Detailed information for compound 1647126

Basic information

Technical information
  • TDR Targets ID: 1647126
  • Name: (6-phosphonopiperidin-2-yl)phosphonic acid
  • MW: 245.107 | Formula: C5H13NO6P2
  • H donors: 5 H acceptors: 6 LogP: -4.96 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OP(=O)(C1CCCC(N1)P(=O)(O)O)O
  • InChi: 1S/C5H13NO6P2/c7-13(8,9)4-2-1-3-5(6-4)14(10,11)12/h4-6H,1-3H2,(H2,7,8,9)(H2,10,11,12)
  • InChiKey: APRIPEPLXOGAFT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6-phosphono-2-piperidyl)phosphonic acid
  • (6-phosphono-2-piperidinyl)phosphonic acid
  • AIDS-133501
  • AIDS133501
  • NSC629303
  • Phosphonic acid, 2,6-piperidinediylbis-
  • NCI60_009508

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.0313 0.044 0.5
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4686 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1602 0.3257 0.3257
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0335 0.0487 0.0478
Loa Loa (eye worm) hypothetical protein 0.0313 0.044 0.0431
Loa Loa (eye worm) phosphatidylinositol 3 0.0662 0.1203 0.1194
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4686 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0335 0.0487 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0378 0.0581 0.0572
Loa Loa (eye worm) phosphatidylinositol 3 0.0313 0.044 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0696 0.1276 0.1276
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0335 0.0487 0.0487
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0918 0.1762 0.1754
Trichomonas vaginalis PIKK family atypical protein kinase 0.1602 0.3257 0.3257
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1958 0.4037 0.4031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0313 0.044 0.0431
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0452 0.0745 0.0745
Leishmania major hypothetical protein, unknown function 0.0313 0.044 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0593 0.1052 0.1052
Leishmania major phosphatidylinositol kinase related protein, putative 0.0313 0.044 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.2551 0.5333 0.5333
Trichomonas vaginalis PIKK family atypical protein kinase 0.3737 0.7924 0.7924
Trichomonas vaginalis fk506-binding protein, putative 0.0116 0.001 0.001
Leishmania major phosphatidylinositol kinase, putative 0.0313 0.044 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.2547 0.5325 0.5325
Trichomonas vaginalis PIKK family atypical protein kinase 0.4686 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0313 0.044 0.0431
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0313 0.044 0.0431
Entamoeba histolytica hypothetical protein 0.0313 0.044 0.0431
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0906 0.1736 0.1728
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1613 0.3282 0.3276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0906 0.1736 0.1736
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1602 0.3257 0.3251
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0313 0.044 0.0431
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.059 0.1046 0.1037
Echinococcus multilocularis Zinc finger, PHD finger 0.0335 0.0487 0.0478
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0116 0.001 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0335 0.0487 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.3497 0.74 0.74
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0906 0.1736 0.1728
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.001 0.001
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0444 0.0726 0.0717
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0519 0.089 0.089
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.012 0.0017 0.0008
Entamoeba histolytica hypothetical protein 0.0313 0.044 0.0431
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0409 0.065 0.0641
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0906 0.1736 0.1728
Trichomonas vaginalis PIKK family atypical protein kinase 0.3497 0.74 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.3144 0.6628 0.6628
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0313 0.044 0.0431
Trichomonas vaginalis immunophilin, putative 0.0116 0.001 0.001
Schistosoma mansoni fkbp-rapamycin associated protein 0.0906 0.1736 0.1728
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0705 0.1297 0.1289
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.374 0.7933 0.7931
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0313 0.044 0.0431
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0313 0.044 0.0431
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0313 0.044 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.3497 0.74 0.74
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4686 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4686 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0313 0.044 0.9023
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0444 0.0726 0.0717
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0378 0.0581 0.0572
Onchocerca volvulus 0.0313 0.044 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0313 0.044 0.0431
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0313 0.044 0.9023
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0519 0.089 0.0881
Trichomonas vaginalis PIKK family atypical protein kinase 0.0918 0.1762 0.1762
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4686 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1009 0.1961 0.2185
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0116 0.001 0.5
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0705 0.1297 0.1289
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0313 0.044 0.0431
Trypanosoma brucei target of rapamycin kinase 3, putative 0.374 0.7933 0.7931
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4686 1 1
Loa Loa (eye worm) hypothetical protein 0.1009 0.1961 0.1953
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0519 0.089 0.0881
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0187 0.0163 0.0154
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0519 0.089 0.089
Giardia lamblia Phosphatidylinositol 4-kinase 0.0313 0.044 0.0431
Entamoeba histolytica hypothetical protein 0.0906 0.1736 0.1728
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0313 0.044 0.9023
Brugia malayi FAT domain containing protein 0.0696 0.1276 0.1268
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0335 0.0487 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0313 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.4686 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0335 0.0487 0.0478
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1656 0.3376 0.337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0313 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.3497 0.74 0.74
Toxoplasma gondii FATC domain-containing protein 0.0906 0.1736 0.1862
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0313 0.044 0.0431
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0335 0.0487 0.0478
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0335 0.0487 0.0067
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0313 0.044 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.3497 0.74 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.2801 0.588 0.588
Toxoplasma gondii target of rapamycin (TOR), putative 0.3497 0.74 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0313 0.044 0.0431
Entamoeba histolytica hypothetical protein 0.0313 0.044 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.2547 0.5325 0.5325
Schistosoma mansoni hypothetical protein 0.0696 0.1276 0.1268
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1656 0.3376 0.337
Plasmodium vivax hypothetical protein 0.0313 0.044 0.9023
Leishmania major hypothetical protein, conserved 0.0411 0.0655 0.0646
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1656 0.3376 0.337
