Detailed information for compound 1643394

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.358 | Formula: C18H16N6O3
  • H donors: 2 H acceptors: 2 LogP: 0.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC(=O)Nc1nc2ccccc2n2c1nn(c2=O)c1ccc(cc1)OC
  • InChi: 1S/C18H16N6O3/c1-27-12-8-6-11(7-9-12)24-18(26)23-14-5-3-2-4-13(14)20-16(17(23)22-24)21-15(25)10-19/h2-9H,10,19H2,1H3,(H,20,21,25)
  • InChiKey: FBVZEEMDUJPBCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sex peptide receptor 0.0046 0.0422 0.0571
Brugia malayi nuclear hormone receptor 0.0009 0.0023 0.0013
Brugia malayi Serotonin receptor 0.0046 0.0422 0.0412
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0384 0.0519
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0047
Echinococcus granulosus lamin 0.0019 0.0128 0.0173
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0245 0.258 0.2536
Echinococcus granulosus somatostatin receptor 0.0046 0.0422 0.0571
Brugia malayi brahma associated protein 60 kDa 0.069 0.7391 0.7388
Brugia malayi Latrophilin receptor protein 2 0.0025 0.0199 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0422 0.0532
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0047
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0422 0.0571
Echinococcus multilocularis lamin dm0 0.0019 0.0128 0.0161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0023 0.0013
Leishmania major hypothetical protein, conserved 0.0245 0.258 0.2536
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0012 0.0059 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0422 0.0532
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0422 0.0532
Onchocerca volvulus 0.0019 0.0128 0.0142
Brugia malayi nuclear receptor NHR-88 0.0009 0.0023 0.0013
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0308 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Brugia malayi hypothetical protein 0.0012 0.0059 0.0048
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0422 0.0411
Echinococcus multilocularis GPCR, family 2 0.0025 0.0199 0.0251
Schistosoma mansoni biogenic amine receptor 0.0046 0.0422 0.0571
Brugia malayi neuropeptide F receptor 0.0046 0.0422 0.0412
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0114 0.1161 0.1462
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0011 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0422 0.0532
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0308 0.0417
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.0422 0.0532
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.0422 0.0571
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0422 0.0532
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0931 1 1
Brugia malayi hypothetical protein 0.0046 0.0422 0.0412
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.0422 0.0532
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0012 0.0059 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Schistosoma mansoni ap endonuclease 0.0016 0.0093 0.0126
Echinococcus granulosus RING finger protein 185 0.0012 0.0059 0.0079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.008 0.0795 0.0785
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0422 0.0532
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0422 0.0571
Echinococcus granulosus dnaJ subfamily B 0.0374 0.3969 0.537
Brugia malayi hypothetical protein 0.0046 0.0422 0.0412
Echinococcus granulosus GPCR family 2 0.0025 0.0199 0.0269
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.0422 0.0411
Schistosoma mansoni myosin xvIII 0.0046 0.0422 0.0571
Onchocerca volvulus 0.0026 0.0208 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0023 0.0032
Trichomonas vaginalis glutaminase, putative 0.0263 0.2767 0.3743
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0029 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0245 0.258 0.3438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0023 0.0012
Schistosoma mansoni hypothetical protein 0.0272 0.2866 0.3877
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.016 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0245 0.258 0.2536
Echinococcus granulosus cell growth regulator with ring finger domain 0.0012 0.0059 0.0079
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0422 0.0532
Onchocerca volvulus 0.0046 0.0422 0.0541
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus lamin dm0 0.0019 0.0128 0.0173
Schistosoma mansoni RNA binding protein 0.0245 0.258 0.3491
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.0422 0.0571
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0012 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0422 0.0571
Brugia malayi brahma associated protein 60 kDa 0.069 0.7391 0.7388
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0384 0.1388
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.016 0.0138
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0422 0.0532
Brugia malayi G-protein coupled receptor 0.0046 0.0422 0.0412
Brugia malayi ORL1-like opioid receptor 0.0046 0.0422 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0422 0.0571
Brugia malayi Zinc finger protein 183 homolog 0.0012 0.0059 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Brugia malayi Serotonin receptor 0.0046 0.0422 0.0412
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0093 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0023 0.0013
