Detailed information for compound 1647151

Basic information

Technical information
  • TDR Targets ID: 1647151
  • Name: ethyl N-ethyl-N-[2-oxo-6-phenyl-4-(trifluorom ethyl)-1H-pyridin-3-yl]carbamate
  • MW: 354.324 | Formula: C17H17F3N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1c(cc([nH]c1=O)c1ccccc1)C(F)(F)F)C(=O)OCC
  • InChi: 1S/C17H17F3N2O3/c1-3-22(16(24)25-4-2)14-12(17(18,19)20)10-13(21-15(14)23)11-8-6-5-7-9-11/h5-10H,3-4H2,1-2H3,(H,21,23)
  • InChiKey: MCMOXMOETHCJQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-ethyl-N-[2-oxo-6-phenyl-4-(trifluoromethyl)-1H-pyridin-3-yl]carbamic acid ethyl ester
  • N-ethyl-N-[2-keto-6-phenyl-4-(trifluoromethyl)-1H-pyridin-3-yl]carbamic acid ethyl ester
  • NSC706160
  • NCI60_037843

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0313 0.0566 0.0556
Trichomonas vaginalis PIKK family atypical protein kinase 0.2225 0.5844 0.5844
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0251 0.0396 0.0385
Plasmodium vivax hypothetical protein, conserved 0.0251 0.0396 0.8727
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0112 0.0011 0.0011
Schistosoma mansoni voltage-gated potassium channel 0.0126 0.005 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.2032 0.531 0.531
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0406 0.0823 0.0813
Loa Loa (eye worm) hypothetical protein 0.0474 0.101 0.1
Loa Loa (eye worm) phosphatidylinositol 3 0.0584 0.1315 0.1305
Trichomonas vaginalis PIKK family atypical protein kinase 0.2231 0.5859 0.5859
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0272 0.0452 0.0452
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0272 0.0452 0.0442
Schistosoma mansoni hypothetical protein 0.0556 0.1236 0.1226
Trypanosoma cruzi target of rapamycin kinase 3 0.298 0.7926 0.7924
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0447 0.0937 0.0927
Schistosoma mansoni hypothetical protein 0.0251 0.0396 0.0385
Toxoplasma gondii FATC domain-containing protein 0.0725 0.1703 0.1868
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0251 0.0396 0.0385
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0447 0.0937 0.0927
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0725 0.1703 0.1693
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0313 0.0566 0.0556
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0396 0.0385
Onchocerca volvulus 0.0251 0.0396 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2977 0.7918 0.7918
Loa Loa (eye worm) hypothetical protein 0.0725 0.1703 0.1693
Trichomonas vaginalis PIKK family atypical protein kinase 0.2035 0.5318 0.5318
Giardia lamblia Hypothetical protein 0.0251 0.0396 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0474 0.101 0.101
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0272 0.0452 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.3732 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0251 0.0396 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.2787 0.7392 0.7392
Entamoeba histolytica hypothetical protein 0.0406 0.0823 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.128 0.3236 0.3236
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3732 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0725 0.1703 0.1693
Trichomonas vaginalis PIKK family atypical protein kinase 0.2977 0.7918 0.7918
Mycobacterium tuberculosis Conserved hypothetical protein 0.0251 0.0396 0.5
Leishmania major phosphatidylinositol 4-kinase, putative 0.0251 0.0396 0.0385
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1332 0.3379 0.3372
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0725 0.1703 0.1693
Plasmodium vivax hypothetical protein 0.0251 0.0396 0.8727
Leishmania major hypothetical protein, conserved 0.0345 0.0655 0.0644
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1332 0.3379 0.3372
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0272 0.0452 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0556 0.1236 0.1236
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1332 0.3379 0.3372
Loa Loa (eye worm) hypothetical protein 0.0376 0.0741 0.0731
Echinococcus multilocularis 0.0251 0.0396 0.0385
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0335 0.0627 0.0617
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0115 0.0021 0.001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3732 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0196 0.0244 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0807 0.1929 0.1929
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1332 0.3379 0.3372
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0115 0.0021 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1332 0.3379 0.3372
Trichomonas vaginalis PIKK family atypical protein kinase 0.2231 0.5859 0.5859
Trichomonas vaginalis PIKK family atypical protein kinase 0.128 0.3236 0.3236
Echinococcus multilocularis serine protein kinase ATM 0.0725 0.1703 0.1693
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0313 0.0566 0.0566
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3732 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0313 0.0566 0.0566
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1291 0.3266 0.3259
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0313 0.0566 0.0556
Entamoeba histolytica protein kinase rad3, putative 0.0725 0.1703 0.1693
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3732 1 1
Giardia lamblia GTOR 0.3732 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0292 0.051 0.0499