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0335 0.0487 0.0478
Leishmania major phosphatidylinositol 4-kinase, putative 0.0313 0.044 0.0431
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1656 0.3376 0.337
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0906 0.1736 0.1728
Trichomonas vaginalis PIKK family atypical protein kinase 0.1602 0.3257 0.3257
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4686 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0906 0.1736 0.1728
Trichomonas vaginalis PIKK family atypical protein kinase 0.3737 0.7924 0.7924
Mycobacterium tuberculosis Conserved hypothetical protein 0.0313 0.044 0.5
Loa Loa (eye worm) hypothetical protein 0.0906 0.1736 0.1728
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0378 0.0581 0.0581
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0378 0.0581 0.0581
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4686 1 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1656 0.3376 0.337
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.012 0.0017 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1656 0.3376 0.337
Trichomonas vaginalis PIKK family atypical protein kinase 0.2801 0.588 0.588
Trichomonas vaginalis PIKK family atypical protein kinase 0.1602 0.3257 0.3257
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4686 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0206 0.0205 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1961 0.1961
Loa Loa (eye worm) hypothetical protein 0.0444 0.0726 0.0717
Echinococcus multilocularis 0.0313 0.044 0.0431
Echinococcus granulosus potassium voltage gated channel subfamily H 0.012 0.0017 0.0008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0401 0.0632 0.0623
Trypanosoma cruzi target of rapamycin kinase 3 0.374 0.7933 0.7931
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0519 0.089 0.0881
Trichomonas vaginalis PIKK family atypical protein kinase 0.2801 0.588 0.588
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0696 0.1276 0.1268
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0335 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.0696 0.1276 0.1268
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0335 0.0487 0.0478
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0041 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.2547 0.5325 0.5325
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0475 0.0795 0.0786
Loa Loa (eye worm) hypothetical protein 0.0593 0.1052 0.1043
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0378 0.0581 0.0572
Plasmodium vivax hypothetical protein, conserved 0.0313 0.044 0.9023
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0313 0.044 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.2791 0.5857 0.5857
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.001 0.001
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0335 0.0487 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.4686 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0313 0.044 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.3497 0.74 0.74
Entamoeba histolytica hypothetical protein 0.0475 0.0795 0.0786
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0906 0.1736 0.1728
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.059 0.1046 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.2551 0.5333 0.5333
Giardia lamblia Hypothetical protein 0.0313 0.044 0.0431
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0519 0.089 0.0881
Echinococcus multilocularis serine protein kinase ATM 0.0906 0.1736 0.1728
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0378 0.0581 0.0572
Onchocerca volvulus 0.0313 0.044 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0313 0.044 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.3737 0.7924 0.7924
Schistosoma mansoni hypothetical protein 0.0313 0.044 0.0431
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0906 0.1736 0.1728
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0313 0.044 0.0431
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0313 0.044 0.9023
Trichomonas vaginalis PIKK family atypical protein kinase 0.2551 0.5333 0.5333
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0705 0.1297 0.1289
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0378 0.0581 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.3737 0.7924 0.7924
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0335 0.0487 0.0478
Loa Loa (eye worm) phosphatidylinositol 3 0.1613 0.3282 0.3276
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0313 0.044 0.0431
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0906 0.1736 0.1728
Trichomonas vaginalis PIKK family atypical protein kinase 0.3497 0.74 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.2551 0.5333 0.5333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0593 0.1052 0.1052
Loa Loa (eye worm) phosphatidylinositol 3 0.0313 0.044 0.0431
Loa Loa (eye worm) phosphatidylinositol 3 0.4686 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0378 0.0581 0.0581
Leishmania major phosphatidylinositol 3-kinase, putative 0.0335 0.0487 0.0478
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0313 0.044 0.9023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0906 0.1736 0.1736
Echinococcus granulosus serine protein kinase ATM 0.0906 0.1736 0.1728
Loa Loa (eye worm) phosphatidylinositol 3 0.0313 0.044 0.0431
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0519 0.089 0.089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0444 0.0726 0.0717
Loa Loa (eye worm) phosphatidylinositol kinase 0.0313 0.044 0.0431
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2209 0.4584 0.4578
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0335 0.0487 0.0478
Loa Loa (eye worm) phosphatidylinositol 3 0.0313 0.044 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.3737 0.7924 0.7924
Trichomonas vaginalis PIKK family atypical protein kinase 0.3991 0.8479 0.8479
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0335 0.0487 0.0478
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0335 0.0487 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0313 0.044 0.0431
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4686 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0335 0.0487 0.0478
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0335 0.0487 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.1613 0.3282 0.3282
Giardia lamblia GTOR 0.4686 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0356 0.0535 0.0526
Entamoeba histolytica protein kinase rad3, putative 0.0906 0.1736 0.1728
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4686 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.0581 0.0572
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1613 0.3282 0.3276
Leishmania major phosphatidylinositol 3-kinase, putative 0.1602 0.3257 0.3251
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0041 0.0032
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0452 0.0745 0.0745
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0593 0.1052 0.1043
Loa Loa (eye worm) hypothetical protein 0.0946 0.1823 0.1815
Trichomonas vaginalis PIKK family atypical protein kinase 0.3041 0.6403 0.6403
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0313 0.044 0.044
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0335 0.0487 0.0067
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.012 0.0017 0.0008
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0696 0.1276 0.1268
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0335 0.0487 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.1259 0.2508 0.2508
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0313 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.2791 0.5857 0.5857

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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