Detailed information for compound 1647113

Basic information

Technical information
  • TDR Targets ID: 1647113
  • Name: ethyl 2-(carbamoylamino)-1-hydroxy-1,3-dimeth yl-9-oxo-8-oxa-2-azaspiro[4.4]non-3-ene-4-car boxylate
  • MW: 313.306 | Formula: C13H19N3O6
  • H donors: 3 H acceptors: 4 LogP: -0.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(C)N(C(C21CCOC2=O)(C)O)NC(=O)N
  • InChi: 1S/C13H19N3O6/c1-4-21-9(17)8-7(2)16(15-11(14)19)12(3,20)13(8)5-6-22-10(13)18/h20H,4-6H2,1-3H3,(H3,14,15,19)
  • InChiKey: NZFSQGCYEUAVCR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 1-hydroxy-1,3-dimethyl-9-oxo-2-ureido-8-oxa-2-azaspiro[4.4]non-3-ene-4-carboxylate
  • 1-hydroxy-1,3-dimethyl-9-oxo-2-ureido-8-oxa-2-azaspiro[4.4]non-3-ene-4-carboxylic acid ethyl ester
  • 1-hydroxy-9-keto-1,3-dimethyl-2-ureido-8-oxa-2-azaspiro[4.4]non-3-ene-4-carboxylic acid ethyl ester
  • ethyl 2-(aminocarbonylamino)-1-hydroxy-1,3-dimethyl-9-oxo-8-oxa-2-azaspiro[4.4]non-3-ene-4-carboxylate
  • NCI60_012619
  • AIDS-136438
  • AIDS136438
  • Ethyl 7-((aminocarbonyl)amino)-6-hydroxy-6,8-dimethyl-1-oxo-2-oxa-7-azaspiro[4.4]non-8-ene-9-carboxylate
  • NSC637898

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0035 0.0008
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0202 0.0546 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.741 0.7408
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.741 0.7408
Entamoeba histolytica hypothetical protein 0.0202 0.0546 0.0513
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0202 0.0546 0.052
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0202 0.0546 0.0531
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0202 0.0546 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.741 0.7408
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0202 0.0546 1
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0035 0.0008
Giardia lamblia Hypothetical protein 0.0202 0.0546 0.0385
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0202 0.0546 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0044 0.0035 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0333 0.0325
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0062 0.0054
Echinococcus multilocularis Zinc finger, PHD finger 0.0202 0.0546 0.0531
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0084 0.0165 0.0149
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0659 0.2024 0.2418
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3127 1 1
Entamoeba histolytica hypothetical protein 0.0202 0.0546 0.0513
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0457 0.1372 0.1358
Loa Loa (eye worm) hypothetical protein 0.0659 0.2024 0.2024
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0043 0.0032 0.0024
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0591 0.1805 0.1777
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0202 0.0546 0.0385
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0202 0.0546 0.0531
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0202 0.0546 0.0531
Entamoeba histolytica protein kinase 2, putative 0.0085 0.0168 0.0133
Giardia lamblia GTOR 0.3127 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0202 0.0546 0.0513
Loa Loa (eye worm) hypothetical protein 0.0457 0.1372 0.1372
Brugia malayi p70 ribosomal S6 kinase beta 0.0127 0.0306 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.741 0.7408
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0333 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.2097 0.6673 0.667
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0591 0.1805 0.1792
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0202 0.0546 0.0538
Echinococcus multilocularis serine:threonine protein kinase N2 0.0044 0.0035 0.0019
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0202 0.0546 0.0538
Echinococcus multilocularis rac serine:threonine kinase 0.0093 0.0195 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.741 0.7408
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0591 0.1805 0.1523
Loa Loa (eye worm) phosphatidylinositol 3 0.0202 0.0546 0.0546
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0202 0.0546 0.0531
Echinococcus multilocularis serine protein kinase ATM 0.0591 0.1805 0.1792
Trichomonas vaginalis PIKK family atypical protein kinase 0.1049 0.3283 0.3278
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0202 0.0546 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.1686 0.5343 0.5339
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0093 0.0195 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.1688 0.5351 0.5347
Trichomonas vaginalis PIKK family atypical protein kinase 0.2487 0.7932 0.7931
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0202 0.0546 0.0513
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0202 0.0546 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0202 0.0546 0.0538
Echinococcus multilocularis nervana 2 0.0084 0.0165 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.1805 0.1799
Trichomonas vaginalis conserved hypothetical protein 0.0457 0.1372 0.1365
