Detailed information for compound 1679045

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.437 | Formula: C20H25FN4O2
  • H donors: 1 H acceptors: 3 LogP: 2.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1ccc(cc1)F
  • InChi: 1S/C20H25FN4O2/c21-15-5-7-16(8-6-15)24-11-13-25(14-12-24)20(27)18-4-2-1-3-17(18)19(26)23-10-9-22/h5-8,17-18H,1-4,10-14H2,(H,23,26)/t17-,18-/m1/s1
  • InChiKey: ZKSDUCXACMZPEQ-QZTJIDSGSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.2223 0.2223
Loa Loa (eye worm) ctsf protein 0.0086 0.0489 0.0552
Brugia malayi hypothetical protein 0.0178 0.2181 0.2181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0489 0.2241
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0178 0.2181 0.981
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0489 0.2198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Echinococcus multilocularis cysteine protease 0.0086 0.0489 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.0489 0.0552
Echinococcus granulosus cathepsin b 0.0181 0.2223 0.2223
Leishmania major cathepsin L-like protease 0.0086 0.0489 0.1998
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.0193 0.0597
Loa Loa (eye worm) cathepsin B 0.007 0.0193 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Onchocerca volvulus 0.0086 0.0489 0.0489
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.0489 1
Echinococcus multilocularis cathepsin b 0.0181 0.2223 0.2172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Onchocerca volvulus 0.0063 0.0066 0.0066
Brugia malayi Cathepsin L-like precursor 0.0086 0.0489 0.0489
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0489 0.2198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0489 0.2241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0063 0.0066 0.0298
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.0193 0.0866
Loa Loa (eye worm) aminopeptidase N 0.0178 0.2181 0.2464
Onchocerca volvulus 0.0086 0.0489 0.0489
Giardia lamblia Cathepsin B precursor 0.007 0.0193 0.5
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.0489 0.0489
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0178 0.2181 0.2129
Brugia malayi Cathepsin L-like precursor 0.0086 0.0489 0.0489
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.0489 1
Leishmania major cathepsin L-like protease 0.0086 0.0489 0.1998
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0489 0.2241
Loa Loa (eye worm) hypothetical protein 0.0063 0.0066 0.0075
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0178 0.2181 0.2129
Loa Loa (eye worm) fibroinase 0.0086 0.0489 0.0552
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0489 0.2241
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2223 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.0193 0.0597
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2223 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0489 0.2198
Brugia malayi Cathepsin L-like precursor 0.0086 0.0489 0.0489
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.2223 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0489 0.2241
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.0489 0.0425
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.1034 0.0975
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0178 0.2181 0.2129
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0193 0.0866
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.0489 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Brugia malayi Cathepsin L-like precursor 0.0086 0.0489 0.0489
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Onchocerca volvulus 0.0086 0.0489 0.0489
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0178 0.2181 0.2129
Leishmania major cathepsin L-like protease 0.0086 0.0489 0.1998
Onchocerca volvulus 0.0086 0.0489 0.0489
Loa Loa (eye worm) cysteine protease 0.0086 0.0489 0.0552
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0063 0.0066 0.0298
Toxoplasma gondii cathepsin B 0.007 0.0193 0.299
Schistosoma mansoni aminopeptidase A (M01 family) 0.0063 0.0066 0.0298
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0063 0.0066 0.0298
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0178 0.2181 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.0489 0.0552
Onchocerca volvulus 0.0086 0.0489 0.0489
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0489 0.2198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Echinococcus multilocularis cysteine protease 0.0086 0.0489 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Loa Loa (eye worm) TATA binding protein associated factor 0.0063 0.0066 0.0075
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.0489 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0193 0.0883
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.0489 0.0489
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0178 0.2181 0.2181
Brugia malayi TATA binding protein associated factor 0.0063 0.0066 0.0066
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.0489 0.2198
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0116 0.1034 0.4652
Plasmodium vivax vivapain-2 0.0086 0.0489 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.2223 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.0489 1
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0489 0.0489
Onchocerca volvulus 0.0086 0.0489 0.0489
Toxoplasma gondii cathepsin CPL 0.0086 0.0489 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0063 0.0066 0.0298
Trypanosoma cruzi Aminopeptidase M1, putative 0.0178 0.2181 0.981
