Detailed information for compound 1647144

Basic information

Technical information
  • TDR Targets ID: 1647144
  • Name: 1,2,3,5,6,7-hexahydropyrrolizine-8-carbaldehy de
  • MW: 139.195 | Formula: C8H13NO
  • H donors: 0 H acceptors: 1 LogP: 0.63 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CC12CCCN2CCC1
  • InChi: 1S/C8H13NO/c10-7-8-3-1-5-9(8)6-2-4-8/h7H,1-6H2
  • InChiKey: VVWRHELZTWIQIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1,2,3,5,6,7-hexahydropyrrolizine-8-carboxaldehyde
  • pyrrolizidine-8-carbaldehyde
  • AIDS-152633
  • NSC697384
  • Tetrahydro-1H-pyrrolizine-7a(5H)-carbaldehyde
  • NCI60_034722
  • AIDS152633

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0657 0.1069 0.1069
Trichomonas vaginalis PIKK family atypical protein kinase 0.3376 0.6411 0.6411
Loa Loa (eye worm) hypothetical protein 0.1051 0.1842 0.1835
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0368 0.0501 0.0061
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0347 0.0459 0.0459
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0121 0.0016 0.0007
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0743 0.1238 0.1231
Leishmania major phosphatidylinositol 3-kinase, putative 0.1775 0.3266 0.326
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0038 0.0029
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0487 0.0736 0.0736
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0368 0.0501 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.1397 0.2524 0.2524
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0347 0.0459 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.3096 0.5862 0.5862
Giardia lamblia GTOR 0.5202 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.039 0.0545 0.0537
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1787 0.3289 0.3283
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0412 0.0587 0.0579
Entamoeba histolytica protein kinase rad3, putative 0.1004 0.175 0.1743
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5202 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2452 0.4597 0.4592
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0368 0.0501 0.0493
Loa Loa (eye worm) phosphatidylinositol 3 0.0347 0.0459 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.4147 0.7927 0.7927
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0555 0.0867 0.0867
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0479 0.0719 0.0711
Loa Loa (eye worm) phosphatidylinositol kinase 0.0347 0.0459 0.045
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0368 0.0501 0.0493
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5202 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0368 0.0501 0.0501
Trichomonas vaginalis PIKK family atypical protein kinase 0.1787 0.3289 0.3289
Trichomonas vaginalis PIKK family atypical protein kinase 0.4431 0.8485 0.8485
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0368 0.0501 0.0493
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0368 0.0501 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0347 0.0459 0.045
Loa Loa (eye worm) phosphatidylinositol 3 0.1787 0.3289 0.3283
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0347 0.0459 0.045
Echinococcus multilocularis serine protein kinase ATM 0.1004 0.175 0.1743
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0347 0.0459 0.9139
Trichomonas vaginalis PIKK family atypical protein kinase 0.4147 0.7927 0.7927
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0368 0.0501 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.283 0.5339 0.5339
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0771 0.1293 0.1285
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0412 0.0587 0.0579
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0347 0.0459 0.9139
Trichomonas vaginalis PIKK family atypical protein kinase 0.1004 0.175 0.175
Loa Loa (eye worm) phosphatidylinositol 3 0.0347 0.0459 0.045
Echinococcus granulosus serine protein kinase ATM 0.1004 0.175 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.283 0.5339 0.5339
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0657 0.1069 0.1061
Trichomonas vaginalis PIKK family atypical protein kinase 0.3881 0.7404 0.7404
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0412 0.0587 0.0587
Loa Loa (eye worm) phosphatidylinositol 3 0.5202 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0347 0.0459 0.045
Leishmania major phosphatidylinositol 3-kinase, putative 0.0368 0.0501 0.0493
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1004 0.175 0.1743
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0627 0.1009 0.1001
Trichomonas vaginalis PIKK family atypical protein kinase 0.283 0.5339 0.5339
Giardia lamblia Hypothetical protein 0.0347 0.0459 0.045
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0368 0.0501 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.5202 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3881 0.7404 0.7404
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0347 0.0459 0.045
Entamoeba histolytica hypothetical protein 0.0511 0.0781 0.0773
Schistosoma mansoni hypothetical protein 0.0347 0.0459 0.045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1004 0.175 0.1743
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0347 0.0459 0.045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0555 0.0867 0.0859
Trichomonas vaginalis PIKK family atypical protein kinase 0.1004 0.175 0.175
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0412 0.0587 0.0579
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0347 0.0459 0.045
Onchocerca volvulus 0.0347 0.0459 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4147 0.7927 0.7927
Loa Loa (eye worm) hypothetical protein 0.0771 0.1293 0.1285
Trichomonas vaginalis PIKK family atypical protein kinase 0.311 0.5888 0.5888
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0368 0.0501 0.0501
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0368 0.0501 0.0493
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0743 0.1238 0.1231
Trypanosoma cruzi target of rapamycin kinase 3 0.4151 0.7935 0.7933
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0555 0.0867 0.0859
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0412 0.0587 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.3096 0.5862 0.5862
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0347 0.0459 0.045
Plasmodium vivax hypothetical protein, conserved 0.0347 0.0459 0.9139
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0118 0.0009 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0038 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.2826 0.5331 0.5331
Trichomonas vaginalis conserved hypothetical protein 0.0657 0.1069 0.1069
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0511 0.0781 0.0773
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.183 0.3374 0.3368
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0121 0.0016 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.183 0.3374 0.3368
Trichomonas vaginalis PIKK family atypical protein kinase 0.1775 0.3266 0.3266
Trichomonas vaginalis PIKK family atypical protein kinase 0.311 0.5888 0.5888
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1004 0.175 0.1743
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0412 0.0587 0.0587
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5202 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0412 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0479 0.0719 0.0711
Echinococcus multilocularis 0.0347 0.0459 0.045
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0121 0.0016 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0435 0.0633 0.0625
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0208 0.0186 0.0178
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5202 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1118 0.1974 0.1974
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.183 0.3374 0.3368
