Detailed information for compound 1647120

Basic information

Technical information
  • TDR Targets ID: 1647120
  • Name: 5-(1-azido-2-bromo-2-chloroethyl)-1-[4-hydrox y-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4 -dione
  • MW: 410.608 | Formula: C11H13BrClN5O5
  • H donors: 3 H acceptors: 4 LogP: 1.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(CC1O)n1cc(c(=O)[nH]c1=O)C(C(Br)Cl)N=[N+]=[N-]
  • InChi: 1S/C11H13BrClN5O5/c12-9(13)8(16-17-14)4-2-18(11(22)15-10(4)21)7-1-5(20)6(3-19)23-7/h2,5-9,19-20H,1,3H2,(H,15,21,22)
  • InChiKey: OICPZMOAZDBOLS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(1-azido-2-bromo-2-chloro-ethyl)-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
  • 5-(1-azido-2-bromo-2-chloroethyl)-1-[4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]pyrimidine-2,4-dione
  • 5-(1-azido-2-bromo-2-chloro-ethyl)-1-(4-hydroxy-5-methylol-tetrahydrofuran-2-yl)pyrimidine-2,4-quinone
  • 5-(1-azido-2-bromo-2-chloro-ethyl)-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
  • NSC651428
  • NCI60_017973

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major phosphatidylinositol 3-kinase, putative 0.05 0.0644 0.053
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2516 0.344 0.3413
Leishmania major hypothetical protein, conserved 0.0579 0.0753 0.064
Plasmodium vivax hypothetical protein 0.0479 0.0614 0.9421
Schistosoma mansoni immunophilin 0.0106 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.107 0.1434 0.1434
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2516 0.344 0.344
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7245 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.2461 0.3363 0.3282
Mycobacterium tuberculosis Conserved hypothetical protein 0.0479 0.0614 0.5
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0123 0.0121 0.0121
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1391 0.1879 0.1879
Trichomonas vaginalis PIKK family atypical protein kinase 0.5772 0.7957 0.7934
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0479 0.0614 0.0499
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2516 0.344 0.344
Toxoplasma gondii FATC domain-containing protein 0.1391 0.1879 0.1853
Schistosoma mansoni immunophilin 0.0123 0.0121 0.0121
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0125 0.0123 0.0123
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2516 0.344 0.3413
Trichomonas vaginalis PIKK family atypical protein kinase 0.2461 0.3363 0.3288
Trichomonas vaginalis PIKK family atypical protein kinase 0.433 0.5957 0.5911
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2516 0.344 0.344
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0545 0.0705 0.0592
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1391 0.1879 0.1779
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7245 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0545 0.0705 0.0592
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.0097 0.0097
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0613 0.08 0.08
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0568 0.0738 0.0625
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0125 0.0123 0.0123
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0479 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.1549 0.2098 0.2098
Loa Loa (eye worm) hypothetical protein 0.0106 0.0097 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.7245 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0211 0.0242 0.0123
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.05 0.0644 0.0605
Brugia malayi FAT domain containing protein 0.107 0.1434 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.433 0.5957 0.5911
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.05 0.0644 0.0044
Loa Loa (eye worm) hypothetical protein 0.0912 0.1215 0.1215
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0689 0.0906 0.0906
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5778 0.7965 0.794
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0545 0.0705 0.0705
Trichomonas vaginalis immunophilin, putative 0.0123 0.0121 0.0009
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0479 0.0614 0.0574
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0479 0.0614 0.9421
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0123 0.0121 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.4305 0.5922 0.5876
Trichomonas vaginalis PIKK family atypical protein kinase 0.3928 0.5398 0.5346
Schistosoma mansoni voltage-gated potassium channel 0.0136 0.0139 0.0139
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.088 0.1171 0.1171
Entamoeba histolytica hypothetical protein 0.0645 0.0844 0.0733
Loa Loa (eye worm) FKBP5 protein 0.0123 0.0121 0.0121
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1391 0.1879 0.1879
Entamoeba histolytica hypothetical protein 0.0479 0.0614 0.0499
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0762 0.1007 0.1007
Trichomonas vaginalis PIKK family atypical protein kinase 0.3933 0.5406 0.5354
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.05 0.0644 0.053
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0645 0.0844 0.0733
Schistosoma mansoni immunophilin 0.0123 0.0121 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.54 0.7441 0.7412
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0479 0.0614 0.0508
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0089 0.0048
Giardia lamblia GTOR 0.7245 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1391 0.1879 0.1845
Schistosoma mansoni hypothetical protein 0.0479 0.0614 0.0614
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0479 0.0614 0.0614
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1391 0.1879 0.1879
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0545 0.0705 0.06
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0689 0.0906 0.0803
Trichomonas vaginalis PIKK family atypical protein kinase 0.5772 0.7957 0.7934
