TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 519.61 | Formula: C25H33N3O7S
H donors: 2 H acceptors: 5 LogP: 3.14 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: COCCOc1ccc(c(c1)Oc1ncc(cc1C)NC(=O)C)/C=C/C(=O)NS(=O)(=O)CCCCC
InChi: 1S/C25H33N3O7S/c1-5-6-7-14-36(31,32)28-24(30)11-9-20-8-10-22(34-13-12-33-4)16-23(20)35-25-18(2)15-21(17-26-25)27-19(3)29/h8-11,15-17H,5-7,12-14H2,1-4H3,(H,27,29)(H,28,30)/b11-9+
InChiKey: DQGPXTGUPAEMKA-PKNBQFBNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	peroxisome proliferator-activated receptor gamma	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	ecdysone induced protein 78C	peroxisome proliferator-activated receptor gamma	477 aa	447 aa	28.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0119	0.0591	0.0475
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0122	0.0122
Loa Loa (eye worm)	phosphatidylinositol 3	0.1838	1	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0033	0.0122	0.0122
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0119	0.0591	0.031
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0348	0.1844	0.1601
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0119	0.0591	0.0095
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0119	0.0591	0.0095
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0119	0.0591	0.0591
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0617	0.3315	0.2895
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0119	0.0591	0.0591
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0122	0.0004
Entamoeba histolytica	PH domain containing protein kinase, putative	0.007	0.0325	0.0206
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.007	0.0325	0.0035
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0119	0.0591	0.0591
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0119	0.0591	0.031
Entamoeba histolytica	protein kinase, putative	0.0102	0.05	0.0383
Echinococcus granulosus	nervana 2	0.0063	0.0286	0.0286
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0119	0.0591	0.0591
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0142	0.0142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0617	0.3315	0.3235
Giardia lamblia	GTOR	0.1838	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0119	0.0591	0.0479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0229	0.1195	0.1091
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0033	0.0122	0.0122
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1838	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0119	0.0591	0.031
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0033	0.0122	0.0122
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0119	0.0591	0.0479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0617	0.3315	0.3235
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0119	0.0591	0.031
Echinococcus granulosus	serine:threonine protein kinase N2	0.0033	0.0122	0.0122
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0764	0.412	0.381
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0119	0.0591	0.018
Trypanosoma cruzi	target of rapamycin kinase 3	0.1464	0.795	0.7889
Schistosoma mansoni	serine/threonine-protein kinase	0.007	0.0325	0.0325
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0129	0.0011
Plasmodium vivax	hypothetical protein, conserved	0.0119	0.0591	1
Loa Loa (eye worm)	hypothetical protein	0.0229	0.1195	0.1195
Echinococcus granulosus	serine protein kinase ATM	0.0348	0.1844	0.1844
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1838	1	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0119	0.0591	0.0591
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0119	0.0591	0.0591
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0348	0.1844	0.1415
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0617	0.3315	0.2895
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0119	0.0591	0.0479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1098	0.5952	0.5904
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0119	0.0591	0.031
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0991	0.5365	0.531
Echinococcus granulosus	protein kinase C gamma type	0.0033	0.0122	0.0122
Echinococcus multilocularis	protein kinase c iota type	0.0033	0.0122	0.0122
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0348	0.1844	0.1844
Entamoeba histolytica	PH domain containing protein kinase, putative	0.007	0.0325	0.0206
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1464	0.795	0.7842
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0119	0.0591	0.0591
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.05	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1367	0.7423	0.7392
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0033	0.0122	0.0122
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1838	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0119	0.0591	1
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0033	0.0122	0.0122
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0119	0.0591	0.0479
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0119	0.0591	0.018
Loa Loa (eye worm)	phosphatidylinositol 3	0.0119	0.0591	0.0591
Echinococcus granulosus	serine/threonine protein kinase	0.007	0.0325	0.0325
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1838	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0119	0.0591	0.0479
Schistosoma mansoni	hypothetical protein	0.0269	0.1413	0.1413
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1098	0.5952	0.5904
Trichomonas vaginalis	conserved hypothetical protein	0.0229	0.1195	0.1091
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0119	0.0591	0.0591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0991	0.5365	0.531
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.05	0.0387
Entamoeba histolytica	hypothetical protein	0.0119	0.0591	0.0475
Entamoeba histolytica	hypothetical protein	0.0119	0.0591	0.0475
Echinococcus granulosus	Glutaredoxin protein 5	0.0063	0.0286	0.0286
Onchocerca volvulus		0.0119	0.0591	0.5
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0119	0.0591	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0064	0.029	0.029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1088	0.5892	0.5843
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0142	0.0142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1367	0.7423	0.7392
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0102	0.05	0.05
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1838	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0348	0.1844	0.1844
Giardia lamblia	Hypothetical protein	0.0119	0.0591	0.031
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0993	0.5373	0.5318
Loa Loa (eye worm)	phosphatidylinositol 3	0.0119	0.0591	0.0591
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0033	0.0122	0.0122
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0119	0.0591	0.031
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0122	0.0122
