TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 454.582 | Formula: C25H30N2O4S
H donors: 1 H acceptors: 4 LogP: 4.67 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCc1ccc(cc1)S(=O)(=O)NC(=O)C1(C)CCN1C(=O)C/C=C/c1ccccc1
InChi: 1S/C25H30N2O4S/c1-3-4-9-21-14-16-22(17-15-21)32(30,31)26-24(29)25(2)18-19-27(25)23(28)13-8-12-20-10-6-5-7-11-20/h5-8,10-12,14-17H,3-4,9,13,18-19H2,1-2H3,(H,26,29)/b12-8+
InChiKey: REVLOZJLMGHQBK-XYOKQWHBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	synuclein, alpha (non A4 component of amyloid precursor)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2774	0.7392	0.7392
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.025	0.0396	0.0386
Entamoeba histolytica	hypothetical protein	0.025	0.0396	0.0386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2022	0.531	0.531
Toxoplasma gondii	target of rapamycin (TOR), putative	0.2774	0.7392	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.025	0.0396	0.0386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2221	0.5859	0.5859
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2774	0.7392	0.7392
Trichomonas vaginalis	PIKK family atypical protein kinase	0.025	0.0396	0.0396
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0721	0.1703	0.1694
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.027	0.0452	0.0442
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1326	0.3379	0.3372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3714	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.025	0.0396	0.0396
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.027	0.0452	0.0442
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.027	0.0452	0.0442
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.027	0.0452	0.008
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.025	0.0396	0.0386
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0177	0.0194	0.0183
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0445	0.0937	0.0927
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.025	0.0396	0.8729
Loa Loa (eye worm)	hypothetical protein	0.0553	0.1236	0.1227
Giardia lamblia	Phosphatidylinositol 4-kinase	0.025	0.0396	0.0386
Entamoeba histolytica	hypothetical protein	0.0721	0.1703	0.1694
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0445	0.0937	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1929	0.192
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.3714	1	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.2966	0.7926	0.7924
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0732	0.1733	0.1733
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.025	0.0396	0.8729
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0445	0.0937	0.0927
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.025	0.0396	0.0386
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.025	0.0396	0.0386
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0622	0.1428	0.1419
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0803	0.1929	0.2191
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0111	0.0011	0.5
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.3714	1	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.3714	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.3714	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0311	0.0566	0.0556
Onchocerca volvulus		0.025	0.0396	0.5
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0374	0.0741	0.0731
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.025	0.0396	0.8729
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.025	0.0396	0.0386
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.025	0.0396	0.0386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2774	0.7392	0.7392
Trichomonas vaginalis	immunophilin, putative	0.0111	0.0011	0.0011
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0721	0.1703	0.1694
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2492	0.6611	0.6611
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2774	0.7392	0.7392
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.025	0.0396	0.0386
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.025	0.0396	0.0386
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0622	0.1428	0.1419
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.2966	0.7926	0.7924
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0341	0.0649	0.0638
Entamoeba histolytica	hypothetical protein	0.025	0.0396	0.0386
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0445	0.0937	0.0937
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0115	0.0021	0.001
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0374	0.0741	0.0731
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0111	0.0011	0.0011
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0721	0.1703	0.1694
Echinococcus multilocularis	Zinc finger, PHD finger	0.027	0.0452	0.0442
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0471	0.101	0.1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0721	0.1703	0.1703
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2774	0.7392	0.7392
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.027	0.0452	0.0442
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0111	0.0011	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0721	0.1703	0.1694
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1285	0.3266	0.3259
Entamoeba histolytica	hypothetical protein	0.025	0.0396	0.0386
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0721	0.1703	0.1694
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.025	0.0396	0.0386
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.025	0.0396	0.0386
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1274	0.3236	0.3228
Trichomonas vaginalis	fk506-binding protein, putative	0.0111	0.0011	0.0011
Leishmania major	phosphatidylinositol kinase related protein, putative	0.025	0.0396	0.0386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2025	0.5318	0.5318
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2963	0.7918	0.7918
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0513	0.1125	0.1115
Leishmania major	hypothetical protein, unknown function	0.025	0.0396	0.0386
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.025	0.0396	0.0386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3714	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2022	0.531	0.531
Leishmania major	phosphatidylinositol kinase, putative	0.025	0.0396	0.0386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1274	0.3236	0.3236
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0732	0.1733	0.1724
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.027	0.0452	0.0452
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0553	0.1236	0.1227
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0382	0.0763	0.0763
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.025	0.0396	0.0386
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1554	0.4012	0.4005
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.027	0.0452	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.3714	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.025	0.0396	0.0386
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0311	0.0566	0.0556
Loa Loa (eye worm)	hypothetical protein	0.025	0.0396	0.0386
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.027	0.0452	0.0442
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1274	0.3236	0.3236
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.3714	1	1
Brugia malayi	FAT domain containing protein	0.0553	0.1236	0.1227
Mycobacterium leprae	conserved hypothetical protein	0.025	0.0396	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2215	0.5844	0.5844
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.025	0.0396	0.0396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0998	0.247	0.247
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.027	0.0452	0.0442
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0382	0.0763	0.0763
