TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 417.479 | Formula: C24H24FN5O
H donors: 0 H acceptors: 3 LogP: 3.67 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(nc1)CN1CCC(CC1)Oc1ncnc2c1ccn2Cc1ccccc1
InChi: 1S/C24H24FN5O/c25-19-6-7-20(26-14-19)16-29-11-8-21(9-12-29)31-24-22-10-13-30(23(22)27-17-28-24)15-18-4-2-1-3-5-18/h1-7,10,13-14,17,21H,8-9,11-12,15-16H2
InChiKey: APNKIFBEFRZJNR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sodium channel, voltage-gated, type IX, alpha subunit	Starlite/ChEMBL	References
Homo sapiens	sodium channel, voltage-gated, type V, alpha subunit	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Leishmania major	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Leishmania infantum	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Leishmania donovani	calcium channel protein, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	Get druggable targets OG5_126819	All targets in OG5_126819
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Leishmania mexicana	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania braziliensis	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0196	0.5113	0.5074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.027	0.7283	0.7261
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0023	0.0081	0.0074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.5733	0.5698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.027	0.7283	0.7261
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0023	0.0081	0.0014
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0023	0.0081	0.0081
Echinococcus multilocularis		0.0023	0.0081	0.0081
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0023	0.0081	0.0014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.027	0.7283	0.7261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.1402	0.1332
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0023	0.0081	0.0074
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0122	0.2953	0.2895
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0023	0.0081	0.0081
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0023	0.0081	0.0074
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0023	0.0081	0.0074
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0363	1	1
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0023	0.0081	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0947	0.0873
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0021	0.0007	0.0007
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0069	0.1402	0.1396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0718	0.0642
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0612	0.0536
Echinococcus granulosus	sodium channel protein	0.0094	0.2129	0.2129
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0363	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0289	0.783	0.7813
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0023	0.0081	0.0014
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0069	0.1402	0.1344
Echinococcus multilocularis	sodium channel protein	0.0094	0.2129	0.2129
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0363	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0076	0.1631	0.1563
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0045	0.0718	0.0712
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0023	0.0081	0.0074
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0023	0.0081	0.0014
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0023	0.0081	0.0081
Entamoeba histolytica	protein kinase, putative	0.0033	0.0375	0.0368
Entamoeba histolytica	protein kinase, putative	0.0033	0.0375	0.0368
Giardia lamblia	Hypothetical protein	0.0023	0.0081	0.0074
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0363	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0363	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.027	0.7283	0.7261
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0023	0.0081	0.0081
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0023	0.0081	0.0014
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0069	0.1402	0.1396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0289	0.783	0.7813
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1402	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.027	0.7283	0.7261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0243	0.6509	0.6481
Entamoeba histolytica	protein kinase rad3, putative	0.0069	0.1402	0.1396
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0023	0.0081	1
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0375	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0718	0.0642
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.0375	0.0296
Toxoplasma gondii	target of rapamycin (TOR), putative	0.027	0.7283	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0069	0.1402	0.1332
Echinococcus multilocularis	Zinc finger, PHD finger	0.0023	0.0081	0.0081
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0023	0.0081	0.0074
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.005	0.0869	0.0795
Schistosoma mansoni	hypothetical protein	0.0023	0.0081	0.0014
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0122	0.2953	0.2895
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0069	0.1402	0.1344
Loa Loa (eye worm)	phosphatidylinositol 3	0.0122	0.2953	0.2895
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0023	0.0081	0.0081
Toxoplasma gondii	FATC domain-containing protein	0.0069	0.1402	0.1835
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0023	0.0081	0.0081
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0023	0.0081	0.0074
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0363	1	1
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0023	0.0081	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0196	0.5122	0.5082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0196	0.5113	0.5074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0289	0.783	0.7813
Plasmodium vivax	hypothetical protein	0.0023	0.0081	1
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0053	0.0947	0.0947
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.0081	1
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0375	0.0296
Entamoeba histolytica	hypothetical protein	0.0023	0.0081	0.0074
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0151	0.3801	0.375
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0122	0.2953	0.2948
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1631	0.1563
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0081	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0054	0.0989	0.0928
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0023	0.0081	0.0074
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0023	0.0081	0.0074
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0023	0.0081	0.0074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0363	1	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0053	0.0947	0.0947
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0067	0.006
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0023	0.0081	0.0074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0122	0.2953	0.2895
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0363	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0023	0.0081	0.0074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0215	0.567	0.5634
Echinococcus granulosus	serine threonine protein kinase nrc	0.0021	0.0007	0.0007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0097	0.2242	0.2178
Onchocerca volvulus		0.0023	0.0081	0.5