Loa Loa (eye worm) hypothetical protein 0.0108 0.01 0.01
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0479 0.0614 0.0614
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0479 0.0614 0.0614
Loa Loa (eye worm) phosphatidylinositol 3 0.2472 0.338 0.338
Trichomonas vaginalis PIKK family atypical protein kinase 0.1391 0.1879 0.1787
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0479 0.0614 0.0614
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.05 0.0644 0.0644
Trichomonas vaginalis PIKK family atypical protein kinase 0.3933 0.5406 0.5354
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.107 0.1434 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.5772 0.7957 0.7934
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0545 0.0705 0.0705
Entamoeba histolytica hypothetical protein 0.0479 0.0614 0.0499
Plasmodium vivax hypothetical protein, conserved 0.0479 0.0614 0.9421
Echinococcus multilocularis serine protein kinase ATM 0.1391 0.1879 0.1879
Loa Loa (eye worm) hypothetical protein 0.0479 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.1391 0.1879 0.1879
Trichomonas vaginalis PIKK family atypical protein kinase 0.3933 0.5406 0.5354
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.088 0.1171 0.1171
Toxoplasma gondii target of rapamycin (TOR), putative 0.54 0.7441 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.05 0.0644 0.0644
Onchocerca volvulus 0.0479 0.0614 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0545 0.0705 0.06
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7245 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.05 0.0644 0.0644
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3418 0.4692 0.4627
Onchocerca volvulus 0.0479 0.0614 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.5772 0.7957 0.7934
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0689 0.0906 0.0803
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0479 0.0614 0.0614
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0613 0.08 0.08
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.05 0.0644 0.053
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7245 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2472 0.338 0.3305
Plasmodium falciparum phosphatidylinositol 3-kinase 0.05 0.0644 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.6175 0.8516 0.8499
Leishmania major hypothetical protein, unknown function 0.0479 0.0614 0.0499
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0123 0.0121 0.0121
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.05 0.0644 0.053
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.05 0.0644 0.0644
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7245 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0523 0.0675 0.0561
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0545 0.0705 0.06
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2472 0.338 0.3299
Loa Loa (eye worm) phosphatidylinositol 3 0.7245 1 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.1391 0.1879 0.1879
Loa Loa (eye worm) phosphatidylinositol 3 0.0479 0.0614 0.0614
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0125 0.0123 0.0123
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.05 0.0644 0.0605
Loa Loa (eye worm) hypothetical protein 0.0076 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.4702 0.6472 0.6433
Loa Loa (eye worm) phosphatidylinositol 3 0.0836 0.111 0.111
Loa Loa (eye worm) hypothetical protein 0.1467 0.1985 0.1985
Trichomonas vaginalis conserved hypothetical protein 0.0912 0.1215 0.1116
Schistosoma mansoni voltage-gated potassium channel 0.0136 0.0139 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.2461 0.3363 0.3288
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0621 0.0812 0.0708
Trichomonas vaginalis PIKK family atypical protein kinase 0.1946 0.2649 0.2566
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.05 0.0644 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4305 0.5922 0.5876
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0479 0.0614 0.0614
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0121 0.0079
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0123 0.0121 0.5
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0123 0.0121 0.5
Echinococcus multilocularis 0.0479 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0912 0.1215 0.1116
Loa Loa (eye worm) phosphatidylinositol 3 0.0066 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.2461 0.3363 0.3288
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7245 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0479 0.0614 0.0614
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.05 0.0644 0.0538
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0545 0.0705 0.0592
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0479 0.0614 0.0508
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7245 1 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.05 0.0644 0.0644
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0123 0.0121 0.0121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0479 0.0614 0.0614
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0621 0.0812 0.0708
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3022 0.4141 0.407
Trichomonas vaginalis PIKK family atypical protein kinase 0.2461 0.3363 0.3288
Trichomonas vaginalis PIKK family atypical protein kinase 0.1402 0.1895 0.1804
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.107 0.1434 0.1434
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.05 0.0644 0.0044
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7245 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0479 0.0614 0.9421
Trichomonas vaginalis PIKK family atypical protein kinase 0.3928 0.5398 0.5346
Loa Loa (eye worm) phosphatidylinositol 3 0.0479 0.0614 0.0614
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.088 0.1171 0.1171
