Detailed information for compound 1630291

Basic information

Technical information
  • TDR Targets ID: 1630291
  • Name: N-hydroxy-4-(2-morpholin-4-ylethylamino)quino lin-5-amine oxide hydrochloride
  • MW: 338.789 | Formula: C15H19ClN4O3
  • H donors: 1 H acceptors: 3 LogP: 2.47 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cccc2c1c(NCCN1CCOCC1)ccn2.Cl
  • InChi: 1S/C15H18N4O3.ClH/c20-19(21)14-3-1-2-12-15(14)13(4-5-16-12)17-6-7-18-8-10-22-11-9-18;/h1-5H,6-11H2,(H,16,17);1H
  • InChiKey: HJTYTAKBQVCYDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-morpholin-4-ylethyl)-5-nitroquinolin-4-amine hydrochloride
  • N-hydroxy-4-(2-morpholinoethylamino)quinolin-5-amine oxide hydrochloride
  • N-(2-morpholinoethyl)-5-nitro-quinolin-4-amine hydrochloride
  • N-hydroxy-4-(2-morpholinoethylamino)-5-quinolinamine oxide hydrochloride
  • N-(2-morpholinoethyl)-5-nitro-4-quinolinamine hydrochloride
  • 2-morpholinoethyl-(5-nitro-4-quinolyl)amine hydrochloride
  • N-(2-morpholin-4-ylethyl)-5-nitro-quinolin-4-amine hydrochloride
  • NSC646859

