Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.0457 | 0.2978 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0026 | 0.0225 | 0.1466 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.1 | 0.651 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0026 | 0.0225 | 0.1405 |
Echinococcus granulosus | lamin | 0.0029 | 0.0261 | 0.1959 |
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.0022 | 0.0172 | 0.5 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0026 | 0.0225 | 0.0464 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.055 | 0.3576 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0026 | 0.0225 | 0.0192 |
Echinococcus granulosus | cpg binding protein | 0.0065 | 0.0696 | 0.6697 |
Mycobacterium ulcerans | carbohydrate kinase CbhK | 0.0022 | 0.0172 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0053 | 0.055 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0045 | 0.0447 | 0.037 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0081 | 0.0508 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0261 | 0.0283 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0081 | 0.0508 |
Echinococcus multilocularis | ribokinase | 0.0022 | 0.0172 | 0.0092 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0261 | 0.1959 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0053 | 0.055 | 0.5112 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0081 | 0.0508 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0447 | 0.2914 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0026 | 0.0225 | 0.0192 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0081 | 0.0508 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.055 | 0.3576 |
Echinococcus multilocularis | adenosine kinase | 0.0022 | 0.0172 | 0.0092 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0022 | 0.0172 | 0.7635 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0081 | 0.0508 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0022 | 0.0172 | 0.7635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0081 | 0.0508 |
Echinococcus multilocularis | pseudouridine metabolizing bifunctional protein | 0.0022 | 0.0172 | 0.0092 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.0091 | 0.1 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0019 | 0.0139 | 0.0061 |
Echinococcus granulosus | adenosine kinase | 0.0022 | 0.0172 | 0.0993 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0026 | 0.0225 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.055 | 0.3576 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.0091 | 0.1 | 0.0927 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0172 | 0.1104 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0261 | 0.1959 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0172 | 0.0148 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0503 | 0.3278 |
Brugia malayi | Kinase associated domain 1 family protein | 0.0045 | 0.0447 | 0.053 |
Onchocerca volvulus | 0.0029 | 0.0261 | 0.0137 | |
Mycobacterium tuberculosis | Ribokinase RbsK | 0.0022 | 0.0172 | 0.5 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0015 | 0.0097 | 0.0016 |
Onchocerca volvulus | 0.0029 | 0.0261 | 0.0137 | |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0053 | 0.055 | 0.0722 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0081 | 0.0508 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0081 | 0.0508 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0045 | 0.0457 | 0.4095 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0135 | 0.1535 | 1 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0026 | 0.0225 | 0.1571 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0026 | 0.0225 | 0.1451 |
Schistosoma mansoni | cpg binding protein | 0.0065 | 0.0696 | 0.4537 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0081 | 0.0508 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0026 | 0.0225 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0254 | 0.0273 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0022 | 0.0172 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0081 | 0.0508 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0053 | 0.055 | 0.3306 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0261 | 0.0246 |
Mycobacterium tuberculosis | Adenosine kinase | 0.0022 | 0.0172 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0097 | 0.0176 |
Schistosoma mansoni | lamin | 0.0029 | 0.0261 | 0.1698 |
Trichomonas vaginalis | ribokinase, putative | 0.0022 | 0.0172 | 0.1104 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0015 | 0.0097 | 0.063 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0261 | 0.0283 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0053 | 0.055 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0019 | 0.0123 |
Trichomonas vaginalis | chaperonin, putative | 0.0026 | 0.0225 | 0.1451 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0053 | 0.055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0172 | 0.0148 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0099 | 0.0038 |
Schistosoma mansoni | cpg binding protein | 0.0065 | 0.0696 | 0.4537 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0503 | 0.0614 |
Trichomonas vaginalis | ribokinase, putative | 0.0022 | 0.0172 | 0.1104 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0261 | 0.0283 |
Echinococcus granulosus | calcium activated potassium channel | 0.0045 | 0.0457 | 0.4095 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0081 | 0.0508 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.055 | 1 |
Entamoeba histolytica | ribokinase, putative | 0.0022 | 0.0172 | 0.7635 |
Mycobacterium ulcerans | fructokinase, PfkB | 0.0022 | 0.0172 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.0022 | 0.0172 | 0.1119 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0081 | 0.0508 |
