Detailed information for compound 1647158

Basic information

Technical information
  • TDR Targets ID: 1647158
  • Name: 2-amino-N,N'-bis[18-hydroxy-7,11,14-trimethyl -2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8- oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan -6-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dica rboxamide
  • MW: 1287.42 | Formula: C62H86N12O18
  • H donors: 7 H acceptors: 15 LogP: 1.81 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC1CN2C(C1)C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC(C(C(=O)NC(C2=O)C(C)C)NC(=O)c1ccc(c2c1nc1c(o2)c(C)c(=O)c(c1C(=O)NC1C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C(=O)C2N(C(=O)C(NC1=O)C(C)C)CC(C2)O)C)N)C)C
  • InChi: 1S/C62H86N12O18/c1-25(2)42-59(86)73-21-33(75)19-36(73)57(84)69(13)23-38(77)71(15)48(27(5)6)61(88)90-31(11)44(55(82)65-42)67-53(80)35-18-17-29(9)51-46(35)64-47-40(41(63)50(79)30(10)52(47)92-51)54(81)68-45-32(12)91-62(89)49(28(7)8)72(16)39(78)24-70(14)58(85)37-20-34(76)22-74(37)60(87)43(26(3)4)66-56(45)83/h17-18,25-28,31-34,36-37,42-45,48-49,75-76H,19-24,63H2,1-16H3,(H,65,82)(H,66,83)(H,67,80)(H,68,81)
  • InChiKey: QCMODBTXTMOEPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-N,N'-bis(18-hydroxy-3,10-diisopropyl-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl)-4,6-dimethyl-3-oxo-phenoxazine-1,9-dicarboxamide
  • 2-amino-N,N'-bis(18-hydroxy-3,10-diisopropyl-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl)-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboxamide
  • 2-amino-N,N'-bis(18-hydroxy-3,10-diisopropyl-2,5,9,12,15-pentaketo-7,11,14-trimethyl-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl)-3-keto-4,6-dimethyl-phenoxazine-1,9-dicarboxamide
  • 2-amino-N,N'-bis[18-hydroxy-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-4,6-dimethyl-3-oxo-phenoxazine-1,9-dicarboxamide
  • NCI60_030537
  • NSC684904

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0335 0.0487 0.0479
Loa Loa (eye worm) hypothetical protein 0.0698 0.1277 0.127
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0335 0.0487 0.0487
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0698 0.1277 0.127
Trichomonas vaginalis PIKK family atypical protein kinase 0.2812 0.588 0.588
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0517 0.0883 0.0875
Trypanosoma cruzi target of rapamycin kinase 3 0.3755 0.7932 0.7931
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0008 0.0008
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0314 0.0441 0.0433
Plasmodium vivax hypothetical protein, conserved 0.0314 0.0441 0.9042
Trichomonas vaginalis PIKK family atypical protein kinase 0.2801 0.5856 0.5856
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0378 0.058 0.0572
Loa Loa (eye worm) hypothetical protein 0.0595 0.1052 0.1045
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0475 0.079 0.0782
Trichomonas vaginalis PIKK family atypical protein kinase 0.2557 0.5324 0.5324
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0041 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.2561 0.5333 0.5333
Giardia lamblia Hypothetical protein 0.0314 0.0441 0.0433
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0588 0.1036 0.1029
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0909 0.1736 0.173
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0314 0.0441 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.351 0.74 0.74
Entamoeba histolytica hypothetical protein 0.0475 0.079 0.0782
Trichomonas vaginalis PIKK family atypical protein kinase 0.4704 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0335 0.0487 0.0479
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0314 0.0441 0.0433
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0909 0.1736 0.173
Schistosoma mansoni hypothetical protein 0.0314 0.0441 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.3751 0.7924 0.7924
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.0441 0.0433
Onchocerca volvulus 0.0314 0.0441 0.5
Echinococcus multilocularis serine protein kinase ATM 0.0909 0.1736 0.173
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0378 0.058 0.0572
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0517 0.0883 0.0875
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0335 0.0487 0.0479
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1661 0.3374 0.3368
Leishmania major hypothetical protein, conserved 0.0411 0.0652 0.0644
Plasmodium vivax hypothetical protein 0.0314 0.0441 0.9042
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1661 0.3374 0.3368
Schistosoma mansoni hypothetical protein 0.0698 0.1277 0.127
Mycobacterium tuberculosis Conserved hypothetical protein 0.0314 0.0441 0.5
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0909 0.1736 0.173
Trichomonas vaginalis PIKK family atypical protein kinase 0.3751 0.7924 0.7924
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4704 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1607 0.3257 0.3257
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0909 0.1736 0.173
Leishmania major phosphatidylinositol 4-kinase, putative 0.0314 0.0441 0.0433
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1661 0.3374 0.3368
Trichomonas vaginalis PIKK family atypical protein kinase 0.2812 0.588 0.588
Trichomonas vaginalis PIKK family atypical protein kinase 0.1607 0.3257 0.3257
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1661 0.3374 0.3368
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.012 0.0017 0.0009
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1661 0.3374 0.3368
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4704 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0378 0.058 0.058
