Detailed information for compound 1647124

Basic information

Technical information
  • TDR Targets ID: 1647124
  • Name: 1,3-Dichloro-5,6-dimethoxy-2-(4-methoxyphenyl )-1H-indene
  • MW: 351.224 | Formula: C18H16Cl2O3
  • H donors: 0 H acceptors: 0 LogP: 4.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1=C(Cl)c2c(C1Cl)cc(c(c2)OC)OC
  • InChi: 1S/C18H16Cl2O3/c1-21-11-6-4-10(5-7-11)16-17(19)12-8-14(22-2)15(23-3)9-13(12)18(16)20/h4-9,17H,1-3H3
  • InChiKey: WKDRHEQPUCIDRZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS131317
  • NSC623165
  • NCI60_006907
  • AIDS-131317

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fk506-binding protein, putative 0.0112 0.0011 0.0011
Leishmania major phosphatidylinositol kinase related protein, putative 0.0258 0.0402 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.2092 0.532 0.532
Trichomonas vaginalis PIKK family atypical protein kinase 0.3061 0.7918 0.7918
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0524 0.1115 0.1105
Leishmania major hypothetical protein, unknown function 0.0258 0.0402 0.0391
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0258 0.0402 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.3838 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0258 0.0402 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.2089 0.5312 0.5312
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0745 0.1707 0.1698
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1327 0.3268 0.3261
Entamoeba histolytica hypothetical protein 0.0258 0.0402 0.0391
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0745 0.1707 0.1698
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0258 0.0402 0.0391
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0258 0.0402 0.0391
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1316 0.3238 0.3231
Echinococcus multilocularis Zinc finger, PHD finger 0.0278 0.0457 0.0446
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0487 0.1015 0.1005
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.7393 0.7393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.1707 0.1707
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0278 0.0457 0.0446
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0112 0.0011 0.5
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.035 0.0649 0.0639
Entamoeba histolytica hypothetical protein 0.0258 0.0402 0.0391
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0455 0.0931 0.0931
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0116 0.002 0.001
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0384 0.0739 0.0729
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0112 0.0011 0.0011
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0745 0.1707 0.1698
Mycobacterium leprae conserved hypothetical protein 0.0258 0.0402 0.5
Loa Loa (eye worm) hypothetical protein 0.0258 0.0402 0.0391
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0278 0.0457 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.3238 0.3238
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3838 1 1
Brugia malayi FAT domain containing protein 0.0571 0.1241 0.1232
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0278 0.0457 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3838 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0258 0.0402 0.0391
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.032 0.0568 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.3238 0.3238
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0756 0.1737 0.1728
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0278 0.0457 0.0457
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0571 0.1241 0.1232
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0392 0.076 0.076
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1605 0.4015 0.4008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0258 0.0402 0.0391
Loa Loa (eye worm) hypothetical protein 0.0829 0.1933 0.1924
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3838 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3064 0.7927 0.7925
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0179 0.019 0.0179
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0455 0.0931 0.0921
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0258 0.0402 0.8769
Loa Loa (eye worm) hypothetical protein 0.0571 0.1241 0.1232
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0455 0.0931 0.0931
Giardia lamblia Phosphatidylinositol 4-kinase 0.0258 0.0402 0.0391
Entamoeba histolytica hypothetical protein 0.0745 0.1707 0.1698
Schistosoma mansoni fkbp-rapamycin associated protein 0.0745 0.1707 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.7393 0.7393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0258 0.0402 0.0402
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0278 0.0457 0.0446
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1368 0.3378 0.3371
Trichomonas vaginalis PIKK family atypical protein kinase 0.3838 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0278 0.0457 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0258 0.0402 0.0402
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0278 0.0457 0.0446
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0278 0.0457 0.0078
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0258 0.0402 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.7393 0.7393
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0258 0.0402 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.2089 0.5312 0.5312
Entamoeba histolytica hypothetical protein 0.0258 0.0402 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.2294 0.5862 0.5862
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0258 0.0402 0.0391
Toxoplasma gondii target of rapamycin (TOR), putative 0.2865 0.7393 1
Trichomonas vaginalis immunophilin, putative 0.0112 0.0011 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0745 0.1707 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.2575 0.6613 0.6613
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0258 0.0402 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.7393 0.7393
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0258 0.0402 0.0391
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0634 0.1411 0.1402
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3064 0.7927 0.7925
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0258 0.0402 0.0391
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0258 0.0402 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.7393 0.7393
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3838 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3838 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.032 0.0568 0.0558
Onchocerca volvulus 0.0258 0.0402 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0384 0.0739 0.0729
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0258 0.0402 0.8769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0756 0.1737 0.1737
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0258 0.0402 0.8769
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0455 0.0931 0.0921
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0258 0.0402 0.0391
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0258 0.0402 0.0391
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0634 0.1411 0.1402
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0829 0.1933 0.219
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0112 0.0011 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3838 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0455 0.0931 0.0921
Trypanosoma cruzi target of rapamycin kinase 3 0.3064 0.7927 0.7925
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0278 0.0457 0.0446
Schistosoma mansoni hypothetical protein 0.0571 0.1241 0.1232
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0278 0.0457 0.0457
Loa Loa (eye worm) phosphatidylinositol 3 0.0593 0.13 0.129
Trichomonas vaginalis PIKK family atypical protein kinase 0.2294 0.5862 0.5862
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0414 0.0819 0.0809
Loa Loa (eye worm) hypothetical protein 0.0487 0.1015 0.1005
