Detailed information for compound 1647147

Basic information

Technical information
  • TDR Targets ID: 1647147
  • Name: ethyl 3-(4-cyanophenoxy)-7-(trifluoromethyl)q uinoxaline-2-carboxylate
  • MW: 387.312 | Formula: C19H12F3N3O3
  • H donors: 0 H acceptors: 4 LogP: 4.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1nc2cc(ccc2nc1Oc1ccc(cc1)C#N)C(F)(F)F
  • InChi: 1S/C19H12F3N3O3/c1-2-27-18(26)16-17(28-13-6-3-11(10-23)4-7-13)25-14-8-5-12(19(20,21)22)9-15(14)24-16/h3-9H,2H2,1H3
  • InChiKey: IOFRWSKLODSMPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(4-cyanophenoxy)-7-(trifluoromethyl)-2-quinoxalinecarboxylic acid ethyl ester
  • 3-(4-cyanophenoxy)-7-(trifluoromethyl)quinoxaline-2-carboxylic acid ethyl ester
  • NSC697104
  • AIDS-152545
  • AIDS152545
  • Ethyl 3-(4-cyanophenoxy)-7-(trifluoromethyl)-2-quinoxalinecarboxylate
  • NCI60_034580

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0704 0.1151 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.1789 0.3266 0.3266
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5244 1 1
Loa Loa (eye worm) hypothetical protein 0.0349 0.0459 0.0451
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0371 0.0502 0.0493
Mycobacterium leprae conserved hypothetical protein 0.0349 0.0459 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0491 0.0735 0.0735
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0349 0.0459 0.0451
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.219 0.4048 0.4042
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1024 0.1774 0.1766
Trichomonas vaginalis PIKK family atypical protein kinase 0.1789 0.3266 0.3266
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0777 0.1293 0.1286
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0371 0.0502 0.0502
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.0587 0.0579
Loa Loa (eye worm) phosphatidylinositol 3 0.0349 0.0459 0.0451
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5244 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0371 0.0502 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0349 0.0459 0.0451
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1789 0.3266 0.326
Entamoeba histolytica hypothetical protein 0.0349 0.0459 0.0451
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1012 0.1751 0.1743
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0349 0.0459 0.0451
Loa Loa (eye worm) hypothetical protein 0.1012 0.1751 0.1743
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1801 0.3289 0.3283
Trichomonas vaginalis PIKK family atypical protein kinase 0.5244 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.2848 0.5331 0.5331
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0349 0.0459 0.0451
Loa Loa (eye worm) hypothetical protein 0.0662 0.107 0.1062
Leishmania major hypothetical protein, unknown function 0.0349 0.0459 0.0451
Trichomonas vaginalis fk506-binding protein, putative 0.0118 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.418 0.7927 0.7927
Leishmania major phosphatidylinositol kinase related protein, putative 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.2853 0.5339 0.5339
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1012 0.1751 0.1743
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0483 0.0719 0.0711
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0118 0.0009 0.0009
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0447 0.065 0.0641
Entamoeba histolytica hypothetical protein 0.0349 0.0459 0.0451
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0122 0.0016 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0559 0.0867 0.0867
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0371 0.0502 0.0493
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0118 0.0009 0.5
Schistosoma mansoni fkbp-rapamycin associated protein 0.1012 0.1751 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.3912 0.7404 0.7404
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0631 0.1009 0.1001
Echinococcus multilocularis Zinc finger, PHD finger 0.0371 0.0502 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.3912 0.7404 0.7404
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0349 0.0459 0.0451
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0349 0.0459 0.0451
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4185 0.7935 0.7933
Schistosoma mansoni hypothetical protein 0.0777 0.1293 0.1286
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.3518 0.6636 0.6636
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.3912 0.7404 0.7404
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1012 0.1751 0.1743
Trichomonas vaginalis immunophilin, putative 0.0118 0.0009 0.0009
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0118 0.0009 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1127 0.1975 0.2182
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5244 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0349 0.0459 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.0777 0.1293 0.1293
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0559 0.0867 0.0859
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0349 0.0459 0.9142
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.1024 0.1774 0.1774
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0349 0.0459 0.9142
Onchocerca volvulus 0.0349 0.0459 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0415 0.0587 0.0579
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0483 0.0719 0.0711
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5244 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5244 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0748 0.1237 0.1229
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0349 0.0459 0.9142
Giardia lamblia Phosphatidylinositol 4-kinase 0.0349 0.0459 0.0451
Entamoeba histolytica hypothetical protein 0.1012 0.1751 0.1743
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0559 0.0867 0.0867
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0559 0.0867 0.0859
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.019 0.0148 0.014
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5244 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4185 0.7935 0.7933
Loa Loa (eye worm) hypothetical protein 0.1127 0.1975 0.1967
Trichomonas vaginalis PIKK family atypical protein kinase 0.3135 0.5888 0.5888
Toxoplasma gondii target of rapamycin (TOR), putative 0.3912 0.7404 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0349 0.0459 0.0451
Entamoeba histolytica hypothetical protein 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.2848 0.5331 0.5331
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.3912 0.7404 0.7404
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0371 0.0502 0.0493
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0371 0.0502 0.0061
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0349 0.0459 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.5244 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0371 0.0502 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.3912 0.7404 0.7404
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1012 0.1751 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0349 0.0459 0.0459
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1845 0.3374 0.3368
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0371 0.0502 0.0493
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5244 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1789 0.3266 0.3266
Mycobacterium tuberculosis Conserved hypothetical protein 0.0349 0.0459 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.418 0.7927 0.7927
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1012 0.1751 0.1743
Leishmania major phosphatidylinositol 4-kinase, putative 0.0349 0.0459 0.0451