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0202 0.0546 0.0385
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0035 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0202 0.0546 0.0531
Loa Loa (eye worm) hypothetical protein 0.0044 0.0035 0.0035
Echinococcus multilocularis Glutaredoxin protein 5 0.0084 0.0165 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0035 0.0008
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0202 0.0546 0.0531
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0202 0.0546 0.0385
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0202 0.0546 0.0531
Entamoeba histolytica protein kinase, putative 0.0136 0.0333 0.0299
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0202 0.0546 0.0531
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0044 0.0035 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.203 0.6455 0.6452
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0044 0.0035 0.0035
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1049 0.3283 0.3265
Echinococcus multilocularis protein kinase c epsilon type 0.0044 0.0035 0.0019
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1049 0.3283 0.3052
Onchocerca volvulus 0.0202 0.0546 0.5
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3127 1 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0044 0.0035 0.0035
Echinococcus granulosus protein kinase c epsilon type 0.0044 0.0035 0.0019
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3127 1 1
Brugia malayi protein kinase C II. 0.0044 0.0035 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.2487 0.7932 0.7931
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0202 0.0546 0.0221
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1479 0.4673 0.449
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0035 0.0027
Loa Loa (eye worm) hypothetical protein 0.0202 0.0546 0.0546
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0044 0.0035 0.0019
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0202 0.0546 0.0385
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0591 0.1805 0.1783
Plasmodium vivax hypothetical protein, conserved 0.0202 0.0546 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0202 0.0546 0.0538
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3127 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0202 0.0546 0.0531
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0202 0.0546 0.0546
Schistosoma mansoni fkbp-rapamycin associated protein 0.0591 0.1805 0.1783
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0202 0.0546 0.0513
Brugia malayi Protein kinase domain containing protein 0.0044 0.0035 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.1049 0.3283 0.3278
Trichomonas vaginalis PIKK family atypical protein kinase 0.1688 0.5351 0.5347
Loa Loa (eye worm) hypothetical protein 0.0202 0.0546 0.0546
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0202 0.0546 0.0338
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0591 0.1805 0.1792
Trichomonas vaginalis PIKK family atypical protein kinase 0.2487 0.7932 0.7931
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0202 0.0546 0.0385
Loa Loa (eye worm) hypothetical protein 0.0591 0.1805 0.1805
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0202 0.0546 0.0221
Brugia malayi Protein kinase domain containing protein 0.0044 0.0035 0.0019
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0202 0.0546 0.0531
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0085 0.0168 0.0152
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0202 0.0546 0.052
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0127 0.0306 0.0306
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0202 0.0546 0.0513
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0035 0.0008
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0044 0.0035 0.0019
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0202 0.0546 0.0385
Trypanosoma brucei target of rapamycin kinase 3, putative 0.249 0.7941 0.787
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0202 0.0546 0.0531
Echinococcus multilocularis serine:threonine protein kinase N2 0.0044 0.0035 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0333 0.0325
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3127 1 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0044 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.1868 0.5933 0.5929
Trichomonas vaginalis PIKK family atypical protein kinase 0.1049 0.3283 0.3278
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0333 0.0325
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0202 0.0546 0.0538
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3127 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0202 0.0546 0.0538
Plasmodium vivax hypothetical protein 0.0202 0.0546 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2487 0.7932 0.7931
Trichomonas vaginalis PIKK family atypical protein kinase 0.1049 0.3283 0.3278
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0202 0.0546 0.052
Echinococcus granulosus protein kinase C gamma type 0.0044 0.0035 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0202 0.0546 0.0538