Plasmodium vivax hypothetical protein, conserved 0.069 0.7391 1
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0422 0.0411
Onchocerca volvulus 0.0046 0.0422 0.0541
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0023 0.0032
Schistosoma mansoni neuropeptide receptor 0.0046 0.0422 0.0571
Echinococcus multilocularis RING finger protein 185 0.0012 0.0059 0.0074
Echinococcus granulosus neuropeptide receptor 0.0046 0.0422 0.0571
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0012 0.0059 0.0079
Onchocerca volvulus 0.069 0.7391 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.0422 0.0571
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0023 0.003
Echinococcus multilocularis orexin receptor type 2 0.0046 0.0422 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0023 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0023 0.0013
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus multilocularis cpg binding protein 0.0028 0.0224 0.0282
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0093 0.1386
Brugia malayi RING zinc finger protein 0.0012 0.0059 0.0048
Echinococcus granulosus ring and YY1 binding protein 0.0245 0.258 0.3491
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0012 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0022 0.016 0.0149
Loa Loa (eye worm) hypothetical protein 0.0245 0.258 0.2571
Onchocerca volvulus 0.0046 0.0422 0.0541
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0422 0.0571
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0012 0.0059 0.0079
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0012 0.0059 0.0079
Onchocerca volvulus 0.0245 0.258 0.347
Schistosoma mansoni hypothetical protein 0.0374 0.3969 0.537
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0422 0.0571
Echinococcus multilocularis geminin 0.0272 0.2866 0.3608
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.0199 0.0188
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0023 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.016 0.0102
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0422 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0023 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.016 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Onchocerca volvulus 0.0046 0.0422 0.0541
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0308 1
Brugia malayi hypothetical protein 0.0046 0.0422 0.0412
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0308 1
Brugia malayi hypothetical protein 0.0046 0.0422 0.0412
Brugia malayi cytoplasmic intermediate filament protein 0.001 0.0033 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0093 0.0047
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0422 0.0571
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0308 0.0417
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0422 0.0532
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0012 0.0059 0.0079
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0422 0.0571
Trichomonas vaginalis ion channel nompc, putative 0.0012 0.0059 0.0079
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0308 0.0417
Trypanosoma brucei hypothetical protein, conserved 0.0245 0.258 0.2536
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.0422 0.0532
Leishmania major hypothetical protein, conserved 0.0245 0.258 0.2536
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0023 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0422 0.0571
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.0422 0.0571
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.0422 0.0411
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0007 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Brugia malayi Neuralized family protein 0.0012 0.0059 0.0048
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0023 0.0032
Echinococcus granulosus g protein coupled receptor 0.0046 0.0422 0.0571
Echinococcus granulosus serotonin receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) glutaminase 0.0263 0.2767 0.2759
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0114 0.1161 0.1571
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0023 0.0013
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0012 0.0059 0.0074
Brugia malayi B-box zinc finger family protein 0.0012 0.0059 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0023 0.0013
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Brugia malayi Dopamine receptor protein 1 0.0046 0.0422 0.0412
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Brugia malayi hypothetical protein 0.0046 0.0422 0.0412
Brugia malayi AKH receptor 0.0046 0.0422 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Schistosoma mansoni hypothetical protein 0.069 0.7391 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.0422 0.0532
Trypanosoma cruzi hypothetical protein, conserved 0.0245 0.258 0.2536
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0208 0.0196
Chlamydia trachomatis SWIB complex protein 0.069 0.7391 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0012
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0012 0.0059 0.0079
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0422 0.0571
Schistosoma mansoni hypothetical protein 0.0046 0.0422 0.0571
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.0422 0.0411
