Detailed information for compound 1647137

Basic information

Technical information
  • TDR Targets ID: 1647137
  • Name: [[2-[1-[(2,4-dinitrophenyl)amino]ethenyl]chro men-4-ylidene]amino]thiourea
  • MW: 426.406 | Formula: C18H14N6O5S
  • H donors: 3 H acceptors: 4 LogP: 3.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)N/N=c/1\cc(oc2c1cccc2)C(=C)Nc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-]
  • InChi: 1S/C18H14N6O5S/c1-10(20-13-7-6-11(23(25)26)8-15(13)24(27)28)17-9-14(21-22-18(19)30)12-4-2-3-5-16(12)29-17/h2-9,20H,1H2,(H3,19,22,30)/b21-14+
  • InChiKey: HXNDNUNHSNUWDD-KGENOOAVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [[2-[1-[(2,4-dinitrophenyl)amino]vinyl]chromen-4-ylidene]amino]thiourea
  • [[2-[1-[(2,4-dinitrophenyl)amino]vinyl]-4-chromenylidene]amino]thiourea
  • NSC649804
  • NCI60_017360
  • 2-(1-(2,4-Bis(hydroxy(oxido)amino)anilino)vinyl)-4H-chromen-4-one thiosemicarbazone
  • AIDS-139766
  • AIDS139766

