Detailed information for compound 1647114

Basic information

Technical information
  • TDR Targets ID: 1647114
  • Name: 8-(2-dimethylaminoethoxy)-N-hydroxyquinolin-5 -amine oxide hydrochloride
  • MW: 297.737 | Formula: C13H16ClN3O3
  • H donors: 0 H acceptors: 3 LogP: 2.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCOc1ccc(c2c1nccc2)[N+](=O)[O-])C.Cl
  • InChi: 1S/C13H15N3O3.ClH/c1-15(2)8-9-19-12-6-5-11(16(17)18)10-4-3-7-14-13(10)12;/h3-7H,8-9H2,1-2H3;1H
  • InChiKey: MWLBVVMAWMDWFO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N,N-dimethyl-2-(5-nitroquinolin-8-yl)oxyethanamine hydrochloride
  • N,N-dimethyl-2-[(5-nitro-8-quinolyl)oxy]ethanamine hydrochloride
  • 8-(2-dimethylaminoethoxy)-N-hydroxy-quinolin-5-amine oxide hydrochloride
  • 8-(2-dimethylaminoethoxy)-N-hydroxy-5-quinolinamine oxide hydrochloride
  • dimethyl-[2-[(5-nitro-8-quinolyl)oxy]ethyl]amine hydrochloride
  • N,N-dimethyl-2-(5-nitroquinolin-8-yl)oxy-ethanamine hydrochloride
  • 8-[2-(Dimethylamino)ethoxy]-5-nitroquinoline
  • NSC644498

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.042 0.0479 0.92
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0485 0.0583 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.5053 0.7929 0.7911
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0441 0.0513 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.3445 0.5343 0.5304
Brugia malayi FAT domain containing protein 0.0938 0.1311 0.1311
Entamoeba histolytica hypothetical protein 0.042 0.0479 0.0398
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1219 0.1764 0.1694
Trichomonas vaginalis PIKK family atypical protein kinase 0.2168 0.329 0.3234
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0485 0.0583 0.0503
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6341 1 1
Mycobacterium leprae conserved hypothetical protein 0.042 0.0479 0.5
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0441 0.0513 1
Loa Loa (eye worm) hypothetical protein 0.0799 0.1089 0.1089
Toxoplasma gondii target of rapamycin (TOR), putative 0.4727 0.7406 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3445 0.5343 0.5304
Schistosoma mansoni fkbp-rapamycin associated protein 0.1219 0.1764 0.1749
Entamoeba histolytica hypothetical protein 0.1219 0.1764 0.1694
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.042 0.0479 0.0479
Loa Loa (eye worm) phosphatidylinositol 3 0.042 0.0479 0.0479
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0551 0.069 0.069
Leishmania major phosphatidylinositol 4-kinase, putative 0.042 0.0479 0.0398
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0626 0.081 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.5053 0.7929 0.7911
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.042 0.0479 0.0398
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2991 0.4613 0.4568
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0441 0.0513 0.0433
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0441 0.0513 0.0433
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0441 0.0513 0.0433
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.042 0.0479 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.5403 0.8492 0.848
Leishmania major phosphatidylinositol 3-kinase, putative 0.0441 0.0513 0.0433
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2168 0.329 0.3234
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0441 0.0513 0.0513
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6341 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0463 0.0549 0.0469
Loa Loa (eye worm) phosphatidylinositol 3 0.6341 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1219 0.1764 0.1749
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6341 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2168 0.329 0.3234
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0485 0.0583 0.0503
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.056 0.0703 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.2157 0.3272 0.3215
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0174 0.0084 0.5
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0813 0.1111 0.1111
Loa Loa (eye worm) hypothetical protein 0.1283 0.1867 0.1867
Trichomonas vaginalis PIKK family atypical protein kinase 0.4115 0.6421 0.6391
Loa Loa (eye worm) phosphatidylinositol 3 0.077 0.1041 0.1041
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0441 0.0513 0.0433
Echinococcus multilocularis fk506 binding protein 0.0174 0.0084 0.0084
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.042 0.0479 0.0398
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.015 0.0045 0.0045
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.042 0.0479 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.377 0.5866 0.5831
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0441 0.0513 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.1703 0.2542 0.2479
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2211 0.3359 0.3347
Trichomonas vaginalis conserved hypothetical protein 0.0938 0.1311 0.1238
Loa Loa (eye worm) phosphatidylinositol 3 0.042 0.0479 0.0479
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2211 0.3359 0.3303
Leishmania major hypothetical protein, conserved 0.0518 0.0637 0.0558
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0441 0.0513 0.0433
Echinococcus multilocularis serine protein kinase ATM 0.1219 0.1764 0.1764
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2211 0.3359 0.3359
Schistosoma mansoni phosphatidylinositol 4-kinase 0.042 0.0479 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.5053 0.7929 0.7911
