TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.651 | Formula: C16H13BrClN3O
H donors: 2 H acceptors: 1 LogP: 3.26 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cc(Br)c(c(c1)C1=NC(=NC(C1)c1ccccc1)N)O
InChi: 1S/C16H13BrClN3O/c17-12-7-10(18)6-11(15(12)22)14-8-13(20-16(19)21-14)9-4-2-1-3-5-9/h1-7,13,22H,8H2,(H2,19,20)
InChiKey: LHDPNKPECLCVAY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	serine protein kinase ATM	0.0573	0.1659	0.1647
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0258	0.0548	0.0535
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0388	0.1005	0.0993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2341	0.7909	0.7909
Onchocerca volvulus		0.0199	0.0338	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0199	0.0338	0.0325
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0573	0.1659	0.1647
Schistosoma mansoni	hypothetical protein	0.0199	0.0338	0.0325
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0199	0.0338	0.0325
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0219	0.0407	0.0394
Entamoeba histolytica	hypothetical protein	0.0348	0.0865	0.0853
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2191	0.7381	0.7381
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2932	1	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0573	0.1659	0.1647
Giardia lamblia	Hypothetical protein	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1602	0.5299	0.5299
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0388	0.1005	0.0993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.16	0.5291	0.5291
Schistosoma mansoni	voltage-gated potassium channel	0.0121	0.0062	0.0048
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0348	0.0865	0.0853
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0388	0.1005	0.1005
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0258	0.0548	0.0548
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0107	0.0014	0.0014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1752	0.5827	0.5827
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0199	0.0338	0.0325
Plasmodium vivax	hypothetical protein, conserved	0.0199	0.0338	0.8241
Trichomonas vaginalis	conserved hypothetical protein	0.0374	0.0954	0.0954
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.2343	0.7918	0.7915
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0219	0.0407	0.0394
Loa Loa (eye worm)	phosphatidylinositol 3	0.052	0.1471	0.1459
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1753	0.5832	0.5832
Loa Loa (eye worm)	hypothetical protein	0.0438	0.1183	0.1171
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0219	0.0407	0.0394
Trichomonas vaginalis	conserved hypothetical protein	0.0637	0.1888	0.1888
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.2932	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0189	0.0301	0.0288
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0319	0.0763	0.0751
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.028	0.0623	0.061
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0111	0.0026	0.0012
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0199	0.0338	0.0325
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0258	0.0548	0.0548
Entamoeba histolytica	hypothetical protein	0.0573	0.1659	0.1647
Giardia lamblia	GTOR	0.2932	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0258	0.0548	0.0548
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0111	0.0026	0.0012
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1061	0.3385	0.3376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1753	0.5832	0.5832
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1011	0.3208	0.3208
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1061	0.3385	0.3376
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1061	0.3385	0.3376
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0199	0.0338	0.0325
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0573	0.1659	0.1647
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.2932	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1011	0.3208	0.3208
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0199	0.0338	0.5
Entamoeba histolytica	protein kinase rad3, putative	0.0573	0.1659	0.1647
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2341	0.7909	0.7909
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0454	0.1237	0.1225
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1061	0.3385	0.3376
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0219	0.0407	0.0394
Leishmania major	hypothetical protein, conserved	0.0289	0.0657	0.0644
Plasmodium vivax	hypothetical protein	0.0199	0.0338	0.8241
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1061	0.3385	0.3376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0788	0.242	0.242
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0219	0.0407	0.0407
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1752	0.5827	0.5827
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0199	0.0338	0.0338
Schistosoma mansoni	voltage-gated potassium channel	0.0121	0.0062	0.0048
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1011	0.3208	0.3199
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0327	0.079	0.079
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0219	0.0407	0.0394
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0199	0.0338	0.0325
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0111	0.0026	0.0012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1902	0.636	0.636
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0388	0.1005	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0589	0.1716	0.1705
Brugia malayi	FAT domain containing protein	0.0438	0.1183	0.1171
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.2932	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0573	0.1659	0.1659
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0258	0.0548	0.0535
Loa Loa (eye worm)	phosphatidylinositol 3	0.1022	0.3246	0.3237
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.2932	1	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0239	0.0478	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2494	0.845	0.845
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0199	0.0338	0.0325
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0219	0.0407	0.0394
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0219	0.0407	0.0394
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0219	0.0407	0.0407
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.2932	1	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1022	0.3246	0.3237
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0219	0.0407	0.0394
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0374	0.0954	0.0942
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0199	0.0338	0.0325
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0319	0.0763	0.0751
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.138	0.4511	0.4504
Echinococcus multilocularis	Zinc finger, PHD finger	0.0219	0.0407	0.0394
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2341	0.7909	0.7909
Onchocerca volvulus		0.0199	0.0338	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1602	0.5299	0.5299
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0438	0.1183	0.1171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2191	0.7381	0.7381
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0219	0.0407	0.0098
Loa Loa (eye worm)	phosphatidylinositol 3	0.2932	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0258	0.0548	0.0535
Loa Loa (eye worm)	phosphatidylinositol 3	0.0199	0.0338	0.0325
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0199	0.0338	0.8241
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0573	0.1659	0.1647
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0199	0.0338	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0573	0.1659	0.1659