Echinococcus multilocularis	Glutaredoxin protein 5	0.0063	0.0286	0.0286
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0119	0.0591	0.0475
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0119	0.0591	0.031
Loa Loa (eye worm)	hypothetical protein	0.0269	0.1413	0.1413
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0122	0.0122
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0119	0.0591	1
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0119	0.0591	0.0475
Loa Loa (eye worm)	phosphatidylinositol 3	0.0617	0.3315	0.3315
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0348	0.1844	0.1747
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1838	1	1
Echinococcus granulosus	nervana 2	0.0063	0.0286	0.0286
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0348	0.1844	0.1844
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0122	0.0122
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0348	0.1844	0.1601
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0063	0.0286	0.0286
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0617	0.3315	0.3235
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0617	0.3315	0.3315
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0033	0.0122	0.0122
Trichomonas vaginalis	conserved hypothetical protein	0.0387	0.2062	0.1967
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0122	0.0122
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0142	0.0142
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0033	0.0122	0.0122
Entamoeba histolytica	protein kinase, putative	0.0096	0.0466	0.0349
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0119	0.0591	0.0479
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0119	0.0591	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0119	0.0591	0.0591
Schistosoma mansoni	serine/threonine kinase	0.0033	0.0122	0.0122
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0348	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0116	0.0116
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.05	0.0387
Echinococcus multilocularis		0.0119	0.0591	0.0591
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0122	0.0122
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0119	0.0591	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0375	0.1992	0.1992
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0229	0.1195	0.0932
Trypanosoma cruzi	Protein kinase B	0.007	0.0325	0.0035
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0122	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0493	0.2641	0.2553
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1088	0.5892	0.5843
Trichomonas vaginalis	conserved hypothetical protein	0.0269	0.1413	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1462	0.7942	0.7918
Schistosoma mansoni	hypothetical protein	0.0119	0.0591	0.0591
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.05	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1367	0.7423	0.7392
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0119	0.0591	0.0479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0993	0.5373	0.5318
Entamoeba histolytica	protein kinase rad3, putative	0.0348	0.1844	0.1744
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0119	0.0591	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0119	0.0591	0.0591
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0119	0.0591	0.0591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.157	0.8529	0.8512
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0119	0.0591	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.0064	0.029	0.029
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0119	0.0591	0.0095
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0119	0.0591	0.0591
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1838	1	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0119	0.0591	0.0591
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0617	0.3315	0.2963
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0119	0.0591	0.0479
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0119	0.0591	0.0591
Echinococcus multilocularis	rac serine:threonine kinase	0.007	0.0325	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0993	0.5373	0.5318
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0119	0.0591	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1462	0.7942	0.7918
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0119	0.0591	0.018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0991	0.5365	0.531
Entamoeba histolytica	hypothetical protein	0.0348	0.1844	0.1744
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0617	0.3315	0.3315
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0119	0.0591	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0591	0.0591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1367	0.7423	0.7392
Loa Loa (eye worm)	hypothetical protein	0.0348	0.1844	0.1844
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0119	0.0591	0.0479
Schistosoma mansoni	serine/threonine-protein kinase	0.007	0.0325	0.0325
Onchocerca volvulus		0.0119	0.0591	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0129	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0348	0.1844	0.1747
Brugia malayi	protein kinase C II.	0.0033	0.0122	0.0122
Echinococcus multilocularis	nervana 2	0.0063	0.0286	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0122	0.0004
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0119	0.0591	0.0591
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0033	0.0122	0.0122
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0119	0.0591	0.031
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0348	0.1844	0.1747
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0269	0.1413	0.1413
Echinococcus multilocularis	nervana 2	0.0063	0.0286	0.0286
Echinococcus multilocularis	Zinc finger, PHD finger	0.0119	0.0591	0.0591
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1838	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0387	0.2062	0.2294
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0063	0.0286	0.0286
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0119	0.0591	0.0591
Entamoeba histolytica	protein kinase, putative	0.0102	0.05	0.0383
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.016	0.016
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0119	0.0591	0.0591
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0033	0.0122	0.0122
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0119	0.0591	0.0591
Echinococcus multilocularis	serine threonine protein kinase	0.0033	0.0122	0.0122
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0119	0.0591	0.0591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1367	0.7423	0.7392
Plasmodium vivax	hypothetical protein	0.0119	0.0591	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0119	0.0591	0.0591
Entamoeba histolytica	hypothetical protein	0.0119	0.0591	0.0475
