Detailed information for compound 1632793

Basic information

Technical information
  • TDR Targets ID: 1632793
  • Name: 1-adamantyl-tris(hydroxymethyl)phosphanium
  • MW: 259.302 | Formula: C13H24O3P+
  • H donors: 3 H acceptors: 3 LogP: 0.86 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[P+](C12CC3CC(C2)CC(C1)C3)(CO)CO
  • InChi: 1S/C13H24O3P/c14-7-17(8-15,9-16)13-4-10-1-11(5-13)3-12(2-10)6-13/h10-12,14-16H,1-9H2/q+1
  • InChiKey: OCZIZUGXOJUBMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-adamantyl-tris(hydroxymethyl)phosphonium
  • 1-adamantyl-trimethylol-phosphonium
  • NCI60_030483
  • AIDS-159032
  • AIDS159032
  • NSC684829 (CHLORIDE SALT)
  • Phosphonium, tris(hydroxymethyl)tricyclo[3.3.1.13,7]dec-1-yl-
  • ZINC04207777

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.3678 0.6682 0.6682
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0364 0.0588 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.4088 0.7436 0.7436
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1055 0.1859 0.1679
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0186 0.0261 0.0045
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0162 0.0217 0.0191
Loa Loa (eye worm) hypothetical protein 0.0811 0.1411 0.1411
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4374 0.7961 0.7916
Leishmania major hypothetical protein, unknown function 0.0364 0.0588 0.0379
Entamoeba histolytica hypothetical protein 0.0364 0.0588 0.0379
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0364 0.0588 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.4088 0.7436 0.7436
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5482 1 1
Giardia lamblia GTOR 0.5482 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0364 0.0588 0.913
Mycobacterium tuberculosis Conserved hypothetical protein 0.0364 0.0588 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0422 0.0695 0.0695
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0162 0.0217 0.0217
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0482 0.0805 0.0805
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0364 0.0588 0.913
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0549 0.0929 0.0728
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0364 0.0588 0.0588
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1065 0.1878 0.1698
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1175 0.2079 0.2178
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0162 0.0217 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.5482 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0364 0.0588 0.0563
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0811 0.1411 0.1411
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5482 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.4374 0.7961 0.7956
Trichomonas vaginalis conserved hypothetical protein 0.1175 0.2079 0.2079
Schistosoma mansoni immunophilin 0.0162 0.0217 0.0217
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0162 0.0217 0.0191
Loa Loa (eye worm) hypothetical protein 0.0067 0.0043 0.0043
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0549 0.0929 0.0905
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.0364 0.0364
Loa Loa (eye worm) FKBP5 protein 0.0162 0.0217 0.0217
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0717 0.1239 0.1239
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0364 0.0588 0.913
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0364 0.0588 0.0588
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0549 0.0929 0.0929
Schistosoma mansoni fkbp-rapamycin associated protein 0.1055 0.1859 0.1859
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0027 0.0027
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0364 0.0588 0.0588
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0383 0.0623 0.0052
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5482 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4088 0.7436 0.7436
Loa Loa (eye worm) phosphatidylinositol 3 0.0364 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.1055 0.1859 0.1859
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0383 0.0623 0.0623
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1915 0.344 0.344
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0383 0.0623 0.0623
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0383 0.0623 0.0598
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0364 0.0588 0.0563
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0364 0.0588 0.0588
Toxoplasma gondii target of rapamycin (TOR), putative 0.4088 0.7436 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4088 0.7436 0.7436
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0364 0.0588 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.3277 0.5945 0.5945
Giardia lamblia Hypothetical protein 0.0364 0.0588 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.2975 0.5389 0.5389
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0162 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0364 0.0588 0.0588
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0162 0.0217 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0082 0.0056
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1866 0.335 0.3203
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0064 0.0037 0.0037
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5482 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0364 0.0588 0.0588
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0383 0.0623 0.0416
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0691 0.119 0.1167
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5482 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0383 0.0623 0.0598
Mycobacterium leprae conserved hypothetical protein 0.0364 0.0588 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0422 0.0695 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.1866 0.335 0.335
Trichomonas vaginalis PIKK family atypical protein kinase 0.1065 0.1878 0.1878
Trichomonas vaginalis conserved hypothetical protein 0.0811 0.1411 0.1411