Schistosoma mansoni	voltage-gated potassium channel	0.0125	0.005	0.0039
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1274	0.3236	0.3228
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0553	0.1236	0.1227
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.025	0.0396	0.0396
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.027	0.0452	0.008
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0115	0.0021	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0471	0.101	0.101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.241	0.6385	0.6385
Loa Loa (eye worm)	hypothetical protein	0.0748	0.1777	0.1768
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.3714	1	1
Entamoeba histolytica	protein kinase rad3, putative	0.0721	0.1703	0.1694
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1285	0.3266	0.3259
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0311	0.0566	0.0556
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0291	0.051	0.05
Giardia lamblia	GTOR	0.3714	1	1
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.025	0.0396	0.0386
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.027	0.0452	0.0442
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.027	0.0452	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3161	0.8467	0.8467
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1285	0.3266	0.3266
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.027	0.0452	0.0452
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.3714	1	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.027	0.0452	0.0442
Loa Loa (eye worm)	phosphatidylinositol kinase	0.025	0.0396	0.0386
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0374	0.0741	0.0731
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0445	0.0937	0.0937
Loa Loa (eye worm)	phosphatidylinositol 3	0.025	0.0396	0.0386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2963	0.7918	0.7918
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.027	0.0452	0.0442
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.1749	0.4553	0.4547
Leishmania major	phosphatidylinositol 3-kinase, putative	0.027	0.0452	0.0442
Loa Loa (eye worm)	phosphatidylinositol 3	0.3714	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0311	0.0566	0.0566
Loa Loa (eye worm)	phosphatidylinositol 3	0.025	0.0396	0.0386
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0513	0.1125	0.1115
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2025	0.5318	0.5318
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2774	0.7392	0.7392
Loa Loa (eye worm)	phosphatidylinositol 3	0.025	0.0396	0.0386
Echinococcus granulosus	serine protein kinase ATM	0.0721	0.1703	0.1694
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0721	0.1703	0.1703
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.025	0.0396	0.8729
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0311	0.0566	0.0556
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.027	0.0452	0.0442
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2025	0.5318	0.5318
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2963	0.7918	0.7918
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0622	0.1428	0.1419
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.025	0.0396	0.8729
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0721	0.1703	0.1694
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.025	0.0396	0.0386
Loa Loa (eye worm)	phosphatidylinositol 3	0.1285	0.3266	0.3259
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2963	0.7918	0.7918
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.025	0.0396	0.0386
Onchocerca volvulus		0.025	0.0396	0.5
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0311	0.0566	0.0556
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0721	0.1703	0.1694
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0445	0.0937	0.0927
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.025	0.0396	0.0386
Toxoplasma gondii	FATC domain-containing protein	0.0721	0.1703	0.1868
Schistosoma mansoni	hypothetical protein	0.025	0.0396	0.0386
Entamoeba histolytica	hypothetical protein	0.0404	0.0823	0.0813
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2774	0.7392	0.7392
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.025	0.0396	0.0386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3714	1	1
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.027	0.0452	0.0442
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2025	0.5318	0.5318
Trichomonas vaginalis	conserved hypothetical protein	0.0471	0.101	0.101
Giardia lamblia	Hypothetical protein	0.025	0.0396	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0721	0.1703	0.1694
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0404	0.0823	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0471	0.101	0.1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2022	0.531	0.531
Schistosoma mansoni	voltage-gated potassium channel	0.0125	0.005	0.0039
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0111	0.0011	0.0011
Plasmodium vivax	hypothetical protein, conserved	0.025	0.0396	0.8729
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.025	0.0396	0.0386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2215	0.5844	0.5844
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0311	0.0566	0.0556
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0445	0.0937	0.0927
Trypanosoma cruzi	target of rapamycin kinase 3	0.2966	0.7926	0.7924
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.027	0.0452	0.0442
Schistosoma mansoni	hypothetical protein	0.0553	0.1236	0.1227
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.027	0.0452	0.0452
Loa Loa (eye worm)	phosphatidylinositol 3	0.0581	0.1314	0.1305
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2221	0.5859	0.5859
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1929	0.1929
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.3714	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0195	0.0244	0.0233
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0115	0.0021	0.001
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0333	0.0627	0.0617
Echinococcus multilocularis		0.025	0.0396	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0374	0.0741	0.0731
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.3714	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0311	0.0566	0.0566
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0311	0.0566	0.0566
Echinococcus multilocularis	serine protein kinase ATM	0.0721	0.1703	0.1694
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1274	0.3236	0.3236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2221	0.5859	0.5859
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1326	0.3379	0.3372
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0115	0.0021	0.001
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1326	0.3379	0.3372
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0721	0.1703	0.1694
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1326	0.3379	0.3372
Leishmania major	phosphatidylinositol 4-kinase, putative	0.025	0.0396	0.0386
Mycobacterium tuberculosis	Conserved hypothetical protein	0.025	0.0396	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2963	0.7918	0.7918
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0721	0.1703	0.1694
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.3714	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1274	0.3236	0.3236
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1326	0.3379	0.3372
Trichomonas vaginalis	conserved hypothetical protein	0.0553	0.1236	0.1236
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.027	0.0452	0.0442
Plasmodium vivax	hypothetical protein	0.025	0.0396	0.8729
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1326	0.3379	0.3372
Leishmania major	hypothetical protein, conserved	0.0343	0.0655	0.0644

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2001078

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1647154