Detailed information for compound 1635407

Basic information

Technical information
  • TDR Targets ID: 1635407
  • Name: N-[3-methoxy-4-(3H-pyrido[3,2-e]indol-9-ylami no)phenyl]methanesulfonamide
  • MW: 382.436 | Formula: C19H18N4O3S
  • H donors: 3 H acceptors: 3 LogP: 2.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1Nc1ccnc2c1c1cc[nH]c1cc2)NS(=O)(=O)C
  • InChi: 1S/C19H18N4O3S/c1-26-18-11-12(23-27(2,24)25)3-4-15(18)22-17-8-10-21-16-6-5-14-13(19(16)17)7-9-20-14/h3-11,20,23H,1-2H3,(H,21,22)
  • InChiKey: BQZXELLNFXDJTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • NCI60_037718

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.445 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.019 0.0333 0.0184
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0957 0.2075 0.2184
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.0108 0.0071
Mycobacterium leprae conserved hypothetical protein 0.0297 0.0576 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0149 0.0241 0.0241
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0378 0.076 0.0617
Loa Loa (eye worm) hypothetical protein 0.0418 0.0851 0.0851
Loa Loa (eye worm) hypothetical protein 0.0069 0.0058 0.0058
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0357 0.0712 0.0568
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.445 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.086 0.1853 0.1853
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0357 0.0712 0.0712
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.157 0.3466 0.3466
Trichomonas vaginalis PIKK family atypical protein kinase 0.266 0.5938 0.5876
Trichomonas vaginalis PIKK family atypical protein kinase 0.152 0.3352 0.3249
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.157 0.3466 0.3466
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.011 0.0152 0.0115
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0149 0.0241 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.086 0.1853 0.1727
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.157 0.3466 0.3466
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0297 0.0576 0.043
Echinococcus multilocularis serine protein kinase ATM 0.086 0.1853 0.1853
Trichomonas vaginalis PIKK family atypical protein kinase 0.3548 0.7953 0.7922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0297 0.0576 0.043
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0095 0.0118 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.152 0.3352 0.3249
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.445 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.157 0.3466 0.3441
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.066 0.14 0.14
Leishmania major hypothetical protein, conserved 0.0388 0.0782 0.064
Plasmodium vivax hypothetical protein 0.0297 0.0576 0.9045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.157 0.3466 0.3466
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0095 0.0118 0.0118
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0317 0.0621 1
Entamoeba histolytica hypothetical protein 0.0297 0.0576 0.043
Loa Loa (eye worm) hypothetical protein 0.0095 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0297 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.3548 0.7953 0.7922
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0487 0.1008 0.1008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0357 0.0712 0.0568
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.086 0.1853 0.1853
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0297 0.0576 0.0576
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0297 0.0576 0.0576
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.086 0.1853 0.1853
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.445 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.332 0.7437 0.7397
Loa Loa (eye worm) phosphatidylinositol 3 0.006 0.0037 0.0037
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.011 0.0152 0.0152
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0447 0.0917 0.0776
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0297 0.0576 0.043
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0317 0.0621 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.2422 0.5398 0.5327
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0553 0.1158 0.1158
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0297 0.0576 0.043
Entamoeba histolytica hypothetical protein 0.086 0.1853 0.1727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.011 0.0152 0.0115
Entamoeba histolytica hypothetical protein 0.0447 0.0917 0.0776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0563 0.1179 0.1042
Schistosoma mansoni voltage-gated potassium channel 0.0163 0.0272 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.2418 0.539 0.5319
Plasmodium vivax hypothetical protein, conserved 0.0297 0.0576 0.9045
Trichomonas vaginalis PIKK family atypical protein kinase 0.265 0.5915 0.5852
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0297 0.0576 0.9045
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.011 0.0152 0.0115
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.014 0.0219 0.0067
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0357 0.0712 0.0568
Trypanosoma cruzi target of rapamycin kinase 3 0.3551 0.7962 0.7954
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0487 0.1008 0.0869
Brugia malayi FAT domain containing protein 0.066 0.14 0.14
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0317 0.0621 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.266 0.5938 0.5876
Loa Loa (eye worm) hypothetical protein 0.066 0.14 0.14
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0317 0.0621 0.0476
