Detailed information for compound 1647136

Basic information

Technical information
  • TDR Targets ID: 1647136
  • Name: 5-bromo-6-nitro-1H-indole-2,3-dione
  • MW: 271.024 | Formula: C8H3BrN2O4
  • H donors: 1 H acceptors: 4 LogP: 1.24 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(=O)Nc2c1cc(Br)c(c2)[N+](=O)[O-]
  • InChi: 1S/C8H3BrN2O4/c9-4-1-3-5(2-6(4)11(14)15)10-8(13)7(3)12/h1-2H,(H,10,12,13)
  • InChiKey: LLNUDSDAFYWGRT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-bromo-6-nitro-indoline-2,3-dione
  • 5-bromo-6-nitroindoline-2,3-dione
  • 5-bromo-6-nitro-isatin
  • NCI60_017171
  • NSC649178

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0174 0.0208 0.0197
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0422 0.0958 0.0948
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0422 0.0958 0.0958
Giardia lamblia Phosphatidylinositol 4-kinase 0.023 0.0378 0.0367
Entamoeba histolytica hypothetical protein 0.0664 0.1689 0.1679
Loa Loa (eye worm) hypothetical protein 0.0509 0.122 0.1209
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.023 0.0378 0.8588
Loa Loa (eye worm) hypothetical protein 0.0739 0.1916 0.1907
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2725 0.7923 0.7921
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3411 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2548 0.7389 0.7389
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.023 0.0378 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.1859 0.5304 0.5304
Entamoeba histolytica hypothetical protein 0.023 0.0378 0.0367
Toxoplasma gondii target of rapamycin (TOR), putative 0.2548 0.7389 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.204 0.5851 0.5851
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.023 0.0378 0.0367
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1223 0.3381 0.3373
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.025 0.0438 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.023 0.0378 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.2548 0.7389 0.7389
Schistosoma mansoni fkbp-rapamycin associated protein 0.0664 0.1689 0.1679
Trichomonas vaginalis PIKK family atypical protein kinase 0.3411 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.025 0.0438 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.023 0.0378 0.0378
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.023 0.0378 0.0367
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.025 0.0438 0.0427
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.025 0.0438 0.0086
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.023 0.0378 0.0367
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.023 0.0378 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.2548 0.7389 0.7389
Trichomonas vaginalis immunophilin, putative 0.0109 0.0012 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0664 0.1689 0.1679
Trichomonas vaginalis PIKK family atypical protein kinase 0.2548 0.7389 0.7389
Trichomonas vaginalis PIKK family atypical protein kinase 0.2289 0.6604 0.6604
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.023 0.0378 0.0367
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.023 0.0378 0.0367
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0596 0.1485 0.1475
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2725 0.7923 0.7921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0674 0.1722 0.1722
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.023 0.0378 0.0367
Plasmodium falciparum phosphatidylinositol 4-kinase 0.023 0.0378 0.8588
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0422 0.0958 0.0948
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0596 0.1485 0.1475
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.023 0.0378 0.0367
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3411 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0739 0.1916 0.2194
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0109 0.0012 0.5
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3411 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3411 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0352 0.0748 0.0737
Onchocerca volvulus 0.023 0.0378 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0291 0.056 0.0549
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.023 0.0378 0.8588
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1183 0.326 0.3252
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0664 0.1689 0.1679
Schistosoma mansoni phosphatidylinositol 4-kinase 0.023 0.0378 0.0367
Entamoeba histolytica hypothetical protein 0.023 0.0378 0.0367
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0664 0.1689 0.1679
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1172 0.3227 0.3219
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.023 0.0378 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.1861 0.5312 0.5312
Leishmania major phosphatidylinositol kinase related protein, putative 0.023 0.0378 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.2722 0.7915 0.7915
Trichomonas vaginalis fk506-binding protein, putative 0.0109 0.0012 0.0012
Leishmania major hypothetical protein, unknown function 0.023 0.0378 0.0367
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0489 0.116 0.115
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.023 0.0378 0.0367
Leishmania major phosphatidylinositol kinase, putative 0.023 0.0378 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.1859 0.5304 0.5304
Trichomonas vaginalis PIKK family atypical protein kinase 0.3411 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0113 0.0022 0.0011
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0422 0.0958 0.0958
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.032 0.0649 0.0638
Entamoeba histolytica hypothetical protein 0.023 0.0378 0.0367
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0012 0.0012
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0352 0.0748 0.0737
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0664 0.1689 0.1679
Echinococcus multilocularis Zinc finger, PHD finger 0.025 0.0438 0.0427
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0433 0.0992 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.2548 0.7389 0.7389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0664 0.1689 0.1689
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0109 0.0012 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.025 0.0438 0.0427
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.025 0.0438 0.0427
Loa Loa (eye worm) hypothetical protein 0.023 0.0378 0.0367
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3411 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1172 0.3227 0.3227
Brugia malayi FAT domain containing protein 0.0509 0.122 0.1209
Mycobacterium leprae conserved hypothetical protein 0.023 0.0378 0.5
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0509 0.122 0.1209
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.025 0.0438 0.0438
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0674 0.1722 0.1712
Trichomonas vaginalis PIKK family atypical protein kinase 0.1172 0.3227 0.3227
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1428 0.4001 0.3994
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.023 0.0378 0.0367
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.036 0.0771 0.0771
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.025 0.0438 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3411 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.023 0.0378 0.0367
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0291 0.056 0.0549
Entamoeba histolytica protein kinase rad3, putative 0.0664 0.1689 0.1679
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3411 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.056 0.0549
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1183 0.326 0.3252
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0271 0.05 0.0489
Giardia lamblia GTOR 0.3411 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.023 0.0378 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.2035 0.5838 0.5838
