Detailed information for compound 1647149

Basic information

Technical information
  • TDR Targets ID: 1647149
  • Name: 4-[[1-chloro-4-[4-(2-hydroxyethyl)piperazine- 1-carbonyl]acridin-9-yl]amino]-N-(5-methyl-1, 2-oxazol-3-yl)benzenesulfonamide
  • MW: 621.106 | Formula: C30H29ClN6O5S
  • H donors: 3 H acceptors: 6 LogP: 3.99 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCN1CCN(CC1)C(=O)c1ccc(c2c1nc1ccccc1c2Nc1ccc(cc1)S(=O)(=O)Nc1noc(c1)C)Cl
  • InChi: 1S/C30H29ClN6O5S/c1-19-18-26(34-42-19)35-43(40,41)21-8-6-20(7-9-21)32-28-22-4-2-3-5-25(22)33-29-23(10-11-24(31)27(28)29)30(39)37-14-12-36(13-15-37)16-17-38/h2-11,18,38H,12-17H2,1H3,(H,32,33)(H,34,35)
  • InChiKey: OVHIUNRMDHFMQG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[1-chloro-4-[4-(2-hydroxyethyl)piperazine-1-carbonyl]acridin-9-yl]amino]-N-(5-methylisoxazol-3-yl)benzenesulfonamide
  • 4-[[1-chloro-4-[[4-(2-hydroxyethyl)-1-piperazinyl]-oxomethyl]-9-acridinyl]amino]-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
  • 4-[[1-chloro-4-[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl-acridin-9-yl]amino]-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
  • NSC644054
  • NCI60_014946
  • 4-((1-Chloro-4-((4-(2-hydroxyethyl)-1-piperazinyl)carbonyl)-9-acridinyl)amino)-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
  • AIDS-138075
  • AIDS138075

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0286 0.0424 0.0415
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0349 0.0575 0.0566
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.427 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0307 0.0474 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1785 0.4028 0.4022
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0421 0.0749 0.0749
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0286 0.0424 0.0415
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0838 0.1751 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.1461 0.3249 0.3249
Trichomonas vaginalis conserved hypothetical protein 0.0635 0.1262 0.1262
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0307 0.0474 0.0474
Mycobacterium leprae conserved hypothetical protein 0.0286 0.0424 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0625 0.1238 0.123
Trichomonas vaginalis PIKK family atypical protein kinase 0.1461 0.3249 0.3249
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.427 1 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.0424 0.0415
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0307 0.0474 0.0465
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0307 0.0474 0.0465
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0114 0.001 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0827 0.1724 0.1716
Trichomonas vaginalis PIKK family atypical protein kinase 0.3187 0.7397 0.7397
Loa Loa (eye worm) hypothetical protein 0.0541 0.1037 0.1028
Echinococcus multilocularis Zinc finger, PHD finger 0.0307 0.0474 0.0465
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0827 0.1724 0.1716
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0413 0.073 0.0721
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0114 0.001 0.001
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0379 0.0648 0.0639
Entamoeba histolytica hypothetical protein 0.0286 0.0424 0.0415
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0486 0.0904 0.0904
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0117 0.0019 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.427 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0286 0.0424 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.2323 0.5319 0.5319
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0286 0.0424 0.0415
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0555 0.1071 0.1062
Leishmania major hypothetical protein, unknown function 0.0286 0.0424 0.0415
Trichomonas vaginalis fk506-binding protein, putative 0.0114 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.3405 0.7922 0.7922
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.5327 0.5327
Leishmania major phosphatidylinositol kinase related protein, putative 0.0286 0.0424 0.0415
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0286 0.0424 0.0415
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1461 0.3249 0.3242
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0827 0.1724 0.1716
Entamoeba histolytica hypothetical protein 0.0286 0.0424 0.0415
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0286 0.0424 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.1724 0.1724
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1473 0.3276 0.327
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0286 0.0424 0.8929
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0349 0.0575 0.0566
Onchocerca volvulus 0.0286 0.0424 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0413 0.073 0.0721
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.427 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.427 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0921 0.1949 0.2187
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0114 0.001 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.427 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0286 0.0424 0.0415
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0667 0.1339 0.1331
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.0904 0.0895
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0286 0.0424 0.8929
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0286 0.0424 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0838 0.1751 0.1751