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0031 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0089 0.1224 0.2959
Brugia malayi Glycosyl hydrolases family 31 protein 0.0117 0.1722 0.1722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.156 0.3621
Echinococcus multilocularis 0.0031 0.0194 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0172 0.2689 0.6415
Leishmania major phosphatidylinositol kinase related protein, putative 0.0031 0.0194 0.047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0194 0.0194
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0582 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0194 0.024
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0031 0.0194 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0194 0.047
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0031 0.0194 0.024
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.019 0.3008 0.2939
Echinococcus granulosus lysosomal alpha glucosidase 0.0117 0.1722 0.164
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0904 0.1997
Leishmania major hypothetical protein, unknown function 0.0031 0.0194 0.047
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0031 0.0194 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0716 0.1533
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0031 0.0194 0.0098
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0194 0.024
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0021 0 0.5
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0 0.5
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0031 0.0194 0.047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.1277 0.292
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0031 0.0194 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0716 0.1533
Echinococcus multilocularis serine protein kinase ATM 0.0092 0.1277 0.1191
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0182 0.2866 0.6855
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0097 0.0323
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0194 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0164 0.2547 0.6064
Schistosoma mansoni fkbp-rapamycin associated protein 0.0092 0.1277 0.1191
Entamoeba histolytica hypothetical protein 0.0031 0.0194 0.0646
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0092 0.1277 0.292
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0031 0.0194 0.024
Echinococcus multilocularis lysosomal alpha glucosidase 0.0117 0.1722 0.164
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0194 0.0646
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.019 0.3008 0.7271
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.283 0.6765
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0194 0.0646
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0097 0.0323
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0031 0.0194 0.0646
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0071 0.0904 0.0815
Leishmania major phosphatidylinositol 4-kinase, putative 0.0031 0.0194 0.047
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0031 0.0194 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.2724 0.6504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.4137 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0103 0.1464 0.5003
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0031 0.0194 0.0646
Leishmania major hypothetical protein, conserved 0.0031 0.0194 0.047
Echinococcus multilocularis Zinc finger, PHD finger 0.0031 0.0194 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0092 0.1277 0.1277
Entamoeba histolytica hypothetical protein 0.0031 0.0194 0.0646
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0253 0.4137 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.1596 0.371
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.0097 0.0097
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.019 0.3008 0.2939
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.019 0.3008 0.2939
Onchocerca volvulus 0.0031 0.0194 0.231
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0031 0.0194 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0194 0.0355
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0031 0.0194 0.0098
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0031 0.0194 0.024
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0031 0.0194 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.2866 0.6854
Toxoplasma gondii FATC domain-containing protein 0.0092 0.1277 0.4316
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0026 0.0097 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.2866 0.6854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.2866 0.6854
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0031 0.0194 0.0098
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0031 0.0194 0.0646
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0092 0.1277 0.1191
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.019 0.3008 0.2939
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0 0.5
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0182 0.2867 0.9531
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0194 0.0646
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0031 0.0194 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0172 0.2688 0.6414
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0194 0.024
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0182 0.2866 0.6929
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.2866 0.6854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0172 0.2688 0.6414
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0194 0.024
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.019 0.3008 0.7205
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0092 0.1277 0.1191
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0031 0.0194 0.0098
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0194 0.047
Giardia lamblia GTOR 0.019 0.3008 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0194 0.047
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0031 0.0194 0.0098
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.0194 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0194 0.0098
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.0194 0.5
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0031 0.0194 0.0098
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0047 0.0478 0.0942
Schistosoma mansoni alpha-glucosidase 0.0101 0.1431 0.1347
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0031 0.0194 0.0098
Brugia malayi FAT domain containing protein 0.0071 0.0904 0.0904
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0031 0.0194 0.0098
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0111 0.1606 0.3736
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.019 0.3008 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.019 0.3008 0.7271
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0 0.5
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0582 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0031 0.0194 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.156 0.3621
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0031 0.0194 0.024
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0194 0.047
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0031 0.0194 0.0098
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0194 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0031 0.0194 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.3008 0.7205
Entamoeba histolytica hypothetical protein 0.0092 0.1277 0.4245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0194 0.047
Leishmania major phosphatidylinositol 3-kinase, putative 0.0164 0.2547 0.6156
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.283 0.6765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.1738 0.4061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0172 0.2689 0.6415
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0031 0.0194 0.0098
Echinococcus granulosus serine protein kinase ATM 0.0092 0.1277 0.1191
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0194 0.0646
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0164 0.2547 0.6064
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0092 0.1277 0.1191
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.3008 0.7205
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0194 0.5
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0117 0.1722 0.4162
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0582 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0172 0.2689 0.6415
Loa Loa (eye worm) hypothetical protein 0.0089 0.1224 0.2959
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0031 0.0194 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0172 0.2689 0.6415
Onchocerca volvulus 0.0031 0.0194 0.231
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0194 0.0098
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0031 0.0194 0.0098
Entamoeba histolytica hypothetical protein 0.0031 0.0194 0.0646
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.019 0.3008 0.7205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0336 0.059
Loa Loa (eye worm) phosphatidylinositol kinase 0.0031 0.0194 0.047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0092 0.1277 0.1277
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0031 0.0194 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0194 0.024
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0092 0.1277 0.1191
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.019 0.3008 1
Mycobacterium ulcerans hypothetical protein 0.0021 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0194 0.024
Schistosoma mansoni hypothetical protein 0.0031 0.0194 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.2866 0.6854
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0194 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.283 0.6765
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0031 0.0194 0.0098
Loa Loa (eye worm) hypothetical protein 0.0061 0.0716 0.1732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.1277 0.292
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0031 0.0194 0.024
Onchocerca volvulus 0.0068 0.0841 1
Plasmodium vivax hypothetical protein 0.0031 0.0194 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.2724 0.6504
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.283 0.6765
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0031 0.0194 0.0098
Entamoeba histolytica hypothetical protein 0.0031 0.0194 0.0646
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0021 0 0.5
Leishmania major alpha glucosidase II subunit, putative 0.0026 0.0097 0.0235
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0194 0.047
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.019 0.3008 0.2939
Loa Loa (eye worm) hypothetical protein 0.0031 0.0194 0.047
Loa Loa (eye worm) hypothetical protein 0.0071 0.0904 0.2185
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0194 0.0355
Entamoeba histolytica protein kinase rad3, putative 0.0092 0.1277 0.4245
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.283 0.6765
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0194 0.0194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0194 0.0194
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0194 0.0355
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0194 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.3008 0.7205
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0031 0.0194 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0164 0.2547 0.6064
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0031 0.0194 0.0098
Loa Loa (eye worm) phosphatidylinositol 3 0.0253 0.4137 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0031 0.0194 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0194 0.047
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0031 0.0194 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.019 0.3008 0.3008
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0031 0.0194 0.5
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0031 0.0194 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0172 0.2688 0.6414
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0194 0.024
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0582 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0031 0.0194 0.0098
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0031 0.0194 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.283 0.6765
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0071 0.0904 0.0815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.2867 0.6856
Schistosoma mansoni alpha-glucosidase 0.0101 0.1431 0.1347
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0031 0.0194 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1464 0.3384
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0031 0.0194 0.0098
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0031 0.0194 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0194 0.0194
Loa Loa (eye worm) phosphatidylinositol 3 0.019 0.3008 0.7271
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0194 0.047
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0092 0.1277 0.1191
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.283 0.6765
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0194 0.024
Loa Loa (eye worm) hypothetical protein 0.0092 0.1277 0.3086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0164 0.2547 0.6064
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0031 0.0194 0.0098
Toxoplasma gondii target of rapamycin (TOR), putative 0.018 0.283 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0194 0.0194
Echinococcus multilocularis lysosomal alpha glucosidase 0.0117 0.1722 0.164
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0031 0.0194 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.1783 0.4174
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0031 0.0194 0.0098
Schistosoma mansoni hypothetical protein 0.0071 0.0904 0.0815
Trypanosoma cruzi target of rapamycin kinase 3 0.0182 0.2866 0.2796
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0061 0.0716 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.156 0.3621
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0194 0.0355
Leishmania major phosphatidylinositol kinase, putative 0.0031 0.0194 0.047
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0031 0.0194 0.0098
Loa Loa (eye worm) hypothetical protein 0.0103 0.1464 0.354
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0253 0.4137 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0164 0.2547 0.6064
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0031 0.0194 0.024
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0031 0.0194 0.024
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0582 1 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.974 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.932 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.86 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.788 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.777 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.693 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.649 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.566 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.479 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.38 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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