Detailed information for compound 1647141

Basic information

Technical information
  • TDR Targets ID: 1647141
  • Name: 5,6-di(furan-2-yl)-1,2,4-triazin-3-amine
  • MW: 228.207 | Formula: C11H8N4O2
  • H donors: 1 H acceptors: 3 LogP: 0.37 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nnc(c(n1)c1ccco1)c1ccco1
  • InChi: 1S/C11H8N4O2/c12-11-13-9(7-3-1-5-16-7)10(14-15-11)8-4-2-6-17-8/h1-6H,(H2,12,13,15)
  • InChiKey: FXQZYFBJCFGSAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5,6-bis(2-furyl)-1,2,4-triazin-3-amine
  • [5,6-bis(2-furyl)-1,2,4-triazin-3-yl]amine
  • 5,6-Di(2-furyl)-1,2,4-triazin-3-amine
  • 5,6-Di(2-furyl)-1,2,4-triazin-3-ylamine
  • AIDS-152279
  • AIDS152279
  • NSC695602
  • NCI60_034185
  • ZINC01517010

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1766 0.3375 0.3369
Trichomonas vaginalis PIKK family atypical protein kinase 0.1711 0.3262 0.3262
Trichomonas vaginalis PIKK family atypical protein kinase 0.2995 0.5885 0.5885
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1766 0.3375 0.3369
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0121 0.0016 0.0007
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5011 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.04 0.0585 0.0585
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0968 0.1745 0.1737
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.04 0.0585 0.0585
Echinococcus multilocularis 0.0334 0.0452 0.0443
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0121 0.0016 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.0633 0.0624
Loa Loa (eye worm) hypothetical protein 0.0467 0.0722 0.0713
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5011 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0208 0.0194 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.1077 0.1969 0.1969
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1766 0.3375 0.3369
Leishmania major hypothetical protein, conserved 0.0434 0.0654 0.0646
Plasmodium vivax hypothetical protein 0.0334 0.0452 0.9095
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0356 0.0496 0.0487
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1766 0.3375 0.3369
Brugia malayi FAT domain containing protein 0.0743 0.1287 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.3995 0.7926 0.7926
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0968 0.1745 0.1737
Mycobacterium tuberculosis Conserved hypothetical protein 0.0334 0.0452 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1711 0.3262 0.3262
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5011 1 1
Toxoplasma gondii FATC domain-containing protein 0.0968 0.1745 0.1861
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1766 0.3375 0.3369
Leishmania major phosphatidylinositol 4-kinase, putative 0.0334 0.0452 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.2727 0.5337 0.5337
Giardia lamblia Hypothetical protein 0.0334 0.0452 0.0443
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0614 0.1024 0.1015
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0968 0.1745 0.1737
Trichomonas vaginalis PIKK family atypical protein kinase 0.5011 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3738 0.7402 0.7402
Entamoeba histolytica hypothetical protein 0.0498 0.0787 0.0778
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0334 0.0452 0.0443
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0356 0.0496 0.0487
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0334 0.0452 0.0443
Schistosoma mansoni hypothetical protein 0.0334 0.0452 0.0443
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0968 0.1745 0.1737
Onchocerca volvulus 0.0334 0.0452 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0334 0.0452 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.3995 0.7926 0.7926
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0542 0.0876 0.0868
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.04 0.0585 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0968 0.1745 0.1745
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0356 0.0496 0.0487
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0731 0.1261 0.1253
Trichomonas vaginalis PIKK family atypical protein kinase 0.2995 0.5885 0.5885
Loa Loa (eye worm) hypothetical protein 0.0743 0.1287 0.1279
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0356 0.0496 0.0496
Trypanosoma cruzi target of rapamycin kinase 3 0.3999 0.7934 0.7932
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0542 0.0876 0.0868
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0334 0.0452 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.2983 0.586 0.586
Plasmodium vivax hypothetical protein, conserved 0.0334 0.0452 0.9095
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0118 0.0009 0.0009
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.04 0.0585 0.0576
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0498 0.0787 0.0778
Trichomonas vaginalis conserved hypothetical protein 0.0633 0.1062 0.1062
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0039 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.2723 0.5328 0.5328
Loa Loa (eye worm) phosphatidylinositol 3 0.0334 0.0452 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.3995 0.7926 0.7926
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0356 0.0496 0.0487
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2362 0.4592 0.4587
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0467 0.0722 0.0713
Loa Loa (eye worm) phosphatidylinositol kinase 0.0334 0.0452 0.0443
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0542 0.0876 0.0876
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0356 0.0496 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.1723 0.3286 0.3286
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5011 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0356 0.0496 0.0487
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0356 0.0496 0.0487
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0356 0.0496 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0334 0.0452 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.4267 0.8482 0.8482
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0334 0.0452 0.0443
Echinococcus multilocularis serine protein kinase ATM 0.0968 0.1745 0.1737
Loa Loa (eye worm) phosphatidylinositol 3 0.1723 0.3286 0.328
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0334 0.0452 0.9095
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.04 0.0585 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.3995 0.7926 0.7926
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0743 0.1287 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.2727 0.5337 0.5337
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0356 0.0496 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0968 0.1745 0.1745
Echinococcus granulosus serine protein kinase ATM 0.0968 0.1745 0.1737
Loa Loa (eye worm) phosphatidylinositol 3 0.0334 0.0452 0.0443
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0334 0.0452 0.9095
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.04 0.0585 0.0585
Loa Loa (eye worm) phosphatidylinositol 3 0.5011 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0334 0.0452 0.0443
Leishmania major phosphatidylinositol 3-kinase, putative 0.0356 0.0496 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.2727 0.5337 0.5337
Trichomonas vaginalis PIKK family atypical protein kinase 0.3738 0.7402 0.7402
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0633 0.1062 0.1054
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0731 0.1261 0.1253
Loa Loa (eye worm) hypothetical protein 0.1012 0.1835 0.1827
Trichomonas vaginalis PIKK family atypical protein kinase 0.3252 0.6408 0.6408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0633 0.1062 0.1062
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0356 0.0496 0.0063
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0334 0.0452 0.0452
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0121 0.0016 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0475 0.0739 0.0739
