Detailed information for compound 1647146

Basic information

Technical information
  • TDR Targets ID: 1647146
  • Name: 5,6-bis(1,2-dihydroxyethyl)-1,4-dioxane-2,3-d ione
  • MW: 236.176 | Formula: C8H12O8
  • H donors: 4 H acceptors: 6 LogP: -2.3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(C1OC(=O)C(=O)OC1C(CO)O)O
  • InChi: 1S/C8H12O8/c9-1-3(11)5-6(4(12)2-10)16-8(14)7(13)15-5/h3-6,9-12H,1-2H2
  • InChiKey: NPXVGARLFHBJTQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5,6-bis(1,2-dihydroxyethyl)-1,4-dioxane-2,3-quinone
  • NSC661460
  • NCI60_021413
  • 5,6-Bis-(1,2-dihydroxy-ethyl)-[1,4]dioxane-2,3-dione
  • AIDS-142901
  • AIDS142901

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.1035 0.1964 0.1957
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4808 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3838 0.7933 0.7931
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0321 0.0445 0.9057
Brugia malayi FAT domain containing protein 0.0713 0.128 0.1273
Giardia lamblia Phosphatidylinositol 4-kinase 0.0321 0.0445 0.0437
Entamoeba histolytica hypothetical protein 0.0929 0.174 0.1733
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0527 0.0882 0.0882
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0187 0.0158 0.015
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0527 0.0882 0.0875
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0342 0.049 0.0482
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0342 0.049 0.0065
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0321 0.0445 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.3588 0.7401 0.7401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.0445 0.0445
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0929 0.174 0.1733
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0342 0.049 0.0482
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1697 0.3375 0.3369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.0445 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.4808 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0342 0.049 0.0482
Entamoeba histolytica hypothetical protein 0.0321 0.0445 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.2613 0.5326 0.5326
Trichomonas vaginalis PIKK family atypical protein kinase 0.2874 0.5882 0.5882
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0321 0.0445 0.0437
Toxoplasma gondii target of rapamycin (TOR), putative 0.3588 0.7401 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3588 0.7401 0.7401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0321 0.0445 0.0437
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0321 0.0445 0.0437
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3838 0.7933 0.7931
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0713 0.128 0.1272
Trichomonas vaginalis immunophilin, putative 0.0116 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0929 0.174 0.1733
Trichomonas vaginalis PIKK family atypical protein kinase 0.3226 0.663 0.663
Trichomonas vaginalis PIKK family atypical protein kinase 0.3588 0.7401 0.7401
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0321 0.0445 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.3588 0.7401 0.7401
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0321 0.0445 0.0437
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0321 0.0445 0.0437
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0386 0.0582 0.0574
Onchocerca volvulus 0.0321 0.0445 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0452 0.0723 0.0716
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0321 0.0445 0.9057
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4808 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4808 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0321 0.0445 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0713 0.128 0.128
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0116 0.0008 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1035 0.1964 0.2184
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4808 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0941 0.1764 0.1764
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0321 0.0445 0.9057
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0527 0.0882 0.0875
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0321 0.0445 0.0437
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0321 0.0445 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.4808 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2613 0.5326 0.5326
Leishmania major phosphatidylinositol kinase, putative 0.0321 0.0445 0.0437
Trichomonas vaginalis fk506-binding protein, putative 0.0116 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.2617 0.5334 0.5334
Trichomonas vaginalis PIKK family atypical protein kinase 0.3834 0.7925 0.7925
Leishmania major phosphatidylinositol kinase related protein, putative 0.0321 0.0445 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0608 0.1056 0.1056
Leishmania major hypothetical protein, unknown function 0.0321 0.0445 0.0437
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0321 0.0445 0.0437
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1643 0.3259 0.3253
Loa Loa (eye worm) hypothetical protein 0.0929 0.174 0.1733
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1654 0.3284 0.3278
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0929 0.174 0.1733
Entamoeba histolytica hypothetical protein 0.0321 0.0445 0.0437
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0321 0.0445 0.0437
Schistosoma mansoni fkbp-rapamycin associated protein 0.0929 0.174 0.1733
Trichomonas vaginalis PIKK family atypical protein kinase 0.3588 0.7401 0.7401
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0342 0.049 0.0482
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0116 0.0008 0.5
Echinococcus multilocularis Zinc finger, PHD finger 0.0342 0.049 0.0482
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0598 0.1034 0.1027
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0929 0.174 0.1733
Entamoeba histolytica hypothetical protein 0.0321 0.0445 0.0437
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0417 0.0649 0.0641
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0527 0.0882 0.0882
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.012 0.0017 0.0008
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0452 0.0723 0.0716
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0008 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0321 0.0445 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.067 0.1187 0.118
Loa Loa (eye worm) hypothetical protein 0.0321 0.0445 0.0437
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0342 0.049 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.1643 0.3259 0.3259
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4808 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0386 0.0582 0.0574
Loa Loa (eye worm) phosphatidylinositol 3 0.0321 0.0445 0.0437
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0342 0.049 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4808 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0321 0.0445 0.0437
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.046 0.0741 0.0741
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2009 0.4039 0.4034
Trichomonas vaginalis PIKK family atypical protein kinase 0.1643 0.3259 0.3259
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0941 0.1764 0.1757
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0342 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0713 0.128 0.1273
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0364 0.0537 0.0529
Giardia lamblia GTOR 0.4808 1 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1654 0.3284 0.3278
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0386 0.0582 0.0574
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4808 1 1