Leishmania major phosphatidylinositol 4-kinase, putative 0.0479 0.0614 0.0499
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0121 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.3933 0.5406 0.5354
Trichomonas vaginalis PIKK family atypical protein kinase 0.5772 0.7957 0.7934
Leishmania major phosphatidylinositol kinase, putative 0.0479 0.0614 0.0499
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0479 0.0614 0.0499
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2461 0.3363 0.3282
Echinococcus granulosus serine protein kinase ATM 0.1391 0.1879 0.1879
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0479 0.0614 0.0499
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0479 0.0614 0.0574
Entamoeba histolytica protein kinase rad3, putative 0.1391 0.1879 0.1779
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2472 0.338 0.3299
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.05 0.0644 0.0538
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0121 0.0079
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1391 0.1879 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.54 0.7441 0.7412
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0762 0.1007 0.1007
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.05 0.0644 0.0644
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1391 0.1879 0.1879
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0613 0.08 0.08
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0123 0.0121 0.0009
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0123 0.0121 0.0009
Entamoeba histolytica hypothetical protein 0.0479 0.0614 0.0499
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0577 0.075 0.0637
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0689 0.0906 0.0803
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0125 0.0123 0.0123
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0121 0.0079
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5778 0.7965 0.794
Loa Loa (eye worm) hypothetical protein 0.107 0.1434 0.1434
Leishmania major phosphatidylinositol kinase related protein, putative 0.0479 0.0614 0.0499
Trichomonas vaginalis PIKK family atypical protein kinase 0.54 0.7441 0.7412
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0479 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.486 0.6692 0.6654
Trichomonas vaginalis fk506-binding protein, putative 0.0123 0.0121 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1391 0.1879 0.1879
Trichomonas vaginalis PIKK family atypical protein kinase 0.54 0.7441 0.7412
Giardia lamblia Hypothetical protein 0.0479 0.0614 0.0499
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0479 0.0614 0.9421
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0479 0.0614 0.0614
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0123 0.0121 0.0121
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0545 0.0705 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.0479 0.0614 0.0508
Loa Loa (eye worm) hypothetical protein 0.0613 0.08 0.08
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7245 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7245 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1549 0.2098 0.2009
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0123 0.0121 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.7245 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0479 0.0614 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.107 0.1434 0.1337
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0689 0.0906 0.0868
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0479 0.0614 0.9421
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0479 0.0614 0.0574
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1402 0.1895 0.1796
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0123 0.0121 0.0121
Echinococcus multilocularis fk506 binding protein 0.0123 0.0121 0.0121
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7245 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.5778 0.7965 0.7957
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1549 0.2098 0.2174
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0912 0.1215 0.1178
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0479 0.0614 0.9421
Loa Loa (eye worm) phosphatidylinositol 3 0.0479 0.0614 0.0614
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0689 0.0906 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.1391 0.1879 0.1787
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0689 0.0906 0.0868
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0191 0.0215 0.0215
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.0097 0.0097
Schistosoma mansoni phosphatidylinositol 4-kinase 0.05 0.0644 0.0644
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.05 0.0644 0.0644
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0479 0.0614 0.0574
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.05 0.0644 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.7245 1 1
Mycobacterium leprae conserved hypothetical protein 0.0479 0.0614 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0479 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.54 0.7441 0.7412
Entamoeba histolytica hypothetical protein 0.1391 0.1879 0.1779
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2516 0.344 0.344
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.05 0.0644 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0479 0.0614 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.54 0.7441 0.7412
Trichomonas vaginalis PIKK family atypical protein kinase 0.433 0.5957 0.5911
Trichomonas vaginalis PIKK family atypical protein kinase 0.3928 0.5398 0.5346
Giardia lamblia Phosphatidylinositol 4-kinase 0.0479 0.0614 0.0499
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0479 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.54 0.7441 0.7412

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.