TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 329.864 | Formula: C20H24ClNO
H donors: 0 H acceptors: 1 LogP: 4.72 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC1C(=O)C(C)C(N(C1c1ccccc1)C)c1ccccc1.Cl
InChi: 1S/C20H23NO.ClH/c1-14-18(16-10-6-4-7-11-16)21(3)19(15(2)20(14)22)17-12-8-5-9-13-17;/h4-15,18-19H,1-3H3;1H
InChiKey: PQNXBEFNFIBWMC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2329	0.5846	0.5846
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0263	0.0405	0.0405
Trichomonas vaginalis	PIKK family atypical protein kinase	0.105	0.2478	0.2478
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0283	0.0459	0.045
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0396	0.0757	0.0757
Schistosoma mansoni	voltage-gated potassium channel	0.0127	0.0048	0.0039
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1339	0.324	0.3233
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0581	0.1244	0.1236
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0116	0.002	0.0011
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0263	0.0405	0.0405
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0283	0.0459	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0787	0.1787	0.1779
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2535	0.6388	0.6388
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0495	0.1018	0.1018
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.3907	1	1
Entamoeba histolytica	protein kinase rad3, putative	0.0758	0.1709	0.1701
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0324	0.0568	0.0559
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.135	0.3269	0.3263
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0304	0.0514	0.0505
Giardia lamblia	GTOR	0.3907	1	1
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0263	0.0405	0.0396
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0283	0.0459	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0283	0.0459	0.045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3326	0.847	0.847
Trichomonas vaginalis	PIKK family atypical protein kinase	0.135	0.3269	0.3269
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0283	0.0459	0.0459
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.3907	1	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0283	0.0459	0.045
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0263	0.0405	0.0396
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0388	0.0736	0.0727
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.046	0.0924	0.0924
Loa Loa (eye worm)	phosphatidylinositol 3	0.0263	0.0405	0.0396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3116	0.7919	0.7919
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0283	0.0459	0.045
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.184	0.4559	0.4554
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0283	0.0459	0.045
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0324	0.0568	0.0568
Loa Loa (eye worm)	phosphatidylinositol 3	0.0263	0.0405	0.0396
Loa Loa (eye worm)	phosphatidylinositol 3	0.3907	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.213	0.5321	0.5321
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0528	0.1105	0.1097
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2917	0.7394	0.7394
Loa Loa (eye worm)	phosphatidylinositol 3	0.0263	0.0405	0.0396
Echinococcus granulosus	serine protein kinase ATM	0.0758	0.1709	0.1701
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0758	0.1709	0.1709
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0263	0.0405	0.8801
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0639	0.1396	0.1388
Trichomonas vaginalis	PIKK family atypical protein kinase	0.213	0.5321	0.5321
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0324	0.0568	0.0559
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0283	0.0459	0.045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3116	0.7919	0.7919
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0263	0.0405	0.8801
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0758	0.1709	0.1701
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0263	0.0405	0.0396
Loa Loa (eye worm)	phosphatidylinositol 3	0.135	0.3269	0.3263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3116	0.7919	0.7919
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0263	0.0405	0.0396
Onchocerca volvulus		0.0263	0.0405	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0758	0.1709	0.1701
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0324	0.0568	0.0559
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.046	0.0924	0.0916
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0263	0.0405	0.0396
Toxoplasma gondii	FATC domain-containing protein	0.0758	0.1709	0.1866
Schistosoma mansoni	hypothetical protein	0.0263	0.0405	0.0396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2917	0.7394	0.7394
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0263	0.0405	0.0396
Entamoeba histolytica	hypothetical protein	0.0418	0.0815	0.0806
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3907	1	1
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0283	0.0459	0.045
Trichomonas vaginalis	conserved hypothetical protein	0.0495	0.1018	0.1018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.213	0.5321	0.5321
Giardia lamblia	Hypothetical protein	0.0263	0.0405	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0758	0.1709	0.1701
Loa Loa (eye worm)	hypothetical protein	0.0495	0.1018	0.101
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0418	0.0815	0.0806
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2126	0.5312	0.5312
Schistosoma mansoni	voltage-gated potassium channel	0.0127	0.0048	0.0039
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0112	0.0009	0.0009
Plasmodium vivax	hypothetical protein, conserved	0.0263	0.0405	0.8801
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2329	0.5846	0.5846
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0263	0.0405	0.0396
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0324	0.0568	0.0559
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.046	0.0924	0.0916
Trypanosoma cruzi	target of rapamycin kinase 3	0.312	0.7927	0.7925
Schistosoma mansoni	hypothetical protein	0.0581	0.1244	0.1236
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0283	0.0459	0.045
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0283	0.0459	0.0459
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2336	0.5863	0.5863
Loa Loa (eye worm)	phosphatidylinositol 3	0.0597	0.1287	0.1278
Trichomonas vaginalis	conserved hypothetical protein	0.0844	0.1935	0.1935
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0197	0.0233	0.0224
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.3907	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0116	0.002	0.0011
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0347	0.0627	0.0618
Echinococcus multilocularis		0.0263	0.0405	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0388	0.0736	0.0727
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.3907	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0324	0.0568	0.0568
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0324	0.0568	0.0568
Echinococcus multilocularis	serine protein kinase ATM	0.0758	0.1709	0.1701
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1339	0.324	0.324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2336	0.5863	0.5863
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1391	0.3377	0.3371
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0116	0.002	0.0011
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1391	0.3377	0.3371
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0758	0.1709	0.1701
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1391	0.3377	0.3371
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0263	0.0405	0.0396
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0263	0.0405	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3116	0.7919	0.7919
