Detailed information for compound 1647138

Basic information

Technical information
  • TDR Targets ID: 1647138
  • Name: [[4-[[6-[[4-[(Z)-(carbamothioylhydrazinyliden e)methyl]phenoxy]methyl]pyridin-2-yl]methoxy] phenyl]methylideneamino]thiourea
  • MW: 493.604 | Formula: C23H23N7O2S2
  • H donors: 4 H acceptors: 1 LogP: 2.41 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)N/N=C\c1ccc(cc1)OCc1cccc(n1)COc1ccc(cc1)/C=N/NC(=S)N
  • InChi: 1S/C23H23N7O2S2/c24-22(33)29-26-12-16-4-8-20(9-5-16)31-14-18-2-1-3-19(28-18)15-32-21-10-6-17(7-11-21)13-27-30-23(25)34/h1-13H,14-15H2,(H3,24,29,33)(H3,25,30,34)/b26-12-,27-13+
  • InChiKey: QKIKXJHJUBRLPQ-MKMZHBJZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [[4-[[6-[[4-[(Z)-(carbamothioylhydrazono)methyl]phenoxy]methyl]-2-pyridyl]methoxy]phenyl]methyleneamino]thiourea
  • [[4-[[6-[[4-[(Z)-(thiocarbamoylhydrazono)methyl]phenoxy]methyl]-2-pyridyl]methoxy]benzylidene]amino]thiourea
  • NSC715647

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0335 0.0451 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.2995 0.5859 0.5859
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0357 0.0494 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.1351 0.2517 0.2517
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.073 0.1253 0.1247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.1062 0.1062
Trichomonas vaginalis PIKK family atypical protein kinase 0.3264 0.6408 0.6408
Loa Loa (eye worm) hypothetical protein 0.1016 0.1835 0.1829
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0335 0.0451 0.0451
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0357 0.0494 0.0063
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0122 0.0016 0.001
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0475 0.0736 0.0736
Leishmania major phosphatidylinositol 3-kinase, putative 0.1717 0.3261 0.3257
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0039 0.0033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.04 0.0583 0.0577
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1729 0.3285 0.3281
Entamoeba histolytica protein kinase rad3, putative 0.0971 0.1744 0.1739
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.503 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0379 0.0539 0.0533
Giardia lamblia GTOR 0.503 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0357 0.0494 0.0494
Trichomonas vaginalis PIKK family atypical protein kinase 0.1729 0.3285 0.3285
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0357 0.0494 0.0488
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.503 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0357 0.0494 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0357 0.0494 0.0488
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0335 0.0451 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.4284 0.8483 0.8483
Loa Loa (eye worm) phosphatidylinositol 3 0.0335 0.0451 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.401 0.7926 0.7926
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0357 0.0494 0.0488
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2371 0.4591 0.4588
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0467 0.0719 0.0713
Loa Loa (eye worm) phosphatidylinositol kinase 0.0335 0.0451 0.0445
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0542 0.0871 0.0871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0971 0.1744 0.1744
Loa Loa (eye worm) phosphatidylinositol 3 0.0335 0.0451 0.0445
Echinococcus granulosus serine protein kinase ATM 0.0971 0.1744 0.1739
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0335 0.0451 0.9107
Loa Loa (eye worm) phosphatidylinositol 3 0.503 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0335 0.0451 0.0445
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.04 0.0583 0.0583
Leishmania major phosphatidylinositol 3-kinase, putative 0.0357 0.0494 0.0488
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0636 0.1062 0.1056
Trichomonas vaginalis PIKK family atypical protein kinase 0.2737 0.5336 0.5336
Trichomonas vaginalis PIKK family atypical protein kinase 0.3753 0.7402 0.7402
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0335 0.0451 0.0445
Echinococcus multilocularis serine protein kinase ATM 0.0971 0.1744 0.1739
Loa Loa (eye worm) phosphatidylinositol 3 0.1729 0.3285 0.3281
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0335 0.0451 0.9107
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.04 0.0583 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.401 0.7926 0.7926
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0357 0.0494 0.0488
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0746 0.1286 0.128
Trichomonas vaginalis PIKK family atypical protein kinase 0.2737 0.5336 0.5336
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0335 0.0451 0.0445
Schistosoma mansoni hypothetical protein 0.0335 0.0451 0.0445
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0971 0.1744 0.1739
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0335 0.0451 0.0445
Onchocerca volvulus 0.0335 0.0451 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.401 0.7926 0.7926
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0542 0.0871 0.0866
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.04 0.0583 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0971 0.1744 0.1744
Giardia lamblia Hypothetical protein 0.0335 0.0451 0.0445
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0614 0.1017 0.1012
Trichomonas vaginalis PIKK family atypical protein kinase 0.2737 0.5336 0.5336