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0378 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0909 0.1736 0.173
Echinococcus granulosus potassium voltage gated channel subfamily H 0.012 0.0017 0.0009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0401 0.0629 0.0622
Echinococcus multilocularis 0.0314 0.0441 0.0433
Loa Loa (eye worm) hypothetical protein 0.0444 0.0722 0.0715
Trichomonas vaginalis conserved hypothetical protein 0.1012 0.1961 0.1961
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0203 0.0199 0.0191
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4704 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0357 0.0534 0.0526
Giardia lamblia GTOR 0.4704 1 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1619 0.3282 0.3276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.058 0.0572
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4704 1 1
Entamoeba histolytica protein kinase rad3, putative 0.0909 0.1736 0.173
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0698 0.1277 0.127
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0314 0.0441 0.0441
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.012 0.0017 0.0009
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0335 0.0487 0.0066
Loa Loa (eye worm) hypothetical protein 0.0949 0.1824 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.3053 0.6404 0.6404
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0595 0.1052 0.1045
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0452 0.074 0.074
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0041 0.0033
Leishmania major phosphatidylinositol 3-kinase, putative 0.1607 0.3257 0.3251
Trichomonas vaginalis PIKK family atypical protein kinase 0.2801 0.5856 0.5856
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0314 0.0441 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.1264 0.2508 0.2508
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0335 0.0487 0.0479
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0909 0.1736 0.173
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0314 0.0441 0.0433
Loa Loa (eye worm) phosphatidylinositol 3 0.1619 0.3282 0.3276
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0378 0.058 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.2561 0.5333 0.5333
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0701 0.1284 0.1277
Trichomonas vaginalis PIKK family atypical protein kinase 0.3751 0.7924 0.7924
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0335 0.0487 0.0479
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0314 0.0441 0.9042
Echinococcus granulosus serine protein kinase ATM 0.0909 0.1736 0.173
Loa Loa (eye worm) phosphatidylinositol 3 0.0314 0.0441 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0909 0.1736 0.1736
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0314 0.0441 0.9042
Leishmania major phosphatidylinositol 3-kinase, putative 0.0335 0.0487 0.0479
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0378 0.058 0.058
Loa Loa (eye worm) phosphatidylinositol 3 0.0314 0.0441 0.0433
Loa Loa (eye worm) phosphatidylinositol 3 0.4704 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.351 0.74 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.1052 0.1052
Trichomonas vaginalis PIKK family atypical protein kinase 0.2561 0.5333 0.5333
Trichomonas vaginalis PIKK family atypical protein kinase 0.3751 0.7924 0.7924
Loa Loa (eye worm) phosphatidylinositol 3 0.0314 0.0441 0.0433
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0335 0.0487 0.0479
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2217 0.4584 0.458
Loa Loa (eye worm) phosphatidylinositol kinase 0.0314 0.0441 0.0433
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0444 0.0722 0.0715
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0517 0.0883 0.0883
Trichomonas vaginalis PIKK family atypical protein kinase 0.1619 0.3282 0.3282
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0335 0.0487 0.0487
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0335 0.0487 0.0479
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4704 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0314 0.0441 0.0433
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0335 0.0487 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0335 0.0487 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.4006 0.848 0.848
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0314 0.0441 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.4704 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2557 0.5324 0.5324
Leishmania major phosphatidylinositol kinase, putative 0.0314 0.0441 0.0433
Trichomonas vaginalis fk506-binding protein, putative 0.0116 0.0008 0.0008
Leishmania major phosphatidylinositol kinase related protein, putative 0.0314 0.0441 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.3751 0.7924 0.7924
Trichomonas vaginalis PIKK family atypical protein kinase 0.2561 0.5333 0.5333
Trichomonas vaginalis conserved hypothetical protein 0.0595 0.1052 0.1052
Leishmania major hypothetical protein, unknown function 0.0314 0.0441 0.0433
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0314 0.0441 0.0433
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1607 0.3257 0.3251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0909 0.1736 0.1736
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1619 0.3282 0.3276
Entamoeba histolytica hypothetical protein 0.0314 0.0441 0.0433
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0909 0.1736 0.173
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0314 0.0441 0.0433
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0909 0.1736 0.173