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0245 0.258 0.2536
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0308 0.0388
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.0422 0.0571
Echinococcus multilocularis lamin 0.0019 0.0128 0.0161
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0114 0.1161 0.1152
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0011 0.0014
Schistosoma mansoni neuropeptide receptor 0.0046 0.0422 0.0571
Schistosoma mansoni zinc finger protein 0.0012 0.0059 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0023 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0422 0.0532
Echinococcus granulosus hypothetical protein 0.0046 0.0422 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0114 0.1161 0.1571
Brugia malayi RING finger protein 20 0.0012 0.0059 0.0048
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.0422 0.0532
Brugia malayi latrophilin 2 splice variant baaae 0.0055 0.0519 0.0509
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0025 0.0199 0.0269
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0047
Loa Loa (eye worm) glutaminase 2 0.0263 0.2767 0.2759
Echinococcus granulosus g protein coupled receptor 0.0046 0.0422 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0023 0.0013
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.0422 0.0532
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0023 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0009 0.0022 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0422 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0023 0.0013
Schistosoma mansoni hypothetical protein 0.001 0.0029 0.004
Brugia malayi follicle stimulating hormone receptor 0.0046 0.0422 0.0412
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0007
Onchocerca volvulus Putative RING finger protein 207 0.0012 0.0059 0.0048
Echinococcus granulosus Zinc finger RanBP2 type 0.0245 0.258 0.3491
Trypanosoma cruzi hypothetical protein, conserved 0.0245 0.258 0.2536
Schistosoma mansoni TRABID protein (C64 family) 0.0245 0.258 0.3491
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0023 0.0032
Onchocerca volvulus 0.0046 0.0422 0.0541
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0093 0.0083
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.0422 0.0571
Mycobacterium ulcerans glutaminase 0.0263 0.2767 1
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0245 0.258 0.3248
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0245 0.258 0.2536
Echinococcus multilocularis ring finger protein 113a 0.0012 0.0059 0.0074
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0422 0.0532
Echinococcus multilocularis ring and YY1 binding protein 0.0245 0.258 0.3248
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.016 0.0102
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0012 0.0059 0.0074
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Schistosoma mansoni ring finger protein 151 0.0012 0.0059 0.0079
Echinococcus granulosus cpg binding protein 0.0028 0.0224 0.0303
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.069 0.7391 0.7388
Schistosoma mansoni hypothetical protein 0.0046 0.0422 0.0571
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0422 0.0571
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0023 0.003
Brugia malayi GnHR receptor homolog 0.0046 0.0422 0.0412
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.069 0.7391 1
Brugia malayi CXXC zinc finger family protein 0.0026 0.0208 0.0197
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Brugia malayi SWIB/MDM2 domain containing protein 0.069 0.7391 0.7388
Loa Loa (eye worm) hypothetical protein 0.0931 1 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0245 0.258 0.2572
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0093 0.0126
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Schistosoma mansoni opsin-like receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0245 0.258 0.2571
Onchocerca volvulus 0.0046 0.0422 0.0541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0023 0.0012
Echinococcus granulosus g protein coupled receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0093 0.0035
Schistosoma mansoni neuropeptide receptor 0.0046 0.0422 0.0571
Schistosoma mansoni hypothetical protein 0.069 0.7391 1
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0012 0.0059 0.0079
Brugia malayi Calcitonin receptor-like protein seb-1 0.008 0.0795 0.0785
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0245 0.258 0.2572
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.0422 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0308 0.0417
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0093 0.2428
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0308 0.0251
Schistosoma mansoni cpg binding protein 0.0028 0.0224 0.0303
Echinococcus granulosus intermediate filament protein 0.0019 0.0128 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0023 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0023 0.0032
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0043 0.0384 0.0519
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0012
Chlamydia trachomatis DNA topoisomerase I 0.069 0.7391 0.5
Onchocerca volvulus 0.0245 0.258 0.347
Onchocerca volvulus 0.0012 0.0059 0.0048
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0422 0.0571