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1602	0.5299	0.5299
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0219	0.0407	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2341	0.7909	0.7909
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0559	0.1611	0.16
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0258	0.0548	0.0535
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0199	0.0338	0.8241
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1022	0.3246	0.3237
Loa Loa (eye worm)	hypothetical protein	0.0573	0.1659	0.1647
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0199	0.0338	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0319	0.0763	0.0751
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0107	0.0014	0.0014
Entamoeba histolytica	hypothetical protein	0.0199	0.0338	0.0325
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0287	0.065	0.0637
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0111	0.0026	0.0012
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0388	0.1005	0.0993
Echinococcus granulosus	serine protein kinase ATM	0.0573	0.1659	0.1647
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0388	0.1005	0.1005
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0219	0.0407	0.0394
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0219	0.0407	0.0394
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0107	0.0014	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2191	0.7381	0.7381
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0573	0.1659	0.1647
Entamoeba histolytica	hypothetical protein	0.0199	0.0338	0.0325
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0573	0.1659	0.1647
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0199	0.0338	0.0325
Toxoplasma gondii	FATC domain-containing protein	0.0573	0.1659	0.1875
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1022	0.3246	0.3246
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1011	0.3208	0.3208
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0438	0.1183	0.1171
Leishmania major	hypothetical protein, unknown function	0.0199	0.0338	0.0325
Trichomonas vaginalis	fk506-binding protein, putative	0.0107	0.0014	0.0014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1602	0.5299	0.5299
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2341	0.7909	0.7909
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2932	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.16	0.5291	0.5291
Leishmania major	phosphatidylinositol kinase, putative	0.0199	0.0338	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1011	0.3208	0.3208
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0583	0.1696	0.1685
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0454	0.1237	0.1225
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0219	0.0407	0.0407
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0199	0.0338	0.0325
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0327	0.079	0.079
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1229	0.3978	0.397
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.2932	1	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0219	0.0407	0.0098
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0258	0.0548	0.0535
Mycobacterium leprae	conserved hypothetical protein	0.0199	0.0338	0.5
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1011	0.3208	0.3199
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.2932	1	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0199	0.0338	0.0338
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0219	0.0407	1
Trichomonas vaginalis	conserved hypothetical protein	0.0438	0.1183	0.1183
Echinococcus multilocularis		0.0199	0.0338	0.0325
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2191	0.7381	0.7381
Loa Loa (eye worm)	phosphatidylinositol 3	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1753	0.5832	0.5832
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2191	0.7381	0.7381
Entamoeba histolytica	hypothetical protein	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.16	0.5291	0.5291
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0219	0.0407	0.0394
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2932	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0199	0.0338	0.0338
Toxoplasma gondii	target of rapamycin (TOR), putative	0.2191	0.7381	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0573	0.1659	0.1647
Loa Loa (eye worm)	phosphatidylinositol 3	0.0199	0.0338	0.0325
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0219	0.0407	0.0394
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1061	0.3385	0.3376
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0219	0.0407	0.0394
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0219	0.0407	0.0394
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0199	0.0338	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0374	0.0954	0.0942
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0171	0.024	0.0226
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0199	0.0338	0.8241
Schistosoma mansoni	hypothetical protein	0.0438	0.1183	0.1171
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0573	0.1659	0.1647
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0388	0.1005	0.0993
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0199	0.0338	0.0325
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.2932	1	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.2343	0.7918	0.7915
Loa Loa (eye worm)	hypothetical protein	0.0637	0.1888	0.1877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0374	0.0954	0.0954
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0199	0.0338	0.8241
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0583	0.1696	0.1696
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0637	0.1888	0.22
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0107	0.0014	0.5
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.2932	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0199	0.0338	0.0325
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0559	0.1611	0.16
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.2932	1	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.2932	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0199	0.0338	0.8241
Loa Loa (eye worm)	phosphatidylinositol 3	0.0199	0.0338	0.0325
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0258	0.0548	0.0535
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0319	0.0763	0.0751
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0199	0.0338	0.0325
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2191	0.7381	0.7381
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2191	0.7381	0.7381
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0199	0.0338	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1967	0.6589	0.6589
Trichomonas vaginalis	immunophilin, putative	0.0107	0.0014	0.0014
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0573	0.1659	0.1647
Trypanosoma cruzi	target of rapamycin kinase 3	0.2343	0.7918	0.7915
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0559	0.1611	0.16
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0199	0.0338	0.0325

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-5.538	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.484	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.965	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.914	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.872	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.784	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.772	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.745	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2005650

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1647148