Detailed information for compound 1635431

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 554.621 | Formula: C23H26F3KN2O6S
  • H donors: 1 H acceptors: 4 LogP: 4.49 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCS(=O)(=O)[N-]C(=O)/C=C/c1ccc(cc1Oc1ccc(cn1)C(F)(F)F)OCCOC.[K+]
  • InChi: 1S/C23H27F3N2O6S.K/c1-3-4-5-14-35(30,31)28-21(29)10-7-17-6-9-19(33-13-12-32-2)15-20(17)34-22-11-8-18(16-27-22)23(24,25)26;/h6-11,15-16H,3-5,12-14H2,1-2H3,(H,28,29);/q;+1/p-1/b10-7+;
  • InChiKey: WZYDVPRGVISVIY-HCUGZAAXSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor gamma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus ecdysone induced protein 78C peroxisome proliferator-activated receptor gamma 477 aa 447 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Zinc finger, PHD finger 0.0219 0.0559 0.0546
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0219 0.0559 0.049
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0219 0.0559 0.0546
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0642 0.1816 0.1757
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0055 0.0072 0.5
Loa Loa (eye worm) hypothetical protein 0.0716 0.2035 0.2035
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3397 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0219 0.0559 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0497 0.1383 0.1377
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3397 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3397 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0219 0.0559 0.0552
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0219 0.0559 0.0546
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0219 0.0559 0.049
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0014 0.0014
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0219 0.0559 0.0552
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0219 0.0559 0.0536
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0219 0.0559 0.049
Toxoplasma gondii target of rapamycin (TOR), putative 0.2526 0.7414 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2526 0.7414 0.7412
Trichomonas vaginalis PIKK family atypical protein kinase 0.2278 0.6677 0.6675
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0219 0.0559 0.0546
Schistosoma mansoni immunophilin 0.0055 0.0072 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0642 0.1816 0.1811
Schistosoma mansoni immunophilin 0.0048 0.0049 0.0026
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0497 0.1383 0.1371
Trypanosoma cruzi target of rapamycin kinase 3 0.2704 0.7943 0.7928
Giardia lamblia Hypothetical protein 0.0219 0.0559 0.049
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0219 0.0559 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.2526 0.7414 0.7412
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0219 0.0559 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2526 0.7414 0.7412
Trichomonas vaginalis PIKK family atypical protein kinase 0.203 0.5938 0.5935
Trichomonas vaginalis PIKK family atypical protein kinase 0.1831 0.5349 0.5346
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0219 0.0559 0.0546
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0219 0.0559 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0219 0.0559 0.049
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3397 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0219 0.0559 0.049
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0642 0.1816 0.1757
Trichomonas vaginalis PIKK family atypical protein kinase 0.2526 0.7414 0.7412
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0219 0.0559 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.1139 0.3292 0.3287
Plasmodium vivax hypothetical protein, conserved 0.0219 0.0559 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0219 0.0559 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0219 0.0559 0.049
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0219 0.0559 0.0552
Echinococcus multilocularis fk506 binding protein 0.0055 0.0072 0.0058
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0423 0.1165 0.1101
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0219 0.0559 0.049
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0219 0.0559 0.0546
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0219 0.0559 0.0546
Echinococcus granulosus serine protein kinase ATM 0.0642 0.1816 0.1805
Trichomonas vaginalis PIKK family atypical protein kinase 0.3397 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2704 0.7943 0.7928
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0716 0.2035 0.2153
Loa Loa (eye worm) hypothetical protein 0.0048 0.0049 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0642 0.1816 0.1811
Loa Loa (eye worm) phosphatidylinositol 3 0.1139 0.3292 0.3292
Schistosoma mansoni hypothetical protein 0.0497 0.1383 0.1363
Schistosoma mansoni hypothetical protein 0.0219 0.0559 0.0536
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1411 0.41 0.4057
Leishmania major phosphatidylinositol kinase related protein, putative 0.0219 0.0559 0.049
Loa Loa (eye worm) phosphatidylinositol 3 0.0219 0.0559 0.0559
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3397 1 1
Plasmodium vivax hypothetical protein 0.0219 0.0559 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0219 0.0559 0.049
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0219 0.0559 0.0552
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1139 0.3292 0.3243
