Detailed information for compound 1647142

Basic information

Technical information
  • TDR Targets ID: 1647142
  • Name: 2-methoxy-4-(8-methoxy-4-methylidenechroman-2 -yl)phenol
  • MW: 298.333 | Formula: C18H18O4
  • H donors: 1 H acceptors: 1 LogP: 3.44 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1O)C1CC(=C)c2c(O1)c(OC)ccc2
  • InChi: 1S/C18H18O4/c1-11-9-16(12-7-8-14(19)17(10-12)21-3)22-18-13(11)5-4-6-15(18)20-2/h4-8,10,16,19H,1,9H2,2-3H3
  • InChiKey: MXYXASHSXFVAMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-methoxy-4-(8-methoxy-4-methylene-chroman-2-yl)phenol
  • 2-methoxy-4-(8-methoxy-4-methylene-2-chromanyl)phenol
  • 2-methoxy-4-(8-methoxy-4-methylidene-chroman-2-yl)phenol
  • 2-Methoxy-4-(8-methoxy-4-methylene-3,4-dihydro-2H-chromen-2-yl)phenol
  • 4'-Hydroxy-3',8-dimethoxy flavanone
  • AIDS-137413
  • AIDS137413
  • NSC641526
  • NCI60_014048

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0788 0.1295 0.1288
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4243 0.7935 0.7934
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0354 0.0461 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.3567 0.6636 0.6636
Trichomonas vaginalis PIKK family atypical protein kinase 0.3967 0.7404 0.7404
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0354 0.0461 0.0454
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1026 0.1752 0.1745
Trichomonas vaginalis immunophilin, putative 0.0118 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.3967 0.7404 0.7404
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0354 0.0461 0.0454
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0354 0.0461 0.0454
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0354 0.0461 0.9162
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0419 0.0587 0.0579
Onchocerca volvulus 0.0354 0.0461 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0486 0.0716 0.0708
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5317 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5317 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0118 0.0008 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1142 0.1976 0.2181
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5317 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0354 0.0461 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0788 0.1295 0.1295
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0354 0.0461 0.9162
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0562 0.0861 0.0853
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0354 0.0461 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.1037 0.1775 0.1775
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5317 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4243 0.7935 0.7934
Loa Loa (eye worm) hypothetical protein 0.1142 0.1976 0.1969
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0354 0.0461 0.9162
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.075 0.1223 0.1216
Giardia lamblia Phosphatidylinositol 4-kinase 0.0354 0.0461 0.0454
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0562 0.0861 0.0861
Entamoeba histolytica hypothetical protein 0.1026 0.1752 0.1745
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0562 0.0861 0.0853
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0189 0.0143 0.0135
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0376 0.0503 0.0495
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0376 0.0503 0.006
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0354 0.0461 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0461 0.0461
Trichomonas vaginalis PIKK family atypical protein kinase 0.5317 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0503 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.3967 0.7404 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0461 0.0461
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1026 0.1752 0.1745
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0376 0.0503 0.0495
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1869 0.3372 0.3367
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0354 0.0461 0.0454
Toxoplasma gondii target of rapamycin (TOR), putative 0.3967 0.7404 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3179 0.5889 0.5889
Entamoeba histolytica hypothetical protein 0.0354 0.0461 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.2888 0.5331 0.5331
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0354 0.0461 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.3967 0.7404 0.7404
Mycobacterium leprae conserved hypothetical protein 0.0354 0.0461 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0707 0.1139 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.1814 0.3267 0.3267
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5317 1 1
Loa Loa (eye worm) hypothetical protein 0.0354 0.0461 0.0454
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0503 0.0495
Loa Loa (eye worm) phosphatidylinositol 3 0.0354 0.0461 0.0454
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0419 0.0587 0.0579
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5317 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0376 0.0503 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0495 0.0732 0.0732
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2221 0.4049 0.4044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0354 0.0461 0.0454
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1037 0.1775 0.1768
Trichomonas vaginalis PIKK family atypical protein kinase 0.1814 0.3267 0.3267
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0376 0.0503 0.0503
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0788 0.1295 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.5317 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0354 0.0461 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.2888 0.5331 0.5331
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0354 0.0461 0.0454
Loa Loa (eye worm) hypothetical protein 0.0672 0.1072 0.1064
Leishmania major hypothetical protein, unknown function 0.0354 0.0461 0.0454
Trichomonas vaginalis fk506-binding protein, putative 0.0118 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.4239 0.7927 0.7927
Trichomonas vaginalis PIKK family atypical protein kinase 0.2892 0.5339 0.5339
Leishmania major phosphatidylinositol kinase related protein, putative 0.0354 0.0461 0.0454
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0354 0.0461 0.0454
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1814 0.3267 0.3261
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1026 0.1752 0.1745
Entamoeba histolytica hypothetical protein 0.0354 0.0461 0.0454
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0354 0.0461 0.0454
Loa Loa (eye worm) hypothetical protein 0.1026 0.1752 0.1745
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1825 0.3289 0.3284
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0376 0.0503 0.0495
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0118 0.0008 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3967 0.7404 0.7404
Schistosoma mansoni fkbp-rapamycin associated protein 0.1026 0.1752 0.1745
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0634 0.0999 0.0992
Echinococcus multilocularis Zinc finger, PHD finger 0.0376 0.0503 0.0495
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1026 0.1752 0.1745
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0486 0.0716 0.0708
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0118 0.0008 0.0008
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0451 0.0648 0.064
Entamoeba histolytica hypothetical protein 0.0354 0.0461 0.0454
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0562 0.0861 0.0861
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0122 0.0015 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.1825 0.3289 0.3284
Echinococcus multilocularis serine protein kinase ATM 0.1026 0.1752 0.1745
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0354 0.0461 0.0454
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0503 0.0495
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0419 0.0587 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.4239 0.7927 0.7927