Schistosoma mansoni cpg binding protein 0.0028 0.0224 0.0303
Brugia malayi sulfakinin receptor protein 0.0046 0.0422 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0047
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0245 0.258 0.2572
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0047
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.0422 0.0571
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0023 0.0012
Brugia malayi hypothetical protein 0.0012 0.0059 0.0048
Schistosoma mansoni zinc finger protein 0.0245 0.258 0.3491
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0384 0.0519
Schistosoma mansoni intermediate filament proteins 0.0019 0.0128 0.0173
Onchocerca volvulus 0.0012 0.0059 0.0048
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0012 0.0059 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0025 0.0199 0.0188
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.0422 0.0411
Onchocerca volvulus RING finger protein 141 homolog 0.0012 0.0059 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0422 0.0532
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0043 0.0384 0.0327
Onchocerca volvulus 0.0046 0.0422 0.0541
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0023 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0023 0.0013
Onchocerca volvulus 0.0019 0.0128 0.0142
Onchocerca volvulus 0.0046 0.0422 0.0541
Schistosoma mansoni lamin 0.0019 0.0128 0.0173
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0023 0.0032
Brugia malayi RE15519p 0.0046 0.0422 0.0412
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0422 0.0532
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Schistosoma mansoni microtubule-associated protein tau 0.0483 0.5156 0.6976
Onchocerca volvulus 0.0046 0.0422 0.0541
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0012 0.0059 0.0079
Trichomonas vaginalis hypothetical protein 0.0012 0.0059 0.0079
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.0422 0.0571
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.0422 0.0411
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.0422 0.0541
Trypanosoma cruzi WLM domain containing protein, putative 0.0245 0.258 0.2536
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0114 0.1161 0.1151
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0422 0.0532
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0.0093 0.0337
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Schistosoma mansoni adenoreceptor 0.0046 0.0422 0.0571
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.0422 0.0412
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0023 0.0032
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0741 0.7943 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.0422 0.0532
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0422 0.0571
Onchocerca volvulus 0.0046 0.0422 0.0541
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0422 0.0532
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0023 0.0013
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0113
Echinococcus multilocularis 0.0012 0.0059 0.0074
Schistosoma mansoni amine GPCR 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0422 0.0532
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0422 0.0571
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.0422 0.0412
Loa Loa (eye worm) hypothetical protein 0.0055 0.0519 0.0508
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.0422 0.0571
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0093 0.0082
Brugia malayi glutaminase DH11.1 0.0263 0.2767 0.2759
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0043 0.0384 0.0483
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0023 0.0032
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.069 0.7391 1
Trichomonas vaginalis conserved hypothetical protein 0.069 0.7391 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.0422 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus multilocularis SWI:SNF matrix associated 0.069 0.7391 0.9305
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.069 0.7391 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0308 0.0388
Echinococcus granulosus fmrfamide receptor 0.0046 0.0422 0.0571
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0308 0.0417
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0012 0.0059 0.0079
Echinococcus granulosus Upstream activation factor subunit UAF30 0.069 0.7391 1
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0012 0.0059 0.0079
Onchocerca volvulus 0.0012 0.0059 0.0048
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0012
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0245 0.258 0.3438
Leishmania major hypothetical protein, conserved 0.0245 0.258 0.2536
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.0422 0.0532
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Onchocerca volvulus 0.0046 0.0422 0.0541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0023 0.0012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.0199 0.0251
Echinococcus granulosus g-protein coupled receptor 0.0046 0.0422 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0114 0.1161 0.1571
Echinococcus multilocularis sex peptide receptor 0.0046 0.0422 0.0532
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0422 0.0532
