TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 303.243 | Formula: C13H14NNaO6
H donors: 2 H acceptors: 4 LogP: 1.52 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C(C(=O)[O-])NC(=O)OCc1ccccc1.[Na+]
InChi: 1S/C13H15NO6.Na/c1-2-19-12(17)10(11(15)16)14-13(18)20-8-9-6-4-3-5-7-9;/h3-7,10H,2,8H2,1H3,(H,14,18)(H,15,16);/q;+1/p-1
InChiKey: DSEZUGIFEFRNCP-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0604	0.1389	0.1389
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0267	0.0565	0.0552
Entamoeba histolytica	hypothetical protein	0.0782	0.1822	0.1667
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1386	0.3297	0.3293
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1717	0.4104	0.3992
Mycobacterium leprae	conserved hypothetical protein	0.0267	0.0565	0.5
Leishmania major	hypothetical protein, conserved	0.0267	0.0565	0.0387
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0267	0.0565	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.4133	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0267	0.0565	0.056
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0267	0.0565	0.0387
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0267	0.0565	0.056
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0267	0.0565	0.0387
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.4133	1	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1386	0.3297	0.317
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0515	0.1171	0.1171
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0267	0.0565	0.0387
Loa Loa (eye worm)	phosphatidylinositol 3	0.0267	0.0565	0.056
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0111	0.0186	0.018
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0267	0.0565	0.056
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0267	0.0565	0.0565
Trichomonas vaginalis	fk506-binding protein, putative	0.0111	0.0186	0.0186
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0111	0.0186	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0267	0.0565	0.056
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0782	0.1822	0.1667
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0267	0.0565	0.056
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0267	0.0565	0.0565
Entamoeba histolytica	protein kinase rad3, putative	0.0782	0.1822	0.1667
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3074	0.7416	0.7416
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0111	0.0186	0.018
Plasmodium vivax	hypothetical protein	0.0267	0.0565	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1386	0.3297	0.3297
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0782	0.1822	0.1667
Entamoeba histolytica	hypothetical protein	0.0267	0.0565	0.0387
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0782	0.1822	0.1817
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0267	0.0565	0.056
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1386	0.3297	0.3293
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0267	0.0565	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3287	0.7936	0.7936
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0267	0.0565	0.0565
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2232	0.536	0.536
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0111	0.0186	0.018
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0267	0.0565	0.0565
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0267	0.0565	0.0565
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0267	0.0565	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2228	0.5352	0.5352
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0267	0.0565	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4133	1	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0782	0.1822	0.1817
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0267	0.0565	0.056
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0267	0.0565	0.056
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0267	0.0565	0.0387
Schistosoma mansoni	hypothetical protein	0.0604	0.1389	0.1377
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0267	0.0565	0.0387
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.4133	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0871	0.204	0.204
Loa Loa (eye worm)	FKBP5 protein	0.0111	0.0186	0.018
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.4133	1	1
Giardia lamblia	GTOR	0.4133	1	1
Onchocerca volvulus		0.0267	0.0565	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0267	0.0565	0.0565
Leishmania major	phosphatidylinositol kinase, putative	0.0267	0.0565	0.0387
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0267	0.0565	0.0565
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0267	0.0565	0.0387
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0267	0.0565	0.0552
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3074	0.7416	0.7416
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0111	0.0186	0.0172
Toxoplasma gondii	FATC domain-containing protein	0.0782	0.1822	0.1835
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2772	0.668	0.668
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3074	0.7416	0.7416
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0267	0.0565	0.056
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0267	0.0565	0.0387
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.3291	0.7945	0.7906
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0604	0.1389	0.1384
Schistosoma mansoni	immunophilin	0.0096	0.0149	0.0134
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3074	0.7416	0.7416
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0267	0.0565	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2228	0.5352	0.5352
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0267	0.0565	0.0552
Trichomonas vaginalis	PIKK family atypical protein kinase	0.247	0.5941	0.5941
Leishmania major	hypothetical protein, unknown function	0.0267	0.0565	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3074	0.7416	0.7416
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0267	0.0565	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1386	0.3297	0.317
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0267	0.0565	0.0387
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0782	0.1822	0.181
Toxoplasma gondii	target of rapamycin (TOR), putative	0.3074	0.7416	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0267	0.0565	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4133	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0267	0.0565	0.056
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0267	0.0565	0.0387
Plasmodium vivax	hypothetical protein, conserved	0.0267	0.0565	1
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0267	0.0565	1
Schistosoma mansoni	immunophilin	0.0111	0.0186	0.0172
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0267	0.0565	0.056
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0267	0.0565	0.056
Echinococcus granulosus	serine protein kinase ATM	0.0782	0.1822	0.1817
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0267	0.0565	0.056
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0267	0.0565	0.0387
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0515	0.1171	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0871	0.204	0.2035
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.3291	0.7945	0.7906
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.4133	1	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0149	0.0143
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0111	0.0186	0.0186
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.4133	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0871	0.204	0.2153
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0267	0.0565	1
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0111	0.0186	0.5
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0565	0.056
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0267	0.0565	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0267	0.0565	0.0565