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0383 0.0623 0.0623
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0162 0.0217 0.0217
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0364 0.0588 0.0588
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2288 0.4126 0.3996
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0489 0.0819 0.0819
Loa Loa (eye worm) hypothetical protein 0.0691 0.119 0.119
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0364 0.0588 0.0379
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0162 0.0217 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.2979 0.5397 0.5397
Leishmania major phosphatidylinositol 4-kinase, putative 0.0364 0.0588 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.4369 0.7953 0.7953
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5482 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2975 0.5389 0.5389
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0364 0.0588 0.913
Loa Loa (eye worm) phosphatidylinositol 3 0.0364 0.0588 0.0588
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1055 0.1859 0.1859
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0364 0.0588 0.0588
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0364 0.0588 0.0563
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1055 0.1859 0.1837
Trichomonas vaginalis PIKK family atypical protein kinase 0.1876 0.3369 0.3369
Leishmania major phosphatidylinositol kinase related protein, putative 0.0364 0.0588 0.0379
Leishmania major phosphatidylinositol 3-kinase, putative 0.1866 0.335 0.3203
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0614 0.1048 0.1048
Leishmania major phosphatidylinositol 3-kinase, putative 0.0383 0.0623 0.0416
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0383 0.0623 0.0416
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0168 0.0229 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.4088 0.7436 0.7436
Entamoeba histolytica protein kinase rad3, putative 0.1055 0.1859 0.1679
Loa Loa (eye worm) hypothetical protein 0.0482 0.0805 0.0805
Trichomonas vaginalis fk506-binding protein, putative 0.0162 0.0217 0.0217
Schistosoma mansoni immunophilin 0.0162 0.0217 0.0217
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.045 0.0747 0.0542
Entamoeba histolytica hypothetical protein 0.0364 0.0588 0.0379
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0064 0.0037 0.0037
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0221 0.0326 0.0326
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0549 0.0929 0.0929
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1055 0.1859 0.1859
Trichomonas vaginalis PIKK family atypical protein kinase 0.2979 0.5397 0.5397
Brugia malayi FAT domain containing protein 0.0811 0.1411 0.1411
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0422 0.0695 0.0695
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0383 0.0623 0.0623
Trichomonas vaginalis PIKK family atypical protein kinase 0.4369 0.7953 0.7953
Giardia lamblia Phosphatidylinositol 4-kinase 0.0364 0.0588 0.0379
Loa Loa (eye worm) phosphatidylinositol 3 0.1876 0.3369 0.3369
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1055 0.1859 0.1859
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0364 0.0588 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0691 0.119 0.119
Trichomonas vaginalis PIKK family atypical protein kinase 0.4088 0.7436 0.7436
Trichomonas vaginalis PIKK family atypical protein kinase 0.2979 0.5397 0.5397
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0383 0.0623 0.0623
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5482 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0588 0.0588
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0422 0.0695 0.0695
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0364 0.0588 0.913
Trichomonas vaginalis PIKK family atypical protein kinase 0.1055 0.1859 0.1859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0588 0.0588
Entamoeba histolytica hypothetical protein 0.1055 0.1859 0.1679
Echinococcus multilocularis voltage gated potassium channel 0.0064 0.0037 0.0037
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0549 0.0929 0.0905
Loa Loa (eye worm) phosphatidylinositol kinase 0.0364 0.0588 0.0588
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0482 0.0805 0.0805
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0383 0.0623 0.0623
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2586 0.4674 0.4556
Trichomonas vaginalis PIKK family atypical protein kinase 0.4369 0.7953 0.7953
Echinococcus multilocularis 0.0364 0.0588 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.4671 0.8509 0.8509
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0162 0.0217 0.0217
Leishmania major phosphatidylinositol kinase, putative 0.0364 0.0588 0.0379
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0383 0.0623 0.0623
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0383 0.0623 0.0623
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0383 0.0623 1
Loa Loa (eye worm) phosphatidylinositol 3 0.5482 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1876 0.3369 0.3223
Echinococcus multilocularis Zinc finger, PHD finger 0.0383 0.0623 0.0623
Trichomonas vaginalis PIKK family atypical protein kinase 0.5482 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0403 0.066 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.5482 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1055 0.1859 0.1859
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0422 0.0695 0.0695
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1876 0.3369 0.3223
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0037 0.0037
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0221 0.0326 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.1866 0.335 0.335
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0489 0.0819 0.0819
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0221 0.0326 0.0326
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0037 0.0037
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0383 0.0623 0.0052
Loa Loa (eye worm) hypothetical protein 0.0139 0.0176 0.0176
