TDR Targets

Basic information

Technical information

TDR Targets ID: 1647125
Name: acetic acid; N-[(2Z)-2-hydroxyiminocyclohexyl ]hydroxylamine
MW: 204.224 | Formula: C8H16N2O4
H donors: 4 H acceptors: 4 LogP: -1.72 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)O.O/N=C\1/CCCCC1NO
InChi: 1S/C6H12N2O2.C2H4O2/c9-7-5-3-1-2-4-6(5)8-10;1-2(3)4/h5,7,9-10H,1-4H2;1H3,(H,3,4)/b8-6-;
InChiKey: RWPYLBIFODZUGF-PHZXCRFESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

acetic acid; 2-(hydroxyamino)cyclohexan-1-one oxime
acetic acid; 2-(hydroxyamino)-1-cyclohexanone oxime
ethanoic acid; N-[(2Z)-2-hydroxyiminocyclohexyl]hydroxylamine
NSC663917

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	phosphatidylinositol 3	0.1956	0.3293	0.3288
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0379	0.0473	0.0466
Echinococcus multilocularis	serine protein kinase ATM	0.1099	0.1761	0.1755
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0379	0.0473	0.9231
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0845	0.1306	0.1299
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4548	0.7929	0.7929
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0401	0.0512	0.0505
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0445	0.0591	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3102	0.5343	0.5343
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0379	0.0473	0.9231
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1099	0.1761	0.1761
Loa Loa (eye worm)	phosphatidylinositol 3	0.0379	0.0473	0.0466
Echinococcus granulosus	serine protein kinase ATM	0.1099	0.1761	0.1755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4255	0.7406	0.7406
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.072	0.1083	0.1076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3102	0.5343	0.5343
Loa Loa (eye worm)	phosphatidylinositol 3	0.0379	0.0473	0.0466
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0445	0.0591	0.0591
Loa Loa (eye worm)	phosphatidylinositol 3	0.5706	1	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0401	0.0512	0.0505
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0401	0.0512	0.0505
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.2691	0.4607	0.4603
Loa Loa (eye worm)	phosphatidylinositol 3	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4548	0.7929	0.7929
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0588	0.0847	0.0847
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0512	0.0711	0.0704
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0379	0.0473	0.0466
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0401	0.0512	0.0505
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.5706	1	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0401	0.0512	0.0512
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1956	0.3293	0.3293
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4861	0.8489	0.8489
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0401	0.0512	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0401	0.0512	0.0505
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0379	0.0473	0.0466
Giardia lamblia	GTOR	0.5706	1	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0423	0.0552	0.0545
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1956	0.3293	0.3288
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0445	0.0591	0.0583
Entamoeba histolytica	protein kinase rad3, putative	0.1099	0.1761	0.1755
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.5706	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.072	0.1083	0.1083
Loa Loa (eye worm)	hypothetical protein	0.1153	0.1858	0.1851
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3703	0.6418	0.6418
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0123	0.0014	0.0007
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0379	0.0473	0.0473
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0401	0.0512	0.0056
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0778	0.1186	0.118
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1944	0.3272	0.3267
Schistosoma mansoni	voltage-gated potassium channel	0.0134	0.0035	0.0027
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0521	0.0726	0.0726
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0401	0.0512	0.0505
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1533	0.2536	0.2536
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0379	0.0473	0.0473
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3394	0.5866	0.5866
Plasmodium vivax	hypothetical protein	0.0379	0.0473	0.9231
Leishmania major	hypothetical protein, conserved	0.0479	0.0652	0.0644
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1999	0.3371	0.3366
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0401	0.0512	0.0505
Brugia malayi	FAT domain containing protein	0.0845	0.1306	0.1299
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1999	0.3371	0.3366
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1944	0.3272	0.3272
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.5706	1	1
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.1099	0.1761	0.1755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4548	0.7929	0.7929
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0379	0.0473	0.5
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1999	0.3371	0.3366
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0379	0.0473	0.0466
Toxoplasma gondii	FATC domain-containing protein	0.1099	0.1761	0.1858
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1999	0.3371	0.3366
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0123	0.0014	0.0007
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1999	0.3371	0.3366
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1944	0.3272	0.3272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3411	0.5895	0.5895
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1099	0.1761	0.1755
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0445	0.0591	0.0591
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.5706	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0445	0.0591	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0512	0.0711	0.0704
Echinococcus multilocularis		0.0379	0.0473	0.0466
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0123	0.0014	0.0007
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0468	0.0633	0.0625
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.5706	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0209	0.0169	0.0161
Trichomonas vaginalis	conserved hypothetical protein	0.1224	0.1984	0.1984
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3411	0.5895	0.5895
Loa Loa (eye worm)	hypothetical protein	0.0845	0.1306	0.1299
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0401	0.0512	0.0512
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0401	0.0512	0.0505
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0778	0.1186	0.118
Trypanosoma cruzi	target of rapamycin kinase 3	0.4552	0.7937	0.7936
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0588	0.0847	0.084
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0445	0.0591	0.0583
Plasmodium vivax	hypothetical protein, conserved	0.0379	0.0473	0.9231
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3394	0.5866	0.5866
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0119	0.0008	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0134	0.0035	0.0027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3097	0.5335	0.5335
Trichomonas vaginalis	conserved hypothetical protein	0.072	0.1083	0.1083
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0544	0.0768	0.0761
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.1099	0.1761	0.1755
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0661	0.0977	0.097
