Detailed information for compound 1647135

Basic information

Technical information
  • TDR Targets ID: 1647135
  • Name: N-[(2,4-dichlorophenyl)methylideneamino]benze nesulfonamide
  • MW: 329.202 | Formula: C13H10Cl2N2O2S
  • H donors: 1 H acceptors: 2 LogP: 3.78 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)/C=N/NS(=O)(=O)c1ccccc1
  • InChi: 1S/C13H10Cl2N2O2S/c14-11-7-6-10(13(15)8-11)9-16-17-20(18,19)12-4-2-1-3-5-12/h1-9,17H/b16-9+
  • InChiKey: GXHCURFFVDKZPK-CXUHLZMHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(2,4-dichlorophenyl)methyleneamino]benzenesulfonamide
  • N-[(2,4-dichlorobenzylidene)amino]benzenesulfonamide
  • 3W-0627
  • AIDS-131323
  • AIDS131323
  • N'-(2,4-Dichlorobenzylidene)benzenesulfonohydrazide
  • NSC623220
  • NCI60_006926

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0341 0.0458 0.9145
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0758 0.1292 0.1286
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0362 0.05 0.0493
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0405 0.0585 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.4077 0.7927 0.7927
Trichomonas vaginalis PIKK family atypical protein kinase 0.2782 0.5338 0.5338
Loa Loa (eye worm) phosphatidylinositol 3 0.1757 0.3287 0.3282
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0341 0.0458 0.0451
Echinococcus multilocularis serine protein kinase ATM 0.0987 0.1749 0.1743
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0646 0.1068 0.1061
Trichomonas vaginalis PIKK family atypical protein kinase 0.2782 0.5338 0.5338
Trichomonas vaginalis PIKK family atypical protein kinase 0.3816 0.7403 0.7403
Loa Loa (eye worm) phosphatidylinositol 3 0.5115 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0405 0.0585 0.0585
Loa Loa (eye worm) phosphatidylinositol 3 0.0341 0.0458 0.0451
Leishmania major phosphatidylinositol 3-kinase, putative 0.0362 0.05 0.0493
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0341 0.0458 0.9145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0987 0.1749 0.1749
Loa Loa (eye worm) phosphatidylinositol 3 0.0341 0.0458 0.0451
Echinococcus granulosus serine protein kinase ATM 0.0987 0.1749 0.1743
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0544 0.0863 0.0863
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.047 0.0716 0.0709
Loa Loa (eye worm) phosphatidylinositol kinase 0.0341 0.0458 0.0451
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2411 0.4596 0.4592
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0362 0.05 0.0493
Loa Loa (eye worm) phosphatidylinositol 3 0.0341 0.0458 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.4077 0.7927 0.7927
Trichomonas vaginalis PIKK family atypical protein kinase 0.4357 0.8485 0.8485
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0362 0.05 0.0493
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0362 0.05 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0341 0.0458 0.0451
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0362 0.05 0.0493
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5115 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0362 0.05 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.1757 0.3287 0.3287
Giardia lamblia GTOR 0.5115 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0383 0.0543 0.0536
Entamoeba histolytica protein kinase rad3, putative 0.0987 0.1749 0.1743
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5115 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0405 0.0585 0.0578
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1757 0.3287 0.3282
Leishmania major phosphatidylinositol 3-kinase, putative 0.1745 0.3265 0.326
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0038 0.003
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0478 0.0732 0.0732
Loa Loa (eye worm) hypothetical protein 0.1033 0.1842 0.1836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.1068 0.1068
Trichomonas vaginalis PIKK family atypical protein kinase 0.3319 0.6411 0.6411
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.012 0.0016 0.0008
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0362 0.05 0.0061
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0341 0.0458 0.0458
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0728 0.1232 0.1225
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0362 0.05 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.1374 0.2523 0.2523
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0341 0.0458 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.3044 0.5861 0.5861
Brugia malayi FAT domain containing protein 0.0758 0.1292 0.1286
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1799 0.3372 0.3367
Leishmania major hypothetical protein, conserved 0.0438 0.0651 0.0644
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1799 0.3372 0.3367
Plasmodium vivax hypothetical protein 0.0341 0.0458 0.9145
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0362 0.05 0.0493
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1799 0.3372 0.3367
Leishmania major phosphatidylinositol 4-kinase, putative 0.0341 0.0458 0.0451
Toxoplasma gondii FATC domain-containing protein 0.0987 0.1749 0.1859
Trichomonas vaginalis PIKK family atypical protein kinase 0.1745 0.3265 0.3265
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5115 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4077 0.7927 0.7927