Giardia lamblia GTOR 0.3397 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0219 0.0559 0.049
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0219 0.0559 1
Trichomonas vaginalis conserved hypothetical protein 0.0423 0.1165 0.1159
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0219 0.0559 0.049
Loa Loa (eye worm) hypothetical protein 0.0219 0.0559 0.0559
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0072 0.0058
Trichomonas vaginalis fk506-binding protein, putative 0.0055 0.0072 0.0065
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0219 0.0559 0.0546
Loa Loa (eye worm) phosphatidylinositol 3 0.0219 0.0559 0.0559
Mycobacterium leprae conserved hypothetical protein 0.0219 0.0559 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0072 0.0058
Toxoplasma gondii FATC domain-containing protein 0.0642 0.1816 0.1835
Echinococcus multilocularis 0.0219 0.0559 0.0546
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0219 0.0559 0.0546
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0219 0.0559 0.0546
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0055 0.0072 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.2526 0.7414 0.7412
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0642 0.1816 0.1805
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0219 0.0559 0.0546
Entamoeba histolytica hypothetical protein 0.0642 0.1816 0.1757
Giardia lamblia Phosphatidylinositol 4-kinase 0.0219 0.0559 0.049
Schistosoma mansoni fkbp-rapamycin associated protein 0.0642 0.1816 0.1797
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1139 0.3292 0.3243
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0219 0.0559 0.049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1139 0.3292 0.3283
Onchocerca volvulus 0.0219 0.0559 0.5
Entamoeba histolytica hypothetical protein 0.0219 0.0559 0.049
Loa Loa (eye worm) FKBP5 protein 0.0055 0.0072 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7935 0.7934
Trichomonas vaginalis PIKK family atypical protein kinase 0.1834 0.5357 0.5354
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0219 0.0559 0.0552
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3397 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0219 0.0559 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.1831 0.5349 0.5346
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0219 0.0559 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.29 0.8524 0.8523
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0219 0.0559 0.0552
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0219 0.0559 0.0536
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0219 0.0559 0.049
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3397 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0219 0.0559 0.0546
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1139 0.3292 0.3243
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0219 0.0559 0.0546
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0219 0.0559 0.0552
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0219 0.0559 0.049
Loa Loa (eye worm) phosphatidylinositol 3 0.0219 0.0559 0.0559
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1606 0.468 0.4642
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0219 0.0559 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7935 0.7934
Leishmania major phosphatidylinositol kinase, putative 0.0219 0.0559 0.049
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0219 0.0559 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.1834 0.5357 0.5354
Trichomonas vaginalis PIKK family atypical protein kinase 0.2526 0.7414 0.7412
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0219 0.0559 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.3397 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0219 0.0559 0.0552
Leishmania major hypothetical protein, unknown function 0.0219 0.0559 0.049
Leishmania major hypothetical protein, conserved 0.0219 0.0559 0.049
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0219 0.0559 0.049
Loa Loa (eye worm) hypothetical protein 0.0642 0.1816 0.1816
Echinococcus multilocularis serine protein kinase ATM 0.0642 0.1816 0.1805
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0497 0.1383 0.1371
Trichomonas vaginalis PIKK family atypical protein kinase 0.1834 0.5357 0.5354
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7935 0.7934
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0219 0.0559 0.0552
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0219 0.0559 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0072 0.0065
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1139 0.3292 0.3243
Entamoeba histolytica protein kinase rad3, putative 0.0642 0.1816 0.1757
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0219 0.0559 0.049
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0048 0.0049 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0911 0.2616 0.261
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0219 0.0559 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.2009 0.5878 0.5875
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0219 0.0559 0.0536
Schistosoma mansoni immunophilin 0.0055 0.0072 0.0048
Leishmania major phosphatidylinositol 3-kinase, putative 0.1139 0.3292 0.3243
Loa Loa (eye worm) phosphatidylinositol 3 0.0219 0.0559 0.0559
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0219 0.0559 0.049
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0219 0.0559 0.049