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0093 0.0126
Echinococcus multilocularis microtubule associated protein 2 0.0483 0.5156 0.6491
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0422 0.0571
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.0422 0.0571
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.0422 0.0532
Toxoplasma gondii aldehyde dehydrogenase 0.0043 0.0384 0.0444
Loa Loa (eye worm) RiNg Finger protein family member 0.0012 0.0059 0.0047
Onchocerca volvulus 0.0012 0.0059 0.0048
Schistosoma mansoni amine GPCR 0.0046 0.0422 0.0571
Schistosoma mansoni hypothetical protein 0.0025 0.0199 0.0269
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0422 0.0532
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0384 0.1388
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0245 0.258 0.2572
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0056 0.0526 0.0712
Schistosoma mansoni peter pan-related 0.0012 0.0059 0.0079
Treponema pallidum exodeoxyribonuclease (exoA) 0.0016 0.0093 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0422 0.0571
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0308 0.0298
Schistosoma mansoni hypothetical protein 0.0272 0.2866 0.3877
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0007
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.0422 0.0571
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0043 0.0384 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.0422 0.0532
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.0422 0.0571
Schistosoma mansoni amine GPCR 0.0046 0.0422 0.0571
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0012 0.0059 0.0048
Brugia malayi hypothetical protein 0.0014 0.0076 0.0066
Brugia malayi hypothetical protein 0.0022 0.016 0.015
Trypanosoma brucei hypothetical protein, conserved 0.0245 0.258 0.2536
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0308 0.0417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0114 0.1161 0.1571
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.0422 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0422 0.0532
Schistosoma mansoni hypothetical protein 0.0046 0.0422 0.0571
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0245 0.258 0.3248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0023 0.0012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0422 0.0571
Schistosoma mansoni neuropeptide receptor 0.0046 0.0422 0.0571
Schistosoma mansoni ap endonuclease 0.0016 0.0093 0.0126
Loa Loa (eye worm) intermediate filament protein 0.0019 0.0128 0.0117
Brugia malayi Dopamine receptor 0.0046 0.0422 0.0412
Schistosoma mansoni peter pan-related 0.0012 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.0128 0.0117
Trypanosoma brucei C-8 sterol isomerase, putative 0.0931 1 1
Loa Loa (eye worm) hypothetical protein 0.0245 0.258 0.2571
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.0422 0.0571
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0422 0.0571
Brugia malayi hypothetical protein 0.0046 0.0422 0.0412
Onchocerca volvulus 0.0046 0.0422 0.0541
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0023 0.003
Schistosoma mansoni hypothetical protein 0.0012 0.0059 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus multilocularis SWI:SNF matrix associated 0.069 0.7391 0.9305
Echinococcus multilocularis serotonin receptor 0.0046 0.0422 0.0532
Brugia malayi hypothetical protein 0.0012 0.0059 0.0048
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus SWI:SNF matrix associated 0.069 0.7391 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0047
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0016 0.0093 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0093 0.0047
Trypanosoma cruzi WLM domain containing protein, putative 0.0245 0.258 0.2536
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0059 0.0079
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0047
Schistosoma mansoni glutaminase 0.0263 0.2767 0.3743
Loa Loa (eye worm) hypothetical protein 0.0476 0.5074 0.5068
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Loa Loa (eye worm) pigment dispersing factor receptor c 0.008 0.0795 0.0784
Echinococcus granulosus geminin 0.0272 0.2866 0.3877
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0023 0.0032
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.0128 0.0118
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0012 0.0059 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0384 0.1388
Echinococcus granulosus ring finger protein 113a 0.0012 0.0059 0.0079
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0023 0.0032
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.0422 0.0532
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0012 0.0059 0.0079
Brugia malayi hypothetical protein 0.0046 0.0422 0.0412
Toxoplasma gondii histone lysine methyltransferase SET1 0.005 0.0462 0.055
Brugia malayi hypothetical protein 0.0046 0.0422 0.0412
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0012 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus neuropeptide s receptor 0.0046 0.0422 0.0571
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.016 0.0138
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0422 0.0411
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0422 0.0532