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1845 0.3374 0.3368
Toxoplasma gondii FATC domain-containing protein 0.1012 0.1751 0.186
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0371 0.0502 0.0493
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1845 0.3374 0.3368
Leishmania major hypothetical protein, conserved 0.0449 0.0654 0.0646
Plasmodium vivax hypothetical protein 0.0349 0.0459 0.9142
Brugia malayi FAT domain containing protein 0.0777 0.1293 0.1286
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1845 0.3374 0.3368
Loa Loa (eye worm) hypothetical protein 0.0483 0.0719 0.0711
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0439 0.0633 0.0625
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0122 0.0016 0.0007
Echinococcus multilocularis 0.0349 0.0459 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.1975 0.1975
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0209 0.0186 0.0177
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5244 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0122 0.0016 0.0007
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1845 0.3374 0.3368
Trichomonas vaginalis PIKK family atypical protein kinase 0.3135 0.5888 0.5888
Trichomonas vaginalis PIKK family atypical protein kinase 0.1789 0.3266 0.3266
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1845 0.3374 0.3368
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0415 0.0587 0.0587
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1012 0.1751 0.1743
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0415 0.0587 0.0587
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5244 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0415 0.0587 0.0579
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0118 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.3121 0.5862 0.5862
Plasmodium vivax hypothetical protein, conserved 0.0349 0.0459 0.9142
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.2848 0.5331 0.5331
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0037 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0662 0.107 0.107
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0515 0.0781 0.0773
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0371 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0777 0.1293 0.1286
Trichomonas vaginalis PIKK family atypical protein kinase 0.3135 0.5888 0.5888
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0748 0.1237 0.1229
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0371 0.0502 0.0493
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0559 0.0867 0.0859
Trypanosoma cruzi target of rapamycin kinase 3 0.4185 0.7935 0.7933
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1012 0.1751 0.1743
Schistosoma mansoni hypothetical protein 0.0349 0.0459 0.0451
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.1012 0.1751 0.1751
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0415 0.0587 0.0579
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0559 0.0867 0.0859
Trichomonas vaginalis PIKK family atypical protein kinase 0.418 0.7927 0.7927
Onchocerca volvulus 0.0349 0.0459 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0349 0.0459 0.0451
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1012 0.1751 0.1743
Giardia lamblia Hypothetical protein 0.0349 0.0459 0.0451
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0631 0.1009 0.1001
Trichomonas vaginalis PIKK family atypical protein kinase 0.2853 0.5339 0.5339
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0371 0.0502 0.0493
Entamoeba histolytica hypothetical protein 0.0515 0.0781 0.0773
Trichomonas vaginalis PIKK family atypical protein kinase 0.3912 0.7404 0.7404
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.5244 1 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0349 0.0459 0.9142
Echinococcus granulosus serine protein kinase ATM 0.1012 0.1751 0.1743
Loa Loa (eye worm) phosphatidylinositol 3 0.0349 0.0459 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.1012 0.1751 0.1751
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0662 0.107 0.1062
Trichomonas vaginalis PIKK family atypical protein kinase 0.3912 0.7404 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.2853 0.5339 0.5339
Leishmania major phosphatidylinositol 3-kinase, putative 0.0371 0.0502 0.0493
Loa Loa (eye worm) phosphatidylinositol 3 0.0349 0.0459 0.0451
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0415 0.0587 0.0587
Loa Loa (eye worm) phosphatidylinositol 3 0.5244 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.1801 0.3289 0.3283
Echinococcus multilocularis serine protein kinase ATM 0.1012 0.1751 0.1743
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0349 0.0459 0.0451
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.0587 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.2853 0.5339 0.5339
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0371 0.0502 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.418 0.7927 0.7927
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0777 0.1293 0.1286
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0349 0.0459 0.9142
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5244 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0371 0.0502 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.1801 0.3289 0.3289
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0371 0.0502 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.4466 0.8485 0.8485
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0349 0.0459 0.0451
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0371 0.0502 0.0493
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0371 0.0502 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0371 0.0502 0.0493
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2472 0.4597 0.4592
Trichomonas vaginalis PIKK family atypical protein kinase 0.418 0.7927 0.7927
Loa Loa (eye worm) phosphatidylinositol 3 0.0349 0.0459 0.0451
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0559 0.0867 0.0867
Loa Loa (eye worm) phosphatidylinositol kinase 0.0349 0.0459 0.0451
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0483 0.0719 0.0711
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1801 0.3289 0.3283
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0415 0.0587 0.0579
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5244 1 1
Entamoeba histolytica protein kinase rad3, putative 0.1012 0.1751 0.1743
Giardia lamblia GTOR 0.5244 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0393 0.0545 0.0537
Trichomonas vaginalis PIKK family atypical protein kinase 0.1409 0.2524 0.2524
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0371 0.0502 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.3121 0.5862 0.5862
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0349 0.0459 0.0459
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0371 0.0502 0.0061
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0122 0.0016 0.0007
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0349 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.1059 0.1843 0.1836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0662 0.107 0.107
Trichomonas vaginalis PIKK family atypical protein kinase 0.3403 0.6412 0.6412
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0748 0.1237 0.1229
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0037 0.0029
Leishmania major phosphatidylinositol 3-kinase, putative 0.1789 0.3266 0.326
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0491 0.0735 0.0735

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.144 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.034 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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