Giardia lamblia	Hypothetical protein	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3102	0.5343	0.5343
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0401	0.0512	0.0505
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5706	1	1
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4255	0.7406	0.7406
Entamoeba histolytica	hypothetical protein	0.0544	0.0768	0.0761
Schistosoma mansoni	hypothetical protein	0.0379	0.0473	0.0466
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1099	0.1761	0.1755
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0379	0.0473	0.0466
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0588	0.0847	0.084
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0445	0.0591	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1099	0.1761	0.1761
Onchocerca volvulus		0.0379	0.0473	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4548	0.7929	0.7929
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.4552	0.7937	0.7936
Schistosoma mansoni	hypothetical protein	0.0845	0.1306	0.1299
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0379	0.0473	0.0466
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3828	0.6641	0.6641
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4255	0.7406	0.7406
Trichomonas vaginalis	immunophilin, putative	0.0119	0.0008	0.0008
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1099	0.1761	0.1755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4255	0.7406	0.7406
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0379	0.0473	0.0466
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0379	0.0473	0.0466
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0379	0.0473	0.9231
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0512	0.0711	0.0704
Onchocerca volvulus		0.0379	0.0473	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0445	0.0591	0.0583
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.5706	1	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.5706	1	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.5706	1	1
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0119	0.0008	0.5
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1224	0.1984	0.218
Trichomonas vaginalis	conserved hypothetical protein	0.0845	0.1306	0.1306
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0379	0.0473	0.0466
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0379	0.0473	0.0466
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0379	0.0473	0.9231
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0588	0.0847	0.084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1111	0.1782	0.1782
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.4552	0.7937	0.7936
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.5706	1	1
Loa Loa (eye worm)	hypothetical protein	0.1224	0.1984	0.1978
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0588	0.0847	0.0847
Entamoeba histolytica	hypothetical protein	0.1099	0.1761	0.1755
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0379	0.0473	0.0466
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0778	0.1186	0.118
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0379	0.0473	0.9231
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0588	0.0847	0.084
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.019	0.0134	0.0127
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0379	0.0473	0.0466
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0401	0.0512	0.0505
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0401	0.0512	0.0056
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0401	0.0512	0.0505
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5706	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0379	0.0473	0.0473
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1999	0.3371	0.3366
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0401	0.0512	0.0505
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4255	0.7406	0.7406
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1099	0.1761	0.1755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0379	0.0473	0.0473
Toxoplasma gondii	target of rapamycin (TOR), putative	0.4255	0.7406	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3411	0.5895	0.5895
Entamoeba histolytica	hypothetical protein	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3097	0.5335	0.5335
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4255	0.7406	0.7406
Mycobacterium leprae	conserved hypothetical protein	0.0379	0.0473	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0734	0.1108	0.1101
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.5706	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1944	0.3272	0.3272
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0401	0.0512	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0379	0.0473	0.0466
Loa Loa (eye worm)	phosphatidylinositol 3	0.0379	0.0473	0.0466
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0445	0.0591	0.0583
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.5706	1	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0401	0.0512	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.2382	0.4055	0.4051
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0521	0.0726	0.0726
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0379	0.0473	0.0466
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0401	0.0512	0.0512
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0845	0.1306	0.1299
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1111	0.1782	0.1776
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1944	0.3272	0.3272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3097	0.5335	0.5335
Leishmania major	phosphatidylinositol kinase, putative	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5706	1	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0379	0.0473	0.0466
Leishmania major	hypothetical protein, unknown function	0.0379	0.0473	0.0466
Loa Loa (eye worm)	hypothetical protein	0.072	0.1083	0.1076
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0379	0.0473	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4548	0.7929	0.7929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3102	0.5343	0.5343
Trichomonas vaginalis	fk506-binding protein, putative	0.0119	0.0008	0.0008
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1944	0.3272	0.3267
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0379	0.0473	0.0466
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0379	0.0473	0.0466
Entamoeba histolytica	hypothetical protein	0.0379	0.0473	0.0466
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.1099	0.1761	0.1755
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1956	0.3293	0.3288
Loa Loa (eye worm)	hypothetical protein	0.1099	0.1761	0.1755
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0119	0.0008	0.5
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0401	0.0512	0.0505
Schistosoma mansoni	fkbp-rapamycin associated protein	0.1099	0.1761	0.1755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4255	0.7406	0.7406
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0661	0.0977	0.097
Echinococcus multilocularis	Zinc finger, PHD finger	0.0401	0.0512	0.0505
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.1099	0.1761	0.1755
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0119	0.0008	0.0008
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0512	0.0711	0.0704
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0123	0.0014	0.0007
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0588	0.0847	0.0847
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0477	0.0648	0.064
Entamoeba histolytica	hypothetical protein	0.0379	0.0473	0.0466

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2005643

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1647125