Detailed information for compound 1623662

Basic information

Technical information
  • TDR Targets ID: 1623662
  • Name: N-(3,4-dichlorophenyl)-2,4-dioxo-1-phenylpyrr olidine-3-carboxamide
  • MW: 363.195 | Formula: C17H12Cl2N2O3
  • H donors: 1 H acceptors: 3 LogP: 3.39 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CN(C(=O)C1C(=O)Nc1ccc(c(c1)Cl)Cl)c1ccccc1
  • InChi: 1S/C17H12Cl2N2O3/c18-12-7-6-10(8-13(12)19)20-16(23)15-14(22)9-21(17(15)24)11-4-2-1-3-5-11/h1-8,15H,9H2,(H,20,23)
  • InChiKey: YRWHBNJWWWTHNR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3,4-dichlorophenyl)-2,4-dioxo-1-phenyl-pyrrolidine-3-carboxamide
  • N-(3,4-Dichlorophenyl)-2,4-dioxo-1-phenyl-3-pyrrolidinecarboxamide
  • N-(3,4-dichlorophenyl)-2,4-diketo-1-phenyl-pyrrolidine-3-carboxamide
  • NCI60_003547
  • 3-Pyrrolidinecarboxamide, N-(3,4-dichlorophenyl)-2,4-dioxo-1-phenyl-
  • 3-Pyrrolidinecarboxamide, N-(3,4-dichlorophenyl)-2, 4-dioxo-1-phenyl-
  • AIDS-130057
  • AIDS130057
  • NSC376484

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6516 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.6516 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0431 0.0596 0.9374
Loa Loa (eye worm) phosphatidylinositol 3 0.0431 0.0596 0.0596
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0118 0.0112 0.0112
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0494 0.0694 0.0589
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.056 0.0795 0.0795
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0633 0.0908 0.0805
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0431 0.0596 0.9374
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0431 0.0596 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.1263 0.1882 0.179
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0118 0.0112 0.0084
Loa Loa (eye worm) hypothetical protein 0.1394 0.2085 0.2085
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6516 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0431 0.0596 0.057
Schistosoma mansoni hypothetical protein 0.0963 0.1418 0.1418
Trichomonas vaginalis PIKK family atypical protein kinase 0.4857 0.7437 0.7408
Trichomonas vaginalis PIKK family atypical protein kinase 0.4371 0.6685 0.6648
Giardia lamblia Hypothetical protein 0.0431 0.0596 0.0489
Loa Loa (eye worm) hypothetical protein 0.1252 0.1865 0.1865
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0146 0.0155 0.0044
Schistosoma mansoni immunophilin 0.0118 0.0112 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0963 0.1418 0.1321
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5197 0.7962 0.7939
Leishmania major phosphatidylinositol kinase related protein, putative 0.0431 0.0596 0.0489
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0431 0.0596 0.0596
Entamoeba histolytica hypothetical protein 0.0431 0.0596 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.4857 0.7437 0.7408
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6516 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0452 0.0629 0.0047
Mycobacterium leprae conserved hypothetical protein 0.0431 0.0596 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4857 0.7437 0.7408
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1252 0.1865 0.1865
Onchocerca volvulus 0.0431 0.0596 0.5
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0452 0.0629 0.0629
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2268 0.3435 0.3417
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0452 0.0629 0.0522
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0452 0.0629 0.0522
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0431 0.0596 0.057
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0431 0.0596 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.4857 0.7437 0.7408
Trichomonas vaginalis PIKK family atypical protein kinase 0.3895 0.5949 0.5903
Loa Loa (eye worm) phosphatidylinositol 3 0.0431 0.0596 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.4857 0.7437 0.7408
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0431 0.0596 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.3533 0.5391 0.5339
Giardia lamblia GTOR 0.6516 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5197 0.7962 0.7939
Trichomonas vaginalis conserved hypothetical protein 0.1394 0.2085 0.1995
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0118 0.0112 0.5
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0118 0.0112 0.0112
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0633 0.0908 0.0805
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0183 0.0213 0.0213
Schistosoma mansoni immunophilin 0.0102 0.0087 0.0087
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0821 0.1198 0.1174
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0431 0.0596 0.9374
Trichomonas vaginalis PIKK family atypical protein kinase 0.1252 0.1865 0.1772
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0633 0.0908 0.0882
Entamoeba histolytica hypothetical protein 0.0431 0.0596 0.0489
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6516 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0452 0.0629 0.0522
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0494 0.0694 0.0589
Loa Loa (eye worm) phosphatidylinositol kinase 0.0431 0.0596 0.0596
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1263 0.1882 0.179
Trichomonas vaginalis PIKK family atypical protein kinase 0.2215 0.3353 0.3277
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0452 0.0629 0.0629
Loa Loa (eye worm) hypothetical protein 0.0963 0.1418 0.1418
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0118 0.0112 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2718 0.4131 0.4064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0431 0.0596 0.0596
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0568 0.0807 0.0703
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0118 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0431 0.0596 0.0596
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0118 0.0112 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.2215 0.3353 0.3277
