TDR Targets

Basic information

Technical information

TDR Targets ID: 1635661
Name: NCI60_039071
MW: 418.465 | Formula: C18H15FN4O3S2
H donors: 1 H acceptors: 4 LogP: 4.05 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1sc2c3c1NC(=O)CN(c3nc(n2)SC)c1ccc(cc1)F
InChi: 1S/C18H15FN4O3S2/c1-3-26-17(25)14-13-12-15(21-18(27-2)22-16(12)28-14)23(8-11(24)20-13)10-6-4-9(19)5-7-10/h4-7H,3,8H2,1-2H3,(H,20,24)
InChiKey: PXOPNZBXMVYVEG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

NSC711096
ZINC00643187
AO-861/37413010

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0178	0.1211	0.3689
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0358	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0378	0.2897	1
Brugia malayi	Trypsin family protein	0.0069	0.0284	0.0981
Brugia malayi	EGF-like domain containing protein	0.0089	0.0455	0.1571
Brugia malayi	EGF-like domain containing protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2897	1
Loa Loa (eye worm)	steroid hormone receptor	0.0378	0.2897	1
Onchocerca volvulus		0.0089	0.0455	0.086
Loa Loa (eye worm)	trypsin family protein	0.0069	0.0284	0.0981
Brugia malayi	Nuclear hormone receptor-like 1	0.02	0.1392	0.4803
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Echinococcus granulosus	protein jagged 1	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Echinococcus granulosus	neurogenic locus notch protein 4	0.0089	0.0455	0.1571
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0089	0.0455	0.0455
Echinococcus multilocularis	neurogenic locus notch protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0284	0.0981
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0178	0.1211	0.3689
Echinococcus multilocularis	slit 2 protein	0.0089	0.0455	0.1571
Onchocerca volvulus		0.0069	0.0284	0.0221
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0133	0.0606
Schistosoma mansoni	septate junction protein	0.0089	0.0455	0.0455
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0178	0.1211	0.418
Brugia malayi	orphan nuclear receptor NR2E1	0.0178	0.1211	0.418
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0208	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Toxoplasma gondii	EGF family domain-containing protein	0.0089	0.0455	0.1458
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0178	0.1211	0.418
Brugia malayi	Cadherin domain containing protein	0.0089	0.0455	0.1571
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0178	0.1211	0.418
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0378	0.2897	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Schistosoma mansoni	nuclear hormone receptor	0.0178	0.1211	0.1211
Schistosoma mansoni	hypothetical protein	0.0089	0.0455	0.0455
Onchocerca volvulus		0.0089	0.0455	0.086
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2897	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0062	0.0225	0.0778
Onchocerca volvulus		0.037	0.2834	0.9766
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.0531	0.1832
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0089	0.0455	0.1571
Brugia malayi	Nuclear hormone receptor E75	0.0178	0.1211	0.418
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0378	0.2897	0.2897
Leishmania major	cathepsin L-like protease	0.0125	0.0757	1
Onchocerca volvulus		0.0089	0.0455	0.086
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0378	0.2897	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0069	0.0284	0.0284
Loa Loa (eye worm)	DR-78	0.0178	0.1211	0.418
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0378	0.2897	1
Schistosoma mansoni	coup transcription factor	0.0378	0.2897	0.2897
Brugia malayi	hypothetical protein	0.0178	0.1211	0.418
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0225	0.0778
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0133	0.046
Echinococcus multilocularis	fibrillin 1	0.0062	0.0225	0.0778
Schistosoma mansoni	notch	0.0089	0.0455	0.0455
Onchocerca volvulus		0.0089	0.0455	0.086
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0358	0.1064
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0378	0.2897	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.0358	0.1236
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.0531	0.1832
Onchocerca volvulus		0.0069	0.0284	0.0221
Trypanosoma cruzi	major cysteine proteinase, putative	0.0098	0.0532	0.6591
Schistosoma mansoni	nuclear receptor	0.0178	0.1211	0.1211
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.0502	0.1734
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.0698	1
Brugia malayi	glutathione reductase	0.0046	0.0097	0.0334
Toxoplasma gondii	PAN domain-containing protein	0.0337	0.2552	1
Loa Loa (eye worm)	hypothetical protein	0.02	0.1392	0.4803
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0378	0.2897	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0378	0.2897	0.2897
Brugia malayi	Nuclear hormone receptor-like 1	0.02	0.1392	0.4803
Echinococcus multilocularis	neurogenic locus notch protein	0.0089	0.0455	0.1571
Mycobacterium tuberculosis	Probable reductase	0.0106	0.0598	0.8342
Echinococcus granulosus	nuclear receptor nhr 48	0.0178	0.1211	0.418
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0062	0.0225	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2897	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.0698	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0378	0.2897	1
Schistosoma mansoni	notch	0.0089	0.0455	0.0455
Brugia malayi	jmjC domain containing protein	0.0094	0.0502	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Schistosoma mansoni	notch	0.0089	0.0455	0.0455
Schistosoma mansoni	notch	0.0089	0.0455	0.0455
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.02	0.1392	0.4803
Echinococcus granulosus	enteropeptidase	0.0069	0.0284	0.0981
Leishmania major	cathepsin L-like protease	0.0125	0.0757	1