Leishmania major phosphatidylinositol 3-kinase, putative 0.1711 0.3262 0.3256
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0039 0.003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0334 0.0452 0.0452
Trichomonas vaginalis PIKK family atypical protein kinase 0.2983 0.586 0.586
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0356 0.0496 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.1346 0.2517 0.2517
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0378 0.0541 0.0532
Giardia lamblia GTOR 0.5011 1 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1723 0.3286 0.328
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.04 0.0585 0.0576
Entamoeba histolytica protein kinase rad3, putative 0.0968 0.1745 0.1737
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5011 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0334 0.0452 0.0443
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.04 0.0585 0.0576
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0356 0.0496 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5011 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0475 0.0739 0.0739
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2093 0.4043 0.4038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0334 0.0452 0.0443
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0743 0.1287 0.1279
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0356 0.0496 0.0496
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0979 0.1769 0.1761
Trichomonas vaginalis PIKK family atypical protein kinase 0.1711 0.3262 0.3262
Mycobacterium leprae conserved hypothetical protein 0.0334 0.0452 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0687 0.1172 0.1164
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0356 0.0496 0.0487
Loa Loa (eye worm) hypothetical protein 0.0334 0.0452 0.0443
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5011 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1711 0.3262 0.3262
Schistosoma mansoni fkbp-rapamycin associated protein 0.0968 0.1745 0.1737
Trichomonas vaginalis PIKK family atypical protein kinase 0.3738 0.7402 0.7402
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0118 0.0009 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0356 0.0496 0.0487
Echinococcus multilocularis Zinc finger, PHD finger 0.0356 0.0496 0.0487
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0614 0.1024 0.1015
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0968 0.1745 0.1737
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0121 0.0016 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0542 0.0876 0.0876
Entamoeba histolytica hypothetical protein 0.0334 0.0452 0.0443
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0431 0.065 0.0641
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0118 0.0009 0.0009
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0467 0.0722 0.0713
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0334 0.0452 0.0443
Leishmania major phosphatidylinositol kinase, putative 0.0334 0.0452 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.2723 0.5328 0.5328
Trichomonas vaginalis PIKK family atypical protein kinase 0.5011 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2727 0.5337 0.5337
Leishmania major phosphatidylinositol kinase related protein, putative 0.0334 0.0452 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.3995 0.7926 0.7926
Trichomonas vaginalis fk506-binding protein, putative 0.0118 0.0009 0.0009
Leishmania major hypothetical protein, unknown function 0.0334 0.0452 0.0443
Loa Loa (eye worm) hypothetical protein 0.0633 0.1062 0.1054
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1711 0.3262 0.3256
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0334 0.0452 0.0443
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1723 0.3286 0.328
Loa Loa (eye worm) hypothetical protein 0.0968 0.1745 0.1737
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0334 0.0452 0.0443
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0968 0.1745 0.1737
Entamoeba histolytica hypothetical protein 0.0334 0.0452 0.0443
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0467 0.0722 0.0713
Onchocerca volvulus 0.0334 0.0452 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.04 0.0585 0.0576
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0334 0.0452 0.9095
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5011 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5011 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0743 0.1287 0.1287
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0334 0.0452 0.0443
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5011 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0118 0.0009 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1077 0.1969 0.2183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0979 0.1769 0.1769
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0334 0.0452 0.0443
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0542 0.0876 0.0868
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0334 0.0452 0.9095
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0334 0.0452 0.0443
Schistosoma mansoni hypothetical protein 0.0743 0.1287 0.1279
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3999 0.7934 0.7932
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0968 0.1745 0.1737
Trichomonas vaginalis immunophilin, putative 0.0118 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.3738 0.7402 0.7402
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0334 0.0452 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.3361 0.6633 0.6633
Trichomonas vaginalis PIKK family atypical protein kinase 0.3738 0.7402 0.7402
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0334 0.0452 0.0443
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0334 0.0452 0.0443
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0334 0.0452 0.0443
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0356 0.0496 0.0487
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0356 0.0496 0.0063
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0356 0.0496 0.0487
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1766 0.3375 0.3369
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0968 0.1745 0.1737
Trichomonas vaginalis PIKK family atypical protein kinase 0.3738 0.7402 0.7402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0334 0.0452 0.0452
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0356 0.0496 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.5011 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0334 0.0452 0.0452
Entamoeba histolytica hypothetical protein 0.0334 0.0452 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.2723 0.5328 0.5328
Toxoplasma gondii target of rapamycin (TOR), putative 0.3738 0.7402 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2995 0.5885 0.5885
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0334 0.0452 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.3738 0.7402 0.7402
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0334 0.0452 0.0443
Loa Loa (eye worm) hypothetical protein 0.1077 0.1969 0.1962
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3999 0.7934 0.7932
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5011 1 1
Entamoeba histolytica hypothetical protein 0.0968 0.1745 0.1737
Giardia lamblia Phosphatidylinositol 4-kinase 0.0334 0.0452 0.0443
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0542 0.0876 0.0876
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0334 0.0452 0.9095
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0731 0.1261 0.1253
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0189 0.0154 0.0145
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0542 0.0876 0.0868

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.302 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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