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0272 0.0452 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.1003 0.247 0.247
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0251 0.0396 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.2225 0.5844 0.5844
Loa Loa (eye worm) hypothetical protein 0.0752 0.1777 0.1768
Trichomonas vaginalis PIKK family atypical protein kinase 0.2422 0.6385 0.6385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0474 0.101 0.101
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0251 0.0396 0.0396
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0115 0.0021 0.001
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0272 0.0452 0.008
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0556 0.1236 0.1226
Leishmania major phosphatidylinositol 3-kinase, putative 0.128 0.3236 0.3228
Schistosoma mansoni voltage-gated potassium channel 0.0126 0.005 0.0039
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0384 0.0763 0.0763
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0251 0.0396 0.8727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0725 0.1703 0.1703
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0396 0.0385
Echinococcus granulosus serine protein kinase ATM 0.0725 0.1703 0.1693
Trichomonas vaginalis PIKK family atypical protein kinase 0.2787 0.7392 0.7392
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0516 0.1125 0.1116
Trichomonas vaginalis PIKK family atypical protein kinase 0.2035 0.5318 0.5318
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0313 0.0566 0.0566
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0396 0.0385
Loa Loa (eye worm) phosphatidylinositol 3 0.3732 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0272 0.0452 0.0442
Loa Loa (eye worm) phosphatidylinositol 3 0.1291 0.3266 0.3259
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0251 0.0396 0.0385
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0725 0.1703 0.1693
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0251 0.0396 0.8727
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0625 0.1429 0.1419
Trichomonas vaginalis PIKK family atypical protein kinase 0.2035 0.5318 0.5318
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0272 0.0452 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.2977 0.7918 0.7918
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0313 0.0566 0.0556
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0272 0.0452 0.0442
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3732 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0272 0.0452 0.0452
Trichomonas vaginalis PIKK family atypical protein kinase 0.1291 0.3266 0.3266
Trichomonas vaginalis PIKK family atypical protein kinase 0.3176 0.8467 0.8467
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0272 0.0452 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0272 0.0452 0.0442
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0251 0.0396 0.0385
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0272 0.0452 0.0442
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1758 0.4552 0.4546
Trichomonas vaginalis PIKK family atypical protein kinase 0.2977 0.7918 0.7918
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0396 0.0385
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0447 0.0937 0.0937
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0376 0.0741 0.0731
Loa Loa (eye worm) phosphatidylinositol kinase 0.0251 0.0396 0.0385
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.128 0.3236 0.3228
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0251 0.0396 0.0385
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0251 0.0396 0.0385
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0725 0.1703 0.1693
Entamoeba histolytica hypothetical protein 0.0251 0.0396 0.0385
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1291 0.3266 0.3259
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0725 0.1703 0.1693
Leishmania major phosphatidylinositol kinase, putative 0.0251 0.0396 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.2032 0.531 0.531
Trichomonas vaginalis PIKK family atypical protein kinase 0.3732 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0396 0.0385
Leishmania major hypothetical protein, unknown function 0.0251 0.0396 0.0385
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0516 0.1125 0.1116
Trichomonas vaginalis PIKK family atypical protein kinase 0.2977 0.7918 0.7918
Leishmania major phosphatidylinositol kinase related protein, putative 0.0251 0.0396 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.2035 0.5318 0.5318
Trichomonas vaginalis fk506-binding protein, putative 0.0112 0.0011 0.0011
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0725 0.1703 0.1693
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0112 0.0011 0.0011
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0376 0.0741 0.0731
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0447 0.0937 0.0937
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0115 0.0021 0.001
Entamoeba histolytica hypothetical protein 0.0251 0.0396 0.0385
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0343 0.0649 0.0638
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0112 0.0011 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0272 0.0452 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.2787 0.7392 0.7392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0725 0.1703 0.1703
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0474 0.101 0.1