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3409 0.793 0.7928
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0667 0.1339 0.1331
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0286 0.0424 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.6622 0.6622
Trichomonas vaginalis PIKK family atypical protein kinase 0.3187 0.7397 0.7397
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0286 0.0424 0.0415
Schistosoma mansoni fkbp-rapamycin associated protein 0.0827 0.1724 0.1716
Trichomonas vaginalis immunophilin, putative 0.0114 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.3187 0.7397 0.7397
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0286 0.0424 0.0415
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0286 0.0424 0.0415
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0307 0.0474 0.0071
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0307 0.0474 0.0465
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0286 0.0424 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.427 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0286 0.0424 0.0424
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0307 0.0474 0.0465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0286 0.0424 0.0424
Toxoplasma gondii FATC domain-containing protein 0.0827 0.1724 0.1864
Trichomonas vaginalis PIKK family atypical protein kinase 0.3187 0.7397 0.7397
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1514 0.3376 0.3369
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0307 0.0474 0.0465
Trichomonas vaginalis PIKK family atypical protein kinase 0.2553 0.5872 0.5872
Toxoplasma gondii target of rapamycin (TOR), putative 0.3187 0.7397 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0286 0.0424 0.0415
Entamoeba histolytica hypothetical protein 0.0286 0.0424 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.2323 0.5319 0.5319
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0286 0.0424 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.3187 0.7397 0.7397
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.427 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3409 0.793 0.7928
Loa Loa (eye worm) hypothetical protein 0.0921 0.1949 0.1942
Brugia malayi FAT domain containing protein 0.0635 0.1262 0.1253
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0286 0.0424 0.8929
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0486 0.0904 0.0904
Entamoeba histolytica hypothetical protein 0.0827 0.1724 0.1716
Giardia lamblia Phosphatidylinositol 4-kinase 0.0286 0.0424 0.0415
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0486 0.0904 0.0895
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0181 0.0172 0.0163
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0117 0.0019 0.0009
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1514 0.3376 0.3369
Trichomonas vaginalis PIKK family atypical protein kinase 0.1461 0.3249 0.3249
Trichomonas vaginalis PIKK family atypical protein kinase 0.2553 0.5872 0.5872
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1514 0.3376 0.3369
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0349 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0827 0.1724 0.1716
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0349 0.0575 0.0575
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.427 1 1
Loa Loa (eye worm) hypothetical protein 0.0413 0.073 0.0721
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0371 0.0629 0.062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0117 0.0019 0.0009
Echinococcus multilocularis 0.0286 0.0424 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0921 0.1949 0.1949
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.02 0.0216 0.0207
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.427 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0307 0.0474 0.0465
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1514 0.3376 0.3369
Plasmodium vivax hypothetical protein 0.0286 0.0424 0.8929
Leishmania major hypothetical protein, conserved 0.0381 0.0654 0.0644
Schistosoma mansoni hypothetical protein 0.0635 0.1262 0.1253
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1514 0.3376 0.3369
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.427 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1461 0.3249 0.3249
Mycobacterium tuberculosis Conserved hypothetical protein 0.0286 0.0424 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3405 0.7922 0.7922
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0827 0.1724 0.1716
Leishmania major phosphatidylinositol 4-kinase, putative 0.0286 0.0424 0.0415
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1514 0.3376 0.3369
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0827 0.1724 0.1716
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0827 0.1724 0.1716
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.5327 0.5327
Giardia lamblia Hypothetical protein 0.0286 0.0424 0.0415
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0541 0.1037 0.1028
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0307 0.0474 0.0465
Entamoeba histolytica hypothetical protein 0.0444 0.0803 0.0794
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0286 0.0424 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.3187 0.7397 0.7397
Trichomonas vaginalis PIKK family atypical protein kinase 0.427 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0827 0.1724 0.1716
Schistosoma mansoni hypothetical protein 0.0286 0.0424 0.0415
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0286 0.0424 0.0415
