Detailed information for compound 1632791

Basic information

Technical information
  • TDR Targets ID: 1632791
  • Name: 2-(dimethylaminomethyl)-2,5-bis(phenylmethyl) cyclopentan-1-one
  • MW: 321.456 | Formula: C22H27NO
  • H donors: 0 H acceptors: 1 LogP: 4.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CC1(CCC(C1=O)Cc1ccccc1)Cc1ccccc1)C
  • InChi: 1S/C22H27NO/c1-23(2)17-22(16-19-11-7-4-8-12-19)14-13-20(21(22)24)15-18-9-5-3-6-10-18/h3-12,20H,13-17H2,1-2H3
  • InChiKey: NVUZYMYMQSYKHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(dimethylaminomethyl)-2,5-bis(phenylmethyl)-1-cyclopentanone
  • 2,5-bis(benzyl)-2-(dimethylaminomethyl)cyclopentan-1-one
  • NCI60_013135

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.1223 0.2081 0.2081
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5714 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.4558 0.7961 0.7956
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0166 0.0216 0.0191
Schistosoma mansoni immunophilin 0.0166 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0067 0.0041 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.024 0.0346 0.0346
Loa Loa (eye worm) FKBP5 protein 0.0166 0.0216 0.0216
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0563 0.0915 0.0892
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0025 0.0025
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.073 0.121 0.121
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0378 0.0591 0.9176
Schistosoma mansoni fkbp-rapamycin associated protein 0.1098 0.186 0.186
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0563 0.0915 0.0915
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.1098 0.186 0.186
Trichomonas vaginalis PIKK family atypical protein kinase 0.426 0.7436 0.7436
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0591 0.0591
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1992 0.3436 0.3436
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0397 0.0624 0.0624
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0591 0.0591
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5714 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0397 0.0624 0.0049
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0397 0.0624 0.0624
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0397 0.0624 0.06
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0378 0.0591 0.0567
Toxoplasma gondii target of rapamycin (TOR), putative 0.426 0.7436 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.0591 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.3099 0.5389 0.5389
Giardia lamblia Hypothetical protein 0.0378 0.0591 0.0383
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0378 0.0591 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.426 0.7436 0.7436
Trichomonas vaginalis PIKK family atypical protein kinase 0.3415 0.5946 0.5946
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0184 0.0248 0.0033
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1098 0.186 0.1681
Trichomonas vaginalis PIKK family atypical protein kinase 0.426 0.7436 0.7436
Trichomonas vaginalis PIKK family atypical protein kinase 0.3833 0.6683 0.6683
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0591 0.0591
Leishmania major hypothetical protein, unknown function 0.0378 0.0591 0.0383
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0166 0.0216 0.0191
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4558 0.7961 0.7916
Loa Loa (eye worm) hypothetical protein 0.0845 0.1413 0.1413
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0378 0.0591 0.0591
Entamoeba histolytica hypothetical protein 0.0378 0.0591 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.426 0.7436 0.7436
Giardia lamblia GTOR 0.5714 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5714 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0378 0.0591 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0436 0.0693 0.0693
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0166 0.0216 0.0216
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0496 0.0798 0.0798
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0378 0.0591 0.9176
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1109 0.1879 0.17
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0563 0.0915 0.0715
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0378 0.0591 0.9176
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.0591 0.0591
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0378 0.0591 0.0567
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0845 0.1413 0.1413
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0166 0.0216 0.0191
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1223 0.2081 0.2176
Trichomonas vaginalis PIKK family atypical protein kinase 0.5714 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0166 0.0216 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.3104 0.5397 0.5397
Trichomonas vaginalis PIKK family atypical protein kinase 0.4553 0.7953 0.7953
Leishmania major phosphatidylinositol 4-kinase, putative 0.0378 0.0591 0.0383
Loa Loa (eye worm) hypothetical protein 0.072 0.1193 0.1193
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0378 0.0591 0.0383
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0591 0.0591
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5714 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3099 0.5389 0.5389
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0378 0.0591 0.9176
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1098 0.186 0.184
Trichomonas vaginalis PIKK family atypical protein kinase 0.1954 0.3369 0.3369
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0378 0.0591 0.0591
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1098 0.186 0.186
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0378 0.0591 0.0567
Leishmania major phosphatidylinositol kinase related protein, putative 0.0378 0.0591 0.0383
Leishmania major phosphatidylinositol 3-kinase, putative 0.1943 0.335 0.3204