Trichomonas vaginalis PIKK family atypical protein kinase 0.351 0.74 0.74
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0335 0.0487 0.0479
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0116 0.0008 0.5
Echinococcus multilocularis Zinc finger, PHD finger 0.0335 0.0487 0.0479
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0588 0.1036 0.1029
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0909 0.1736 0.173
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0409 0.0647 0.064
Entamoeba histolytica hypothetical protein 0.0314 0.0441 0.0433
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.012 0.0017 0.0009
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0517 0.0883 0.0883
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0444 0.0722 0.0715
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0008 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0314 0.0441 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0659 0.1191 0.1184
Loa Loa (eye worm) hypothetical protein 0.0314 0.0441 0.0433
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0335 0.0487 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.1607 0.3257 0.3257
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4704 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0378 0.058 0.0572
Loa Loa (eye worm) phosphatidylinositol 3 0.0314 0.0441 0.0433
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0335 0.0487 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4704 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.0441 0.0433
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0452 0.074 0.074
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1966 0.4037 0.4032
Trichomonas vaginalis PIKK family atypical protein kinase 0.1607 0.3257 0.3257
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0921 0.1761 0.1755
Trichomonas vaginalis conserved hypothetical protein 0.0698 0.1277 0.1277
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0335 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.1012 0.1961 0.1955
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4704 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3755 0.7932 0.7931
Brugia malayi FAT domain containing protein 0.0698 0.1277 0.127
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0314 0.0441 0.9042
Giardia lamblia Phosphatidylinositol 4-kinase 0.0314 0.0441 0.0433
Entamoeba histolytica hypothetical protein 0.0909 0.1736 0.173
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0517 0.0883 0.0883
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0184 0.0158 0.015
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0517 0.0883 0.0875
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0335 0.0487 0.0066
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0335 0.0487 0.0479
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0314 0.0441 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0441 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.351 0.74 0.74
Toxoplasma gondii FATC domain-containing protein 0.0909 0.1736 0.1862
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1661 0.3374 0.3368
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0335 0.0487 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.4704 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0441 0.0441
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0335 0.0487 0.0479
Entamoeba histolytica hypothetical protein 0.0314 0.0441 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.2557 0.5324 0.5324
Toxoplasma gondii target of rapamycin (TOR), putative 0.351 0.74 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0314 0.0441 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.2812 0.588 0.588
Trichomonas vaginalis PIKK family atypical protein kinase 0.351 0.74 0.74
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.0441 0.0433
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0314 0.0441 0.0433
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0701 0.1284 0.1277
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3755 0.7932 0.7931
Schistosoma mansoni fkbp-rapamycin associated protein 0.0909 0.1736 0.173
Trichomonas vaginalis immunophilin, putative 0.0116 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.351 0.74 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.3156 0.6628 0.6628
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0314 0.0441 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.351 0.74 0.74
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0314 0.0441 0.0433
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0314 0.0441 0.0433
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0378 0.058 0.0572
Onchocerca volvulus 0.0314 0.0441 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0444 0.0722 0.0715
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0314 0.0441 0.9042
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4704 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4704 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0314 0.0441 0.0433
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0701 0.1284 0.1277
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0116 0.0008 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1012 0.1961 0.2184
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4704 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0921 0.1761 0.1761
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0517 0.0883 0.0875
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0314 0.0441 0.9042
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0314 0.0441 0.0433

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.