Brugia malayi Cathepsin L-like precursor 0.0086 0.0489 0.0489
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0178 0.2181 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0489 0.2198
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.0489 0.0425
Leishmania major cathepsin L-like protease 0.0086 0.0489 0.1998
Onchocerca volvulus Cathepsin F homolog 0.0086 0.0489 0.0489
Onchocerca volvulus 0.0086 0.0489 0.0489
Trypanosoma cruzi aminopeptidase, putative 0.0178 0.2181 0.981
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0116 0.1034 0.4652
Leishmania major cathepsin L-like protease 0.0086 0.0489 0.1998
Onchocerca volvulus 0.0178 0.2181 0.2181
Loa Loa (eye worm) hypothetical protein 0.0116 0.1034 0.1168
Loa Loa (eye worm) hypothetical protein 0.0063 0.0066 0.0075
Mycobacterium ulcerans aminopeptidase N PepN 0.0178 0.2181 1
Giardia lamblia Cathepsin B precursor 0.007 0.0193 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0489 0.2241
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0178 0.2181 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.0489 0.2241
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0178 0.2181 0.2181
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0178 0.2181 1
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0489 0.2198
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0178 0.2181 0.981
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0489 0.2241
Loa Loa (eye worm) hypothetical protein 0.0063 0.0066 0.0075
Onchocerca volvulus 0.0606 1 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0063 0.0066 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Echinococcus granulosus cathepsin l1 0.0086 0.0489 0.0489
Entamoeba histolytica cysteine protease, putative 0.0086 0.0489 0.2241
Loa Loa (eye worm) hypothetical protein 0.0428 0.6738 0.7611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0489 0.2241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0489 0.2241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0489 0.2241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.0489 0.2241
Loa Loa (eye worm) hypothetical protein 0.0086 0.0489 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0063 0.0066 0.0298
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0063 0.0066 0.0304
Trypanosoma brucei Aminopeptidase M1, putative 0.0178 0.2181 1
Brugia malayi hypothetical protein 0.0063 0.0066 0.0066
Leishmania major cathepsin L-like protease 0.0086 0.0489 0.1998
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0116 0.1034 0.1168
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0489 0.0489
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0063 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0178 0.2181 0.2181
Brugia malayi Peptidase family M1 containing protein 0.0178 0.2181 0.2181
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0063 0.0066 0.0298
Plasmodium vivax vivapain-2 0.0086 0.0489 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0178 0.2181 0.981
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2223 1
Leishmania major cysteine peptidase A (CPA) 0.0086 0.0489 0.1998
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0178 0.2181 0.2129
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0178 0.2181 0.2129
Loa Loa (eye worm) peptidase family M1 containing protein 0.0491 0.7885 0.8906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Echinococcus multilocularis aminopeptidase N 0.0606 1 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0178 0.2181 0.2181
Trypanosoma brucei Aminopeptidase M1, putative 0.0178 0.2181 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Entamoeba histolytica aminopeptidase, putative 0.0178 0.2181 1
Echinococcus granulosus leukotriene A 4 hydrolase 0.0063 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0178 0.2181 1
Brugia malayi Peptidase family M1 containing protein 0.0063 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0489 0.2241
Leishmania major cathepsin L-like protease 0.0086 0.0489 0.1998
Giardia lamblia Cathepsin B precursor 0.007 0.0193 0.5
Loa Loa (eye worm) hypothetical protein 0.0181 0.2223 0.2511
Echinococcus granulosus aminopeptidase N 0.0606 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0489 0.2241
Loa Loa (eye worm) hypothetical protein 0.0543 0.8853 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0063 0.0066 0.0075
Echinococcus multilocularis cathepsin b 0.0181 0.2223 0.2172
Trypanosoma cruzi aminopeptidase, putative 0.0063 0.0066 0.0298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0489 0.1998
Brugia malayi Cathepsin L-like precursor 0.0086 0.0489 0.0489
Echinococcus granulosus cathepsin b 0.0181 0.2223 0.2223
Leishmania major cathepsin L-like protease 0.0086 0.0489 0.1998

Activities

Activity type Activity value Assay description Source Reference
Fu (ADMET) = 39 % Fraction unbound in human plasma ChEMBL. 22984809
IC50 (binding) = 0.023 uM Inhibition of human recombinant cathepsin-k using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay ChEMBL. 22984809
IC50 (binding) = 0.315 uM Inhibition of human recombinant cathepsin-B using Z-Arg-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay ChEMBL. 22984809
IC50 (binding) = 1.68 uM Inhibition of human recombinant cathepsin-S using Z-Val-Val-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay ChEMBL. 22984809
IC50 (binding) > 10 uM Inhibition of human recombinant cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay ChEMBL. 22984809

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.