Detailed information for compound 1647132

Basic information

Technical information
  • TDR Targets ID: 1647132
  • Name: N-(furan-2-ylmethyl)-N-(phenylcarbamothioyl)f uran-2-carboxamide
  • MW: 326.37 | Formula: C17H14N2O3S
  • H donors: 1 H acceptors: 1 LogP: 3.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(N(C(=O)c1ccco1)Cc1ccco1)Nc1ccccc1
  • InChi: 1S/C17H14N2O3S/c20-16(15-9-5-11-22-15)19(12-14-8-4-10-21-14)17(23)18-13-6-2-1-3-7-13/h1-11H,12H2,(H,18,23)
  • InChiKey: QGBHHTDMULYQTI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-furylmethyl)-N-(phenylcarbamothioyl)furan-2-carboxamide
  • N-(2-furylmethyl)-N-[(phenylamino)-thioxomethyl]-2-furancarboxamide
  • N-(2-furylmethyl)-N-(phenylthiocarbamoyl)-2-furamide
  • AIDS-142534
  • AIDS142534
  • N-(2-Furoyl)-N-(2-furylmethyl)-N'-phenylthiourea
  • NSC659778
  • NCI60_021041

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.1233 0.1984 0.1979
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5746 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4585 0.7937 0.7936
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.019 0.0132 0.0126
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0591 0.0845 0.0839
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0781 0.1182 0.1176
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0382 0.0474 0.9238
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0591 0.0845 0.0845
Giardia lamblia Phosphatidylinositol 4-kinase 0.0382 0.0474 0.0467
Entamoeba histolytica hypothetical protein 0.1107 0.1761 0.1756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0474 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.4286 0.7406 0.7406
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1107 0.1761 0.1756
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2013 0.337 0.3366
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0403 0.0512 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0474 0.0474
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0403 0.0512 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.5746 1 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0403 0.0512 0.0506
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0403 0.0512 0.0056
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0382 0.0474 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.4286 0.7406 0.7406
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0382 0.0474 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.3119 0.5335 0.5335
Entamoeba histolytica hypothetical protein 0.0382 0.0474 0.0467
Toxoplasma gondii target of rapamycin (TOR), putative 0.4286 0.7406 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3435 0.5895 0.5895
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0382 0.0474 0.0467
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1107 0.1761 0.1756
Trichomonas vaginalis immunophilin, putative 0.0119 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.3855 0.6641 0.6641
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0382 0.0474 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.4286 0.7406 0.7406
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0382 0.0474 0.0467
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4585 0.7937 0.7936
Schistosoma mansoni hypothetical protein 0.0851 0.1306 0.1301
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0382 0.0474 0.0467
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0382 0.0474 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.4286 0.7406 0.7406
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5746 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5746 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0447 0.059 0.0584
Onchocerca volvulus 0.0382 0.0474 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0515 0.071 0.0704
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0382 0.0474 0.9238
Trichomonas vaginalis PIKK family atypical protein kinase 0.1119 0.1782 0.1782
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0591 0.0845 0.0839
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0382 0.0474 0.9238
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0382 0.0474 0.0467
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0382 0.0474 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0851 0.1306 0.1306
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1233 0.1984 0.2179
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0119 0.0007 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5746 1 1
Trichomonas vaginalis fk506-binding protein, putative 0.0119 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.3124 0.5343 0.5343
Leishmania major phosphatidylinositol kinase related protein, putative 0.0382 0.0474 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.458 0.7929 0.7929
Loa Loa (eye worm) hypothetical protein 0.0725 0.1083 0.1077
Leishmania major hypothetical protein, unknown function 0.0382 0.0474 0.0467
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0382 0.0474 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.5746 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3119 0.5335 0.5335
Leishmania major phosphatidylinositol kinase, putative 0.0382 0.0474 0.0467
Loa Loa (eye worm) hypothetical protein 0.1107 0.1761 0.1756
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.197 0.3293 0.3289
Entamoeba histolytica hypothetical protein 0.0382 0.0474 0.0467
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1107 0.1761 0.1756
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0382 0.0474 0.0467
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0382 0.0474 0.0467
