Detailed information for compound 1626837

Basic information

Technical information
  • TDR Targets ID: 1626837
  • Name: (4-aminocinnolin-3-yl)-phenylmethanone
  • MW: 249.267 | Formula: C15H11N3O
  • H donors: 1 H acceptors: 3 LogP: 2.73 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1nnc2c(c1N)cccc2)c1ccccc1
  • InChi: 1S/C15H11N3O/c16-13-11-8-4-5-9-12(11)17-18-14(13)15(19)10-6-2-1-3-7-10/h1-9H,(H2,16,17)
  • InChiKey: LXBJYSXWAMBHKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4-aminocinnolin-3-yl)-phenyl-methanone
  • (4-amino-3-cinnolinyl)-phenylmethanone
  • NSC701013
  • NCI60_036298

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0211 0.0348 0.8351
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0271 0.055 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.791 0.791
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0231 0.0414 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0579 0.1575 0.1567
Trichomonas vaginalis PIKK family atypical protein kinase 0.1698 0.5302 0.5302
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0211 0.0348 0.0338
Loa Loa (eye worm) hypothetical protein 0.0606 0.1666 0.1658
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1081 0.3249 0.3242
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0271 0.055 0.0541
Loa Loa (eye worm) phosphatidylinositol 3 0.0211 0.0348 0.0338
Loa Loa (eye worm) phosphatidylinositol 3 0.3108 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0231 0.0414 0.0095
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0464 0.1192 0.1184
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.7383 0.7383
Trichomonas vaginalis PIKK family atypical protein kinase 0.1698 0.5302 0.5302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0606 0.1666 0.1666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0211 0.0348 0.0348
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0606 0.1666 0.1658
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0211 0.0348 0.8351
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0334 0.0758 0.0749
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0211 0.0348 0.0338
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0396 0.0964 0.0955
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.791 0.791
Onchocerca volvulus 0.0211 0.0348 0.5
Echinococcus multilocularis Zinc finger, PHD finger 0.0231 0.0414 0.0405
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1462 0.4518 0.4513
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0231 0.0414 0.0405
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0231 0.0414 0.0405
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0211 0.0348 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.2643 0.8453 0.8453
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0231 0.0414 0.0405
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1081 0.3249 0.3242
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3108 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0231 0.0414 0.0414
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0251 0.0483 0.0474
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3108 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0606 0.1666 0.1666
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3108 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0271 0.055 0.0541
Loa Loa (eye worm) phosphatidylinositol 3 0.1081 0.3249 0.3242
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0342 0.0784 0.0784
Leishmania major phosphatidylinositol 3-kinase, putative 0.1071 0.3212 0.3206
Schistosoma mansoni voltage-gated potassium channel 0.0124 0.006 0.005
Brugia malayi FAT domain containing protein 0.0464 0.1192 0.1184
Loa Loa (eye worm) hypothetical protein 0.0625 0.1727 0.1719
Trichomonas vaginalis PIKK family atypical protein kinase 0.2016 0.6364 0.6364
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0404 0.0991 0.0991
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0114 0.0025 0.0015
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0231 0.0414 0.0405
Loa Loa (eye worm) phosphatidylinositol kinase 0.0211 0.0348 0.0338
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0211 0.0348 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.1856 0.5829 0.5829
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0231 0.0414 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0835 0.2429 0.2429
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1122 0.3383 0.3376
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0471 0.1215 0.1206
Plasmodium vivax hypothetical protein 0.0211 0.0348 0.8351
Leishmania major hypothetical protein, conserved 0.0303 0.0655 0.0646
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1122 0.3383 0.3376
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0231 0.0414 0.0405
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0606 0.1666 0.1658
Leishmania major phosphatidylinositol 4-kinase, putative 0.0211 0.0348 0.0338
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1122 0.3383 0.3376
Entamoeba histolytica protein kinase rad3, putative 0.0606 0.1666 0.1658
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.791 0.791
Mycobacterium tuberculosis Conserved hypothetical protein 0.0211 0.0348 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1071 0.3212 0.3212
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3108 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0271 0.055 0.055
Giardia lamblia GTOR 0.3108 1 1
Entamoeba histolytica hypothetical protein 0.0606 0.1666 0.1658
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0271 0.055 0.055
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1122 0.3383 0.3376
Trichomonas vaginalis PIKK family atypical protein kinase 0.1071 0.3212 0.3212
Trichomonas vaginalis PIKK family atypical protein kinase 0.1858 0.5836 0.5836
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1122 0.3383 0.3376
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0114 0.0025 0.0015
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0193 0.0289 0.028
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3108 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0675 0.1894 0.1894
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0211 0.0348 0.0338
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0114 0.0025 0.0015
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0293 0.0622 0.0613
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0334 0.0758 0.0749
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2483 0.7919 0.7917
Trichomonas vaginalis conserved hypothetical protein 0.0396 0.0964 0.0964
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0231 0.0414 0.0405
Loa Loa (eye worm) hypothetical protein 0.0464 0.1192 0.1184
Trichomonas vaginalis PIKK family atypical protein kinase 0.1858 0.5836 0.5836
Loa Loa (eye worm) phosphatidylinositol 3 0.0539 0.144 0.1432
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0231 0.0414 0.0405
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0404 0.0991 0.0991
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0363 0.0856 0.0847
Schistosoma mansoni voltage-gated potassium channel 0.0124 0.006 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.1695 0.5294 0.5294
Plasmodium vivax hypothetical protein, conserved 0.0211 0.0348 0.8351
Trichomonas vaginalis PIKK family atypical protein kinase 0.1856 0.5829 0.5829
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0211 0.0348 0.0338
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0009 0.0009
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0271 0.055 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.3108 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.7383 0.7383
Entamoeba histolytica hypothetical protein 0.0363 0.0856 0.0847
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0211 0.0348 0.0338
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0231 0.0414 0.0405
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0404 0.0991 0.0983
Trichomonas vaginalis PIKK family atypical protein kinase 0.1698 0.5302 0.5302
Giardia lamblia Hypothetical protein 0.0211 0.0348 0.0338