Entamoeba histolytica | fructokinase, putative | 0.0022 | 0.0172 | 0.7635 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0261 | 0.0182 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0261 | 0.0246 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0261 | 0.0182 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0026 | 0.0225 | 0.0146 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0503 | 0.4596 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0261 | 0.1698 |
Trypanosoma brucei | protein kinase, putative | 0.0053 | 0.055 | 1 |
Brugia malayi | Adenosine kinase-like | 0.0022 | 0.0172 | 0.0111 |
Echinococcus granulosus | ribokinase | 0.0022 | 0.0172 | 0.0993 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0053 | 0.055 | 0.5112 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.055 | 0.3576 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0081 | 0.0508 |
Brugia malayi | CXXC zinc finger family protein | 0.0062 | 0.0654 | 0.0844 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.0457 | 0.2978 |
Brugia malayi | MAP kinase sur-1 | 0.0053 | 0.055 | 0.0687 |
Brugia malayi | hypothetical protein | 0.0564 | 0.6674 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0081 | 0.0508 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0045 | 0.0457 | 0.4095 |
Schistosoma mansoni | cpg binding protein | 0.0062 | 0.0654 | 0.4261 |
Trichomonas vaginalis | helicase, putative | 0.0014 | 0.0081 | 0.0508 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0503 | 0.065 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0503 | 0.4596 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0053 | 0.055 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0261 | 0.0182 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.0457 | 0.2978 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0045 | 0.0457 | 0.038 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.0457 | 0.2978 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0045 | 0.0457 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0447 | 0.0565 |
Schistosoma mansoni | ribokinase | 0.0022 | 0.0172 | 0.1119 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0097 | 0.0016 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0081 | 0.0508 |
Brugia malayi | Protein kinase domain containing protein | 0.0135 | 0.1535 | 0.2183 |
Brugia malayi | Ribokinase | 0.0022 | 0.0172 | 0.0111 |
Loa Loa (eye worm) | histone methyltransferase | 0.0019 | 0.0142 | 0.0103 |
Schistosoma mansoni | adenosine kinase | 0.0022 | 0.0172 | 0.1119 |
Echinococcus granulosus | pseudouridine metabolizing bifunctional protein | 0.0022 | 0.0172 | 0.0993 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0026 | 0.0225 | 0.0229 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0053 | 0.055 | 0.0474 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0503 | 0.3278 |
Onchocerca volvulus | 0.0062 | 0.0654 | 0.0742 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.055 | 0.3587 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.1 | 0.651 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0015 | 0.0097 | 0.0176 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0142 | 0.0062 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0503 | 0.3278 |
Schistosoma mansoni | lamin | 0.0029 | 0.0261 | 0.1698 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0062 | 0.0654 | 0.0879 |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0026 | 0.0225 | 0.1405 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0081 | 0.0508 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0503 | 0.0426 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0053 | 0.055 | 1 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0026 | 0.0225 | 0.1405 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0053 | 0.055 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.6674 | 1 |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0026 | 0.0225 | 0.1405 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0053 | 0.055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0081 | 0.001 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0045 | 0.0457 | 0.038 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.0457 | 0.2978 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0026 | 0.0225 | 0.1466 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0026 | 0.0225 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0503 | 0.0426 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.0135 | 0.1535 | 0.2213 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.055 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0065 | 0.0696 | 0.0621 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0026 | 0.0225 | 0.1466 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0117 | 0.1317 | 1 |
Entamoeba histolytica | kinase, PfkB family | 0.0022 | 0.0172 | 0.7635 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0142 | 0.0668 |
Trichomonas vaginalis | ribokinase, putative | 0.0022 | 0.0172 | 0.1104 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0081 | 0.0508 |
Schistosoma mansoni | serine/threonine kinase | 0.0135 | 0.1535 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0447 | 0.2914 |
Onchocerca volvulus | 0.0564 | 0.6674 | 1 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0131 | 0.1485 | 0.9678 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.747 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.718 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.71 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.585 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.562 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.521 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.48 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.476 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.