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1958 0.3272 0.3268
Echinococcus multilocularis Zinc finger, PHD finger 0.0403 0.0512 0.0506
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0663 0.0974 0.0968
Schistosoma mansoni fkbp-rapamycin associated protein 0.1107 0.1761 0.1756
Trichomonas vaginalis PIKK family atypical protein kinase 0.4286 0.7406 0.7406
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0403 0.0512 0.0506
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0119 0.0007 0.5
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0479 0.0647 0.064
Entamoeba histolytica hypothetical protein 0.0382 0.0474 0.0467
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0591 0.0845 0.0845
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0123 0.0014 0.0008
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0515 0.071 0.0704
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0119 0.0007 0.0007
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1107 0.1761 0.1756
Mycobacterium leprae conserved hypothetical protein 0.0382 0.0474 0.5
Loa Loa (eye worm) hypothetical protein 0.0382 0.0474 0.0467
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0403 0.0512 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.1958 0.3272 0.3272
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5746 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0737 0.1104 0.1097
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0403 0.0512 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5746 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0447 0.059 0.0584
Loa Loa (eye worm) phosphatidylinositol 3 0.0382 0.0474 0.0467
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1119 0.1782 0.1777
Trichomonas vaginalis PIKK family atypical protein kinase 0.1958 0.3272 0.3272
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0403 0.0512 0.0512
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0851 0.1306 0.1301
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2399 0.4056 0.4052
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0523 0.0725 0.0725
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0382 0.0474 0.0467
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0426 0.0552 0.0545
Giardia lamblia GTOR 0.5746 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5746 1 1
Entamoeba histolytica protein kinase rad3, putative 0.1107 0.1761 0.1756
Leishmania major phosphatidylinositol 3-related kinase, putative 0.197 0.3293 0.3289
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0447 0.059 0.0584
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0523 0.0725 0.0725
Schistosoma mansoni voltage-gated potassium channel 0.0135 0.0035 0.0028
Leishmania major phosphatidylinositol 3-kinase, putative 0.1958 0.3272 0.3268
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0781 0.1182 0.1176
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0123 0.0014 0.0008
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0403 0.0512 0.0056
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0382 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.1162 0.1858 0.1853
Trichomonas vaginalis PIKK family atypical protein kinase 0.3729 0.6418 0.6418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0725 0.1083 0.1083
Trichomonas vaginalis PIKK family atypical protein kinase 0.3418 0.5866 0.5866
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0382 0.0474 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.1543 0.2536 0.2536
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0403 0.0512 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.3124 0.5343 0.5343
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0403 0.0512 0.0506
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0447 0.059 0.0584
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0851 0.1306 0.1301
Trichomonas vaginalis PIKK family atypical protein kinase 0.458 0.7929 0.7929
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0382 0.0474 0.9238
Echinococcus multilocularis serine protein kinase ATM 0.1107 0.1761 0.1756
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0382 0.0474 0.0467
Loa Loa (eye worm) phosphatidylinositol 3 0.197 0.3293 0.3289
Leishmania major phosphatidylinositol 3-kinase, putative 0.0403 0.0512 0.0506
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0447 0.059 0.059
Loa Loa (eye worm) phosphatidylinositol 3 0.5746 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0382 0.0474 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.3124 0.5343 0.5343
Trichomonas vaginalis PIKK family atypical protein kinase 0.4286 0.7406 0.7406
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0725 0.1083 0.1077
Echinococcus granulosus serine protein kinase ATM 0.1107 0.1761 0.1756
Loa Loa (eye worm) phosphatidylinositol 3 0.0382 0.0474 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.1107 0.1761 0.1761
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0382 0.0474 0.9238
Loa Loa (eye worm) phosphatidylinositol kinase 0.0382 0.0474 0.0467
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0515 0.071 0.0704
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0591 0.0845 0.0845
Trichomonas vaginalis PIKK family atypical protein kinase 0.458 0.7929 0.7929
Loa Loa (eye worm) phosphatidylinositol 3 0.0382 0.0474 0.0467
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0403 0.0512 0.0506
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.271 0.4608 0.4604
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0382 0.0474 0.0467
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0403 0.0512 0.0506