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0987 0.1749 0.1743
Mycobacterium tuberculosis Conserved hypothetical protein 0.0341 0.0458 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0987 0.1749 0.1743
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0405 0.0585 0.0585
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5115 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0405 0.0585 0.0585
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1799 0.3372 0.3367
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.012 0.0016 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1799 0.3372 0.3367
Trichomonas vaginalis PIKK family atypical protein kinase 0.1745 0.3265 0.3265
Trichomonas vaginalis PIKK family atypical protein kinase 0.3057 0.5888 0.5888
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0203 0.0182 0.0175
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5115 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1099 0.1973 0.1973
Loa Loa (eye worm) hypothetical protein 0.047 0.0716 0.0709
Echinococcus multilocularis 0.0341 0.0458 0.0451
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0427 0.0631 0.0624
Echinococcus granulosus potassium voltage gated channel subfamily H 0.012 0.0016 0.0008
Trypanosoma cruzi target of rapamycin kinase 3 0.4082 0.7935 0.7933
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0544 0.0863 0.0857
Loa Loa (eye worm) hypothetical protein 0.0758 0.1292 0.1286
Trichomonas vaginalis PIKK family atypical protein kinase 0.3057 0.5888 0.5888
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0362 0.05 0.05
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0362 0.05 0.0493
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0728 0.1232 0.1225
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0038 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.2778 0.533 0.533
Trichomonas vaginalis conserved hypothetical protein 0.0646 0.1068 0.1068
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0778 0.0771
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0405 0.0585 0.0578
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0341 0.0458 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.3044 0.5861 0.5861
Plasmodium vivax hypothetical protein, conserved 0.0341 0.0458 0.9145
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0007 0.0007
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0362 0.05 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.5115 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3816 0.7403 0.7403
Entamoeba histolytica hypothetical protein 0.0501 0.0778 0.0771
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0341 0.0458 0.0451
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0987 0.1749 0.1743
Giardia lamblia Hypothetical protein 0.0341 0.0458 0.0451
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0614 0.1004 0.0998
Trichomonas vaginalis PIKK family atypical protein kinase 0.2782 0.5338 0.5338
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0544 0.0863 0.0857
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0405 0.0585 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0987 0.1749 0.1749
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0341 0.0458 0.0451
Onchocerca volvulus 0.0341 0.0458 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4077 0.7927 0.7927
Schistosoma mansoni hypothetical protein 0.0341 0.0458 0.0451
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0987 0.1749 0.1743
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0341 0.0458 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.3431 0.6635 0.6635
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0341 0.0458 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.3816 0.7403 0.7403
Trichomonas vaginalis immunophilin, putative 0.0116 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0987 0.1749 0.1743
Schistosoma mansoni hypothetical protein 0.0758 0.1292 0.1286
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4082 0.7935 0.7933
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0341 0.0458 0.0451
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0341 0.0458 0.0451
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0341 0.0458 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.3816 0.7403 0.7403
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5115 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5115 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0341 0.0458 0.9145
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.047 0.0716 0.0709
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0405 0.0585 0.0578
Onchocerca volvulus 0.0341 0.0458 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0341 0.0458 0.0451
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0544 0.0863 0.0857
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0341 0.0458 0.9145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0998 0.1772 0.1772
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5115 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1099 0.1973 0.2182
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0116 0.0007 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0758 0.1292 0.1292
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0341 0.0458 0.0451
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4082 0.7935 0.7933
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5115 1 1