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0788 0.1295 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.2892 0.5339 0.5339
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0354 0.0461 0.9162
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0354 0.0461 0.9162
Loa Loa (eye worm) phosphatidylinositol 3 0.0354 0.0461 0.0454
Echinococcus granulosus serine protein kinase ATM 0.1026 0.1752 0.1745
Trichomonas vaginalis PIKK family atypical protein kinase 0.1026 0.1752 0.1752
Trichomonas vaginalis PIKK family atypical protein kinase 0.3967 0.7404 0.7404
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0672 0.1072 0.1064
Trichomonas vaginalis PIKK family atypical protein kinase 0.2892 0.5339 0.5339
Leishmania major phosphatidylinositol 3-kinase, putative 0.0376 0.0503 0.0495
Loa Loa (eye worm) phosphatidylinositol 3 0.5317 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0419 0.0587 0.0587
Loa Loa (eye worm) phosphatidylinositol 3 0.0354 0.0461 0.0454
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2507 0.4599 0.4594
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0503 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.4239 0.7927 0.7927
Loa Loa (eye worm) phosphatidylinositol 3 0.0354 0.0461 0.0454
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0562 0.0861 0.0861
Loa Loa (eye worm) phosphatidylinositol kinase 0.0354 0.0461 0.0454
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0486 0.0716 0.0708
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0376 0.0503 0.0495
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5317 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1825 0.3289 0.3289
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0376 0.0503 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.4529 0.8486 0.8486
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0354 0.0461 0.0454
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0376 0.0503 0.0495
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0376 0.0503 1
Giardia lamblia GTOR 0.5317 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0398 0.0545 0.0538
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1825 0.3289 0.3284
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0419 0.0587 0.0579
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5317 1 1
Entamoeba histolytica protein kinase rad3, putative 0.1026 0.1752 0.1745
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0354 0.0461 0.0461
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0376 0.0503 0.006
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0122 0.0015 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.3451 0.6413 0.6413
Loa Loa (eye worm) hypothetical protein 0.1074 0.1845 0.1839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0672 0.1072 0.1072
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.075 0.1223 0.1216
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0037 0.0029
Leishmania major phosphatidylinositol 3-kinase, putative 0.1814 0.3267 0.3261
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0495 0.0732 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.1428 0.2526 0.2526
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0376 0.0503 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.3165 0.5863 0.5863
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0354 0.0461 0.0461
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0376 0.0503 0.0495
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1869 0.3372 0.3367
Plasmodium vivax hypothetical protein 0.0354 0.0461 0.9162
Leishmania major hypothetical protein, conserved 0.0453 0.0652 0.0644
Brugia malayi FAT domain containing protein 0.0788 0.1295 0.1288
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1869 0.3372 0.3367
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5317 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1814 0.3267 0.3267
Mycobacterium tuberculosis Conserved hypothetical protein 0.0354 0.0461 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4239 0.7927 0.7927
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1026 0.1752 0.1745
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1869 0.3372 0.3367
Leishmania major phosphatidylinositol 4-kinase, putative 0.0354 0.0461 0.0454
Toxoplasma gondii FATC domain-containing protein 0.1026 0.1752 0.1859
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0122 0.0015 0.0007
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1869 0.3372 0.3367
Trichomonas vaginalis PIKK family atypical protein kinase 0.3179 0.5889 0.5889
Trichomonas vaginalis PIKK family atypical protein kinase 0.1814 0.3267 0.3267
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1869 0.3372 0.3367
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0419 0.0587 0.0587
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1026 0.1752 0.1745
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0419 0.0587 0.0587
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5317 1 1
Loa Loa (eye worm) hypothetical protein 0.0486 0.0716 0.0708
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0122 0.0015 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0443 0.0632 0.0624
Echinococcus multilocularis 0.0354 0.0461 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.1142 0.1976 0.1976
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0208 0.018 0.0172
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5317 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0376 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0788 0.1295 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.3179 0.5889 0.5889
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0376 0.0503 0.0495
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.075 0.1223 0.1216
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0562 0.0861 0.0853
Trypanosoma cruzi target of rapamycin kinase 3 0.4243 0.7935 0.7934
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0419 0.0587 0.0579
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0118 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.3165 0.5863 0.5863
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0354 0.0461 0.0454
Plasmodium vivax hypothetical protein, conserved 0.0354 0.0461 0.9162
Trichomonas vaginalis PIKK family atypical protein kinase 0.2888 0.5331 0.5331
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0037 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0672 0.1072 0.1072
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0518 0.0777 0.0769
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1026 0.1752 0.1745
Trichomonas vaginalis PIKK family atypical protein kinase 0.2892 0.5339 0.5339
Giardia lamblia Hypothetical protein 0.0354 0.0461 0.0454
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0634 0.0999 0.0992
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0376 0.0503 0.0495
Entamoeba histolytica hypothetical protein 0.0518 0.0777 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.3967 0.7404 0.7404
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0354 0.0461 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.5317 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1026 0.1752 0.1745
Schistosoma mansoni hypothetical protein 0.0354 0.0461 0.0454
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0354 0.0461 0.0454
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0419 0.0587 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.1026 0.1752 0.1752
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0562 0.0861 0.0853
Trichomonas vaginalis PIKK family atypical protein kinase 0.4239 0.7927 0.7927
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0354 0.0461 0.0454
Onchocerca volvulus 0.0354 0.0461 0.5

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.887 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.842 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.671 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.483 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.464 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.447 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.324 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.22 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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