TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 327.374 | Formula: C19H21NO4
H donors: 2 H acceptors: 3 LogP: 0.33 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1C(=O)CC(C(=O)O)N[C@H](c1ccccc1)C
InChi: 1S/C19H21NO4/c1-13(14-8-4-3-5-9-14)20-16(19(22)23)12-17(21)15-10-6-7-11-18(15)24-2/h3-11,13,16,20H,12H2,1-2H3,(H,22,23)/t13-,16?/m0/s1
InChiKey: LLIYADKMWJCWPF-KNVGNIICSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.011	0.0451	0.0418
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.011	0.0451	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0322	0.1723	0.1723
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0322	0.1723	0.1711
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0918	0.5304	0.5304
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.011	0.0451	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1264	0.7384	0.7384
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0451	0.0437
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.011	0.0451	0.0451
Leishmania major	phosphatidylinositol 3-kinase, putative	0.011	0.0451	0.0338
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.17	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.057	0.3216	0.3206
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0322	0.1723	0.1711
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.011	0.0451	0.0437
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0249	0.1285	0.1272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0918	0.5304	0.5304
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.011	0.0451	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1352	0.7911	0.7911
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.011	0.0451	0.0437
Echinococcus multilocularis	fk506 binding protein	0.0054	0.0117	0.0103
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.17	1	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.011	0.0451	0.0437
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.057	0.3216	0.3135
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0451	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1452	0.8507	0.8507
Giardia lamblia	Hypothetical protein	0.011	0.0451	0.0338
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.011	0.0451	0.0338
Schistosoma mansoni	hypothetical protein	0.011	0.0451	0.0418
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.011	0.0451	0.0338
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0804	0.462	0.4556
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1352	0.7911	0.7911
Leishmania major	phosphatidylinositol 4-kinase, putative	0.011	0.0451	0.0338
Echinococcus multilocularis	Zinc finger, PHD finger	0.011	0.0451	0.0437
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.011	0.0451	0.0338
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0451	0.0437
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.011	0.0451	0.0451
Trichomonas vaginalis	PIKK family atypical protein kinase	0.057	0.3216	0.3216
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.17	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0322	0.1723	0.1723
Trichomonas vaginalis	PIKK family atypical protein kinase	0.17	1	1
Onchocerca volvulus		0.011	0.0451	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0456	0.2531	0.2531
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.011	0.0451	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1006	0.5831	0.5831
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0451	0.0437
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0047	0.0073	0.0058
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0054	0.0117	0.0103
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.011	0.0451	0.0338
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.011	0.0451	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1104	0.6419	0.6419
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.011	0.0451	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0346	0.1873	0.1861
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1065	0.1051
Trichomonas vaginalis	immunophilin, putative	0.0054	0.0117	0.0117
Trichomonas vaginalis	PIKK family atypical protein kinase	0.057	0.3216	0.3216
Echinococcus multilocularis		0.011	0.0451	0.0437
Loa Loa (eye worm)	phosphatidylinositol 3	0.17	1	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.057	0.3216	0.3135
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.011	0.0451	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1352	0.7911	0.7911
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0322	0.1723	0.1694
Leishmania major	phosphatidylinositol 3-kinase, putative	0.057	0.3216	0.3135
Entamoeba histolytica	hypothetical protein	0.011	0.0451	0.0338
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0322	0.1723	0.1625
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.011	0.0451	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.011	0.0451	0.0451
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.0451	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.057	0.3216	0.3216
Loa Loa (eye worm)	hypothetical protein	0.0249	0.1285	0.1272
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.057	0.3216	0.3192
Mycobacterium tuberculosis	Conserved hypothetical protein	0.011	0.0451	0.5
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0054	0.0117	0.5
Loa Loa (eye worm)	hypothetical protein	0.011	0.0451	0.0437
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.011	0.0451	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0358	0.1944	0.2153
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0054	0.0117	0.0117
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.17	1	1
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0054	0.0117	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.057	0.3216	0.3216
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.057	0.3216	0.3206
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1016	0.5892	0.5892
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.057	0.3216	0.3135
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.011	0.0451	0.0451
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0322	0.1723	0.1723
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.17	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.011	0.0451	0.0451
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0451	0.0437
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0054	0.0117	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1006	0.5831	0.5831
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.011	0.0451	0.0418
Entamoeba histolytica	hypothetical protein	0.011	0.0451	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0917	0.5296	0.5296
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0054	0.0117	0.0117
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0451	0.0437
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.011	0.0451	0.0451
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.011	0.0451	0.0418
Brugia malayi	FAT domain containing protein	0.0249	0.1285	0.1272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1016	0.5892	0.5892
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.1065	0.1065
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.011	0.0451	0.0338
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0451	0.0437
Trypanosoma cruzi	target of rapamycin kinase 3	0.1354	0.792	0.7895
Loa Loa (eye worm)	hypothetical protein	0.0322	0.1723	0.1711
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.0451	0.0338
Entamoeba histolytica	hypothetical protein	0.011	0.0451	0.0338
Echinococcus multilocularis	serine protein kinase ATM	0.0322	0.1723	0.1711
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.011	0.0451	0.0451
Loa Loa (eye worm)	hypothetical protein	0.011	0.0451	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1352	0.7911	0.7911
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.011	0.0451	0.0338
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.011	0.0451	0.0437
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0322	0.1723	0.1625
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.011	0.0451	0.0418
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0918	0.5304	0.5304
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.011	0.0451	0.0451