Loa Loa (eye worm) phosphatidylinositol 3 0.1049 0.3283 0.3283
Echinococcus multilocularis protein kinase c iota type 0.0044 0.0035 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0035 0.0027
Leishmania major phosphatidylinositol 3-kinase, putative 0.1049 0.3283 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.1686 0.5343 0.5339
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0202 0.0546 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.1868 0.5933 0.5929
Toxoplasma gondii FATC domain-containing protein 0.0591 0.1805 0.2111
Loa Loa (eye worm) phosphatidylinositol 3 0.0202 0.0546 0.0546
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1049 0.3283 0.2895
Loa Loa (eye worm) phosphatidylinositol 3 0.0202 0.0546 0.0546
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0202 0.0546 0.0385
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3127 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.039 0.1153 0.1146
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0202 0.0546 0.0385
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0591 0.1805 0.1666
Schistosoma mansoni serine/threonine-protein kinase 0.0093 0.0195 0.0168
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0044 0.0035 0.0019
Trypanosoma cruzi target of rapamycin kinase 3 0.249 0.7941 0.7905
Entamoeba histolytica PH domain containing protein kinase, putative 0.0093 0.0195 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.3127 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0202 0.0546 0.0221
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0202 0.0546 0.0538
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0202 0.0546 0.0538
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0202 0.0546 0.0338
Echinococcus granulosus Protein kinase C brain isozyme 0.0044 0.0035 0.0019
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3127 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.741 0.7408
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0333 0.0325
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0202 0.0546 0.0513
Echinococcus granulosus serine/threonine protein kinase 0.0093 0.0195 0.0179
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.249 0.7941 0.7822
Echinococcus granulosus protein kinase c iota type 0.0044 0.0035 0.0019
Echinococcus granulosus NDR protein kinase 0.0044 0.0035 0.0019
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0591 0.1805 0.1666
Entamoeba histolytica hypothetical protein 0.0202 0.0546 0.0513
Entamoeba histolytica protein kinase, putative 0.0136 0.0333 0.0299
Echinococcus multilocularis 0.0202 0.0546 0.0531
Schistosoma mansoni serine/threonine-protein kinase 0.0093 0.0195 0.0168
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0202 0.0546 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0016 0.0016
Entamoeba histolytica PH domain containing protein kinase, putative 0.0093 0.0195 0.016
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0202 0.0546 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.1049 0.3283 0.3278
Echinococcus granulosus serine protein kinase ATM 0.0591 0.1805 0.1792
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0202 0.0546 0.0513
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0202 0.0546 0.0513
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0202 0.0546 0.0531
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3127 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0202 0.0546 0.0538
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0044 0.0035 0.0019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0202 0.0546 0.0531
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1299 0.4092 0.3888
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0044 0.0035 0.0019
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1049 0.3283 0.3169
Schistosoma mansoni hypothetical protein 0.0202 0.0546 0.052
Loa Loa (eye worm) phosphatidylinositol kinase 0.0202 0.0546 0.0546
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0202 0.0546 0.052
Loa Loa (eye worm) AGC/NDR protein kinase 0.0044 0.0035 0.0035
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3127 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.039 0.1153 0.1003
Loa Loa (eye worm) phosphatidylinositol 3 0.0202 0.0546 0.0546
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1049 0.3283 0.3169
Echinococcus multilocularis serine threonine protein kinase 0.0044 0.0035 0.0019
Loa Loa (eye worm) phosphatidylinositol 3 0.3127 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0202 0.0546 0.0385
Echinococcus granulosus nervana 2 0.0084 0.0165 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.185 0.5873 0.5869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0839 0.2606 0.26
Schistosoma mansoni serine/threonine kinase 0.0044 0.0035 0.0008
Trypanosoma cruzi Protein kinase B 0.0093 0.0195 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.039 0.1153 0.1146
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0035 0.0008
Loa Loa (eye worm) hypothetical protein 0.0637 0.1954 0.1954
