Detailed information for compound 1635451

Basic information

Technical information
  • TDR Targets ID: 1635451
  • Name: methyl 2-[(2R,3R)-2-[3-(2-methoxy-2-oxoethyl) -1H-indol-2-yl]-2,3-dihydro-1H-indol-3-yl]ace tate
  • MW: 378.421 | Formula: C22H22N2O4
  • H donors: 2 H acceptors: 2 LogP: 3.04 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C[C@@H]1c2ccccc2N[C@H]1c1[nH]c2c(c1CC(=O)OC)cccc2
  • InChi: 1S/C22H22N2O4/c1-27-19(25)11-15-13-7-3-5-9-17(13)23-21(15)22-16(12-20(26)28-2)14-8-4-6-10-18(14)24-22/h3-10,15,21,23-24H,11-12H2,1-2H3/t15-,21-/m1/s1
  • InChiKey: SXRCIANNDWDFLB-QVKFZJNVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-[(2R,3R)-2-[3-(2-methoxy-2-oxo-ethyl)-1H-indol-2-yl]indolin-3-yl]acetate
  • 2-[(2R,3R)-2-[3-(2-methoxy-2-oxoethyl)-1H-indol-2-yl]-3-indolinyl]acetic acid methyl ester
  • 2-[(2R,3R)-2-[3-(2-keto-2-methoxy-ethyl)-1H-indol-2-yl]indolin-3-yl]acetic acid methyl ester
  • methyl 2-[(2R,3R)-2-[3-(2-methoxy-2-oxo-ethyl)-1H-indol-2-yl]-2,3-dihydro-1H-indol-3-yl]ethanoate
  • NCI60_033125

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi p70 ribosomal S6 kinase beta 0.0098 0.0364 0.0352
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.012 0.0486 0.0307
Echinococcus multilocularis 0.012 0.0486 0.0474
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.012 0.0486 0.0474
Loa Loa (eye worm) AGC/NDR protein kinase 0.0033 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.1477 0.7919 0.7917
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.012 0.0486 0.0474
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.1754 0.1743
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.012 0.0486 0.0474
Schistosoma mansoni fkbp-rapamycin associated protein 0.0351 0.1754 0.1743
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1478 0.7928 0.7864
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0013 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0486 0.0486
Trichomonas vaginalis AGC family protein kinase 0.0104 0.04 0.039
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.012 0.0486 0.0478
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1857 1 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0486 0.0486
Leishmania major phosphatidylinositol 3-kinase, putative 0.012 0.0486 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.111 0.5907 0.5903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0623 0.3241 0.3234
Trichomonas vaginalis AGC family protein kinase 0.0104 0.04 0.039
Echinococcus multilocularis rac serine:threonine kinase 0.0071 0.022 0.0207
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.012 0.0486 0.0474
Loa Loa (eye worm) phosphatidylinositol 3 0.1857 1 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0033 0.0013 0.0013
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.012 0.0486 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0623 0.3241 0.3234
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0026 0.0012
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.012 0.0486 0.0194
Schistosoma mansoni serine/threonine-protein kinase 0.0071 0.022 0.0207
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.012 0.0486 0.0478
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0623 0.3241 0.3232
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.1477 0.7919 0.7917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0623 0.3241 0.3234
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0623 0.3241 0.3113
Entamoeba histolytica hypothetical protein 0.012 0.0486 0.0474
Brugia malayi Protein kinase domain containing protein 0.0104 0.04 0.0387
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.012 0.0486 0.0486
Echinococcus granulosus serine threonine protein kinase nrc 0.0065 0.0185 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.1205 0.6432 0.6429
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.012 0.0486 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0486 0.0478
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0044 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.1857 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1857 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0013 0.0004
Echinococcus multilocularis nervana 2 0.0064 0.0181 0.0168
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0623 0.3241 0.3033
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.012 0.0486 0.0478
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0044 0.003
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.012 0.0486 0.0307
Echinococcus multilocularis Glutaredoxin protein 5 0.0064 0.0181 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.1477 0.7919 0.7917
Mycobacterium leprae conserved hypothetical protein 0.012 0.0486 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0878 0.464 0.4475
Trichomonas vaginalis PIKK family atypical protein kinase 0.1003 0.5322 0.5317
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.012 0.0486 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.1754 0.1746
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.012 0.0486 0.0474
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0033 0.0013 0.0013
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0623 0.3241 0.3033
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0486 0.0474
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.012 0.0486 0.0474
Loa Loa (eye worm) phosphatidylinositol kinase 0.012 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.1857 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0486 0.0486
Echinococcus multilocularis serine protein kinase ATM 0.0351 0.1754 0.1743
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.012 0.0486 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.012 0.0486 0.0474
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.012 0.0486 0.0307
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0351 0.1754 0.1598
Trichomonas vaginalis PIKK family atypical protein kinase 0.1381 0.7394 0.7392
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0486 0.0474
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0065 0.0185 0.0172
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.012 0.0486 0.0474
Trichomonas vaginalis AGC family protein kinase 0.0104 0.04 0.039
Entamoeba histolytica protein kinase rad3, putative 0.0351 0.1754 0.1743
Entamoeba histolytica protein kinase, putative 0.0104 0.04 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.1003 0.5322 0.5317