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1219 0.1764 0.1764
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.042 0.0479 0.0398
Leishmania major phosphatidylinositol 3-kinase, putative 0.2157 0.3272 0.3215
Trichomonas vaginalis PIKK family atypical protein kinase 0.6341 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0485 0.0583 0.0583
Giardia lamblia GTOR 0.6341 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1219 0.1764 0.1694
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0485 0.0583 0.0503
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2211 0.3359 0.3359
Trichomonas vaginalis PIKK family atypical protein kinase 0.379 0.5898 0.5863
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2157 0.3272 0.3215
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2211 0.3359 0.3359
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0174 0.0084 0.0084
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0206 0.0135 0.0051
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6341 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1358 0.1987 0.1919
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.042 0.0479 0.0398
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0508 0.062 0.0541
Schistosoma mansoni immunophilin 0.0174 0.0084 0.0066
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0551 0.069 0.069
Trypanosoma cruzi target of rapamycin kinase 3 0.5058 0.7937 0.792
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0626 0.081 0.0733
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0441 0.0513 0.0513
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0813 0.1111 0.1095
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0938 0.1311 0.1311
Trichomonas vaginalis PIKK family atypical protein kinase 0.379 0.5898 0.5863
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0441 0.0513 0.0513
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0583 0.0741 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0799 0.1089 0.1013
Loa Loa (eye worm) FKBP5 protein 0.0174 0.0084 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.3439 0.5335 0.5295
Trichomonas vaginalis PIKK family atypical protein kinase 0.377 0.5866 0.5831
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.042 0.0479 0.0398
Loa Loa (eye worm) phosphatidylinositol 3 0.042 0.0479 0.0479
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0174 0.0084 0.0084
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0485 0.0583 0.0503
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6341 1 1
Entamoeba histolytica hypothetical protein 0.0583 0.0741 0.0662
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.015 0.0045 0.0045
Plasmodium vivax hypothetical protein, conserved 0.042 0.0479 0.92
Trichomonas vaginalis PIKK family atypical protein kinase 0.4727 0.7406 0.7384
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0441 0.0513 0.005
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0698 0.0925 0.0925
Trichomonas vaginalis PIKK family atypical protein kinase 0.3445 0.5343 0.5304
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.042 0.0479 0.0479
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1219 0.1764 0.1764
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0479 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0479 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.5053 0.7929 0.7911
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0626 0.081 0.0733
Echinococcus granulosus serine protein kinase ATM 0.1219 0.1764 0.1764
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0485 0.0583 0.0503
Plasmodium falciparum phosphatidylinositol 4-kinase 0.042 0.0479 0.92
Onchocerca volvulus 0.042 0.0479 0.5
Loa Loa (eye worm) hypothetical protein 0.1219 0.1764 0.1764
Toxoplasma gondii FATC domain-containing protein 0.1219 0.1764 0.1855
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0174 0.0084 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4727 0.7406 0.7384
Trichomonas vaginalis PIKK family atypical protein kinase 0.4253 0.6644 0.6615
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.042 0.0479 0.92
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.042 0.0479 0.0479
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5058 0.7937 0.792
Schistosoma mansoni hypothetical protein 0.0938 0.1311 0.1296
Loa Loa (eye worm) hypothetical protein 0.015 0.0045 0.0045
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.042 0.0479 0.92
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.042 0.0479 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.4727 0.7406 0.7384
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6341 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.6341 1 1
Loa Loa (eye worm) hypothetical protein 0.0551 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.042 0.0479 0.0479
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0485 0.0583 0.0503
Leishmania major phosphatidylinositol kinase related protein, putative 0.042 0.0479 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.1231 0.1783 0.1713
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.042 0.0479 0.0462
Leishmania major hypothetical protein, unknown function 0.042 0.0479 0.0398
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0626 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0938 0.1311 0.1311
Giardia lamblia Hypothetical protein 0.042 0.0479 0.0398
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6341 1 1
Schistosoma mansoni immunophilin 0.0174 0.0084 0.0066
Loa Loa (eye worm) hypothetical protein 0.1358 0.1987 0.1987