Leishmania major C-8 sterol isomerase-like protein 0.0931 1 1
Schistosoma mansoni hypothetical protein 0.0245 0.258 0.3491
Loa Loa (eye worm) hypothetical protein 0.008 0.0795 0.0784
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0012 0.0059 0.0079
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.069 0.7391 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Brugia malayi larval opioid receptor 0.0046 0.0422 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0422 0.0571
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0422 0.0571
Schistosoma mansoni amine GPCR 0.0046 0.0422 0.0571
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0308 0.0251
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.0422 0.0571
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0023 0.0012
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0012 0.0059 0.0074
Onchocerca volvulus 0.0046 0.0422 0.0541
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0422 0.0571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0422 0.0571
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0245 0.258 0.2571
Schistosoma mansoni hypothetical protein 0.0025 0.0199 0.0269
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0023 0.0032
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0245 0.258 0.2536
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0422 0.0411
Schistosoma mansoni amine GPCR 0.0046 0.0422 0.0571
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.0422 0.0412
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0025 0.0199 0.0189
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0093 0.0035
Onchocerca volvulus Protein neuralized homolog 0.0012 0.0059 0.0048
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0245 0.258 0.2536
Schistosoma mansoni hypothetical protein 0.0012 0.0059 0.0079
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0422 0.0571
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0012 0.0059 0.0074
Brugia malayi hypothetical protein 0.0012 0.0059 0.0048
Schistosoma mansoni opsin-like receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Schistosoma mansoni brg-1 associated factor 0.069 0.7391 1
Trichomonas vaginalis ankyrin, putative 0.0012 0.0059 0.0079
Trichomonas vaginalis ankyrin, putative 0.0012 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0012
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.0422 0.0532
Schistosoma mansoni opsin-like receptor 0.0046 0.0422 0.0571
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0422 0.0532
Echinococcus multilocularis zinc finger protein Ran binding 0.0245 0.258 0.3248
Schistosoma mansoni biogenic amine receptor 0.0046 0.0422 0.0571
Schistosoma mansoni hypothetical protein 0.0055 0.0519 0.0702
Onchocerca volvulus 0.0245 0.258 0.347
Echinococcus granulosus zinc finger protein Ran binding 0.0245 0.258 0.3491
Onchocerca volvulus 0.0046 0.0422 0.0541
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.0422 0.0412
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Schistosoma mansoni hypothetical protein 0.0025 0.0199 0.0269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0114 0.1161 0.1462
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0047
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0012
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0245 0.258 0.2536
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.0422 0.0412
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0023 0.003
Brugia malayi putative neuropeptide receptor 0.0046 0.0422 0.0412
Onchocerca volvulus 0.0012 0.0059 0.0048
Echinococcus multilocularis allatostatin A receptor 0.0046 0.0422 0.0532
Schistosoma mansoni lamin 0.0019 0.0128 0.0173
Brugia malayi Melatonin receptor type 1A 0.0046 0.0422 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0023 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0117
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.0422 0.0411
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0422 0.0571
Echinococcus granulosus microtubule associated protein 2 0.0483 0.5156 0.6976
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.001 0.0033 0.0022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Brugia malayi Dopamine receptor protein 2 0.0046 0.0422 0.0412
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0093 0.0117
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0023 0.0032
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0023 0.0032
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.069 0.7391 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Schistosoma mansoni hypothetical protein 0.0046 0.0422 0.0571
Brugia malayi ecdysteroid receptor 0.0009 0.0023 0.0013
Brugia malayi hypothetical protein 0.0046 0.0422 0.0412
Brugia malayi neuropeptide F receptor 0.0046 0.0422 0.0412
Schistosoma mansoni cpg binding protein 0.0026 0.0208 0.0281
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0422 0.0571
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0308 0.0251
Toxoplasma gondii exonuclease III APE 0.0016 0.0093 0.0047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0422 0.0571
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.016 0.0102
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0422 0.0571
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0093 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0114 0.1161 0.1571