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0971 0.1744 0.1739
Trichomonas vaginalis PIKK family atypical protein kinase 0.503 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3753 0.7402 0.7402
Entamoeba histolytica hypothetical protein 0.0499 0.0783 0.0777
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0335 0.0451 0.0445
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0357 0.0494 0.0488
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0335 0.0451 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.2995 0.5859 0.5859
Plasmodium vivax hypothetical protein, conserved 0.0335 0.0451 0.9107
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0117 0.0006 0.0006
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.04 0.0583 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0636 0.1062 0.1062
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0499 0.0783 0.0777
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0039 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.2733 0.5327 0.5327
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0357 0.0494 0.0488
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.073 0.1253 0.1247
Trichomonas vaginalis PIKK family atypical protein kinase 0.3007 0.5885 0.5885
Loa Loa (eye worm) hypothetical protein 0.0746 0.1286 0.128
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0357 0.0494 0.0494
Trypanosoma cruzi target of rapamycin kinase 3 0.4014 0.7934 0.7933
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0542 0.0871 0.0866
Echinococcus multilocularis 0.0335 0.0451 0.0445
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0122 0.0016 0.001
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0424 0.063 0.0624
Loa Loa (eye worm) hypothetical protein 0.0467 0.0719 0.0713
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.503 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0207 0.0189 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.1081 0.1968 0.1968
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1772 0.3373 0.3368
Trichomonas vaginalis PIKK family atypical protein kinase 0.1717 0.3261 0.3261
Trichomonas vaginalis PIKK family atypical protein kinase 0.3007 0.5885 0.5885
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1772 0.3373 0.3368
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0122 0.0016 0.001
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.04 0.0583 0.0583
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.503 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0971 0.1744 0.1739
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.04 0.0583 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.401 0.7926 0.7926
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0971 0.1744 0.1739
Mycobacterium tuberculosis Conserved hypothetical protein 0.0335 0.0451 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1717 0.3261 0.3261
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.503 1 1
Toxoplasma gondii FATC domain-containing protein 0.0971 0.1744 0.186
Leishmania major phosphatidylinositol 4-kinase, putative 0.0335 0.0451 0.0445
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1772 0.3373 0.3368
Plasmodium vivax hypothetical protein 0.0335 0.0451 0.9107
Leishmania major hypothetical protein, conserved 0.0434 0.0652 0.0646
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1772 0.3373 0.3368
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0357 0.0494 0.0488
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1772 0.3373 0.3368
Brugia malayi FAT domain containing protein 0.0746 0.1286 0.128
Trichomonas vaginalis PIKK family atypical protein kinase 0.2733 0.5327 0.5327
Entamoeba histolytica hypothetical protein 0.0335 0.0451 0.0445
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0335 0.0451 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.3007 0.5885 0.5885
Toxoplasma gondii target of rapamycin (TOR), putative 0.3753 0.7402 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3753 0.7402 0.7402
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0335 0.0451 0.0445
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0335 0.0451 0.0445
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0357 0.0494 0.0063
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0357 0.0494 0.0488
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1772 0.3373 0.3368
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0357 0.0494 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0335 0.0451 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.3753 0.7402 0.7402
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0971 0.1744 0.1739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0335 0.0451 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.503 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0357 0.0494 0.0488
Entamoeba histolytica hypothetical protein 0.0971 0.1744 0.1739
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0542 0.0871 0.0871
Giardia lamblia Phosphatidylinositol 4-kinase 0.0335 0.0451 0.0445
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0335 0.0451 0.9107
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.073 0.1253 0.1247
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0188 0.015 0.0144
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0542 0.0871 0.0866
Loa Loa (eye worm) hypothetical protein 0.1081 0.1968 0.1963
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4014 0.7934 0.7933
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.503 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0746 0.1286 0.1286