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0364 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.1109 0.1958 0.1958
Trichomonas vaginalis PIKK family atypical protein kinase 0.3558 0.6462 0.6462
Loa Loa (eye worm) phosphatidylinositol 3 0.0678 0.1167 0.1167
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0717 0.1239 0.1239
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0162 0.0217 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.1472 0.2627 0.2627
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0383 0.0623 0.0623
Trichomonas vaginalis PIKK family atypical protein kinase 0.326 0.5914 0.5914
Onchocerca volvulus 0.0364 0.0588 0.5
Schistosoma mansoni hypothetical protein 0.0811 0.1411 0.1411
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1915 0.344 0.3423
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0383 0.0623 0.0416
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1915 0.344 0.3423
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0162 0.0217 0.0217
Plasmodium vivax hypothetical protein 0.0364 0.0588 0.913
Leishmania major hypothetical protein, conserved 0.0452 0.0751 0.0546
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0364 0.0588 0.0379
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1915 0.344 0.344
Toxoplasma gondii FATC domain-containing protein 0.1055 0.1859 0.1856
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5482 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1866 0.335 0.335
Echinococcus multilocularis fk506 binding protein 0.0162 0.0217 0.0217
Onchocerca volvulus 0.0364 0.0588 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1055 0.1859 0.1859
Trichomonas vaginalis PIKK family atypical protein kinase 0.4369 0.7953 0.7953
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0422 0.0695 0.0489
Loa Loa (eye worm) hypothetical protein 0.0064 0.0037 0.0037
Echinococcus granulosus serine protein kinase ATM 0.1055 0.1859 0.1859
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5482 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0422 0.0695 0.0489
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0207 0.03 0.03
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0162 0.0217 0.0217
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1915 0.344 0.344
Trichomonas vaginalis PIKK family atypical protein kinase 0.3277 0.5945 0.5945
Trichomonas vaginalis PIKK family atypical protein kinase 0.1866 0.335 0.335
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1915 0.344 0.344
Schistosoma mansoni immunophilin 0.0139 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.1175 0.2079 0.2079
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.0364 0.0364
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5482 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0139 0.0176 0.0176
Echinococcus granulosus voltage gated potassium channel 0.0064 0.0037 0.0037
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0482 0.0805 0.0805
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0443 0.0733 0.0528
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0207 0.03 0.03
Loa Loa (eye worm) phosphatidylinositol 3 0.0364 0.0588 0.0588
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0549 0.0929 0.0929
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4374 0.7961 0.7916
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0383 0.0623 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0811 0.1411 0.1411
Trichomonas vaginalis PIKK family atypical protein kinase 0.3277 0.5945 0.5945
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0717 0.1239 0.1239
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0383 0.0623 0.0623
Trichomonas vaginalis PIKK family atypical protein kinase 0.2975 0.5389 0.5389
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0221 0.0326 0.0326
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.051 0.0857 0.0655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.119 0.119
Trichomonas vaginalis immunophilin, putative 0.0162 0.0217 0.0217
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0422 0.0695 0.0489
Loa Loa (eye worm) hypothetical protein 0.0192 0.0273 0.0273
Plasmodium vivax hypothetical protein, conserved 0.0364 0.0588 0.913
Trichomonas vaginalis PIKK family atypical protein kinase 0.326 0.5914 0.5914
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0364 0.0588 0.0563
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0162 0.0217 0.5
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0383 0.0623 0.0416
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0139 0.0176 0.0176
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0162 0.0217 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.4088 0.7436 0.7436
Entamoeba histolytica hypothetical protein 0.051 0.0857 0.0655
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0364 0.0588 0.0588
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5482 1 1
Echinococcus multilocularis serine protein kinase ATM 0.1055 0.1859 0.1859
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0614 0.1048 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.2979 0.5397 0.5397
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0364 0.0588 0.0379
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0422 0.0695 0.067
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1055 0.1859 0.1837
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0549 0.0929 0.0929
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0064 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.4369 0.7953 0.7953
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0364 0.0588 0.0588
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0162 0.0217 0.5
Entamoeba histolytica hypothetical protein 0.0364 0.0588 0.0379
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1055 0.1859 0.1859
Schistosoma mansoni hypothetical protein 0.0364 0.0588 0.0588
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0364 0.0588 0.0588

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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