Leishmania major phosphatidylinositol 3-kinase, putative 0.0397 0.0624 0.0418
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0627 0.1028 0.1028
Trichomonas vaginalis PIKK family atypical protein kinase 0.426 0.7436 0.7436
Entamoeba histolytica protein kinase rad3, putative 0.1098 0.186 0.1681
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0397 0.0624 0.0418
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0167 0.0218 0.0218
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0464 0.0742 0.0538
Entamoeba histolytica hypothetical protein 0.0378 0.0591 0.0383
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.022 0.0311 0.0311
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0563 0.0915 0.0915
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0064 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0496 0.0798 0.0798
Schistosoma mansoni immunophilin 0.0166 0.0216 0.0216
Trichomonas vaginalis fk506-binding protein, putative 0.0166 0.0216 0.0216
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1098 0.186 0.186
Loa Loa (eye worm) hypothetical protein 0.0378 0.0591 0.0591
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0166 0.0216 0.0216
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0166 0.0216 0.0216
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0591 0.0591
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0397 0.0624 0.0418
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.0078 0.0053
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1943 0.335 0.3204
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5714 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0064 0.0036 0.0036
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.072 0.1193 0.1171
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0397 0.0624 0.06
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5714 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0436 0.0693 0.0693
Mycobacterium leprae conserved hypothetical protein 0.0378 0.0591 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1109 0.1879 0.1879
Trichomonas vaginalis PIKK family atypical protein kinase 0.1943 0.335 0.335
Trichomonas vaginalis conserved hypothetical protein 0.0845 0.1413 0.1413
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0397 0.0624 0.0624
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2384 0.4128 0.3998
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0503 0.0811 0.0811
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.0591 0.0591
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0166 0.0216 0.0216
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0417 0.0659 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.5714 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5714 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1098 0.186 0.186
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0036 0.0036
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0436 0.0693 0.0693
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1954 0.3369 0.3222
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0503 0.0811 0.0811
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.022 0.0311 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.1943 0.335 0.335
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.073 0.121 0.121
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0143 0.0175 0.0175
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0397 0.0624 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0036 0.0036
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.022 0.0311 0.0311
Loa Loa (eye worm) phosphatidylinositol 3 0.0691 0.1142 0.1142
Trichomonas vaginalis PIKK family atypical protein kinase 0.3708 0.6463 0.6463
Loa Loa (eye worm) hypothetical protein 0.1156 0.1962 0.1962
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0166 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.3397 0.5914 0.5914
Onchocerca volvulus 0.0378 0.0591 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1534 0.263 0.263
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0397 0.0624 0.0624
Brugia malayi FAT domain containing protein 0.0845 0.1413 0.1413
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0436 0.0693 0.0693
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0397 0.0624 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.3104 0.5397 0.5397
Trichomonas vaginalis PIKK family atypical protein kinase 0.4553 0.7953 0.7953
Giardia lamblia Phosphatidylinositol 4-kinase 0.0378 0.0591 0.0383
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1098 0.186 0.186
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0378 0.0591 0.0567
Loa Loa (eye worm) phosphatidylinositol 3 0.1954 0.3369 0.3369
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0397 0.0624 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0591 0.0591
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0436 0.0693 0.0693
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5714 1 1
Trichomonas vaginalis conserved hypothetical protein 0.072 0.1193 0.1193
Trichomonas vaginalis PIKK family atypical protein kinase 0.426 0.7436 0.7436
Trichomonas vaginalis PIKK family atypical protein kinase 0.3104 0.5397 0.5397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0591 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.1098 0.186 0.186
Entamoeba histolytica hypothetical protein 0.1098 0.186 0.1681
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0378 0.0591 0.9176
Loa Loa (eye worm) phosphatidylinositol kinase 0.0378 0.0591 0.0591
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0496 0.0798 0.0798
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0563 0.0915 0.0892
Echinococcus multilocularis voltage gated potassium channel 0.0064 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.4553 0.7953 0.7953
Echinococcus multilocularis 0.0378 0.0591 0.0591
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2695 0.4677 0.4559
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0397 0.0624 0.0624