Entamoeba histolytica protein kinase rad3, putative 0.0929 0.174 0.1733
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0713 0.128 0.1272
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0321 0.0445 0.0445
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.012 0.0017 0.0008
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0342 0.049 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.312 0.6405 0.6405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0608 0.1056 0.1056
Loa Loa (eye worm) hypothetical protein 0.0971 0.1828 0.1821
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.046 0.0741 0.0741
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.004 0.0032
Leishmania major phosphatidylinositol 3-kinase, putative 0.1643 0.3259 0.3253
Trichomonas vaginalis PIKK family atypical protein kinase 0.2863 0.5858 0.5858
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0321 0.0445 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.1292 0.2512 0.2512
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0342 0.049 0.0482
Echinococcus multilocularis serine protein kinase ATM 0.0929 0.174 0.1733
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0321 0.0445 0.0437
Loa Loa (eye worm) phosphatidylinositol 3 0.1654 0.3284 0.3278
Trichomonas vaginalis PIKK family atypical protein kinase 0.3834 0.7925 0.7925
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0342 0.049 0.0482
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0386 0.0582 0.0574
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0713 0.128 0.1273
Trichomonas vaginalis PIKK family atypical protein kinase 0.2617 0.5334 0.5334
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0321 0.0445 0.9057
Echinococcus granulosus serine protein kinase ATM 0.0929 0.174 0.1733
Loa Loa (eye worm) phosphatidylinositol 3 0.0321 0.0445 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0929 0.174 0.174
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0321 0.0445 0.9057
Leishmania major phosphatidylinositol 3-kinase, putative 0.0342 0.049 0.0482
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0386 0.0582 0.0582
Loa Loa (eye worm) phosphatidylinositol 3 0.0321 0.0445 0.0437
Loa Loa (eye worm) phosphatidylinositol 3 0.4808 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3588 0.7401 0.7401
Trichomonas vaginalis PIKK family atypical protein kinase 0.2617 0.5334 0.5334
Loa Loa (eye worm) hypothetical protein 0.0608 0.1056 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.3834 0.7925 0.7925
Loa Loa (eye worm) phosphatidylinositol 3 0.0321 0.0445 0.0437
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2266 0.4587 0.4582
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0342 0.049 0.0482
Loa Loa (eye worm) phosphatidylinositol kinase 0.0321 0.0445 0.0437
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0452 0.0723 0.0716
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0527 0.0882 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.1654 0.3284 0.3284
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0342 0.049 0.049
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0342 0.049 0.0482
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4808 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0321 0.0445 0.0437
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0342 0.049 0.0482
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0342 0.049 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4095 0.8481 0.8481
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0713 0.128 0.1273
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0342 0.049 0.0482
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0342 0.049 0.049
Schistosoma mansoni hypothetical protein 0.0713 0.128 0.1273
Trichomonas vaginalis PIKK family atypical protein kinase 0.2874 0.5882 0.5882
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0527 0.0882 0.0875
Trypanosoma cruzi target of rapamycin kinase 3 0.3838 0.7933 0.7931
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0008 0.0008
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0321 0.0445 0.0437
Plasmodium vivax hypothetical protein, conserved 0.0321 0.0445 0.9057
Trichomonas vaginalis PIKK family atypical protein kinase 0.2863 0.5858 0.5858
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0386 0.0582 0.0574
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0608 0.1056 0.1048
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0483 0.079 0.0782
Trichomonas vaginalis PIKK family atypical protein kinase 0.2613 0.5326 0.5326
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.004 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.2617 0.5334 0.5334
Giardia lamblia Hypothetical protein 0.0321 0.0445 0.0437
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0598 0.1034 0.1027
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0929 0.174 0.1733
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0321 0.0445 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.3588 0.7401 0.7401
Entamoeba histolytica hypothetical protein 0.0483 0.079 0.0782
Trichomonas vaginalis PIKK family atypical protein kinase 0.4808 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0342 0.049 0.0482
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0321 0.0445 0.0437
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0929 0.174 0.1733
Schistosoma mansoni hypothetical protein 0.0321 0.0445 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.3834 0.7925 0.7925
Onchocerca volvulus 0.0321 0.0445 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0321 0.0445 0.0437
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0386 0.0582 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0929 0.174 0.174
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0527 0.0882 0.0875
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0342 0.049 0.0482
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1697 0.3375 0.3369
Plasmodium vivax hypothetical protein 0.0321 0.0445 0.9057
Leishmania major hypothetical protein, conserved 0.0419 0.0654 0.0646
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1697 0.3375 0.3369
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0713 0.128 0.1272
Mycobacterium tuberculosis Conserved hypothetical protein 0.0321 0.0445 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3834 0.7925 0.7925
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0929 0.174 0.1733
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4808 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1643 0.3259 0.3259
Toxoplasma gondii FATC domain-containing protein 0.0929 0.174 0.1861
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1697 0.3375 0.3369
Leishmania major phosphatidylinositol 4-kinase, putative 0.0321 0.0445 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.1643 0.3259 0.3259
Trichomonas vaginalis PIKK family atypical protein kinase 0.2874 0.5882 0.5882
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1697 0.3375 0.3369
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.012 0.0017 0.0008
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1697 0.3375 0.3369
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4808 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0386 0.0582 0.0582
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0386 0.0582 0.0582
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0929 0.174 0.1733
Echinococcus granulosus potassium voltage gated channel subfamily H 0.012 0.0017 0.0008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0409 0.0631 0.0623
Echinococcus multilocularis 0.0321 0.0445 0.0437
Loa Loa (eye worm) hypothetical protein 0.0452 0.0723 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.1035 0.1964 0.1964
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4808 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0206 0.0199 0.019

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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