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.4133	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0782	0.1822	0.1822
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0267	0.0565	0.0565
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1386	0.3297	0.317
Trichomonas vaginalis	PIKK family atypical protein kinase	0.247	0.5941	0.5941
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1386	0.3297	0.3293
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1386	0.3297	0.3297
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0111	0.0186	0.018
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0782	0.1822	0.1667
Entamoeba histolytica	hypothetical protein	0.0267	0.0565	0.0387
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1386	0.3297	0.317
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0782	0.1822	0.181
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3287	0.7936	0.7936
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0267	0.0565	0.0387
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1386	0.3297	0.317
Loa Loa (eye worm)	phosphatidylinositol 3	0.4133	1	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1386	0.3297	0.3287
Loa Loa (eye worm)	hypothetical protein	0.0604	0.1389	0.1384
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0267	0.0565	0.0387
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0267	0.0565	0.0565
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1386	0.3297	0.3297
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0267	0.0565	1
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0267	0.0565	0.0387
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0267	0.0565	0.056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3287	0.7936	0.7936
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0565	0.056
Echinococcus multilocularis	serine protein kinase ATM	0.0782	0.1822	0.1817
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0267	0.0565	0.0565
Entamoeba histolytica	hypothetical protein	0.0267	0.0565	0.0387
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0267	0.0565	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0782	0.1822	0.1817
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.4133	1	1
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0096	0.0149	0.0143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3074	0.7416	0.7416
Schistosoma mansoni	immunophilin	0.0111	0.0186	0.0172
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0267	0.0565	0.056
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0267	0.0565	0.0387
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0267	0.0565	0.0552
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2232	0.536	0.536
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0267	0.0565	0.0565
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0782	0.1822	0.1667
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0267	0.0565	0.056
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0267	0.0565	0.0565
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0111	0.0186	0.0186
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2228	0.5352	0.5352
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0267	0.0565	0.0552
Entamoeba histolytica	hypothetical protein	0.0267	0.0565	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2445	0.5881	0.5881
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0111	0.0186	0.018
Loa Loa (eye worm)	phosphatidylinositol 3	0.0267	0.0565	0.056
Trypanosoma cruzi	target of rapamycin kinase 3	0.3291	0.7945	0.7906
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0267	0.0565	0.056
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0267	0.0565	0.0387
Trichomonas vaginalis	conserved hypothetical protein	0.0515	0.1171	0.1171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.247	0.5941	0.5941
Brugia malayi	FAT domain containing protein	0.0604	0.1389	0.1384
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0267	0.0565	0.0552
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0267	0.0565	0.0387
Schistosoma mansoni	hypothetical protein	0.0267	0.0565	0.0552
Giardia lamblia	Hypothetical protein	0.0267	0.0565	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.8525	0.8525
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0267	0.0565	0.056
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1386	0.3297	0.317
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0267	0.0565	0.056
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.4133	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0267	0.0565	0.056
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0267	0.0565	0.0387
Echinococcus multilocularis	Zinc finger, PHD finger	0.0267	0.0565	0.056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3287	0.7936	0.7936
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0267	0.0565	0.0387
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0267	0.0565	0.0387
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.1955	0.4684	0.4583
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.4133	1	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0267	0.0565	0.0565
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0267	0.0565	0.0387
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0267	0.0565	0.056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3074	0.7416	0.7416
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0267	0.0565	0.056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2232	0.536	0.536
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0782	0.1822	0.1817
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0782	0.1822	0.1822
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0267	0.0565	0.0387
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0267	0.0565	0.0552
Echinococcus multilocularis	fk506 binding protein	0.0111	0.0186	0.018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2232	0.536	0.536
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0267	0.0565	0.056
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0604	0.1389	0.1384
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3287	0.7936	0.7936
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0267	0.0565	1
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0267	0.0565	0.056
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0782	0.1822	0.1817
Loa Loa (eye worm)	phosphatidylinositol 3	0.1386	0.3297	0.3293
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0096	0.0149	0.0143
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0267	0.0565	0.056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2445	0.5881	0.5881
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0267	0.0565	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1109	0.2621	0.2621
Echinococcus multilocularis		0.0267	0.0565	0.056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1386	0.3297	0.3297
Trichomonas vaginalis	immunophilin, putative	0.0111	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0515	0.1171	0.1166
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2683	0.6462	0.6462
Loa Loa (eye worm)	hypothetical protein	0.0842	0.197	0.1965
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0267	0.0565	0.056
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0267	0.0565	0.0387
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0111	0.0186	0.018
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0267	0.0565	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0782	0.1822	0.1822
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.4133	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1386	0.3297	0.3297
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0267	0.0565	0.0565
Onchocerca volvulus		0.0267	0.0565	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4133	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2028263

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1638490