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6516 1 1
Echinococcus multilocularis 0.0431 0.0596 0.0596
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0452 0.0629 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0821 0.1198 0.1098
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0703 0.1016 0.1016
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0452 0.0629 0.0629
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0452 0.0629 0.0602
Loa Loa (eye worm) hypothetical protein 0.0135 0.0139 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.4857 0.7437 0.7408
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1252 0.1865 0.1842
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.056 0.0795 0.0795
Loa Loa (eye worm) FKBP5 protein 0.0118 0.0112 0.0112
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0118 0.0112 0.0112
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0525 0.0742 0.0637
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0431 0.0596 0.0596
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0156 0.0171 0.0171
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0633 0.0908 0.0805
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1252 0.1865 0.1865
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0816 0.1191 0.1191
Leishmania major phosphatidylinositol 4-kinase, putative 0.0431 0.0596 0.0489
Schistosoma mansoni immunophilin 0.0118 0.0112 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.3539 0.5399 0.5347
Leishmania major phosphatidylinositol kinase, putative 0.0431 0.0596 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.5192 0.7954 0.793
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6516 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0431 0.0596 0.9374
Trichomonas vaginalis PIKK family atypical protein kinase 0.3533 0.5391 0.5339
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0431 0.0596 0.0596
Echinococcus granulosus serine protein kinase ATM 0.1252 0.1865 0.1865
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0431 0.0596 0.0596
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0431 0.0596 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.1252 0.1865 0.1772
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2226 0.337 0.3295
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0431 0.0596 0.0489
Leishmania major phosphatidylinositol 3-kinase, putative 0.2215 0.3353 0.3277
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0633 0.0908 0.0805
Loa Loa (eye worm) phosphatidylinositol 3 0.0431 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.056 0.0795 0.0795
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0452 0.0629 0.0629
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3074 0.4681 0.462
Trichomonas vaginalis PIKK family atypical protein kinase 0.5192 0.7954 0.793
Mycobacterium tuberculosis Conserved hypothetical protein 0.0431 0.0596 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.5553 0.8512 0.8495
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0118 0.0112 0.0112
Leishmania major hypothetical protein, unknown function 0.0431 0.0596 0.0489
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0452 0.0629 0.0629
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0452 0.0629 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0452 0.0629 0.0522
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6516 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2226 0.337 0.3295
Echinococcus multilocularis Zinc finger, PHD finger 0.0452 0.0629 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.5192 0.7954 0.793
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0963 0.1418 0.1418
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0452 0.0629 0.0522
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0494 0.0694 0.0668
Trichomonas vaginalis PIKK family atypical protein kinase 0.3539 0.5399 0.5347
Giardia lamblia Phosphatidylinositol 4-kinase 0.0431 0.0596 0.0489
Loa Loa (eye worm) phosphatidylinositol 3 0.2226 0.337 0.337
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1252 0.1865 0.1772
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0431 0.0596 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.4857 0.7437 0.7408
Trichomonas vaginalis PIKK family atypical protein kinase 0.3539 0.5399 0.5347
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0816 0.1191 0.1191
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0452 0.0629 0.0522
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0494 0.0694 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.6516 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0431 0.0596 0.0489
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0431 0.0596 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0431 0.0596 0.0489
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1252 0.1865 0.1865
Echinococcus multilocularis serine protein kinase ATM 0.1252 0.1865 0.1865
Schistosoma mansoni voltage-gated potassium channel 0.017 0.0193 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.2215 0.3353 0.3277
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0568 0.0807 0.0703
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0156 0.0171 0.0171
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0452 0.0629 0.0047
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0431 0.0596 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.4229 0.6465 0.6425
Loa Loa (eye worm) hypothetical protein 0.1319 0.1968 0.1968
Loa Loa (eye worm) phosphatidylinositol 3 0.0773 0.1125 0.1125
Loa Loa (eye worm) hypothetical protein 0.0821 0.1198 0.1198
Echinococcus multilocularis fk506 binding protein 0.0118 0.0112 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.175 0.2634 0.2551
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0452 0.0629 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.3873 0.5916 0.5869
Loa Loa (eye worm) phosphatidylinositol 3 0.0431 0.0596 0.0596
