TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 373.405 | Formula: C22H19N3O3
H donors: 2 H acceptors: 2 LogP: 3.37 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)COc1ccc(cc1)/C=N\NC(=O)c1ccc(cc1)c1ccccc1
InChi: 1S/C22H19N3O3/c23-21(26)15-28-20-12-6-16(7-13-20)14-24-25-22(27)19-10-8-18(9-11-19)17-4-2-1-3-5-17/h1-14H,15H2,(H2,23,26)(H,25,27)/b24-14-
InChiKey: REMBLIRVWWMSOX-OYKKKHCWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Starlite/ChEMBL	No references
Homo sapiens	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed), beta	Starlite/ChEMBL	No references
Homo sapiens	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Leishmania braziliensis	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma brucei	Mitochondrial import inner membrane translocase subunit TIM50	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	peptidase Clp S14 family	Get druggable targets OG5_127187	All targets in OG5_127187
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Candida albicans	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium yoelii	NLI interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	Heat shock protein 70, related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kDa protein 1A:1B	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Onchocerca volvulus		Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Giardia lamblia	Cytosolic HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Leishmania donovani	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	ATP-dependent Clp protease, proteolytic subunit ClpP, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Entamoeba histolytica	heat shock protein 70 family	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	NLI interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Neospora caninum	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma brucei	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania donovani	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	similar to Heat shock 70 kDa protein cognate 4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	Heat Shock protein family member (hsp 3)	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70 family	Get druggable targets OG5_126588	All targets in OG5_126588
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	similar to Heat shock 70 kDa protein homolog, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	dullard protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium knowlesi	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium falciparum	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium parvum	heat shock protein, Hsp70	Get druggable targets OG5_126588	All targets in OG5_126588
Babesia bovis	ATP-dependent Clp protease proteolytic subunit 1, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat Shock protein family member hsp 3	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	CTD small phosphatase protein like	Get druggable targets OG5_127075	All targets in OG5_127075
Brugia malayi	heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Toxoplasma gondii	heat shock protein HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Giardia lamblia	Bip	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	Plasma membrane Sodium Response 1	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	Plasma membrane Sodium Response 1	Get druggable targets OG5_127075	All targets in OG5_127075
Babesia bovis	Dullard-like phosphatase domain containing protein	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	heat shock protein 70kD, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	Probable ClpP-like protease	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Babesia bovis	dnaK protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus multilocularis	heat shock kda protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	heat shock protein 70kD, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium berghei	NLI interacting factor-like phosphatase	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70b	Get druggable targets OG5_126588	All targets in OG5_126588
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	3'partial\|5'partial\|heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	ko:K09490 heat shock 70kDa protein 5, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium hominis	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Trypanosoma brucei gambiense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	heat shock 70kDa protein 5	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	NLI interacting factor-like phosphatase domain-containing protein	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	heat shock 70 kDa protein C precursor	Get druggable targets OG5_126588	All targets in OG5_126588
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium knowlesi	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium vivax	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kda protein 1a	Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Trypanosoma brucei gambiense	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	dullard-like phosphatase domain containing protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein kDa heat shock kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma japonicum	ko:K01090 protein phosphatase [EC3.1.3.16], putative	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania major	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Trypanosoma brucei gambiense	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	heat shock protein kDa	Get druggable targets OG5_126588	All targets in OG5_126588
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Mycobacterium tuberculosis	Conserved hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Candida albicans	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium parvum	heat shock 70 (HSP70) protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium vivax	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Neospora caninum	Heat shock protein 70 (Precursor), related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	dullard protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium berghei	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Candida albicans	Cytoplasmic chaperone	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium knowlesi	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	ATP-dependent Clp protease proteolytic subunit, related	Get druggable targets OG5_127187	All targets in OG5_127187
Leishmania mexicana	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	ko:K06275 parvin, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium berghei	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania braziliensis	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	Get druggable targets OG5_127075	All targets in OG5_127075