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.011	0.0451	0.0338
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.011	0.0451	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1264	0.7384	0.7384
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0047	0.0073	0.0058
Schistosoma mansoni	immunophilin	0.0054	0.0117	0.0083
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.17	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1264	0.7384	0.7384
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.011	0.0451	0.0418
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.011	0.0451	0.0338
Schistosoma mansoni	immunophilin	0.0047	0.0073	0.0038
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1354	0.792	0.7895
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0249	0.1285	0.1272
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.011	0.0451	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1264	0.7384	0.7384
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.011	0.0451	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.114	0.6639	0.6639
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0054	0.0117	0.0083
Toxoplasma gondii	FATC domain-containing protein	0.0322	0.1723	0.1835
Loa Loa (eye worm)	FKBP5 protein	0.0054	0.0117	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0358	0.1944	0.1944
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.17	1	1
Giardia lamblia	Phosphatidylinositol 4-kinase	0.011	0.0451	0.0338
Schistosoma mansoni	hypothetical protein	0.0249	0.1285	0.1254
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.011	0.0451	0.0437
Leishmania major	phosphatidylinositol kinase related protein, putative	0.011	0.0451	0.0338
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.011	0.0451	0.0437
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0322	0.1723	0.1711
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.011	0.0451	0.0451
Trichomonas vaginalis	PIKK family atypical protein kinase	0.011	0.0451	0.0451
Leishmania major	phosphatidylinositol kinase, putative	0.011	0.0451	0.0338
Onchocerca volvulus		0.011	0.0451	0.5
Giardia lamblia	GTOR	0.17	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.17	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.0451	0.0338
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0212	0.1065	0.0958
Loa Loa (eye worm)	phosphatidylinositol kinase	0.011	0.0451	0.0437
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0451	0.0437
Echinococcus granulosus	serine protein kinase ATM	0.0322	0.1723	0.1711
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.011	0.0451	0.0437
Schistosoma mansoni	immunophilin	0.0054	0.0117	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0073	0.0058
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.17	1	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1354	0.792	0.7895
Loa Loa (eye worm)	hypothetical protein	0.0358	0.1944	0.1932
Leishmania major	hypothetical protein, unknown function	0.011	0.0451	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1016	0.5892	0.5892
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1264	0.7384	0.7384
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0917	0.5296	0.5296
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.011	0.0451	0.0418
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.0451	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1264	0.7384	0.7384
Plasmodium vivax	hypothetical protein, conserved	0.011	0.0451	1
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.011	0.0451	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.011	0.0451	0.0338
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0451	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.17	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.011	0.0451	0.0338
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1264	0.7384	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0322	0.1723	0.1694
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.011	0.0451	0.0338
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.057	0.3216	0.3135
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.011	0.0451	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0212	0.1065	0.1065
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.057	0.3216	0.3135
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.17	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.011	0.0451	0.0338
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0451	0.0437
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.011	0.0451	0.0338
Leishmania major	hypothetical protein, conserved	0.011	0.0451	0.0338
Mycobacterium leprae	conserved hypothetical protein	0.011	0.0451	0.5
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0706	0.4032	0.3961
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.057	0.3216	0.3206
Entamoeba histolytica	hypothetical protein	0.0322	0.1723	0.1625
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.011	0.0451	0.0418
Trichomonas vaginalis	conserved hypothetical protein	0.0249	0.1285	0.1285
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0451	0.0437
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.011	0.0451	0.0338
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.17	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.011	0.0451	1
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.011	0.0451	0.0338
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.057	0.3216	0.3206
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0451	0.0437
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0322	0.1723	0.1711
Entamoeba histolytica	hypothetical protein	0.011	0.0451	0.0338
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0322	0.1723	0.1625
Trichomonas vaginalis	PIKK family atypical protein kinase	0.057	0.3216	0.3216
Trichomonas vaginalis	PIKK family atypical protein kinase	0.17	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0917	0.5296	0.5296
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.0451	0.0338
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.011	0.0451	0.0338
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.011	0.0451	0.0451
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.011	0.0451	0.0451
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0054	0.0117	0.0103
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.011	0.0451	0.0451
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0918	0.5304	0.5304
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1352	0.7911	0.7911
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0322	0.1723	0.1625
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0451	0.0437
Trichomonas vaginalis	fk506-binding protein, putative	0.0054	0.0117	0.0117
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0054	0.0117	0.5
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.011	0.0451	0.0437
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.011	0.0451	0.0451
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0054	0.0117	0.0103
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0451	0.0437
Plasmodium vivax	hypothetical protein	0.011	0.0451	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0054	0.0117	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1264	0.7384	0.7384
Entamoeba histolytica	protein kinase rad3, putative	0.0322	0.1723	0.1625
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.011	0.0451	0.0451
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0451	0.0437

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 120 uM	Inhibition of Mycobacterium tuberculosis MenB expressed in Escherichia coli BL21 (DE3) assessed as formation of DHNA-CoA from OSB-CoA by enzyme coupled-assay in presence of Escherichia coli MenE preincubated for 1 hr	ChEMBL.	22267981
IC50 (binding)	> 120 uM	Inhibition of Mycobacterium tuberculosis MenB expressed in Escherichia coli BL21 (DE3) assessed as formation of DHNA-CoA from OSB-CoA by enzyme coupled-assay in presence of Escherichia coli MenE	ChEMBL.	22267981
MIC (functional)	= 12.5 ug ml-1	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 5 to 7 days under anaerobic condition by microplate dilution assay	ChEMBL.	22267981

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2024258

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1635436