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.025 0.0438 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0917 0.2455 0.2455
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.036 0.0771 0.0771
Leishmania major phosphatidylinositol 3-kinase, putative 0.1172 0.3227 0.3219
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0054 0.0042
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0509 0.122 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0433 0.0992 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.2213 0.6377 0.6377
Loa Loa (eye worm) hypothetical protein 0.0687 0.1758 0.1748
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.025 0.0438 0.0086
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.023 0.0378 0.0378
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0113 0.0022 0.0011
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0291 0.056 0.056
Loa Loa (eye worm) phosphatidylinositol 3 0.3411 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.023 0.0378 0.0367
Leishmania major phosphatidylinositol 3-kinase, putative 0.025 0.0438 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.2548 0.7389 0.7389
Trichomonas vaginalis PIKK family atypical protein kinase 0.1861 0.5312 0.5312
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0489 0.116 0.115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0664 0.1689 0.1689
Loa Loa (eye worm) phosphatidylinositol 3 0.023 0.0378 0.0367
Echinococcus granulosus serine protein kinase ATM 0.0664 0.1689 0.1679
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.023 0.0378 0.8588
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.023 0.0378 0.8588
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.025 0.0438 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.2722 0.7915 0.7915
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0291 0.056 0.0549
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0596 0.1485 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.1861 0.5312 0.5312
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.023 0.0378 0.0367
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0664 0.1689 0.1679
Loa Loa (eye worm) phosphatidylinositol 3 0.1183 0.326 0.3252
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.025 0.0438 0.0427
Plasmodium falciparum phosphatidylinositol 3-kinase 0.025 0.0438 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.023 0.0378 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.2903 0.8462 0.8462
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.025 0.0438 0.0438
Trichomonas vaginalis PIKK family atypical protein kinase 0.1183 0.326 0.326
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3411 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.025 0.0438 0.0427
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0352 0.0748 0.0737
Loa Loa (eye worm) phosphatidylinositol kinase 0.023 0.0378 0.0367
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0422 0.0958 0.0958
Trichomonas vaginalis PIKK family atypical protein kinase 0.2722 0.7915 0.7915
Loa Loa (eye worm) phosphatidylinositol 3 0.023 0.0378 0.0367
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1606 0.454 0.4533
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.025 0.0438 0.0427
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0382 0.0836 0.0825
Loa Loa (eye worm) hypothetical protein 0.0433 0.0992 0.0982
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0054 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.1859 0.5304 0.5304
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.023 0.0378 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.2035 0.5838 0.5838
Plasmodium vivax hypothetical protein, conserved 0.023 0.0378 0.8588
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0012 0.0012
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0291 0.056 0.0549
Trypanosoma cruzi target of rapamycin kinase 3 0.2725 0.7923 0.7921
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0422 0.0958 0.0948
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.025 0.0438 0.0427
Schistosoma mansoni hypothetical protein 0.0509 0.122 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.204 0.5851 0.5851
Loa Loa (eye worm) phosphatidylinositol 3 0.0556 0.1363 0.1353
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.025 0.0438 0.0438
Onchocerca volvulus 0.023 0.0378 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.023 0.0378 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.2722 0.7915 0.7915
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0422 0.0958 0.0948
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0291 0.056 0.0549
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0664 0.1689 0.1679
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.023 0.0378 0.0367
Schistosoma mansoni hypothetical protein 0.023 0.0378 0.0367
Toxoplasma gondii FATC domain-containing protein 0.0664 0.1689 0.187
Trichomonas vaginalis PIKK family atypical protein kinase 0.3411 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2548 0.7389 0.7389
Entamoeba histolytica hypothetical protein 0.0382 0.0836 0.0825
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.023 0.0378 0.0367
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.025 0.0438 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.1861 0.5312 0.5312
Trichomonas vaginalis conserved hypothetical protein 0.0433 0.0992 0.0992
Giardia lamblia Hypothetical protein 0.023 0.0378 0.0367
Loa Loa (eye worm) hypothetical protein 0.0664 0.1689 0.1679
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0664 0.1689 0.1679
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1223 0.3381 0.3373
Leishmania major phosphatidylinositol 4-kinase, putative 0.023 0.0378 0.0367
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0664 0.1689 0.1679
Trichomonas vaginalis PIKK family atypical protein kinase 0.2722 0.7915 0.7915
Mycobacterium tuberculosis Conserved hypothetical protein 0.023 0.0378 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1172 0.3227 0.3227
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3411 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1223 0.3381 0.3373
Trichomonas vaginalis conserved hypothetical protein 0.0509 0.122 0.122
Leishmania major hypothetical protein, conserved 0.0322 0.0655 0.0644
Plasmodium vivax hypothetical protein 0.023 0.0378 0.8588
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1223 0.3381 0.3373
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.025 0.0438 0.0427
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0192 0.0262 0.0251
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3411 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0739 0.1916 0.1916
Echinococcus multilocularis 0.023 0.0378 0.0367
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0113 0.0022 0.0011
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0312 0.0626 0.0614
Loa Loa (eye worm) hypothetical protein 0.0352 0.0748 0.0737
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0291 0.056 0.056
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3411 1 1
Echinococcus multilocularis serine protein kinase ATM 0.0664 0.1689 0.1679
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0291 0.056 0.056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1223 0.3381 0.3373
Trichomonas vaginalis PIKK family atypical protein kinase 0.1172 0.3227 0.3227
Trichomonas vaginalis PIKK family atypical protein kinase 0.204 0.5851 0.5851
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1223 0.3381 0.3373
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0113 0.0022 0.0011

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.761 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.739 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.736 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.732 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.65 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.647 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.611 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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