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0119	0.0591	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1367	0.7423	0.7392
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1367	0.7423	1
Echinococcus granulosus	Protein kinase C brain isozyme	0.0033	0.0122	0.0122
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0119	0.0591	0.0475
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.05	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1367	0.7423	0.7392
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1233	0.6689	0.6649
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0096	0.0466	0.0466
Brugia malayi	FAT domain containing protein	0.0269	0.1413	0.1413
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0119	0.0591	0.0475
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1838	1	1
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0064	0.029	0.029
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0119	0.0591	0.031
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0119	0.0591	0.018
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0119	0.0591	0.0095
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0348	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.0387	0.2062	0.2062
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0122	0.0122
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0119	0.0591	0.0479
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0269	0.1413	0.1413
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1464	0.795	0.7822
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0119	0.0591	0.031
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0033	0.0122	0.0122
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0122	0.0122
Brugia malayi	p70 ribosomal S6 kinase beta	0.0096	0.0466	0.0466
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0119	0.0591	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0591	0.0591
Entamoeba histolytica	protein kinase 2, putative	0.0064	0.029	0.0171
Mycobacterium leprae	conserved hypothetical protein	0.0119	0.0591	0.5
Schistosoma mansoni	atypical protein kinase C	0.0033	0.0122	0.0122
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0119	0.0591	0.0475
Toxoplasma gondii	FATC domain-containing protein	0.0348	0.1844	0.1982
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1462	0.7942	0.7918
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0119	0.0591	0.0591
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0348	0.1844	0.1744
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0119	0.0591	0.018
Brugia malayi	Hr1 repeat family protein	0.0033	0.0122	0.0122
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0617	0.3315	0.3315
Echinococcus granulosus	protein kinase c iota type	0.0033	0.0122	0.0122
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0119	0.0591	0.0591
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.016	0.016
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0617	0.3315	0.3115
Loa Loa (eye worm)	phosphatidylinositol 3	0.0119	0.0591	0.0591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0617	0.3315	0.3235
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0119	0.0591	0.031
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1462	0.7942	0.7918
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0119	0.0591	0.0591
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1838	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0119	0.0591	0.0479
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.05	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1098	0.5952	0.5904
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0617	0.3315	0.2963
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0122	0.0122
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0156	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1838	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.05	0.0387
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0119	0.0591	0.0591
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1838	1	1
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0033	0.0122	0.0122
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1838	1	1
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0033	0.0122	0.0122
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0617	0.3315	0.3315
Loa Loa (eye worm)	phosphatidylinositol 3	0.0119	0.0591	0.0591
Echinococcus granulosus	protein kinase c epsilon type	0.0033	0.0122	0.0122
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0617	0.3315	0.3115
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0033	0.0122	0.0122
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0119	0.0591	0.0591
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0142	0.0142
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0119	0.0591	0.0591
Brugia malayi	Protein kinase domain containing protein	0.0102	0.05	0.05
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1193	0.6471	0.6429
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0119	0.0591	0.031
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0119	0.0591	0.0475
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0119	0.0591	0.0591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0993	0.5373	0.5318
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0033	0.0122	0.0122
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0617	0.3315	0.3235
Echinococcus multilocularis	serine protein kinase ATM	0.0348	0.1844	0.1844
Echinococcus multilocularis	protein kinase c epsilon type	0.0033	0.0122	0.0122
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0119	0.0591	0.0475
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0119	0.0591	0.0479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1838	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0119	0.0591	0.0479
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0119	0.0591	0.0591
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0119	0.0591	0.031
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0119	0.0591	0.0591
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0348	0.1844	0.1844
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0033	0.0122	0.0122
Echinococcus granulosus	NDR protein kinase	0.0033	0.0122	0.0122
Loa Loa (eye worm)	phosphatidylinositol 3	0.0119	0.0591	0.0591
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0869	0.4699	0.4419
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0119	0.0591	0.0591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1462	0.7942	0.7918
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0122	0.0122

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	> 10000 nM	Transactivation of human PPARgamma1 expressed in CHO-K1 cells co-expressing RXRalpha and PPRE after 1 day by luciferase reporter gene assay	ChEMBL.	22503460

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2024617

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1635434