Detailed information for compound 1647127

Basic information

Technical information
  • TDR Targets ID: 1647127
  • Name: 3-(dichloromethyl-prop-2-enylphosphoryl)prop- 1-ene
  • MW: 213.041 | Formula: C7H11Cl2OP
  • H donors: 0 H acceptors: 1 LogP: 2.11 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCP(=O)(C(Cl)Cl)CC=C
  • InChi: 1S/C7H11Cl2OP/c1-3-5-11(10,6-4-2)7(8)9/h3-4,7H,1-2,5-6H2
  • InChiKey: YJYRCSCBBVCSES-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(allyl-(dichloromethyl)phosphoryl)prop-1-ene
  • 3-(dichloromethyl-prop-2-enyl-phosphoryl)prop-1-ene
  • AIDS-145753
  • AIDS145753
  • Diallyl(dichloromethyl)phosphine oxide
  • NSC671155
  • NCI60_025106

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 0.0244 0.0389 0.0377
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0115 0.0022 0.001
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0328 0.0628 0.0617
Loa Loa (eye worm) hypothetical protein 0.037 0.0747 0.0736
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0197 0.0256 0.0245
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3618 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0783 0.1924 0.1924
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1295 0.3382 0.3374
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.3233 0.3233
Trichomonas vaginalis PIKK family atypical protein kinase 0.2163 0.5855 0.5855
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1295 0.3382 0.3374
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0115 0.0022 0.001
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0306 0.0565 0.0565
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3618 1 1
Echinococcus multilocularis serine protein kinase ATM 0.0703 0.1697 0.1687
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0306 0.0565 0.0565
Trichomonas vaginalis PIKK family atypical protein kinase 0.2887 0.7917 0.7917
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0703 0.1697 0.1687
Mycobacterium tuberculosis Conserved hypothetical protein 0.0244 0.0389 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.3233 0.3233
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3618 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0703 0.1697 0.1687
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1295 0.3382 0.3374
Leishmania major phosphatidylinositol 4-kinase, putative 0.0244 0.0389 0.0377
Plasmodium vivax hypothetical protein 0.0244 0.0389 0.8659
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1295 0.3382 0.3374
Leishmania major hypothetical protein, conserved 0.0338 0.0657 0.0646
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0264 0.0447 0.0435
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1295 0.3382 0.3374
Trichomonas vaginalis conserved hypothetical protein 0.0539 0.1229 0.1229
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0244 0.0389 0.0377
Schistosoma mansoni hypothetical protein 0.0244 0.0389 0.0377
Toxoplasma gondii FATC domain-containing protein 0.0703 0.1697 0.1869
Onchocerca volvulus 0.0244 0.0389 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0244 0.0389 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.2887 0.7917 0.7917
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0441 0.0951 0.094
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0703 0.1697 0.1687
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0306 0.0565 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.1974 0.5316 0.5316
Trichomonas vaginalis conserved hypothetical protein 0.0459 0.1003 0.1003
Giardia lamblia Hypothetical protein 0.0244 0.0389 0.0377
Loa Loa (eye worm) hypothetical protein 0.0703 0.1697 0.1687
Trichomonas vaginalis PIKK family atypical protein kinase 0.3618 1 1
Entamoeba histolytica hypothetical protein 0.04 0.0833 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7391 0.7391
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0244 0.0389 0.0377
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0264 0.0447 0.0435
Plasmodium vivax hypothetical protein, conserved 0.0244 0.0389 0.8659
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0244 0.0389 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.2158 0.5842 0.5842
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0112 0.0012 0.0012
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0306 0.0565 0.0554
Loa Loa (eye worm) hypothetical protein 0.0459 0.1003 0.0992
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.04 0.0833 0.0822
Schistosoma mansoni voltage-gated potassium channel 0.0126 0.0052 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1971 0.5308 0.5308
Schistosoma mansoni hypothetical protein 0.0539 0.1229 0.1219
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0264 0.0447 0.0435
Loa Loa (eye worm) phosphatidylinositol 3 0.0579 0.1343 0.1333
Trichomonas vaginalis PIKK family atypical protein kinase 0.2163 0.5855 0.5855
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0264 0.0447 0.0447
Trypanosoma cruzi target of rapamycin kinase 3 0.289 0.7925 0.7923
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0441 0.0951 0.094
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0264 0.0447 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.1254 0.3264 0.3264
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3618 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0264 0.0447 0.0435
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0264 0.0447 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0264 0.0447 0.0435
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0244 0.0389 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.3079 0.8465 0.8465
Trichomonas vaginalis PIKK family atypical protein kinase 0.2887 0.7917 0.7917
Loa Loa (eye worm) phosphatidylinositol 3 0.0244 0.0389 0.0377
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1704 0.4547 0.454
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0264 0.0447 0.0435
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.037 0.0747 0.0736
Loa Loa (eye worm) phosphatidylinositol kinase 0.0244 0.0389 0.0377
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0441 0.0951 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0703 0.1697 0.1697
Echinococcus granulosus serine protein kinase ATM 0.0703 0.1697 0.1687
Loa Loa (eye worm) phosphatidylinositol 3 0.0244 0.0389 0.0377
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0244 0.0389 0.8659
Loa Loa (eye worm) phosphatidylinositol 3 0.0244 0.0389 0.0377
Loa Loa (eye worm) phosphatidylinositol 3 0.3618 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0306 0.0565 0.0565
Leishmania major phosphatidylinositol 3-kinase, putative 0.0264 0.0447 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7391 0.7391
Trichomonas vaginalis PIKK family atypical protein kinase 0.1974 0.5316 0.5316
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.051 0.1146 0.1136
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0244 0.0389 0.0377
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0703 0.1697 0.1687
Loa Loa (eye worm) phosphatidylinositol 3 0.1254 0.3264 0.3256
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0244 0.0389 0.8659
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0565 0.0554
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0264 0.0447 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.1974 0.5316 0.5316
Trichomonas vaginalis PIKK family atypical protein kinase 0.2887 0.7917 0.7917
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0621 0.1462 0.1451
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0244 0.0389 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.2158 0.5842 0.5842
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0264 0.0447 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.2464 0.2464
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0539 0.1229 0.1219
Loa Loa (eye worm) hypothetical protein 0.0728 0.1769 0.1759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0459 0.1003 0.1003