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1358 0.1987 0.2177
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5058 0.7937 0.792
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6341 1 1
Schistosoma mansoni immunophilin 0.015 0.0045 0.0027
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0187 0.0104 0.0104
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0626 0.081 0.0733
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0626 0.081 0.0733
Entamoeba histolytica protein kinase rad3, putative 0.1219 0.1764 0.1694
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.042 0.0479 0.0479
Onchocerca volvulus 0.042 0.0479 0.5
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0813 0.1111 0.1111
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0441 0.0513 0.005
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2211 0.3359 0.3303
Trichomonas vaginalis PIKK family atypical protein kinase 0.1219 0.1764 0.1694
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.042 0.0479 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.4727 0.7406 0.7384
Trichomonas vaginalis PIKK family atypical protein kinase 0.6341 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0441 0.0513 0.0496
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.042 0.0479 0.0398
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.042 0.0479 0.0479
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0441 0.0513 0.0513
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0441 0.0513 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.4727 0.7406 0.7384
Giardia lamblia Phosphatidylinositol 4-kinase 0.042 0.0479 0.0398
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.042 0.0479 0.92
Trichomonas vaginalis PIKK family atypical protein kinase 0.3439 0.5335 0.5295
Echinococcus multilocularis 0.042 0.0479 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.379 0.5898 0.5863
Trichomonas vaginalis PIKK family atypical protein kinase 0.4727 0.7406 0.7384
Leishmania major phosphatidylinositol kinase, putative 0.042 0.0479 0.0398
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0441 0.0513 0.0433
Mycobacterium tuberculosis Conserved hypothetical protein 0.042 0.0479 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6341 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2157 0.3272 0.3215
Trichomonas vaginalis conserved hypothetical protein 0.0799 0.1089 0.1013
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0441 0.0513 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6341 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0485 0.0583 0.0503
Loa Loa (eye worm) phosphatidylinositol kinase 0.042 0.0479 0.0479
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0441 0.0513 0.0433
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0938 0.1311 0.1311
Trichomonas vaginalis PIKK family atypical protein kinase 0.2157 0.3272 0.3215
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1231 0.1783 0.1713
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2646 0.4058 0.4008
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.056 0.0703 0.0625
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.042 0.0479 0.0398
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.042 0.0479 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.5053 0.7929 0.7911
Trichomonas vaginalis PIKK family atypical protein kinase 0.3445 0.5343 0.5304
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0174 0.0084 0.0084
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.042 0.0479 0.0462
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0799 0.1089 0.1013
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.042 0.0479 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.3439 0.5335 0.5295
Loa Loa (eye worm) phosphatidylinositol 3 0.042 0.0479 0.0479
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6341 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.2168 0.329 0.329
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1219 0.1764 0.1764
Entamoeba histolytica hypothetical protein 0.042 0.0479 0.0398
Entamoeba histolytica hypothetical protein 0.042 0.0479 0.0398
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1219 0.1764 0.1694
Trichomonas vaginalis PIKK family atypical protein kinase 0.2157 0.3272 0.3215
Schistosoma mansoni hypothetical protein 0.042 0.0479 0.0462
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0441 0.0513 0.0496
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0698 0.0925 0.0925
Trichomonas vaginalis PIKK family atypical protein kinase 0.4727 0.7406 0.7384
Trichomonas vaginalis PIKK family atypical protein kinase 0.1219 0.1764 0.1694
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0174 0.0084 0.0066
Echinococcus multilocularis Zinc finger, PHD finger 0.0441 0.0513 0.0513
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0174 0.0084 0.0084
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0626 0.081 0.0733
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0516 0.0634 0.0554
Plasmodium vivax hypothetical protein 0.042 0.0479 0.92
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0174 0.0084 0.0084
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0174 0.0084 0.0084
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0551 0.069 0.069
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1219 0.1764 0.1764

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.219 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.102 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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