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0317 0.0621 0.0621
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0317 0.0621 1
Leishmania major hypothetical protein, unknown function 0.0297 0.0576 0.043
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.011 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.3789 0.8502 0.8478
Leishmania major phosphatidylinositol 3-kinase, putative 0.0317 0.0621 0.0476
Loa Loa (eye worm) phosphatidylinositol 3 0.1531 0.3376 0.3376
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0317 0.0621 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.445 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0418 0.0851 0.0851
Loa Loa (eye worm) hypothetical protein 0.0297 0.0576 0.0576
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0487 0.1008 0.0869
Mycobacterium tuberculosis Conserved hypothetical protein 0.0297 0.0576 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3548 0.7953 0.7922
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0317 0.0621 0.0621
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2097 0.4661 0.4579
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0357 0.0712 0.0677
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.445 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0297 0.0576 0.0576
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0317 0.0621 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.332 0.7437 0.7397
Trichomonas vaginalis PIKK family atypical protein kinase 0.2422 0.5398 0.5327
Trichomonas vaginalis conserved hypothetical protein 0.0563 0.1179 0.1042
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.086 0.1853 0.1853
Loa Loa (eye worm) phosphatidylinositol 3 0.0297 0.0576 0.0576
Echinococcus granulosus serine protein kinase ATM 0.086 0.1853 0.1853
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0297 0.0576 0.0576
Giardia lamblia Phosphatidylinositol 4-kinase 0.0297 0.0576 0.043
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.066 0.1399 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.3548 0.7953 0.7922
Trichomonas vaginalis PIKK family atypical protein kinase 0.2422 0.5398 0.5327
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0357 0.0712 0.0568
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0317 0.0621 0.0586
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0297 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.086 0.1853 0.1727
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1531 0.3376 0.3274
Echinococcus multilocularis fk506 binding protein 0.011 0.0152 0.0152
Loa Loa (eye worm) phosphatidylinositol 3 0.0297 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.265 0.5915 0.5852
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0317 0.0621 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.1195 0.2615 0.25
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0426 0.0868 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.152 0.3352 0.3249
Schistosoma mansoni voltage-gated potassium channel 0.0163 0.0272 0.0272
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.066 0.1399 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.2888 0.6455 0.64
Loa Loa (eye worm) hypothetical protein 0.0563 0.1179 0.1179
Loa Loa (eye worm) hypothetical protein 0.0898 0.194 0.194
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0149 0.0241 0.0241
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0317 0.0621 0.0476
Loa Loa (eye worm) phosphatidylinositol 3 0.0297 0.0576 0.0576
Schistosoma mansoni fkbp-rapamycin associated protein 0.086 0.1853 0.1853
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.445 1 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1531 0.3376 0.3274
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0357 0.0712 0.0712
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0337 0.0667 0.0523
Loa Loa (eye worm) phosphatidylinositol 3 0.445 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0317 0.0621 0.0621
Trichomonas vaginalis conserved hypothetical protein 0.066 0.14 0.1267
Trichomonas vaginalis PIKK family atypical protein kinase 0.152 0.3352 0.3249
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0871 0.1877 0.1752
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0426 0.0868 0.0727
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1859 0.4121 0.403
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0297 0.0576 0.0576
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.011 0.0152 0.5
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0317 0.0621 0.0476
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.445 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0357 0.0712 0.0568
Onchocerca volvulus 0.0297 0.0576 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0317 0.0621 0.0621
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0297 0.0576 0.0576
Giardia lamblia GTOR 0.445 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.152 0.3352 0.3249
Loa Loa (eye worm) phosphatidylinositol 3 0.062 0.1308 0.1308
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0297 0.0576 0.043
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.011 0.0152 0.0152
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.011 0.0152 0.0152
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0487 0.1008 0.0974
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0149 0.0241 0.0241
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0297 0.0576 0.0576
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0386 0.0778 0.0635
Loa Loa (eye worm) FKBP5 protein 0.011 0.0152 0.0152
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.011 0.0152 0.0152
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0418 0.0851 0.0851