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0055 0.0072 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.2205 0.6459 0.6457
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0219 0.0559 0.0546
Loa Loa (eye worm) hypothetical protein 0.0692 0.1964 0.1964
Loa Loa (eye worm) hypothetical protein 0.0423 0.1165 0.1165
Trichomonas vaginalis PIKK family atypical protein kinase 0.3397 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0642 0.1816 0.1805
Trichomonas vaginalis PIKK family atypical protein kinase 0.1139 0.3292 0.3287
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0219 0.0559 0.0552
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3397 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0219 0.0559 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0716 0.2035 0.2029
Loa Loa (eye worm) phosphatidylinositol 3 0.3397 1 1
Trichomonas vaginalis immunophilin, putative 0.0055 0.0072 0.0065
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0219 0.0559 0.0552
Loa Loa (eye worm) phosphatidylinositol 3 0.0219 0.0559 0.0559
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0055 0.0072 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0219 0.0559 0.049
Loa Loa (eye worm) hypothetical protein 0.0219 0.0559 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0642 0.1816 0.1811
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0219 0.0559 0.0546
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3397 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0055 0.0072 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.1139 0.3292 0.3287
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1139 0.3292 0.3243
Trichomonas vaginalis PIKK family atypical protein kinase 0.203 0.5938 0.5935
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1139 0.3292 0.3276
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1139 0.3292 0.3283
Entamoeba histolytica hypothetical protein 0.0219 0.0559 0.049
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0642 0.1816 0.1805
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3397 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1139 0.3292 0.3283
Leishmania major phosphatidylinositol 4-kinase, putative 0.0219 0.0559 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7935 0.7934
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0642 0.1816 0.1757
Brugia malayi FAT domain containing protein 0.0497 0.1383 0.1371
Trichomonas vaginalis PIKK family atypical protein kinase 0.1139 0.3292 0.3287
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0219 0.0559 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1139 0.3292 0.3287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0219 0.0559 0.0552
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0219 0.0559 0.049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0642 0.1816 0.1805
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0219 0.0559 0.0546
Mycobacterium tuberculosis Conserved hypothetical protein 0.0219 0.0559 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7935 0.7934
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0219 0.0559 0.049
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0219 0.0559 0.0546
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0642 0.1816 0.1797
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0219 0.0559 0.049
Entamoeba histolytica hypothetical protein 0.0219 0.0559 0.049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0219 0.0559 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.2526 0.7414 0.7412
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0048 0.0049 0.0035
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0055 0.0072 0.0048
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0219 0.0559 0.0559
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3397 1 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0642 0.1816 0.1757
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0219 0.0559 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.1834 0.5357 0.5354
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0219 0.0559 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.1831 0.5349 0.5346
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0072 0.0065
Onchocerca volvulus 0.0219 0.0559 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0219 0.0559 0.0552
Loa Loa (eye worm) phosphatidylinositol kinase 0.0219 0.0559 0.0559
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0055 0.0072 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.2009 0.5878 0.5875
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0219 0.0559 1
Entamoeba histolytica hypothetical protein 0.0219 0.0559 0.049
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0219 0.0559 0.0546
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2704 0.7943 0.7928
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0219 0.0559 0.0536
Loa Loa (eye worm) hypothetical protein 0.0497 0.1383 0.1383
Trichomonas vaginalis PIKK family atypical protein kinase 0.203 0.5938 0.5935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.1165 0.1159
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0219 0.0559 0.049

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) > 10000 nM Transactivation of human PPARgamma1 expressed in CHO-K1 cells co-expressing RXRalpha and PPRE after 1 day by luciferase reporter gene assay ChEMBL. 22503460

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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