Trichomonas vaginalis PIKK family atypical protein kinase 0.2348 0.6381 0.6381
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0264 0.0447 0.0083
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0244 0.0389 0.0389
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0115 0.0022 0.001
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0378 0.077 0.077
Leishmania major phosphatidylinositol 3-kinase, putative 0.1242 0.3233 0.3225
Schistosoma mansoni voltage-gated potassium channel 0.0126 0.0052 0.004
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1254 0.3264 0.3256
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0565 0.0554
Entamoeba histolytica protein kinase rad3, putative 0.0703 0.1697 0.1687
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3618 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0285 0.0507 0.0496
Giardia lamblia GTOR 0.3618 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0244 0.0389 0.0377
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1514 0.4007 0.4
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0378 0.077 0.077
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0539 0.1229 0.1219
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0264 0.0447 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.3233 0.3233
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0714 0.1729 0.1719
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0565 0.0554
Loa Loa (eye worm) phosphatidylinositol 3 0.0244 0.0389 0.0377
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0264 0.0447 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3618 1 1
Brugia malayi FAT domain containing protein 0.0539 0.1229 0.1219
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0264 0.0447 0.0435
Loa Loa (eye worm) hypothetical protein 0.0244 0.0389 0.0377
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3618 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.3233 0.3233
Mycobacterium leprae conserved hypothetical protein 0.0244 0.0389 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0703 0.1697 0.1687
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0115 0.0022 0.001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0441 0.0951 0.0951
Entamoeba histolytica hypothetical protein 0.0244 0.0389 0.0377
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0336 0.0651 0.064
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0112 0.0012 0.0012
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.037 0.0747 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0703 0.1697 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7391 0.7391
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0112 0.0012 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0264 0.0447 0.0435
Echinococcus multilocularis Zinc finger, PHD finger 0.0264 0.0447 0.0435
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0459 0.1003 0.0992
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1242 0.3233 0.3225
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0244 0.0389 0.0377
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1254 0.3264 0.3256
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0703 0.1697 0.1687
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0244 0.0389 0.0377
Entamoeba histolytica hypothetical protein 0.0244 0.0389 0.0377
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0703 0.1697 0.1687
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0244 0.0389 0.0377
Leishmania major phosphatidylinositol kinase, putative 0.0244 0.0389 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.1971 0.5308 0.5308
Trichomonas vaginalis PIKK family atypical protein kinase 0.3618 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1974 0.5316 0.5316
Leishmania major phosphatidylinositol kinase related protein, putative 0.0244 0.0389 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.2887 0.7917 0.7917
Trichomonas vaginalis fk506-binding protein, putative 0.0112 0.0012 0.0012
Leishmania major hypothetical protein, unknown function 0.0244 0.0389 0.0377
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.051 0.1146 0.1136
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0621 0.1462 0.1451
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0244 0.0389 0.0377
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3618 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0783 0.1924 0.2193
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0112 0.0012 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0714 0.1729 0.1729
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0244 0.0389 0.0377
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0244 0.0389 0.8659
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0441 0.0951 0.094
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.037 0.0747 0.0736
Onchocerca volvulus 0.0244 0.0389 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0306 0.0565 0.0554
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0244 0.0389 0.8659
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3618 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3618 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7391 0.7391
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0244 0.0389 0.0377
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0244 0.0389 0.0377
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0244 0.0389 0.0377
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.289 0.7925 0.7923
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0621 0.1462 0.1451
Trichomonas vaginalis immunophilin, putative 0.0112 0.0012 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0703 0.1697 0.1687
Trichomonas vaginalis PIKK family atypical protein kinase 0.2427 0.6608 0.6608
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0244 0.0389 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7391 0.7391
Entamoeba histolytica hypothetical protein 0.0244 0.0389 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.1971 0.5308 0.5308
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0244 0.0389 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.2163 0.5855 0.5855
Toxoplasma gondii target of rapamycin (TOR), putative 0.2702 0.7391 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7391 0.7391
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0244 0.0389 0.0377
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0244 0.0389 0.0377
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0264 0.0447 0.0435
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0264 0.0447 0.0083
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1295 0.3382 0.3374
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0264 0.0447 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0244 0.0389 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.2702 0.7391 0.7391
Schistosoma mansoni fkbp-rapamycin associated protein 0.0703 0.1697 0.1687
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0264 0.0447 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.3618 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0244 0.0389 0.0389
Giardia lamblia Phosphatidylinositol 4-kinase 0.0244 0.0389 0.0377
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0441 0.0951 0.0951
Entamoeba histolytica hypothetical protein 0.0703 0.1697 0.1687
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0244 0.0389 0.8659
Loa Loa (eye worm) hypothetical protein 0.0539 0.1229 0.1219
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0179 0.0204 0.0193
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0441 0.0951 0.094
Loa Loa (eye worm) hypothetical protein 0.0783 0.1924 0.1914
Trypanosoma brucei target of rapamycin kinase 3, putative 0.289 0.7925 0.7923
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3618 1 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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