Leishmania major hypothetical protein, conserved 0.0446 0.0654 0.0646
Plasmodium vivax hypothetical protein 0.0347 0.0459 0.9139
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0368 0.0501 0.0493
Brugia malayi FAT domain containing protein 0.0771 0.1293 0.1285
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.183 0.3374 0.3368
Trichomonas vaginalis PIKK family atypical protein kinase 0.1775 0.3266 0.3266
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5202 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4147 0.7927 0.7927
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1004 0.175 0.1743
Mycobacterium tuberculosis Conserved hypothetical protein 0.0347 0.0459 0.5
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.183 0.3374 0.3368
Leishmania major phosphatidylinositol 4-kinase, putative 0.0347 0.0459 0.045
Toxoplasma gondii FATC domain-containing protein 0.1004 0.175 0.186
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0347 0.0459 0.045
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0368 0.0501 0.0061
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0368 0.0501 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.5202 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0347 0.0459 0.0459
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0368 0.0501 0.0493
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0368 0.0501 0.0493
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.183 0.3374 0.3368
Trichomonas vaginalis PIKK family atypical protein kinase 0.3881 0.7404 0.7404
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1004 0.175 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0347 0.0459 0.0459
Toxoplasma gondii target of rapamycin (TOR), putative 0.3881 0.7404 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.311 0.5888 0.5888
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0347 0.0459 0.045
Entamoeba histolytica hypothetical protein 0.0347 0.0459 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.2826 0.5331 0.5331
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0347 0.0459 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.3881 0.7404 0.7404
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4151 0.7935 0.7933
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5202 1 1
Loa Loa (eye worm) hypothetical protein 0.1118 0.1974 0.1967
Giardia lamblia Phosphatidylinositol 4-kinase 0.0347 0.0459 0.045
Entamoeba histolytica hypothetical protein 0.1004 0.175 0.1743
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0555 0.0867 0.0867
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0347 0.0459 0.9139
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0743 0.1238 0.1231
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0555 0.0867 0.0859
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0189 0.0149 0.014
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0347 0.0459 0.9139
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0479 0.0719 0.0711
Onchocerca volvulus 0.0347 0.0459 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0412 0.0587 0.0579
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5202 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5202 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5202 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1118 0.1974 0.2182
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0118 0.0009 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0771 0.1293 0.1293
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0347 0.0459 0.045
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0347 0.0459 0.045
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0347 0.0459 0.9139
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0555 0.0867 0.0859
Trichomonas vaginalis PIKK family atypical protein kinase 0.1016 0.1773 0.1773
Schistosoma mansoni hypothetical protein 0.0771 0.1293 0.1285
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4151 0.7935 0.7933
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0347 0.0459 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.3881 0.7404 0.7404
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0347 0.0459 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.349 0.6635 0.6635
Trichomonas vaginalis immunophilin, putative 0.0118 0.0009 0.0009
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1004 0.175 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.3881 0.7404 0.7404
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0347 0.0459 0.045
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0347 0.0459 0.045
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0118 0.0009 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0368 0.0501 0.0493
Schistosoma mansoni fkbp-rapamycin associated protein 0.1004 0.175 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.3881 0.7404 0.7404
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0627 0.1009 0.1001
Echinococcus multilocularis Zinc finger, PHD finger 0.0368 0.0501 0.0493
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1004 0.175 0.1743
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0118 0.0009 0.0009
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0479 0.0719 0.0711
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0555 0.0867 0.0867
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0121 0.0016 0.0007
Entamoeba histolytica hypothetical protein 0.0347 0.0459 0.045
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0444 0.065 0.0641
Leishmania major phosphatidylinositol kinase, putative 0.0347 0.0459 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.2826 0.5331 0.5331
Trichomonas vaginalis PIKK family atypical protein kinase 0.5202 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0347 0.0459 0.045
Leishmania major hypothetical protein, unknown function 0.0347 0.0459 0.045
Loa Loa (eye worm) hypothetical protein 0.0657 0.1069 0.1061
Trichomonas vaginalis PIKK family atypical protein kinase 0.283 0.5339 0.5339
Trichomonas vaginalis PIKK family atypical protein kinase 0.4147 0.7927 0.7927
Leishmania major phosphatidylinositol kinase related protein, putative 0.0347 0.0459 0.045
Trichomonas vaginalis fk506-binding protein, putative 0.0118 0.0009 0.0009
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1775 0.3266 0.326
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0347 0.0459 0.045
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0347 0.0459 0.045
Entamoeba histolytica hypothetical protein 0.0347 0.0459 0.045
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1004 0.175 0.1743
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1787 0.3289 0.3283
Loa Loa (eye worm) hypothetical protein 0.1004 0.175 0.1743
Loa Loa (eye worm) phosphatidylinositol 3 0.0347 0.0459 0.045
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0412 0.0587 0.0579
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5202 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0368 0.0501 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0347 0.0459 0.045
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0487 0.0736 0.0736
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2173 0.4047 0.4042
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0771 0.1293 0.1285
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0368 0.0501 0.0501
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1016 0.1773 0.1766
Trichomonas vaginalis PIKK family atypical protein kinase 0.1775 0.3266 0.3266
Mycobacterium leprae conserved hypothetical protein 0.0347 0.0459 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.07 0.1152 0.1144
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5202 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1775 0.3266 0.3266
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0368 0.0501 0.0493
Loa Loa (eye worm) hypothetical protein 0.0347 0.0459 0.045

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.