Brugia malayi	FAT domain containing protein	0.0053	0.0947	0.0873
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0023	0.0081	0.0074
Entamoeba histolytica	hypothetical protein	0.0023	0.0081	0.0074
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0094	0.2129	0.2065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0236	0.628	0.625
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.005	0.0869	0.0795
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0375	0.0296
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0122	0.2953	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0122	0.2953	0.2895
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0315	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0363	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1558	0.1489
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0023	0.0081	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0363	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0122	0.2953	0.2948
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0023	0.0081	0.0074
Trypanosoma cruzi	Protein kinase B	0.0023	0.0067	0.006
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0363	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0023	0.0081	1
Mycobacterium leprae	conserved hypothetical protein	0.0023	0.0081	0.5
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0023	0.0081	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.031	0.845	0.8437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0289	0.783	0.7813
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0023	0.0081	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0172	0.4411	0.4366
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0023	0.0081	0.0081
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0023	0.0081	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0375	0.0296
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0612	0.0536
Onchocerca volvulus		0.0023	0.0081	0.5
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0076	0.1631	0.2153
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.1402	0.1332
Entamoeba histolytica	hypothetical protein	0.0023	0.0081	0.0074
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0023	0.0081	0.0074
Giardia lamblia	GTOR	0.0363	1	1
Toxoplasma gondii	AGC kinase	0.0031	0.0315	0.0325
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0067	0.006
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0196	0.5122	0.5082
Schistosoma mansoni	hypothetical protein	0.0053	0.0947	0.0886
Trichomonas vaginalis	PIKK family atypical protein kinase	0.027	0.7283	0.7261
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0069	0.1402	0.1396
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0023	0.0081	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0122	0.2953	0.2895
Trypanosoma cruzi	target of rapamycin kinase 3	0.0289	0.7839	0.7838
Echinococcus granulosus	serine protein kinase ATM	0.0069	0.1402	0.1402
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0196	0.5113	0.5074
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0023	0.0067	0.006
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0023	0.0081	1
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0023	0.0081	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.1402	0.1332
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0023	0.0081	0.0081
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0289	0.7839	0.7822
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0023	0.0081	0.0014
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0069	0.1402	0.1402
Entamoeba histolytica	protein kinase, putative	0.0031	0.0315	0.0308
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0718	0.0642
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0021	0.0007	0.0007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0196	0.5122	0.5082
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.005	0.0869	0.0869
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0069	0.1402	0.1402
Trichomonas vaginalis	PIKK family atypical protein kinase	0.027	0.7283	0.7261
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0033	0.0375	0.0296
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0363	1	1
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0023	0.0081	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0215	0.567	0.5634
Echinococcus granulosus	serine/threonine protein kinase	0.0023	0.0067	0.0067
Entamoeba histolytica	hypothetical protein	0.0023	0.0081	0.0074
Plasmodium vivax	hypothetical protein, conserved	0.0023	0.0081	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.005	0.0869	0.0869
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0375	0.0296
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0196	0.5122	0.5082
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0023	0.0081	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0947	0.0873
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.0081	1
Echinococcus multilocularis	serine protein kinase ATM	0.0069	0.1402	0.1402
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.5733	0.5698
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0697	0.0622
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0289	0.7839	0.7822
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0375	0.0296
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0023	0.0081	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0375	0.0296
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0094	0.2129	0.2129
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0363	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.5733	0.5698
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0122	0.2953	0.2895
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0122	0.2953	0.2953
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0122	0.2953	0.2895
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0363	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0023	0.0081	0.0074
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0315	0.0236
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0069	0.1402	0.1332
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0023	0.0081	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0289	0.783	0.7813
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0069	0.1402	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0363	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0122	0.2953	0.2895
Entamoeba histolytica	hypothetical protein	0.0069	0.1402	0.1396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0122	0.2953	0.2895
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0023	0.0081	0.0014
Echinococcus multilocularis	rac serine:threonine kinase	0.0023	0.0067	0.0067
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0375	0.0296
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0023	0.0081	0.0074
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0122	0.2953	0.2905
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0122	0.2953	0.2953
Schistosoma mansoni	voltage-gated potassium channel	0.0054	0.0989	0.0928

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.11 uM	Antagonist activity at human NaV1.5 channel by patchXpress assay	ChEMBL.	22318156
IC50 (functional)	= 0.18 uM	Antagonist activity at human NaV1.7 channel by patchXpress assay	ChEMBL.	22318156
Ki (binding)	= 1.1 uM	Displacement of dofetilide from human ERG	ChEMBL.	22318156

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2012295

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1632764