Schistosoma mansoni	cell polarity protein	0.0089	0.0455	0.0455
Loa Loa (eye worm)	hypothetical protein	0.037	0.2834	0.9784
Onchocerca volvulus	Bile acid receptor homolog	0.0378	0.2897	1
Brugia malayi	nuclear receptor NHR-67	0.0178	0.1211	0.418
Brugia malayi	nuclear hormone receptor	0.0378	0.2897	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.0598	0.8342
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0225	0.0778
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.0598	0.8342
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Schistosoma mansoni	notch	0.0089	0.0455	0.0455
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0284	0.0981
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0358	1
Brugia malayi	ecdysteroid receptor	0.0378	0.2897	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0069	0.0284	0.0284
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0062	0.0225	0.0225
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0178	0.1211	0.418
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0178	0.1211	0.418
Brugia malayi	photoreceptor-specific nuclear receptor	0.0378	0.2897	1
Onchocerca volvulus		0.0069	0.0284	0.0221
Brugia malayi	nuclear receptor RXR	0.0178	0.1211	0.418
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0178	0.1211	0.418
Brugia malayi	GCC2 and GCC3 family protein	0.0089	0.0455	0.1571
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0378	0.2897	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0178	0.1211	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0378	0.2897	1
Brugia malayi	EGF-like domain containing protein	0.0089	0.0455	0.1571
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0062	0.0225	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0378	0.2897	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0378	0.2897	1
Brugia malayi	Probable ClpP-like protease	0.0077	0.0358	0.1236
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0358	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.0698	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.027	0.0931
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0106	0.0598	0.8236
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0378	0.2897	1
Onchocerca volvulus	Neurogenic locus notch homolog	0.0089	0.0455	0.086
Echinococcus granulosus	Mastin	0.0069	0.0284	0.0981
Onchocerca volvulus	Protein ultraspiracle homolog	0.0378	0.2897	1
Onchocerca volvulus		0.0069	0.0284	0.0221
Loa Loa (eye worm)	notch protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.02	0.1392	0.4803
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.037	0.2834	0.2834
Echinococcus multilocularis	protein jagged 2	0.0089	0.0455	0.1571
Echinococcus multilocularis	neurogenic locus protein delta	0.0089	0.0455	0.1571
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0062	0.0225	0.0523
Schistosoma mansoni	nuclear hormone receptor	0.0378	0.2897	0.2897
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0378	0.2897	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.0358	0.3982
Brugia malayi	EGF-like domain containing protein	0.0089	0.0455	0.1571
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0378	0.2897	1
Echinococcus granulosus	delta-like protein 1	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2897	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0097	0.0334
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0097	0.0334
Echinococcus multilocularis	protein jagged 1	0.0089	0.0455	0.1571
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0178	0.1211	0.418
Schistosoma mansoni	egf-like domain protein	0.0062	0.0225	0.0225
Onchocerca volvulus	Slit protein homolog	0.0089	0.0455	0.086
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0378	0.2897	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0378	0.2897	0.2897
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0378	0.2897	1
Echinococcus multilocularis	Mastin	0.0069	0.0284	0.0981
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0069	0.0284	0.0981
Echinococcus multilocularis	ecdysone induced protein 78C	0.0378	0.2897	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0178	0.1211	0.418
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.02	0.1392	0.4803
Loa Loa (eye worm)	hypothetical protein	0.02	0.1392	0.4803
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0178	0.1211	0.418
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Echinococcus granulosus	neurogenic locus notch protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0067	0.027	0.0931
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0378	0.2897	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0378	0.2897	1
Echinococcus multilocularis	neural cadherin	0.0089	0.0455	0.1571
Echinococcus granulosus	neurogenic locus notch protein	0.0089	0.0455	0.1571
Echinococcus granulosus	fibropellin Ia	0.0089	0.0455	0.1571
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0378	0.2897	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0123	0.0423
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2897	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0133	0.0606
Echinococcus granulosus	neurogenic locus protein delta	0.0089	0.0455	0.1571
Schistosoma mansoni	thyroid hormone receptor	0.0378	0.2897	0.2897
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0097	0.0334
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0069	0.0284	0.0981
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Echinococcus multilocularis	neurogenic locus protein delta	0.0089	0.0455	0.1571
Brugia malayi	Trypsin-like protease protein 5	0.0069	0.0284	0.0981
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.02	0.1392	0.4803
Echinococcus granulosus	notch	0.0089	0.0455	0.1571
Brugia malayi	hypothetical protein	0.02	0.1392	0.4803
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0069	0.0284	0.0981