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0606 0.1666 0.1658
Onchocerca volvulus 0.0211 0.0348 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0211 0.0348 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.791 0.791
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0404 0.0991 0.0983
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0271 0.055 0.0541
Echinococcus multilocularis serine protein kinase ATM 0.0606 0.1666 0.1658
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0211 0.0348 0.0338
Schistosoma mansoni hypothetical protein 0.0211 0.0348 0.0338
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0606 0.1666 0.1658
Trichomonas vaginalis immunophilin, putative 0.0109 0.0009 0.0009
Schistosoma mansoni fkbp-rapamycin associated protein 0.0606 0.1666 0.1658
Trichomonas vaginalis PIKK family atypical protein kinase 0.2085 0.6592 0.6592
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0211 0.0348 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.7383 0.7383
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0211 0.0348 0.0338
Trypanosoma cruzi target of rapamycin kinase 3 0.2483 0.7919 0.7917
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0579 0.1575 0.1567
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0211 0.0348 0.0338
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0211 0.0348 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.7383 0.7383
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3108 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3108 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0334 0.0758 0.0749
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0271 0.055 0.0541
Loa Loa (eye worm) phosphatidylinositol 3 0.0211 0.0348 0.0338
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0211 0.0348 0.8351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0617 0.1702 0.1702
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0211 0.0348 0.0338
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0211 0.0348 0.8351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.0964 0.0964
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0579 0.1575 0.1567
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0211 0.0348 0.0338
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3108 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0109 0.0009 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0675 0.1894 0.2198
Loa Loa (eye worm) hypothetical protein 0.0675 0.1894 0.1887
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2483 0.7919 0.7917
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3108 1 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0175 0.023 0.022
Loa Loa (eye worm) hypothetical protein 0.0396 0.0964 0.0955
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0404 0.0991 0.0983
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0606 0.1666 0.1658
Giardia lamblia Phosphatidylinositol 4-kinase 0.0211 0.0348 0.0338
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0211 0.0348 0.8351
Schistosoma mansoni hypothetical protein 0.0464 0.1192 0.1184
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1122 0.3383 0.3376
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0231 0.0414 0.0405
Toxoplasma gondii target of rapamycin (TOR), putative 0.2322 0.7383 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0606 0.1666 0.1658
Loa Loa (eye worm) phosphatidylinositol 3 0.0211 0.0348 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0211 0.0348 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.3108 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0231 0.0414 0.0405
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0211 0.0348 0.0338
Leishmania major phosphatidylinositol 3-kinase, putative 0.0231 0.0414 0.0405
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0231 0.0414 0.0405
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.7383 0.7383
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0211 0.0348 0.0338
Entamoeba histolytica hypothetical protein 0.0211 0.0348 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.1695 0.5294 0.5294
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.7383 0.7383
Loa Loa (eye worm) phosphatidylinositol 3 0.0211 0.0348 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.1858 0.5836 0.5836
Echinococcus multilocularis 0.0211 0.0348 0.0338
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0231 0.0414 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0211 0.0348 0.0348
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3108 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1071 0.3212 0.3206
Trichomonas vaginalis conserved hypothetical protein 0.0464 0.1192 0.1192
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0231 0.0414 0.0095
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3108 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0271 0.055 0.0541
Mycobacterium leprae conserved hypothetical protein 0.0211 0.0348 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0231 0.0414 0.0414
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0471 0.1215 0.1206
Trichomonas vaginalis PIKK family atypical protein kinase 0.1071 0.3212 0.3212
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0617 0.1702 0.1694
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0211 0.0348 0.0338
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0342 0.0784 0.0784
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1302 0.3984 0.3978
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.791 0.791
Trichomonas vaginalis PIKK family atypical protein kinase 0.1698 0.5302 0.5302
Leishmania major phosphatidylinositol kinase related protein, putative 0.0211 0.0348 0.0338
Trichomonas vaginalis fk506-binding protein, putative 0.0109 0.0009 0.0009
Leishmania major hypothetical protein, unknown function 0.0211 0.0348 0.0338
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0464 0.1192 0.1184
Loa Loa (eye worm) hypothetical protein 0.0211 0.0348 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.1695 0.5294 0.5294
Leishmania major phosphatidylinositol kinase, putative 0.0211 0.0348 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.3108 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1081 0.3249 0.3249
Toxoplasma gondii FATC domain-containing protein 0.0606 0.1666 0.1874
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0211 0.0348 0.0338
Entamoeba histolytica hypothetical protein 0.0211 0.0348 0.0338
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0606 0.1666 0.1658
Trichomonas vaginalis PIKK family atypical protein kinase 0.1071 0.3212 0.3212
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0211 0.0348 0.0338
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0231 0.0414 0.0405
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0404 0.0991 0.0991
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.7383 0.7383
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0606 0.1666 0.1658
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0109 0.0009 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0231 0.0414 0.0405
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0404 0.0991 0.0983
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0114 0.0025 0.0015
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0301 0.0648 0.0639
Entamoeba histolytica hypothetical protein 0.0211 0.0348 0.0338
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0334 0.0758 0.0749
Echinococcus granulosus serine protein kinase ATM 0.0606 0.1666 0.1658

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.778 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.725 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.631 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.608 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.605 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.605 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.569 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.562 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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