Echinococcus multilocularis Zinc finger, PHD finger 0.0272 0.0452 0.0442
Brugia malayi FAT domain containing protein 0.0556 0.1236 0.1226
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3732 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.128 0.3236 0.3236
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0272 0.0452 0.0442
Loa Loa (eye worm) hypothetical protein 0.0251 0.0396 0.0385
Mycobacterium leprae conserved hypothetical protein 0.0251 0.0396 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0384 0.0763 0.0763
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0396 0.0385
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1561 0.4011 0.4005
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0556 0.1236 0.1226
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0272 0.0452 0.0452
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0736 0.1733 0.1724
Trichomonas vaginalis PIKK family atypical protein kinase 0.128 0.3236 0.3236
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0396 0.0385
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0313 0.0566 0.0556
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3732 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0272 0.0452 1
Entamoeba histolytica hypothetical protein 0.0725 0.1703 0.1693
Giardia lamblia Phosphatidylinositol 4-kinase 0.0251 0.0396 0.0385
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0447 0.0937 0.0937
Loa Loa (eye worm) hypothetical protein 0.0556 0.1236 0.1226
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0251 0.0396 0.8727
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0447 0.0937 0.0927
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0178 0.0194 0.0184
Trypanosoma brucei target of rapamycin kinase 3, putative 0.298 0.7926 0.7924
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3732 1 1
Loa Loa (eye worm) hypothetical protein 0.0807 0.1929 0.192
Trichomonas vaginalis PIKK family atypical protein kinase 0.2231 0.5859 0.5859
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0396 0.0385
Toxoplasma gondii target of rapamycin (TOR), putative 0.2787 0.7392 1
Entamoeba histolytica hypothetical protein 0.0251 0.0396 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.2032 0.531 0.531
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0396 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.2787 0.7392 0.7392
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0251 0.0396 0.0385
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0272 0.0452 0.0442
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0272 0.0452 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0396 0.0396
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0272 0.0452 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.3732 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1332 0.3379 0.3372
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0272 0.0452 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0396 0.0396
Schistosoma mansoni fkbp-rapamycin associated protein 0.0725 0.1703 0.1693
Trichomonas vaginalis PIKK family atypical protein kinase 0.2787 0.7392 0.7392
Trichomonas vaginalis PIKK family atypical protein kinase 0.2787 0.7392 0.7392
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0396 0.0385
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0251 0.0396 0.0385
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0625 0.1429 0.1419
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.298 0.7926 0.7924
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0251 0.0396 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.2787 0.7392 0.7392
Trichomonas vaginalis PIKK family atypical protein kinase 0.2504 0.6611 0.6611
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0396 0.0385
Trichomonas vaginalis immunophilin, putative 0.0112 0.0011 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0725 0.1703 0.1693
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3732 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0807 0.1929 0.2191
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0112 0.0011 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0625 0.1429 0.1419
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0251 0.0396 0.0385
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0251 0.0396 0.0385
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0447 0.0937 0.0927
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0251 0.0396 0.8727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0736 0.1733 0.1733
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0251 0.0396 0.8727
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0376 0.0741 0.0731
Onchocerca volvulus 0.0251 0.0396 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0313 0.0566 0.0556
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3732 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3732 1 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.865 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.632 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.313 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.295 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.282 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.251 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.232 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.141 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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