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0166 0.0216 0.0216
Leishmania major phosphatidylinositol kinase, putative 0.0378 0.0591 0.0383
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0397 0.0624 0.0624
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0397 0.0624 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.4869 0.851 0.851
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1954 0.3369 0.3222
Echinococcus multilocularis Zinc finger, PHD finger 0.0397 0.0624 0.0624
Loa Loa (eye worm) phosphatidylinositol 3 0.5714 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0397 0.0624 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0563 0.0915 0.0915
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4558 0.7961 0.7916
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0397 0.0624 0.0624
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.073 0.121 0.121
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0397 0.0624 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3415 0.5946 0.5946
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0845 0.1413 0.1413
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0524 0.0847 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.072 0.1193 0.1193
Trichomonas vaginalis immunophilin, putative 0.0166 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.3099 0.5389 0.5389
Echinococcus granulosus potassium voltage gated channel subfamily H 0.022 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0191 0.026 0.026
Plasmodium vivax hypothetical protein, conserved 0.0378 0.0591 0.9176
Trichomonas vaginalis PIKK family atypical protein kinase 0.3397 0.5914 0.5914
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0166 0.0216 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0378 0.0591 0.0567
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0436 0.0693 0.0488
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0143 0.0175 0.0175
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0166 0.0216 0.0216
Entamoeba histolytica hypothetical protein 0.0524 0.0847 0.0645
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0378 0.0591 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.426 0.7436 0.7436
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5714 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0397 0.0624 0.0418
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0627 0.1028 0.1028
Trichomonas vaginalis PIKK family atypical protein kinase 0.3104 0.5397 0.5397
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0378 0.0591 0.0383
Echinococcus multilocularis serine protein kinase ATM 0.1098 0.186 0.186
Trichomonas vaginalis PIKK family atypical protein kinase 0.4553 0.7953 0.7953
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0378 0.0591 0.0591
Entamoeba histolytica hypothetical protein 0.0378 0.0591 0.0383
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0166 0.0216 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0436 0.0693 0.0669
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1098 0.186 0.184
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0064 0.0036 0.0036
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0563 0.0915 0.0915
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0378 0.0591 0.0591
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1098 0.186 0.186
Schistosoma mansoni hypothetical protein 0.0378 0.0591 0.0591
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1992 0.3436 0.342
Schistosoma mansoni hypothetical protein 0.0845 0.1413 0.1413
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0397 0.0624 0.0418
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0166 0.0216 0.0216
Plasmodium vivax hypothetical protein 0.0378 0.0591 0.9176
Leishmania major hypothetical protein, conserved 0.0466 0.0746 0.0542
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1992 0.3436 0.342
Toxoplasma gondii FATC domain-containing protein 0.1098 0.186 0.1855
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0378 0.0591 0.0383
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1992 0.3436 0.3436
Echinococcus multilocularis fk506 binding protein 0.0166 0.0216 0.0216
Onchocerca volvulus 0.0378 0.0591 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4553 0.7953 0.7953
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1098 0.186 0.186
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5714 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1943 0.335 0.335
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0436 0.0693 0.0488
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5714 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0036 0.0036
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0436 0.0693 0.0488
Echinococcus granulosus serine protein kinase ATM 0.1098 0.186 0.186
Trichomonas vaginalis PIKK family atypical protein kinase 0.3415 0.5946 0.5946
Trichomonas vaginalis PIKK family atypical protein kinase 0.1943 0.335 0.335
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1992 0.3436 0.3436
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0205 0.0285 0.0285
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0166 0.0216 0.0216
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1992 0.3436 0.3436
Schistosoma mansoni immunophilin 0.0143 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.1223 0.2081 0.2081
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5714 1 1
Schistosoma mansoni voltage-gated potassium channel 0.024 0.0346 0.0346
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0457 0.0729 0.0525
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0205 0.0285 0.0285
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0591 0.0591
Echinococcus granulosus voltage gated potassium channel 0.0064 0.0036 0.0036
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0143 0.0175 0.0175
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0496 0.0798 0.0798

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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