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0023 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Schistosoma mansoni histamine h1 receptor 0.0046 0.0422 0.0571
Toxoplasma gondii ran binding protein 0.0245 0.258 0.3438
Brugia malayi G protein-coupled receptor 0.0046 0.0422 0.0412
Brugia malayi steroid hormone receptor 0.0009 0.0023 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0245 0.258 0.2571
Brugia malayi YY1-associated factor 2 0.0245 0.258 0.2572
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0016 0.0093 0.1386
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Schistosoma mansoni hypothetical protein 0.0025 0.0199 0.0269
Schistosoma mansoni biogenic amine receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus multilocularis somatostatin receptor 0.0046 0.0422 0.0532
Schistosoma mansoni hypothetical protein 0.0012 0.0059 0.0079
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0422 0.0532
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.0422 0.0412
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0023 0.0032
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0023 0.0032
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0029 0.0037
Echinococcus multilocularis musashi 0.0019 0.0128 0.0161
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.0422 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0025 0.0199 0.0269
Schistosoma mansoni rnf5 0.0012 0.0059 0.0079
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.069 0.7391 0.9305
Onchocerca volvulus 0.0245 0.258 0.347
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.0422 0.0571
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0047
Loa Loa (eye worm) brahma associated protein 0.069 0.7391 0.7388
Echinococcus multilocularis serotonin receptor 0.0046 0.0422 0.0532
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0023 0.0032
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0308 0.0388
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0245 0.258 0.3491
Loa Loa (eye worm) hypothetical protein 0.0036 0.0308 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0023 0.0013
Onchocerca volvulus 0.0046 0.0422 0.0541
Brugia malayi Zinc finger, C2H2 type family protein 0.0012 0.0059 0.0048
Onchocerca volvulus 0.0046 0.0422 0.0541
Echinococcus multilocularis ring finger protein 170 0.0012 0.0059 0.0074
Schistosoma mansoni hypothetical protein 0.069 0.7391 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.0422 0.0541
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0245 0.258 0.347
Trichomonas vaginalis ankyrin, putative 0.0012 0.0059 0.0079
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0308 0.0417
Echinococcus multilocularis dnaJ subfamily B 0.0374 0.3969 0.4996
Brugia malayi hypothetical protein 0.0012 0.0059 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.0199 0.0251
Schistosoma mansoni fusion 0.0245 0.258 0.3491
Leishmania major hypothetical protein, conserved 0.0245 0.258 0.2536
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.0422 0.0571
Echinococcus granulosus orexin receptor type 2 0.0046 0.0422 0.0571
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus ring finger protein 170 0.0012 0.0059 0.0079
Echinococcus granulosus neuropeptide receptor 0.0046 0.0422 0.0571
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.0422 0.0411
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0422 0.0532
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0411
Echinococcus granulosus allatostatin A receptor 0.0046 0.0422 0.0571
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.0422 0.0532
Schistosoma mansoni mind bomb 0.0012 0.0059 0.0079
Schistosoma mansoni coup transcription factor 0.0009 0.0023 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0422 0.0571
Onchocerca volvulus 0.0012 0.0059 0.0048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0422 0.0532
Brugia malayi G-protein coupled receptor 0.0046 0.0422 0.0412
Echinococcus multilocularis SWI:SNF matrix associated 0.069 0.7391 0.9305
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0422 0.0571
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0245 0.258 0.2536
Leishmania major hypothetical protein, conserved 0.0245 0.258 0.2536
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0079
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0009 0.0022 0.0028
Brugia malayi intermediate filament protein 0.0019 0.0128 0.0118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0023 0.0013
Loa Loa (eye worm) RING finger protein 20 0.0012 0.0059 0.0047
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.0422 0.0532
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0023 0.003
Onchocerca volvulus 0.0046 0.0422 0.0541
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0093 0.0126
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0308 0.0251
Leishmania major hypothetical protein, conserved 0.0022 0.016 0.0102
Brugia malayi hypothetical protein 0.0046 0.0422 0.0412
Brugia malayi hypothetical protein 0.0012 0.0059 0.0048

Activities

Activity type Activity value Assay description Source Reference
Kd (functional) = 8.84 Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs ChEMBL. 22277057

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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