Loa Loa (eye worm) hypothetical protein 0.1099 0.1973 0.1967
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0544 0.0863 0.0857
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0184 0.0145 0.0137
Entamoeba histolytica hypothetical protein 0.0987 0.1749 0.1743
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0544 0.0863 0.0863
Giardia lamblia Phosphatidylinositol 4-kinase 0.0341 0.0458 0.0451
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0728 0.1232 0.1225
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0341 0.0458 0.9145
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0362 0.05 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.5115 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.0458 0.0458
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0362 0.05 0.0493
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1799 0.3372 0.3367
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0987 0.1749 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.3816 0.7403 0.7403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.0458 0.0458
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0341 0.0458 0.0451
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0362 0.05 0.0493
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0362 0.05 0.0061
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0341 0.0458 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.3816 0.7403 0.7403
Toxoplasma gondii target of rapamycin (TOR), putative 0.3816 0.7403 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0341 0.0458 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.3057 0.5888 0.5888
Entamoeba histolytica hypothetical protein 0.0341 0.0458 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.2778 0.533 0.533
Mycobacterium leprae conserved hypothetical protein 0.0341 0.0458 0.5
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5115 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1745 0.3265 0.3265
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0362 0.05 0.0493
Loa Loa (eye worm) hypothetical protein 0.0341 0.0458 0.0451
Loa Loa (eye worm) phosphatidylinositol 3 0.0685 0.1146 0.114
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5115 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0362 0.05 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0405 0.0585 0.0578
Loa Loa (eye worm) phosphatidylinositol 3 0.0341 0.0458 0.0451
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0362 0.05 0.05
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0758 0.1292 0.1286
Trichomonas vaginalis PIKK family atypical protein kinase 0.1745 0.3265 0.3265
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0998 0.1772 0.1766
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2136 0.4047 0.4042
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0478 0.0732 0.0732
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0341 0.0458 0.0451
Leishmania major hypothetical protein, unknown function 0.0341 0.0458 0.0451
Loa Loa (eye worm) hypothetical protein 0.0646 0.1068 0.1061
Trichomonas vaginalis PIKK family atypical protein kinase 0.4077 0.7927 0.7927
Trichomonas vaginalis PIKK family atypical protein kinase 0.2782 0.5338 0.5338
Leishmania major phosphatidylinositol kinase related protein, putative 0.0341 0.0458 0.0451
Trichomonas vaginalis fk506-binding protein, putative 0.0116 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.2778 0.533 0.533
Leishmania major phosphatidylinositol kinase, putative 0.0341 0.0458 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.5115 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0341 0.0458 0.0451
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0341 0.0458 0.0451
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0987 0.1749 0.1743
Entamoeba histolytica hypothetical protein 0.0341 0.0458 0.0451
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1757 0.3287 0.3282
Loa Loa (eye worm) hypothetical protein 0.0987 0.1749 0.1743
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1745 0.3265 0.326
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0341 0.0458 0.0451
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0614 0.1004 0.0998
Echinococcus multilocularis Zinc finger, PHD finger 0.0362 0.05 0.0493
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0116 0.0007 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0362 0.05 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.3816 0.7403 0.7403
Schistosoma mansoni fkbp-rapamycin associated protein 0.0987 0.1749 0.1743
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0007 0.0007
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.047 0.0716 0.0709
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0544 0.0863 0.0863
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.012 0.0016 0.0008
Entamoeba histolytica hypothetical protein 0.0341 0.0458 0.0451
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0435 0.0647 0.064
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0987 0.1749 0.1743

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.711 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.562 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.458 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.157 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.113 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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