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.086 0.1853 0.1823
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0317 0.0621 0.0476
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0553 0.1158 0.1158
Toxoplasma gondii target of rapamycin (TOR), putative 0.332 0.7437 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.086 0.1853 0.1853
Loa Loa (eye worm) hypothetical protein 0.013 0.0196 0.0196
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0317 0.0621 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.1531 0.3376 0.3274
Toxoplasma gondii FATC domain-containing protein 0.086 0.1853 0.1861
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0297 0.0576 0.0541
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0297 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.086 0.1853 0.1853
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.152 0.3352 0.3249
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0297 0.0576 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.2422 0.5398 0.5327
Leishmania major phosphatidylinositol kinase, putative 0.0297 0.0576 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.3548 0.7953 0.7922
Schistosoma mansoni immunophilin 0.011 0.0152 0.0152
Leishmania major phosphatidylinositol 4-kinase, putative 0.0297 0.0576 0.043
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0563 0.1179 0.1146
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0297 0.0576 0.0576
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0297 0.0576 0.9045
Trichomonas vaginalis PIKK family atypical protein kinase 0.2418 0.539 0.5319
Trichomonas vaginalis PIKK family atypical protein kinase 0.445 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0871 0.1877 0.1752
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0297 0.0576 0.0541
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0487 0.1008 0.0869
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0297 0.0576 0.9045
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.066 0.14 0.14
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0297 0.0576 0.0541
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.445 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.011 0.0152 0.0115
Loa Loa (eye worm) hypothetical protein 0.0957 0.2075 0.2075
Trichomonas vaginalis PIKK family atypical protein kinase 0.445 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.445 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0418 0.0851 0.0851
Loa Loa (eye worm) phosphatidylinositol kinase 0.0297 0.0576 0.0576
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0357 0.0712 0.0568
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.011 0.0152 0.0152
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0297 0.0576 0.9045
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0297 0.0576 0.0576
Entamoeba histolytica hypothetical protein 0.0297 0.0576 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.332 0.7437 0.7397
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.014 0.0219 0.0067
Entamoeba histolytica protein kinase rad3, putative 0.086 0.1853 0.1727
Trichomonas vaginalis PIKK family atypical protein kinase 0.332 0.7437 0.7397
Giardia lamblia Hypothetical protein 0.0297 0.0576 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.2985 0.6676 0.6625
Leishmania major phosphatidylinositol kinase related protein, putative 0.0297 0.0576 0.043
Schistosoma mansoni hypothetical protein 0.066 0.14 0.14
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3551 0.7962 0.793
Schistosoma mansoni immunophilin 0.011 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.332 0.7437 0.7397
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0297 0.0576 0.0541
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0297 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.2418 0.539 0.5319
Trichomonas vaginalis PIKK family atypical protein kinase 0.266 0.5938 0.5876
Trichomonas vaginalis PIKK family atypical protein kinase 0.332 0.7437 0.7397
Echinococcus multilocularis 0.0297 0.0576 0.0576
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0317 0.0621 0.0621
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.157 0.3466 0.3441
Trichomonas vaginalis PIKK family atypical protein kinase 0.332 0.7437 0.7397
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.086 0.1853 0.1823
Onchocerca volvulus 0.0297 0.0576 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.445 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0297 0.0576 0.043
Echinococcus multilocularis Zinc finger, PHD finger 0.0317 0.0621 0.0621
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0297 0.0576 0.0541
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0317 0.0621 0.0065
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0317 0.0621 0.0476
Schistosoma mansoni immunophilin 0.0095 0.0118 0.0118
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0173 0.0293 0.0293
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0487 0.1008 0.0869
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0487 0.1008 0.0974
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.086 0.1853 0.1727
Entamoeba histolytica hypothetical protein 0.0297 0.0576 0.043
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.066 0.1399 0.1399
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0297 0.0576 0.9045
Trichomonas vaginalis conserved hypothetical protein 0.0957 0.2075 0.1952
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3551 0.7962 0.793
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.445 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.011 0.0152 0.0152
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.011 0.0152 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.