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.012 0.0486 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.1477 0.7919 0.7917
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.012 0.0486 1
Entamoeba histolytica hypothetical protein 0.012 0.0486 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.5313 0.5309
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0351 0.1754 0.15
Leishmania major phosphatidylinositol 3-kinase, putative 0.0623 0.3241 0.3033
Trichomonas vaginalis AGC family protein kinase 0.004 0.0048 0.0039
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.012 0.0486 0.0307
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0351 0.1754 0.1743
Loa Loa (eye worm) hypothetical protein 0.0272 0.1317 0.1317
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.012 0.0486 0.0478
Echinococcus multilocularis adenosine kinase 0.0085 0.0298 0.0285
Echinococcus granulosus adenosine kinase 0.0085 0.0298 0.0285
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.012 0.0486 1
Echinococcus multilocularis nervana 2 0.0064 0.0181 0.0168
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.1381 0.7394 0.7392
Leishmania major phosphatidylinositol 4-kinase, putative 0.012 0.0486 0.0194
Mycobacterium tuberculosis Conserved hypothetical protein 0.012 0.0486 0.5
Schistosoma mansoni hypothetical protein 0.012 0.0486 0.0474
Toxoplasma gondii target of rapamycin (TOR), putative 0.1381 0.7394 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.012 0.0486 0.0474
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0033 0.0013 0.0013
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.012 0.0486 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.1381 0.7394 0.7392
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0391 0.1974 0.2361
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1857 1 1
Trypanosoma cruzi adenosine kinase, putative 0.0085 0.0298 0.0115
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0486 0.0266
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.022 0.0207
Leishmania major hypothetical protein, conserved 0.012 0.0486 0.0194
Echinococcus granulosus Glutaredoxin protein 5 0.0064 0.0181 0.0168
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.012 0.0486 0.0307
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0026 0.0012
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.012 0.0486 0.0474
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1857 1 1
Schistosoma mansoni adenosine kinase 0.0085 0.0298 0.0285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.1754 0.1746
Schistosoma mansoni phosphatidylinositol 4-kinase 0.012 0.0486 0.0474
Leishmania major phosphatidylinositol kinase related protein, putative 0.012 0.0486 0.0194
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0486 0.0474
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0486 0.0266
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0272 0.1317 0.1306
Loa Loa (eye worm) hypothetical protein 0.0391 0.1974 0.1974
Trichomonas vaginalis AGC family protein kinase 0.0104 0.04 0.039
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.012 0.0486 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.1246 0.6652 0.6649
Trichomonas vaginalis PIKK family atypical protein kinase 0.1381 0.7394 0.7392
Brugia malayi FAT domain containing protein 0.0272 0.1317 0.1306
Schistosoma mansoni phosphatidylinositol 4-kinase 0.012 0.0486 0.0474
Trypanosoma cruzi Protein kinase B 0.0071 0.022 0.0036
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0486 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.1381 0.7394 0.7392
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1857 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1003 0.5322 0.5317
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.012 0.0486 0.0307
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.1754 0.1743
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0033 0.0013 0.0013
Schistosoma mansoni serine/threonine-protein kinase 0.0071 0.022 0.0207
Giardia lamblia Phosphatidylinositol 4-kinase 0.012 0.0486 0.0307
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.012 0.0486 0.0478
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0181 0.0168
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.012 0.0486 0.0478
Plasmodium vivax hypothetical protein, conserved 0.012 0.0486 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0486 0.0474
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.012 0.0486 0.0194
Loa Loa (eye worm) hypothetical protein 0.0231 0.1098 0.1098
Schistosoma mansoni hypothetical protein 0.0272 0.1317 0.1306
Trichomonas vaginalis PIKK family atypical protein kinase 0.111 0.5907 0.5903
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.012 0.0486 0.0307
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0486 0.0474
Trypanosoma cruzi adenosine kinase, putative 0.0085 0.0298 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.5313 0.5309
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0486 0.0266
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.012 0.0486 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.1099 0.5847 0.5843
Schistosoma mansoni adenosine kinase 0.0085 0.0298 0.0285
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0486 0.0474
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0181 0.0168
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0351 0.1754 0.1743
Loa Loa (eye worm) phosphatidylinositol 3 0.0623 0.3241 0.3241
Loa Loa (eye worm) hypothetical protein 0.0085 0.0298 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0623 0.3241 0.3234
Trichomonas vaginalis conserved hypothetical protein 0.0391 0.1974 0.1966
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0013 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0104 0.04 0.039
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.012 0.0486 0.0478
Onchocerca volvulus 0.012 0.0486 1
Echinococcus granulosus nervana 2 0.0064 0.0181 0.0168
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.022 0.0207
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0272 0.1317 0.1309
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.012 0.0486 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.1754 0.1746
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.012 0.0486 0.0474
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0623 0.3241 0.3232