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0403 0.0512 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4895 0.8489 0.8489
Trichomonas vaginalis PIKK family atypical protein kinase 0.197 0.3293 0.3293
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0403 0.0512 0.0512
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0403 0.0512 0.0506
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5746 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0591 0.0845 0.0839
Trypanosoma cruzi target of rapamycin kinase 3 0.4585 0.7937 0.7936
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0403 0.0512 0.0506
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0781 0.1182 0.1176
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0403 0.0512 0.0512
Trichomonas vaginalis PIKK family atypical protein kinase 0.3435 0.5895 0.5895
Loa Loa (eye worm) hypothetical protein 0.0851 0.1306 0.1301
Trichomonas vaginalis conserved hypothetical protein 0.0725 0.1083 0.1083
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0547 0.0767 0.076
Trichomonas vaginalis PIKK family atypical protein kinase 0.3119 0.5335 0.5335
Schistosoma mansoni voltage-gated potassium channel 0.0135 0.0035 0.0028
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0119 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.3418 0.5866 0.5866
Plasmodium vivax hypothetical protein, conserved 0.0382 0.0474 0.9238
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0382 0.0474 0.0467
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0447 0.059 0.0584
Entamoeba histolytica hypothetical protein 0.0547 0.0767 0.076
Trichomonas vaginalis PIKK family atypical protein kinase 0.4286 0.7406 0.7406
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0382 0.0474 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.5746 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0403 0.0512 0.0506
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0663 0.0974 0.0968
Giardia lamblia Hypothetical protein 0.0382 0.0474 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.3124 0.5343 0.5343
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1107 0.1761 0.1756
Trichomonas vaginalis PIKK family atypical protein kinase 0.458 0.7929 0.7929
Onchocerca volvulus 0.0382 0.0474 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0382 0.0474 0.0467
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0447 0.059 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.1107 0.1761 0.1761
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0591 0.0845 0.0839
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0382 0.0474 0.0467
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1107 0.1761 0.1756
Schistosoma mansoni hypothetical protein 0.0382 0.0474 0.0467
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2013 0.337 0.3366
Brugia malayi FAT domain containing protein 0.0851 0.1306 0.1301
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0403 0.0512 0.0506
Plasmodium vivax hypothetical protein 0.0382 0.0474 0.9238
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2013 0.337 0.3366
Leishmania major hypothetical protein, conserved 0.0482 0.0651 0.0644
Toxoplasma gondii FATC domain-containing protein 0.1107 0.1761 0.1857
Leishmania major phosphatidylinositol 4-kinase, putative 0.0382 0.0474 0.0467
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2013 0.337 0.3366
Mycobacterium tuberculosis Conserved hypothetical protein 0.0382 0.0474 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.458 0.7929 0.7929
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1107 0.1761 0.1756
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5746 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1958 0.3272 0.3272
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5746 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0447 0.059 0.059
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0447 0.059 0.059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1107 0.1761 0.1756
Trichomonas vaginalis PIKK family atypical protein kinase 0.3435 0.5895 0.5895
Trichomonas vaginalis PIKK family atypical protein kinase 0.1958 0.3272 0.3272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2013 0.337 0.3366
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0123 0.0014 0.0008
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2013 0.337 0.3366
Trichomonas vaginalis conserved hypothetical protein 0.1233 0.1984 0.1984
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0209 0.0167 0.016
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5746 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0471 0.0632 0.0625
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0123 0.0014 0.0008
Echinococcus multilocularis 0.0382 0.0474 0.0467
Loa Loa (eye worm) hypothetical protein 0.0515 0.071 0.0704

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.747 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.19 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.123 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.98 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.87 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.838 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.834 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.783 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.758 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.711 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.479 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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