Echinococcus granulosus	transmembrane protease serine 3	0.0069	0.0284	0.0981
Echinococcus granulosus	FTZ F1 alpha	0.0378	0.2897	1
Echinococcus multilocularis	glycoprotein Antigen 5	0.0069	0.0284	0.0981
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0284	0.0981
Brugia malayi	Thioredoxin reductase	0.0046	0.0097	0.0334
Brugia malayi	Trypsin family protein	0.0069	0.0284	0.0981
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.0598	0.8342
Brugia malayi	Calcium binding EGF domain containing protein	0.0089	0.0455	0.1571
Schistosoma mansoni	hypothetical protein	0.0067	0.027	0.027
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0069	0.0284	0.0981
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0114	0.0666	0.8618
Brugia malayi	nuclear receptor NHR-88	0.0178	0.1211	0.418
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0378	0.2897	0.2897
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0378	0.2897	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2897	1
Echinococcus granulosus	protein jagged 2	0.0089	0.0455	0.1571
Echinococcus granulosus	thyroid hormone receptor alpha	0.0178	0.1211	0.418
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.0358	0.0358
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0378	0.2897	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0178	0.1211	0.418
Schistosoma mansoni	hypothetical protein	0.0089	0.0455	0.0455
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0133	0.046
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0062	0.0225	0.0778
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0378	0.2897	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0125	0.0757	1
Echinococcus granulosus	protein jagged 1	0.0089	0.0455	0.1571
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0378	0.2897	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Echinococcus granulosus	Tolloid protein 1	0.0062	0.0225	0.0778
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0378	0.2897	1
Schistosoma mansoni	thyroid hormone receptor	0.0378	0.2897	0.2897
Onchocerca volvulus	Putative cubilin	0.0089	0.0455	0.086
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0069	0.0284	0.0284
Echinococcus granulosus	laminin	0.0062	0.0225	0.0778
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0378	0.2897	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0358	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Brugia malayi	hypothetical protein	0.0178	0.1211	0.418
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0378	0.2897	1
Schistosoma mansoni	hypothetical protein	0.0069	0.0284	0.0284
Brugia malayi	tailless protein	0.0178	0.1211	0.418
Echinococcus multilocularis	transmembrane protease serine 3	0.0069	0.0284	0.0981
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0225	0.0778
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Brugia malayi	Nuclear hormone receptor E75	0.0178	0.1211	0.418
Brugia malayi	hypothetical protein	0.02	0.1392	0.4803
Brugia malayi	ecdysone receptor	0.0178	0.1211	0.418
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Brugia malayi	Calcium binding EGF domain containing protein	0.0089	0.0455	0.1571
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0089	0.0455	0.086
Loa Loa (eye worm)	Notch2	0.0089	0.0455	0.1571
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0378	0.2897	1
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0062	0.0225	0.0778
Brugia malayi	Calcium binding EGF domain containing protein	0.0089	0.0455	0.1571
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Brugia malayi	EGF-like domain containing protein	0.0089	0.0455	0.1571
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0378	0.2897	1
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0062	0.0225	0.0778
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0378	0.2897	0.2897
Brugia malayi	notch-like transmembrane receptor	0.0089	0.0455	0.1571
Schistosoma mansoni	hypothetical protein	0.0069	0.0284	0.0284
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0378	0.2897	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0178	0.1211	0.418
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0378	0.2897	1
Onchocerca volvulus		0.0178	0.1211	0.3689
Brugia malayi	nuclear hormone receptor family member odr-7	0.0178	0.1211	0.418
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0378	0.2897	1
Echinococcus granulosus	neural cadherin	0.0089	0.0455	0.1571
Schistosoma mansoni	retinoic acid receptor RXR	0.0378	0.2897	0.2897
Giardia lamblia	High cysteine protein	0.0089	0.0455	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0378	0.2897	1
Schistosoma mansoni	laminin gamma-3 chain	0.0089	0.0455	0.0455
Echinococcus granulosus	protein jagged 2	0.0089	0.0455	0.1571
Brugia malayi	steroid hormone receptor	0.0378	0.2897	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0125	0.0757	1
Brugia malayi	Steroid receptor seven-up type 2	0.0378	0.2897	1
Schistosoma mansoni	hypothetical protein	0.0089	0.0455	0.0455
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0089	0.0455	0.1571
Toxoplasma gondii	PAN domain-containing protein	0.0337	0.2552	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Schistosoma mansoni	hypothetical protein	0.0089	0.0455	0.0455
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.0698	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.02	0.1392	0.4803
Schistosoma mansoni	nuclear receptor nhr-48	0.0178	0.1211	0.1211
Schistosoma mansoni	hypothetical protein	0.0089	0.0455	0.0455
Brugia malayi	Trypsin family protein	0.0069	0.0284	0.0981
Brugia malayi	EGF-like domain containing protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.0502	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Brugia malayi	EGF-like domain containing protein	0.0089	0.0455	0.1571
Echinococcus multilocularis	enteropeptidase	0.0069	0.0284	0.0981