Echinococcus granulosus serine/threonine protein kinase 0.0071 0.022 0.0207
Entamoeba histolytica hypothetical protein 0.0351 0.1754 0.1743
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1857 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0486 0.0474
Trypanosoma brucei rac serine-threonine kinase, putative 0.0104 0.04 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0231 0.1098 0.1089
Echinococcus granulosus nervana 2 0.0064 0.0181 0.0168
Loa Loa (eye worm) hypothetical protein 0.0378 0.1903 0.1903
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.012 0.0486 0.0307
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0098 0.0364 0.0364
Trichomonas vaginalis PIKK family atypical protein kinase 0.1099 0.5847 0.5843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0498 0.2559 0.2552
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.012 0.0486 0.0474
Echinococcus granulosus serine protein kinase ATM 0.0351 0.1754 0.1743
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.012 0.0486 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0486 0.0474
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0486 0.0486
Brugia malayi Adenosine kinase-like 0.0085 0.0298 0.0285
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0486 0.0266
Loa Loa (eye worm) hypothetical protein 0.012 0.0486 0.0486
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.012 0.0486 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.1585 0.8513 0.8512
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0623 0.3241 0.3232
Plasmodium falciparum phosphatidylinositol 4-kinase 0.012 0.0486 1
Echinococcus multilocularis Zinc finger, PHD finger 0.012 0.0486 0.0474
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1857 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1477 0.7919 0.7917
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.012 0.0486 0.0194
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0272 0.1317 0.1306
Giardia lamblia Hypothetical protein 0.012 0.0486 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.1381 0.7394 0.7392
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0486 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.1003 0.5322 0.5317
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0351 0.1754 0.1743
Leishmania major hypothetical protein, unknown function 0.012 0.0486 0.0194
Trichomonas vaginalis AGC family protein kinase 0.0104 0.04 0.039
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.012 0.0486 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0486 0.0478
Loa Loa (eye worm) AGC/AKT protein kinase 0.0104 0.04 0.04
Trichomonas vaginalis AGC family protein kinase 0.0104 0.04 0.039
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.012 0.0486 0.0478
Entamoeba histolytica hypothetical protein 0.012 0.0486 0.0474
Giardia lamblia GTOR 0.1857 1 1
Loa Loa (eye worm) hypothetical protein 0.0351 0.1754 0.1754
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.012 0.0486 0.0474
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.012 0.0486 0.0478
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.012 0.0486 0.0474
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0623 0.3241 0.3232
Leishmania major phosphatidylinositol kinase, putative 0.012 0.0486 0.0194
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0033 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.1857 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.012 0.0486 0.0194
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0026 0.0012
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0623 0.3241 0.3113
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.012 0.0486 0.0478
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0771 0.4054 0.3872
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0486 0.0474
Entamoeba histolytica hypothetical protein 0.012 0.0486 0.0474
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0071 0.022 0.0036
Plasmodium falciparum phosphatidylinositol 3-kinase 0.012 0.0486 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0623 0.3241 0.3033
Entamoeba histolytica protein kinase 2, putative 0.0065 0.0185 0.0172
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1857 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0231 0.1098 0.1089
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0351 0.1754 0.1598
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.012 0.0486 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0623 0.3241 0.3234
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1857 1 1
Plasmodium vivax hypothetical protein 0.012 0.0486 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.012 0.0486 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.5313 0.5309
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.012 0.0486 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.111 0.5907 0.5903
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1478 0.7928 0.7864
Entamoeba histolytica protein kinase, putative 0.0098 0.0364 0.0352
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0065 0.0185 0.0172
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0231 0.1098 0.093
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.012 0.0486 0.0474
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0351 0.1754 0.1743
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1857 1 1
Onchocerca volvulus 0.012 0.0486 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.012 0.0486 0.0307
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.012 0.0486 0.0478
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0026 0.0026
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.012 0.0486 0.0474
Entamoeba histolytica protein kinase, putative 0.0104 0.04 0.0387
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1857 1 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0013 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0013 0.0004
Toxoplasma gondii FATC domain-containing protein 0.0351 0.1754 0.2052
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.012 0.0486 0.0478
Toxoplasma gondii AGC kinase 0.0098 0.0364 0.0094
Trypanosoma cruzi target of rapamycin kinase 3 0.1478 0.7928 0.7888
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.012 0.0486 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.1381 0.7394 0.7392

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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