Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | DBF4 zinc finger | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | Zinc finger, DBF type | Get druggable targets OG5_138500 | All targets in OG5_138500 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_138500 | All targets in OG5_138500 |
Schistosoma japonicum | IPR006572,Zinc finger, DBF-type,domain-containing | Get druggable targets OG5_138500 | All targets in OG5_138500 |
Schistosoma japonicum | expressed protein | Get druggable targets OG5_138500 | All targets in OG5_138500 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0271 | 0.1841 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0941 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0271 | 0.1841 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0271 | 0.1841 | 0.9504 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0279 | 0.1937 | 0.249 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0271 | 0.1841 | 0.5 |
Echinococcus multilocularis | Zinc finger, DBF type | 0.0547 | 0.5206 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0271 | 0.1841 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0271 | 0.1841 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0257 | 0.1678 | 0.1895 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0271 | 0.1841 | 0.5 |
Echinococcus multilocularis | 0.0271 | 0.1841 | 0.2269 | |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0226 | 0.1301 | 0.0289 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0271 | 0.1841 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.067 | 0.6705 | 0.6212 |
Brugia malayi | Cytochrome P450 family protein | 0.0271 | 0.1841 | 0.0893 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0271 | 0.1841 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0271 | 0.1841 | 0.2269 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0941 | 1 | 1 |
Brugia malayi | cytochrome P450 | 0.0271 | 0.1841 | 0.0893 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0271 | 0.1841 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0271 | 0.1841 | 0.0893 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0271 | 0.1841 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0271 | 0.1841 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0271 | 0.1841 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0547 | 0.5206 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0271 | 0.1841 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0271 | 0.1841 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0941 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0271 | 0.1841 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0271 | 0.1841 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0271 | 0.1841 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0271 | 0.1841 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0271 | 0.1841 | 0.0621 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.1841 | 0.2269 |
Leishmania major | cytochrome p450-like protein | 0.0941 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0271 | 0.1841 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0271 | 0.1841 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0271 | 0.1841 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0941 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0941 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0941 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0941 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.019 | 0.0853 | 0.4405 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.1937 | 0.0732 |
Brugia malayi | Cytochrome P450 family protein | 0.0941 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0279 | 0.1937 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0271 | 0.1841 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0271 | 0.1841 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0271 | 0.1841 | 0.0621 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.008 uM | Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr | ChEMBL. | 24900258 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.