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0335 0.0451 0.0445
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.503 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0117 0.0006 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1081 0.1968 0.2183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0983 0.1768 0.1768
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0335 0.0451 0.0445
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0335 0.0451 0.9107
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0542 0.0871 0.0866
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0467 0.0719 0.0713
Onchocerca volvulus 0.0335 0.0451 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.04 0.0583 0.0577
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0335 0.0451 0.9107
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.503 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.503 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3753 0.7402 0.7402
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0335 0.0451 0.0445
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0335 0.0451 0.0445
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0335 0.0451 0.0445
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4014 0.7934 0.7933
Schistosoma mansoni hypothetical protein 0.0746 0.1286 0.128
Trichomonas vaginalis immunophilin, putative 0.0117 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0971 0.1744 0.1739
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0335 0.0451 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.3375 0.6632 0.6632
Trichomonas vaginalis PIKK family atypical protein kinase 0.3753 0.7402 0.7402
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0971 0.1744 0.1739
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0542 0.0871 0.0871
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0122 0.0016 0.001
Entamoeba histolytica hypothetical protein 0.0335 0.0451 0.0445
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0432 0.0647 0.0641
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0117 0.0006 0.0006
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0467 0.0719 0.0713
Schistosoma mansoni fkbp-rapamycin associated protein 0.0971 0.1744 0.1739
Trichomonas vaginalis PIKK family atypical protein kinase 0.3753 0.7402 0.7402
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0117 0.0006 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0357 0.0494 0.0488
Echinococcus multilocularis Zinc finger, PHD finger 0.0357 0.0494 0.0488
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0614 0.1017 0.1012
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1717 0.3261 0.3257
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0335 0.0451 0.0445
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1729 0.3285 0.3281
Loa Loa (eye worm) hypothetical protein 0.0971 0.1744 0.1739
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0335 0.0451 0.0445
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0971 0.1744 0.1739
Entamoeba histolytica hypothetical protein 0.0335 0.0451 0.0445
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0335 0.0451 0.0445
Leishmania major phosphatidylinositol kinase, putative 0.0335 0.0451 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.2733 0.5327 0.5327
Trichomonas vaginalis PIKK family atypical protein kinase 0.503 1 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0335 0.0451 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.401 0.7926 0.7926
Trichomonas vaginalis PIKK family atypical protein kinase 0.2737 0.5336 0.5336
Trichomonas vaginalis fk506-binding protein, putative 0.0117 0.0006 0.0006
Leishmania major hypothetical protein, unknown function 0.0335 0.0451 0.0445
Loa Loa (eye worm) hypothetical protein 0.0636 0.1062 0.1056
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2101 0.4043 0.4039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0335 0.0451 0.0445
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0475 0.0736 0.0736
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0746 0.1286 0.128
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0357 0.0494 0.0494
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0983 0.1768 0.1763
Trichomonas vaginalis PIKK family atypical protein kinase 0.1717 0.3261 0.3261
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.04 0.0583 0.0577
Loa Loa (eye worm) phosphatidylinositol 3 0.0335 0.0451 0.0445
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0357 0.0494 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.503 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0686 0.1164 0.1159
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0357 0.0494 0.0488
Loa Loa (eye worm) hypothetical protein 0.0335 0.0451 0.0445
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.503 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1717 0.3261 0.3261
Mycobacterium leprae conserved hypothetical protein 0.0335 0.0451 0.5

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.021 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.98 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.814 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.458 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.246 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.159 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.063 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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