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.1928 0.3271 0.3271
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5658 1 1
Loa Loa (eye worm) hypothetical protein 0.0376 0.0472 0.0464
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0398 0.0511 0.0503
Loa Loa (eye worm) phosphatidylinositol 3 0.0731 0.1112 0.1105
Mycobacterium leprae conserved hypothetical protein 0.0376 0.0472 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1928 0.3271 0.3271
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1102 0.1781 0.1775
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0398 0.0511 0.0511
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0838 0.1305 0.1298
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0376 0.0472 0.0464
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0518 0.0727 0.0727
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2362 0.4055 0.405
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5658 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0398 0.0511 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0442 0.059 0.0583
Loa Loa (eye worm) phosphatidylinositol 3 0.0376 0.0472 0.0464
Entamoeba histolytica hypothetical protein 0.0376 0.0472 0.0464
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.109 0.176 0.1753
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0376 0.0472 0.0464
Loa Loa (eye worm) hypothetical protein 0.109 0.176 0.1753
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.194 0.3293 0.3287
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0376 0.0472 0.0464
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1928 0.3271 0.3266
Loa Loa (eye worm) hypothetical protein 0.0714 0.1081 0.1074
Leishmania major hypothetical protein, unknown function 0.0376 0.0472 0.0464
Trichomonas vaginalis fk506-binding protein, putative 0.0119 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.3077 0.5343 0.5343
Trichomonas vaginalis PIKK family atypical protein kinase 0.451 0.7929 0.7929
Leishmania major phosphatidylinositol kinase related protein, putative 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.5658 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.3072 0.5334 0.5334
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0376 0.0472 0.0464
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0509 0.0712 0.0705
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0119 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0376 0.0472 0.0464
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0474 0.0648 0.064
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0585 0.0849 0.0849
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0123 0.0015 0.0007
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.109 0.176 0.1753
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0658 0.098 0.0973
Echinococcus multilocularis Zinc finger, PHD finger 0.0398 0.0511 0.0503
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0398 0.0511 0.0503
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0119 0.0008 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7406 0.7406
Schistosoma mansoni fkbp-rapamycin associated protein 0.109 0.176 0.1753
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0376 0.0472 0.0464
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7406 0.7406
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7406 0.7406
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.3796 0.664 0.664
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.109 0.176 0.1753
Trichomonas vaginalis immunophilin, putative 0.0119 0.0008 0.0008
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4515 0.7937 0.7935
Schistosoma mansoni hypothetical protein 0.0838 0.1305 0.1298
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0376 0.0472 0.0464
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0585 0.0849 0.0842
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0376 0.0472 0.9222
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.1102 0.1781 0.1781
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0119 0.0008 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1214 0.1983 0.218
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5658 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0376 0.0472 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0838 0.1305 0.1305
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5658 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5658 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0376 0.0472 0.9222
Onchocerca volvulus 0.0376 0.0472 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0442 0.059 0.0583
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0509 0.0712 0.0705
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0585 0.0849 0.0842
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.019 0.0135 0.0128
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0376 0.0472 0.9222
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0775 0.1191 0.1184
Giardia lamblia Phosphatidylinositol 4-kinase 0.0376 0.0472 0.0464
Entamoeba histolytica hypothetical protein 0.109 0.176 0.1753
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0585 0.0849 0.0849
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5658 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4515 0.7937 0.7935
Loa Loa (eye worm) hypothetical protein 0.1214 0.1983 0.1977
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7406 0.7406
Toxoplasma gondii target of rapamycin (TOR), putative 0.422 0.7406 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.3382 0.5894 0.5894
Entamoeba histolytica hypothetical protein 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.3072 0.5334 0.5334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0376 0.0472 0.0472
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0398 0.0511 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.5658 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.109 0.176 0.1753
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7406 0.7406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0376 0.0472 0.0472
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1984 0.3371 0.3366
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0398 0.0511 0.0503
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0398 0.0511 0.0503
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0398 0.0511 0.0056
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0376 0.0472 0.0464
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1984 0.3371 0.3366
Leishmania major phosphatidylinositol 4-kinase, putative 0.0376 0.0472 0.0464
Toxoplasma gondii FATC domain-containing protein 0.109 0.176 0.1858
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5658 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1928 0.3271 0.3271
Mycobacterium tuberculosis Conserved hypothetical protein 0.0376 0.0472 0.5
Echinococcus granulosus serine:threonine protein kinase SMG1 0.109 0.176 0.1753
Trichomonas vaginalis PIKK family atypical protein kinase 0.451 0.7929 0.7929
Brugia malayi FAT domain containing protein 0.0838 0.1305 0.1298
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1984 0.3371 0.3366
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0398 0.0511 0.0503
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1984 0.3371 0.3366
Leishmania major hypothetical protein, conserved 0.0476 0.0652 0.0644
Plasmodium vivax hypothetical protein 0.0376 0.0472 0.9222
Trichomonas vaginalis conserved hypothetical protein 0.1214 0.1983 0.1983
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5658 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0209 0.017 0.0163
Loa Loa (eye worm) hypothetical protein 0.0509 0.0712 0.0705
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0123 0.0015 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0465 0.0632 0.0625
Echinococcus multilocularis 0.0376 0.0472 0.0464
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0442 0.059 0.059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.109 0.176 0.1753
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0442 0.059 0.059
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5658 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0123 0.0015 0.0007
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1984 0.3371 0.3366
Trichomonas vaginalis PIKK family atypical protein kinase 0.3382 0.5894 0.5894
Trichomonas vaginalis PIKK family atypical protein kinase 0.1928 0.3271 0.3271
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1984 0.3371 0.3366
Trichomonas vaginalis PIKK family atypical protein kinase 0.3072 0.5334 0.5334
Schistosoma mansoni voltage-gated potassium channel 0.0134 0.0035 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0714 0.1081 0.1081
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0541 0.0769 0.0762
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0442 0.059 0.0583
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0119 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.3366 0.5866 0.5866
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0376 0.0472 0.0464
Plasmodium vivax hypothetical protein, conserved 0.0376 0.0472 0.9222
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0585 0.0849 0.0842
Trypanosoma cruzi target of rapamycin kinase 3 0.4515 0.7937 0.7935
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0398 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0838 0.1305 0.1298
Trichomonas vaginalis PIKK family atypical protein kinase 0.3382 0.5894 0.5894
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0775 0.1191 0.1184
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0398 0.0511 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.109 0.176 0.176
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0442 0.059 0.0583
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0585 0.0849 0.0842
Trichomonas vaginalis PIKK family atypical protein kinase 0.451 0.7929 0.7929
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0376 0.0472 0.0464
Onchocerca volvulus 0.0376 0.0472 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.109 0.176 0.1753
Schistosoma mansoni hypothetical protein 0.0376 0.0472 0.0464
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0376 0.0472 0.0464
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0398 0.0511 0.0503
Entamoeba histolytica hypothetical protein 0.0541 0.0769 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7406 0.7406
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.5658 1 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.109 0.176 0.1753
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0658 0.098 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.3077 0.5343 0.5343
Giardia lamblia Hypothetical protein 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7406 0.7406
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0714 0.1081 0.1074
Trichomonas vaginalis PIKK family atypical protein kinase 0.3077 0.5343 0.5343
Leishmania major phosphatidylinositol 3-kinase, putative 0.0398 0.0511 0.0503
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0442 0.059 0.059
Loa Loa (eye worm) phosphatidylinositol 3 0.5658 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0376 0.0472 0.0464
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0376 0.0472 0.9222
Echinococcus granulosus serine protein kinase ATM 0.109 0.176 0.1753
Loa Loa (eye worm) phosphatidylinositol 3 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.109 0.176 0.176
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0838 0.1305 0.1298
Trichomonas vaginalis PIKK family atypical protein kinase 0.451 0.7929 0.7929
Trichomonas vaginalis PIKK family atypical protein kinase 0.3077 0.5343 0.5343
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0442 0.059 0.0583
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0398 0.0511 0.0503
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0376 0.0472 0.9222
Loa Loa (eye worm) phosphatidylinositol 3 0.194 0.3293 0.3287
Echinococcus multilocularis serine protein kinase ATM 0.109 0.176 0.1753
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0376 0.0472 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.482 0.8488 0.8488
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0376 0.0472 0.0464
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0398 0.0511 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0398 0.0511 0.0503
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5658 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0398 0.0511 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.3293 0.3293
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0398 0.0511 0.0511
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0585 0.0849 0.0849
Loa Loa (eye worm) phosphatidylinositol kinase 0.0376 0.0472 0.0464
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0509 0.0712 0.0705
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2668 0.4606 0.4602
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0398 0.0511 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.451 0.7929 0.7929
Loa Loa (eye worm) phosphatidylinositol 3 0.0376 0.0472 0.0464
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5658 1 1
Entamoeba histolytica protein kinase rad3, putative 0.109 0.176 0.1753
Leishmania major phosphatidylinositol 3-related kinase, putative 0.194 0.3293 0.3287
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0442 0.059 0.0583
Giardia lamblia GTOR 0.5658 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.042 0.0551 0.0544
Trichomonas vaginalis PIKK family atypical protein kinase 0.152 0.2535 0.2535
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0398 0.0511 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.3366 0.5866 0.5866
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0376 0.0472 0.0472
Schistosoma mansoni voltage-gated potassium channel 0.0134 0.0035 0.0027
Leishmania major phosphatidylinositol 3-kinase, putative 0.1928 0.3271 0.3266
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0518 0.0727 0.0727
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0398 0.0511 0.0056
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0376 0.0472 0.0472
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0123 0.0015 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.3672 0.6417 0.6417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0714 0.1081 0.1081
Loa Loa (eye worm) hypothetical protein 0.1144 0.1856 0.185
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0775 0.1191 0.1184

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.78 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.538 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.536 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.484 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.322 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.087 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.048 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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