Trichomonas vaginalis PIKK family atypical protein kinase 0.2089 0.5312 0.5312
Schistosoma mansoni voltage-gated potassium channel 0.0127 0.0049 0.0038
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0112 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.2288 0.5845 0.5845
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0258 0.0402 0.0391
Plasmodium vivax hypothetical protein, conserved 0.0258 0.0402 0.8769
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.032 0.0568 0.0558
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0258 0.0402 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.7393 0.7393
Entamoeba histolytica hypothetical protein 0.0414 0.0819 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.3838 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0278 0.0457 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.2092 0.532 0.532
Trichomonas vaginalis conserved hypothetical protein 0.0487 0.1015 0.1015
Giardia lamblia Hypothetical protein 0.0258 0.0402 0.0391
Loa Loa (eye worm) hypothetical protein 0.0745 0.1707 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.3061 0.7918 0.7918
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0258 0.0402 0.0391
Onchocerca volvulus 0.0258 0.0402 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.032 0.0568 0.0558
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0745 0.1707 0.1698
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0455 0.0931 0.0921
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0258 0.0402 0.0391
Toxoplasma gondii FATC domain-containing protein 0.0745 0.1707 0.1867
Schistosoma mansoni hypothetical protein 0.0258 0.0402 0.0391
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1368 0.3378 0.3371
Trichomonas vaginalis conserved hypothetical protein 0.0571 0.1241 0.1241
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0278 0.0457 0.0446
Plasmodium vivax hypothetical protein 0.0258 0.0402 0.8769
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1368 0.3378 0.3371
Leishmania major hypothetical protein, conserved 0.0352 0.0654 0.0644
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0745 0.1707 0.1698
Leishmania major phosphatidylinositol 4-kinase, putative 0.0258 0.0402 0.0391
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1368 0.3378 0.3371
Mycobacterium tuberculosis Conserved hypothetical protein 0.0258 0.0402 0.5
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0745 0.1707 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.3061 0.7918 0.7918
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3838 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.3238 0.3238
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.032 0.0568 0.0568
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3838 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.032 0.0568 0.0568
Echinococcus multilocularis serine protein kinase ATM 0.0745 0.1707 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.1316 0.3238 0.3238
Trichomonas vaginalis PIKK family atypical protein kinase 0.2294 0.5862 0.5862
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1368 0.3378 0.3371
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0116 0.002 0.001
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1368 0.3378 0.3371
Trichomonas vaginalis conserved hypothetical protein 0.0829 0.1933 0.1933
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0197 0.0239 0.0228
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3838 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0342 0.0627 0.0617
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0116 0.002 0.001
Echinococcus multilocularis 0.0258 0.0402 0.0391
Loa Loa (eye worm) hypothetical protein 0.0384 0.0739 0.0729
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.03 0.0513 0.0503
Giardia lamblia GTOR 0.3838 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3838 1 1
Entamoeba histolytica protein kinase rad3, putative 0.0745 0.1707 0.1698
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1327 0.3268 0.3261
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.032 0.0568 0.0558
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0392 0.076 0.076
Schistosoma mansoni voltage-gated potassium channel 0.0127 0.0049 0.0038
Leishmania major phosphatidylinositol 3-kinase, putative 0.1316 0.3238 0.3231
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0571 0.1241 0.1232
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0278 0.0457 0.0078
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0116 0.002 0.001
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0258 0.0402 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.249 0.6387 0.6387
Loa Loa (eye worm) hypothetical protein 0.0773 0.1783 0.1774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0487 0.1015 0.1015
Trichomonas vaginalis PIKK family atypical protein kinase 0.2288 0.5845 0.5845
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0258 0.0402 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.1031 0.2475 0.2475
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0278 0.0457 0.0446
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0634 0.1411 0.1402
Trichomonas vaginalis PIKK family atypical protein kinase 0.3061 0.7918 0.7918
Trichomonas vaginalis PIKK family atypical protein kinase 0.2092 0.532 0.532
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0278 0.0457 0.0446
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.032 0.0568 0.0558
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0258 0.0402 0.8769
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0745 0.1707 0.1698
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0258 0.0402 0.0391
Loa Loa (eye worm) phosphatidylinositol 3 0.1327 0.3268 0.3261
Leishmania major phosphatidylinositol 3-kinase, putative 0.0278 0.0457 0.0446
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.032 0.0568 0.0568
Loa Loa (eye worm) phosphatidylinositol 3 0.0258 0.0402 0.0391
Loa Loa (eye worm) phosphatidylinositol 3 0.3838 1 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0524 0.1115 0.1105
Trichomonas vaginalis PIKK family atypical protein kinase 0.2092 0.532 0.532
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.7393 0.7393
Echinococcus granulosus serine protein kinase ATM 0.0745 0.1707 0.1698
Loa Loa (eye worm) phosphatidylinositol 3 0.0258 0.0402 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.1707 0.1707
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0258 0.0402 0.8769
Loa Loa (eye worm) phosphatidylinositol kinase 0.0258 0.0402 0.0391
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0384 0.0739 0.0729
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0455 0.0931 0.0931
Trichomonas vaginalis PIKK family atypical protein kinase 0.3061 0.7918 0.7918
Loa Loa (eye worm) phosphatidylinositol 3 0.0258 0.0402 0.0391
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1807 0.4556 0.4551
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0278 0.0457 0.0446
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0258 0.0402 0.0391
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0278 0.0457 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0278 0.0457 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.3266 0.8469 0.8469
Trichomonas vaginalis PIKK family atypical protein kinase 0.1327 0.3268 0.3268
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0278 0.0457 0.0457
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0278 0.0457 0.0446
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3838 1 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.519 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.184 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.996 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.912 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.869 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.858 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.816 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.746 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.427 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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