Candida albicans	Cytoplasmic chaperone	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	dullard protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium berghei	NLI interacting factor-like phosphatase	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein kDa heat shock kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	TFIIF-stimulated CTD phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock protein 70 (HSP70)	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Toxoplasma gondii	chaperonin protein BiP	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	nuclear LIM interactor-interacting factor 1, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium knowlesi	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kDa protein 1	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70b	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	microsomal stress 70 protein ATPase core precursor, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Babesia bovis	heat shock protein 70 precursor, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	Get druggable targets OG5_127075	All targets in OG5_127075
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Theileria parva	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	heat shock kda protein	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium hominis	heat shock protein 70 precursor	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	CTD small phosphatase-like protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Entamoeba histolytica	70 kDa heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Giardia lamblia	Nuclear LIM interactor-interacting factor 1	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.1 %
Chlamydia trachomatis	hypothetical protein	ATP-dependent Clp protease proteolytic subunit	197 aa	171 aa	22.8 %
Onchocerca volvulus	Putative V-type proton ATPase subunit F	ATP-dependent Clp protease proteolytic subunit	197 aa	194 aa	54.1 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	polymerase (DNA directed), beta	335 aa	303 aa	32.3 %
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	ATP-dependent Clp protease proteolytic subunit	197 aa	172 aa	57.0 %
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	186 aa	40.3 %
Trypanosoma brucei	TFIIF-stimulated CTD phosphatase, putative	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	260 aa	263 aa	27.0 %
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	36.0 %
Plasmodium falciparum	heat shock protein 70	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	654 aa	613 aa	51.9 %
Schistosoma mansoni	neuropeptide receptor	ATP-dependent Clp protease proteolytic subunit	197 aa	174 aa	20.1 %
Plasmodium yoelii	Clp protease	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.6 %
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	180 aa	36.7 %
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	35.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0446	0.1493	0.1298
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0062	0.0108	0.0284
Leishmania major	hypothetical protein, conserved	0.0446	0.1493	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.1198	0.7931
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0094	0.0223	0.0119
Trichomonas vaginalis	conserved hypothetical protein	0.0446	0.1493	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0446	0.1493	0.5
Toxoplasma gondii	hypothetical protein	0.0446	0.1493	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0094	0.0223	1
Schistosoma mansoni	Fxna peptidase (M28 family)	0.0446	0.1493	0.1298
Loa Loa (eye worm)	hypothetical protein	0.2806	1	1
Schistosoma mansoni	glutaminyl cyclase (M28 family)	0.2806	1	1
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0446	0.1493	0.1402
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.1198	0.7015
Onchocerca volvulus	Glutaminyl cyclase homolog	0.2806	1	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0223	0.5
Loa Loa (eye worm)	hypothetical protein	0.0446	0.1493	0.1298
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0446	0.1493	0.1402
Mycobacterium tuberculosis	Probable lipoprotein aminopeptidase LpqL	0.0446	0.1493	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.0505	0.307
Mycobacterium ulcerans	hypothetical protein	0.0192	0.0575	0.2775
Loa Loa (eye worm)	hypothetical protein	0.0446	0.1493	0.1298
Mycobacterium tuberculosis	Conserved protein	0.0446	0.1493	1
Toxoplasma gondii	hypothetical protein	0.0059	0.0095	0.0635
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0062	0.0106	0.4744
Mycobacterium ulcerans	lipoprotein aminopeptidase LpqL	0.0446	0.1493	1
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	0.2806	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.1198	0.7931
Loa Loa (eye worm)	hypothetical protein	0.0446	0.1493	0.1298
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0094	0.0223	0.0119
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0446	0.1493	0.1402
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0223	0.1495
Trichomonas vaginalis	Clan MH, family M28, aminopeptidase S-like metallopeptidase	0.0446	0.1493	0.5
Brugia malayi	nicalin	0.0446	0.1493	0.1298
Echinococcus granulosus	glutaminyl peptide cyclotransferase	0.2806	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0505	0.307
Loa Loa (eye worm)	hypothetical protein	0.0446	0.1493	0.1298
Brugia malayi	leucyl aminopeptidase	0.0446	0.1493	0.1298
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0223	1
Toxoplasma gondii	peptidase, M28 family protein	0.0446	0.1493	1
Leishmania major	glutaminyl cyclase, putative	0.0446	0.1493	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.0575	0.3386
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0446	0.1493	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0223	0.5
Brugia malayi	FXNA	0.0446	0.1493	0.1298
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.1198	0.7931
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0223	0.1495
Loa Loa (eye worm)	leucyl aminopeptidase	0.0446	0.1493	0.1298
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0223	1
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0446	0.1493	1
Trichomonas vaginalis	conserved hypothetical protein	0.0446	0.1493	0.5
Schistosoma mansoni	glutaminyl-peptide cyclotransferase-related	0.0446	0.1493	0.1298
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0446	0.1493	0.1402
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0223	0.5
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0094	0.0223	1
Schistosoma mansoni	nicalin (M28 family)	0.0446	0.1493	0.1298
Mycobacterium ulcerans	hypothetical protein	0.0446	0.1493	1
Trypanosoma brucei	glutaminyl cyclase, putative	0.0446	0.1493	1
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0446	0.1493	0.1402

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 6.662 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1995947

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1624687