Entamoeba histolytica hypothetical protein 0.0202 0.0546 0.0513
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0202 0.0546 0.0531
Loa Loa (eye worm) AGC/AKT protein kinase 0.0136 0.0333 0.0333
Entamoeba histolytica hypothetical protein 0.0591 0.1805 0.1777
Loa Loa (eye worm) phosphatidylinositol 3 0.0202 0.0546 0.0546
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1049 0.3283 0.3272
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0202 0.0546 0.0538
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0202 0.0546 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.3127 1 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0202 0.0546 0.0513
Echinococcus granulosus serine threonine protein kinase nrc 0.0085 0.0168 0.0152
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0202 0.0546 0.052
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0202 0.0546 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.267 0.8522 0.8521
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0202 0.0546 0.052
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0202 0.0546 0.0531
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0202 0.0546 0.0385
Entamoeba histolytica protein kinase rad3, putative 0.0591 0.1805 0.1777
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.741 0.7408
Mycobacterium tuberculosis Conserved hypothetical protein 0.0202 0.0546 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1688 0.5351 0.5347
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0202 0.0546 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.2487 0.7932 0.7931
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0457 0.1372 0.1358
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0333 0.0325
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0202 0.0546 0.0531
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0035 0.0027
Echinococcus granulosus Glutaredoxin protein 5 0.0084 0.0165 0.0149
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0202 0.0546 0.0221
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0202 0.0546 0.0538
Schistosoma mansoni atypical protein kinase C 0.0044 0.0035 0.0008
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0202 0.0546 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.1688 0.5351 0.5347
Mycobacterium leprae conserved hypothetical protein 0.0202 0.0546 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0591 0.1805 0.1792
Echinococcus multilocularis serine:threonine protein kinase 38 0.0044 0.0035 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0333 0.0325
Toxoplasma gondii target of rapamycin (TOR), putative 0.2326 0.741 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3127 1 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0085 0.0168 0.0152
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0202 0.0546 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.185 0.5873 0.5869
Onchocerca volvulus 0.0202 0.0546 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0202 0.0546 0.0538
Giardia lamblia Phosphatidylinositol 4-kinase 0.0202 0.0546 0.0385
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0084 0.0165 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.1686 0.5343 0.5339
Brugia malayi Protein kinase domain containing protein 0.0136 0.0333 0.0317
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0202 0.0546 0.0338
Loa Loa (eye worm) hypothetical protein 0.039 0.1153 0.1153
Brugia malayi FAT domain containing protein 0.0457 0.1372 0.1358
Trichomonas vaginalis PIKK family atypical protein kinase 0.1868 0.5933 0.5929
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0202 0.0546 0.0385
Entamoeba histolytica protein kinase, putative 0.0127 0.0306 0.0271
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0202 0.0546 0.0538
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0202 0.0546 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0044 0.0035 0.0019
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0044 0.0035 0.0035
Brugia malayi Hr1 repeat family protein 0.0044 0.0035 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0659 0.2024 0.2017
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0044 0.0035 0.0035
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1049 0.3283 0.3272
Echinococcus multilocularis nervana 2 0.0084 0.0165 0.0149
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1049 0.3283 0.3272
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0035 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.1805 0.1799
Echinococcus granulosus nervana 2 0.0084 0.0165 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.1805 0.1799
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3127 1 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0591 0.1805 0.1792
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1049 0.3283 0.3052
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0202 0.0546 0.0531
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0202 0.0546 0.0338
Schistosoma mansoni hypothetical protein 0.0457 0.1372 0.1348

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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