Echinococcus multilocularis serine protein kinase ATM 0.0827 0.1724 0.1716
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0349 0.0575 0.0566
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0486 0.0904 0.0895
Trichomonas vaginalis PIKK family atypical protein kinase 0.3405 0.7922 0.7922
Onchocerca volvulus 0.0286 0.0424 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0286 0.0424 0.0415
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0307 0.0474 0.0474
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0635 0.1262 0.1253
Trichomonas vaginalis PIKK family atypical protein kinase 0.2553 0.5872 0.5872
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0307 0.0474 0.0465
Loa Loa (eye worm) hypothetical protein 0.0635 0.1262 0.1253
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0486 0.0904 0.0895
Trypanosoma cruzi target of rapamycin kinase 3 0.3409 0.793 0.7928
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0349 0.0575 0.0566
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0114 0.001 0.001
Plasmodium vivax hypothetical protein, conserved 0.0286 0.0424 0.8929
Trichomonas vaginalis PIKK family atypical protein kinase 0.2544 0.5852 0.5852
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0286 0.0424 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.2323 0.5319 0.5319
Schistosoma mansoni voltage-gated potassium channel 0.0128 0.0044 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0541 0.1037 0.1037
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0444 0.0803 0.0794
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0307 0.0474 0.0465
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2012 0.4573 0.4567
Trichomonas vaginalis PIKK family atypical protein kinase 0.3405 0.7922 0.7922
Loa Loa (eye worm) phosphatidylinositol 3 0.0286 0.0424 0.0415
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0486 0.0904 0.0904
Loa Loa (eye worm) phosphatidylinositol kinase 0.0286 0.0424 0.0415
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0413 0.073 0.0721
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.427 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0307 0.0474 0.0465
Trichomonas vaginalis PIKK family atypical protein kinase 0.1473 0.3276 0.3276
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0307 0.0474 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.3636 0.8475 0.8475
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0286 0.0424 0.0415
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0307 0.0474 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0307 0.0474 0.0465
Loa Loa (eye worm) phosphatidylinositol 3 0.1473 0.3276 0.327
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0827 0.1724 0.1716
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0286 0.0424 0.0415
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0307 0.0474 0.0465
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0667 0.1339 0.1331
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0349 0.0575 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.3405 0.7922 0.7922
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.5327 0.5327
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0286 0.0424 0.8929
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0286 0.0424 0.8929
Echinococcus granulosus serine protein kinase ATM 0.0827 0.1724 0.1716
Loa Loa (eye worm) phosphatidylinositol 3 0.0286 0.0424 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.1724 0.1724
Trichomonas vaginalis PIKK family atypical protein kinase 0.2326 0.5327 0.5327
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0555 0.1071 0.1062
Trichomonas vaginalis PIKK family atypical protein kinase 0.3187 0.7397 0.7397
Leishmania major phosphatidylinositol 3-kinase, putative 0.0307 0.0474 0.0465
Loa Loa (eye worm) phosphatidylinositol 3 0.0286 0.0424 0.0415
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0349 0.0575 0.0575
Loa Loa (eye worm) phosphatidylinositol 3 0.427 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0307 0.0474 0.0071
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0286 0.0424 0.0424
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0117 0.0019 0.0009
Loa Loa (eye worm) hypothetical protein 0.0861 0.1807 0.1799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0541 0.1037 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.2771 0.6397 0.6397
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0635 0.1262 0.1253
Schistosoma mansoni voltage-gated potassium channel 0.0128 0.0044 0.0035
Leishmania major phosphatidylinositol 3-kinase, putative 0.1461 0.3249 0.3242
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0421 0.0749 0.0749
Trichomonas vaginalis PIKK family atypical protein kinase 0.1147 0.2494 0.2494
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0307 0.0474 0.0465
Trichomonas vaginalis PIKK family atypical protein kinase 0.2544 0.5852 0.5852
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0286 0.0424 0.0424
Giardia lamblia GTOR 0.427 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0328 0.0525 0.0516
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0349 0.0575 0.0566
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1473 0.3276 0.327
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.427 1 1
Entamoeba histolytica protein kinase rad3, putative 0.0827 0.1724 0.1716

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.22 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.142 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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