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0758	0.1709	0.1701
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.3907	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1339	0.324	0.324
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1391	0.3377	0.3371
Trichomonas vaginalis	conserved hypothetical protein	0.0581	0.1244	0.1244
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0283	0.0459	0.045
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1391	0.3377	0.3371
Plasmodium vivax	hypothetical protein	0.0263	0.0405	0.8801
Leishmania major	hypothetical protein, conserved	0.0357	0.0653	0.0644
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2917	0.7394	0.7394
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0263	0.0405	0.0396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2126	0.5312	0.5312
Entamoeba histolytica	hypothetical protein	0.0263	0.0405	0.0396
Toxoplasma gondii	target of rapamycin (TOR), putative	0.2917	0.7394	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2336	0.5863	0.5863
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0263	0.0405	0.0396
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0758	0.1709	0.1701
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0263	0.0405	0.0405
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2917	0.7394	0.7394
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1391	0.3377	0.3371
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0283	0.0459	0.045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3907	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0263	0.0405	0.0405
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0283	0.0459	0.045
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0283	0.0459	0.045
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0283	0.0459	0.0077
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0263	0.0405	0.0396
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0179	0.0185	0.0176
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.046	0.0924	0.0916
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0263	0.0405	0.8801
Loa Loa (eye worm)	hypothetical protein	0.0581	0.1244	0.1236
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0263	0.0405	0.0396
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.046	0.0924	0.0924
Entamoeba histolytica	hypothetical protein	0.0758	0.1709	0.1701
Loa Loa (eye worm)	hypothetical protein	0.0844	0.1935	0.1928
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.3907	1	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.312	0.7927	0.7925
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0769	0.1739	0.1739
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.046	0.0924	0.0916
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0263	0.0405	0.8801
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0263	0.0405	0.0396
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0263	0.0405	0.0396
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0639	0.1396	0.1388
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0844	0.1935	0.219
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0112	0.0009	0.5
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.3907	1	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.3907	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.3907	1	1
Onchocerca volvulus		0.0263	0.0405	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0324	0.0568	0.0559
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0388	0.0736	0.0727
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0263	0.0405	0.8801
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0263	0.0405	0.0396
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0263	0.0405	0.0396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2917	0.7394	0.7394
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0758	0.1709	0.1701
Trichomonas vaginalis	immunophilin, putative	0.0112	0.0009	0.0009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2917	0.7394	0.7394
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2621	0.6615	0.6615
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0263	0.0405	0.0396
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0263	0.0405	0.0396
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0639	0.1396	0.1388
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.312	0.7927	0.7925
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0355	0.0647	0.0639
Entamoeba histolytica	hypothetical protein	0.0263	0.0405	0.0396
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0116	0.002	0.0011
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.046	0.0924	0.0924
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0388	0.0736	0.0727
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0112	0.0009	0.0009
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0758	0.1709	0.1701
Echinococcus multilocularis	Zinc finger, PHD finger	0.0283	0.0459	0.045
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0495	0.1018	0.101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2917	0.7394	0.7394
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0758	0.1709	0.1709
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0283	0.0459	0.045
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0112	0.0009	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0758	0.1709	0.1701
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.135	0.3269	0.3263
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0758	0.1709	0.1701
Entamoeba histolytica	hypothetical protein	0.0263	0.0405	0.0396
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0263	0.0405	0.0396
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0263	0.0405	0.0396
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1339	0.324	0.3233
Trichomonas vaginalis	fk506-binding protein, putative	0.0112	0.0009	0.0009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3116	0.7919	0.7919
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0263	0.0405	0.0396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.213	0.5321	0.5321
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0528	0.1105	0.1097
Leishmania major	hypothetical protein, unknown function	0.0263	0.0405	0.0396
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0263	0.0405	0.0396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3907	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2126	0.5312	0.5312
Leishmania major	phosphatidylinositol kinase, putative	0.0263	0.0405	0.0396
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0769	0.1739	0.1731
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1339	0.324	0.324
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0283	0.0459	0.0459
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0581	0.1244	0.1236
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0396	0.0757	0.0757
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0263	0.0405	0.0396
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1634	0.4017	0.4011
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0283	0.0459	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.3907	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0263	0.0405	0.0396
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0324	0.0568	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0263	0.0405	0.0396
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0283	0.0459	0.045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1339	0.324	0.324
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.3907	1	1
Brugia malayi	FAT domain containing protein	0.0581	0.1244	0.1236
Mycobacterium leprae	conserved hypothetical protein	0.0263	0.0405	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4.4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2006061

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1647152