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6516 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0474 0.0662 0.0556
Trichomonas vaginalis PIKK family atypical protein kinase 0.6516 1 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.1252 0.1865 0.1865
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2226 0.337 0.3295
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0494 0.0694 0.0589
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0494 0.0694 0.0589
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1252 0.1865 0.1842
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0494 0.0694 0.0694
Loa Loa (eye worm) phosphatidylinositol 3 0.6516 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0156 0.0171 0.0171
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0118 0.0112 0.0084
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2268 0.3435 0.3435
Trichomonas vaginalis PIKK family atypical protein kinase 0.3895 0.5949 0.5903
Trichomonas vaginalis PIKK family atypical protein kinase 0.2215 0.3353 0.3277
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2268 0.3435 0.3417
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1394 0.2085 0.2175
Trypanosoma cruzi hypothetical protein, conserved 0.0096 0.0079 0.0051
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0202 0.0242 0.0131
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6516 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0043 0.0043
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.056 0.0795 0.0795
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0517 0.0729 0.0624
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0156 0.0171 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0431 0.0596 0.0489
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0963 0.1418 0.1418
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2268 0.3435 0.3435
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0452 0.0629 0.0522
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2268 0.3435 0.3435
Leishmania major hypothetical protein, conserved 0.0527 0.0745 0.064
Plasmodium vivax hypothetical protein 0.0431 0.0596 0.9374
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0102 0.0087 0.0087
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2268 0.3435 0.3435
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0431 0.0596 0.0489
Entamoeba histolytica hypothetical protein 0.1252 0.1865 0.1772
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6516 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2215 0.3353 0.3277
Onchocerca volvulus 0.0431 0.0596 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0102 0.0087 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.5192 0.7954 0.793
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1252 0.1865 0.1865
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0452 0.0629 0.0629
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0431 0.0596 0.0489
Entamoeba histolytica hypothetical protein 0.059 0.0842 0.0738
Toxoplasma gondii target of rapamycin (TOR), putative 0.4857 0.7437 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0118 0.0112 0.0112
Loa Loa (eye worm) phosphatidylinositol 3 0.0063 0.0028 0.0028
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6516 1 1
Toxoplasma gondii FATC domain-containing protein 0.1252 0.1865 0.1854
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0431 0.0596 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.3539 0.5399 0.5347
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0703 0.1016 0.1016
Entamoeba histolytica protein kinase rad3, putative 0.1252 0.1865 0.1772
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0494 0.0694 0.0589
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0633 0.0908 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.5192 0.7954 0.793
Entamoeba histolytica hypothetical protein 0.0431 0.0596 0.0489
Loa Loa (eye worm) hypothetical protein 0.0102 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0431 0.0596 0.0596
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1252 0.1865 0.1865
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0431 0.0596 0.0596
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0431 0.0596 0.0596
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0633 0.0908 0.0908
Trypanosoma cruzi target of rapamycin kinase 3 0.5197 0.7962 0.7956
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0452 0.0629 1
Brugia malayi FAT domain containing protein 0.0963 0.1418 0.1418
Trichomonas vaginalis PIKK family atypical protein kinase 0.3895 0.5949 0.5903
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0452 0.0629 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0821 0.1198 0.1098
Trichomonas vaginalis PIKK family atypical protein kinase 0.3533 0.5391 0.5339
Schistosoma mansoni voltage-gated potassium channel 0.017 0.0193 0.0193
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.059 0.0842 0.0738
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0816 0.1191 0.1191
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0118 0.0112 0.0084
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0494 0.0694 0.0694
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0146 0.0155 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.3873 0.5916 0.5869
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0431 0.0596 0.9374
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0118 0.0112 0.0084
Plasmodium vivax hypothetical protein, conserved 0.0431 0.0596 0.9374

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.176 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.866 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.597 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.415 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.398 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.385 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.325 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.136 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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