zinc finger, PHD finger 0.0447 0.0519 0.0519
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0172 0.0084 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.4803 0.7407 0.7386
Trichomonas vaginalis PIKK family atypical protein kinase 0.1238 0.177 0.17
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0698 0.0915 0.0915
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0447 0.0519 0.0503
Loa Loa (eye worm) phosphatidylinositol 3 0.0426 0.0486 0.0486
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0426 0.0486 0.0486
Entamoeba histolytica hypothetical protein 0.1238 0.177 0.17
Schistosoma mansoni fkbp-rapamycin associated protein 0.1238 0.177 0.1755
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.081 0.1094 0.1078
Trichomonas vaginalis PIKK family atypical protein kinase 0.3499 0.5346 0.5306
Toxoplasma gondii target of rapamycin (TOR), putative 0.4803 0.7407 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0447 0.0519 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.049 0.0586 0.0507
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6443 1 1
Mycobacterium leprae conserved hypothetical protein 0.0426 0.0486 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2202 0.3293 0.3237
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1238 0.177 0.17
Entamoeba histolytica hypothetical protein 0.0426 0.0486 0.0406
Brugia malayi FAT domain containing protein 0.0952 0.1318 0.1318
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.049 0.0586 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.5134 0.793 0.7912
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0447 0.0519 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.3499 0.5346 0.5306
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0426 0.0486 0.9242
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0447 0.0519 0.0519
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6443 1 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2202 0.3293 0.3237
Leishmania major phosphatidylinositol 3-kinase, putative 0.0447 0.0519 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.5491 0.8494 0.8481
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0426 0.0486 0.0486
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0447 0.0519 0.0439
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0447 0.0519 0.0439
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3039 0.4618 0.4573
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0447 0.0519 0.0439
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0426 0.0486 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.5134 0.793 0.7912
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0628 0.0805 0.0727
Leishmania major phosphatidylinositol 4-kinase, putative 0.0426 0.0486 0.0406
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0555 0.0689 0.0689
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2202 0.3293 0.3237
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.049 0.0586 0.0507
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6443 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1238 0.177 0.1755
Loa Loa (eye worm) phosphatidylinositol 3 0.6443 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0469 0.0553 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.173 0.2548 0.2485
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0447 0.0519 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.383 0.5868 0.5833
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0426 0.0486 0.0406
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0148 0.0046 0.0046
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0447 0.0519 0.0439
Echinococcus multilocularis fk506 binding protein 0.0172 0.0084 0.0084
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0426 0.0486 0.0406
Loa Loa (eye worm) hypothetical protein 0.1304 0.1874 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.4181 0.6424 0.6394
Loa Loa (eye worm) phosphatidylinositol 3 0.0768 0.1027 0.1027
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0812 0.1095 0.102
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0172 0.0084 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.219 0.3275 0.3219
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0563 0.0702 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.6443 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.219 0.3275 0.3219
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0426 0.0486 0.0406
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1238 0.177 0.177
Trichomonas vaginalis PIKK family atypical protein kinase 0.5134 0.793 0.7912
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0426 0.0486 0.047
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2243 0.336 0.336
Echinococcus multilocularis serine protein kinase ATM 0.1238 0.177 0.177
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0447 0.0519 0.0439
Leishmania major hypothetical protein, conserved 0.0523 0.0638 0.0559
Loa Loa (eye worm) phosphatidylinositol 3 0.0426 0.0486 0.0486
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2243 0.336 0.3304
Trichomonas vaginalis conserved hypothetical protein 0.0952 0.1318 0.1245
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2243 0.336 0.3348
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0555 0.0689 0.0689
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0512 0.0622 0.0543
Schistosoma mansoni immunophilin 0.0172 0.0084 0.0066
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0426 0.0486 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.1379 0.1992 0.1925
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6443 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0201 0.0131 0.0047
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0172 0.0084 0.0084
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2243 0.336 0.336
Trichomonas vaginalis PIKK family atypical protein kinase 0.3851 0.5902 0.5867
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.219 0.3275 0.3219
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2243 0.336 0.336
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.049 0.0586 0.0507
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1238 0.177 0.17
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.049 0.0586 0.0586
Giardia lamblia GTOR 0.6443 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.049 0.0586 0.0507
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0172 0.0084 0.0084
Loa Loa (eye worm) phosphatidylinositol 3 0.0426 0.0486 0.0486
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0426 0.0486 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.383 0.5868 0.5833
Trichomonas vaginalis PIKK family atypical protein kinase 0.3494 0.5337 0.5298
Loa Loa (eye worm) FKBP5 protein 0.0172 0.0084 0.0084
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.081 0.1094 0.1094
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0585 0.0738 0.066
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0447 0.0519 0.0519
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0952 0.1318 0.1318
Trichomonas vaginalis PIKK family atypical protein kinase 0.3851 0.5902 0.5867
Trichomonas vaginalis conserved hypothetical protein 0.0812 0.1095 0.102
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0447 0.0519 0.0519
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0628 0.0805 0.0727
Trypanosoma cruzi target of rapamycin kinase 3 0.5139 0.7938 0.7921
Loa Loa (eye worm) hypothetical protein 0.1238 0.177 0.177
Onchocerca volvulus 0.0426 0.0486 0.5
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0426 0.0486 0.9242
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.049 0.0586 0.0507
Echinococcus granulosus serine protein kinase ATM 0.1238 0.177 0.177
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0628 0.0805 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.5134 0.793 0.7912
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0486 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0486 0.0406
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1238 0.177 0.177
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0426 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.3499 0.5346 0.5306
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0698 0.0915 0.0915
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0447 0.0519 0.0048
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0148 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.4803 0.7407 0.7386
Entamoeba histolytica hypothetical protein 0.0585 0.0738 0.066
Plasmodium vivax hypothetical protein, conserved 0.0426 0.0486 0.9242
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6443 1 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.449 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.339 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.024 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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