Brugia malayi	nuclear hormone receptor	0.0178	0.1211	0.418
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0358	0.5
Echinococcus multilocularis	Tolloid protein 1	0.0062	0.0225	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Onchocerca volvulus		0.0089	0.0455	0.086
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0531	0.1832
Leishmania major	cathepsin L-like protease	0.0125	0.0757	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0358	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.0531	0.1832
Schistosoma mansoni	nuclear receptor	0.0178	0.1211	0.1211
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0069	0.0284	0.0284
Schistosoma mansoni	hypothetical protein	0.0089	0.0455	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0358	0.1236
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0378	0.2897	1
Schistosoma mansoni	slit	0.0089	0.0455	0.0455
Brugia malayi	conserved hypotetical protein	0.0178	0.1211	0.418
Brugia malayi	nuclear receptor RXR	0.02	0.1392	0.4803
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.0598	0.8342
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0358	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.02	0.1392	0.1392
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0378	0.2897	0.2897
Loa Loa (eye worm)	hypothetical protein	0.02	0.1392	0.4803
Brugia malayi	Muscle positioning protein 4	0.0089	0.0455	0.1571
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.0358	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0358	0.1064
Loa Loa (eye worm)	nuclear hormone receptor	0.0178	0.1211	0.418
Echinococcus multilocularis	protein jagged 1	0.0089	0.0455	0.1571
Echinococcus multilocularis	laminin	0.0062	0.0225	0.0778
Brugia malayi	hypothetical protein	0.0069	0.0284	0.0981
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0044	0.0152
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0378	0.2897	0.2897
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.037	0.2834	0.2834
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.0339	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Schistosoma mansoni	zinc finger protein	0.0178	0.1211	0.1211
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.02	0.1392	0.1392
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0178	0.1211	0.418
Echinococcus multilocularis	FTZ F1 alpha	0.0378	0.2897	1
Echinococcus granulosus	slit 2 protein	0.0089	0.0455	0.1571
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2897	1
Brugia malayi	nuclear receptor NHR-88	0.0378	0.2897	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0378	0.2897	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Schistosoma mansoni	hypothetical protein	0.0089	0.0455	0.0455
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0069	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.037	0.2834	0.9784
Brugia malayi	Trypsin family protein	0.037	0.2834	0.9784
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0225	0.0778
Onchocerca volvulus		0.0378	0.2897	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0125	0.0757	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0097	0.0334
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.0358	0.1236
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0178	0.1211	0.418
Echinococcus granulosus	glycoprotein Antigen 5	0.0069	0.0284	0.0981
Trypanosoma cruzi	cysteine peptidase, putative	0.0125	0.0757	1
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0069	0.0284	0.0981
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0378	0.2897	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0178	0.1211	0.418
Onchocerca volvulus		0.0178	0.1211	0.3689
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2897	1
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0044	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0284	0.0981
Brugia malayi	Fibulin-1 precursor	0.0062	0.0225	0.0778
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Schistosoma mansoni	nuclear hormone receptor	0.0178	0.1211	0.1211
Onchocerca volvulus		0.0069	0.0284	0.0221
Schistosoma mansoni	RAR-like nuclear receptor	0.0378	0.2897	0.2897
Schistosoma mansoni	notch	0.0089	0.0455	0.0455
Schistosoma mansoni	cercarial elastase (S01 family)	0.0069	0.0284	0.0284
Echinococcus multilocularis	fibropellin Ia	0.0089	0.0455	0.1571
Onchocerca volvulus		0.0302	0.2256	0.76
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0284	0.0981
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0378	0.2897	1
Brugia malayi	Cadherin domain containing protein	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1211	0.418
Brugia malayi	Delta serrate ligand family protein	0.0089	0.0455	0.1571
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0069	0.0284	0.0284
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.0598	0.8342
Echinococcus multilocularis	notch	0.0089	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0455	0.1571
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0125	0.0757	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0225	0.0778
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0378	0.2897	1

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4.798	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.745	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.666	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.609	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.497	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.421	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.394	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.334	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.315	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.296	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.006	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2003311

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1635661